The 'petite-negative' yeast Kluyveromyces lactis has a single gene expressing pyruvate decarboxylase activity

Molecular Microbiology

Volumn 19, Issue 1, 1996, Pages 27-36

  Bianchi, Michele M ^a   Tizzani, Lorenza ^a   Destruelle, Monika ^a   Frontali, Laura ^a   Wésolowski Louvel, Micheline ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; GLUCOSE; PYRUVATE DECARBOXYLASE;

AMINO ACID SEQUENCE; ARTICLE; GENE ACTIVATION; GENETIC TRANSCRIPTION; KLUYVEROMYCES; MOLECULAR CLONING; MUTANT; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

KLUYVEROMYCES LACTIS;

EID: 0030049641     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1996.346875.x     Document Type: Article

References (58)

1. Algeri, A.A., Marmiroli, N., Viola, A.M., and Puglisi, P.P. (1977) Dependence of cytoplasmic on mitochondrial protein synthesis in K. lactis CBS2360. II. Genetic studies. Mol Gen Genet 150: 141-145.
2. Bisson, L.F., Coons, D.M., Kruckeberg, A.L., and Lewis, D.A. (1993) Yeast sugar transporters. Crit Rev Biochem Mol Biol 28: 259-308.
3. Boles, E., and Zimmermann F.K. (1993) Induction of pyruvate decarboxylase in glycolysis mutants of Saccharomyces cereviasiae correlates with the concentrations of three-carbon glycolytic metabolites. Arch Microbiol 160: 324-328.
4. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein. Anal Biochem 72: 248-254.
5. Chen, X.J., and Clark-Walker, G.D. (1993) Mutations in MGI genes convert Kluyveromyces lactis into a petite-positive yeast. Genetics 133: 517-525.
6. Chen, X.J., Wésolowski-Louvel, M., Tanguy-Rougeau, C., Bianchi, M.M., Fabiani, L., Saliola, M., Falcone, C., Frontali, L., and Fukuhara, H. (1988) A gene-cloning system for Kluyveromyces lactis and isolation of a chromosomal gene required for killer toxin production. J Gen Microbiol 28: 211-220.
7. Chen, X.J., Wésolowski-Louvel, M., and Fukuhara, H. (1992) Glucose transport in the yeast Kluyveromyces lactis. II. Transcriptional regulation of the glucose transporter gene RAG1. Mol Gen Genet 233: 97-105.
8. Conway, T., Osman, Y.A., Konnan, J.I., Hoffmann, E.M., and Ingram, L.O. (1987) Promoter and nucleotide sequence of the Zymomonas mobilis pyruvate decarboxylase. J Bacteriol 169: 949-954.
9. DeDeken, R.H., (1966) The Crabtree effect: a regulatory system in yeast. J Gen Microbiol 44: 149-156.
10. Deshler, J.O., Larson, G.P., and Rossi, J.J. (1989) Kluyveromyces lactis maintains Saccharomyces cerevisiae intron-encoded splicing signals. Mol Cell Biol 9: 2208-2213.
11. Entian K.-D., Hilberg, F., Opitz, H., and Mecke, D. (1985) Cloning of hexokinase structural genes from Saccharomyces cerevisiae mutants with regulatory mutations responsible for glucose repression. Mol Cell Biol 5: 3035-3040.
12. Ferrera, I., Rossi, C., Landini, M.P., and Puglisi, P.P. (1978) Role of the mitochondrial protein synthesis in the catabolite repression of the petite negative yeast Kluyveromyces lactis. Biochem Biophys Res Commun 80: 340-348.
13. Gancedo, C., and Serrano, R. (1989) Energy-yielding metabolism. In The yeasts. vol. 3. Rose, A.H., and Harrison, J.S. (eds). New York: Academic Press, pp. 205-259.
14. Goffrini, P., Algeri, A.A., Donnini. C., Wésolowski-Louvel, M., and Ferrero, I. (1989) RAG1 and RAG2: nuclear genes involved in the dependence/independence on mitochondrial respiratory function for growth on sugars. Yeast 5: 99-106.
15. Goffrini, P., Wésolowski-Louvel, M., Ferrero, I., and Fukuhara, H. (1990) RAG1 gene of the yeast Kluyveromyces lactis codes for a sugar transporter. Nucl Acids Res 18: 5294.
16. Goffrini, P., Wésolowski-Louvel, M., and Ferrero, I. (1991) A phosphoglucose isomerase gene is involved in the Rag phenotype of the yeast Kluyveromyces lactis. Mol Gen Genet 228: 401-409.
17. Green, D.E., Herbert, D., and Subrahmanyan, V. (1941) Carboxylase. J Biol Chem 138: 327-339.
18. Hawkins, C.F., Borges, A., and Perham, R.N. (1989) A common structural motif in thiamin pyrophosphate-binding enzymes. FEBS Lett 255: 77-82.
19. Hohmann, S. (1991a) Characterization of PDC6, a third structural gene for pyruvate decarboxylase in Saccharomyces cerevisiae. J Bacteriol 173: 7963-7969.
20. Hohmann, S. (1991b) PDC6, a weakly expressed pyruvate decarboxylase gene from yeast, is activated when fused spontaneously under the control of the PDC1 promoter. Curr Genet 20: 373-378.
21. Hohmann, S. (1993) Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Mol Gen Genet 241: 657-666.
22. Hohmann, S., and Cederberg, H. (1990) Autoregulation may control the expression of yeast pyruvate decarboxylase structural genes PDC1 and PDC5. Eur J Biochem 188: 615-621.
23. Hohmann, S., Huse, K., Valentin, E., Mbonyi, K., Thevelein, J.M., and Zimmermann F.K. (1992) Glucose-induced regulatory defects in the Saccharomyces cerevisiae byp1 growth initiation mutant and identification of MIG1 as a partial suppressor. J Bacteriol 174: 4183-4188.
24. Holloway, P., and Subden, R.E. (1993) The isolation and nucleotide sequence of the pyruvate decarboxylase gene from Kluyveromyces marxianus. Curr Genet 24: 274-277.
25. Holloway, P., and Subden, R.E. (1994) The nucleotide sequence and initial characterization of the pyruvate decarboxylase from the yeast Hanseniaspora uvarum. Yeast 10: 1581-1589.
26. Holzer, H., and Goedde, W.H. (1957) Zwei Wege von Pyruvat zu Acetyl-coenzym A in Hefe. Biochem Z 329: 175-191.
27. Hossain, M.A., Hug, E., and Hodges, T.K. (1994) Sequence of a cDNA from Oryza sativa (L.) encoding the pyruvate decarboxylase 1 gene. Plant Physiol 106: 799-800.
28. Kellermann, E., and Hollenberg, C.P. (1988) The glucose-and ethanol-dependent regulation of PDCt from Saccharomyces cerevisiae are controlled by two distinct promoter regions. Curr Genet 14: 337-344.
29. Kellermann, E., Seeboth, P.G., and Hollenberg, P. (1986) Analysis of the primary structure and promoter function of a pyruvate decarboxylase gene (PDC1) from Saccharomyces cerevisiae. Nucl Acids Res 14: 8963-8977.
30. Kuo, D.J., Dikdan, G., and Iordan, F. (1986) Resolution of brewers' yeast pyruvate decarboxylase into two isozymes. J Biol Chem 261: 3316-3319.
31. Lobo, Z., and Maitra, P.K. (1977) Genetics of yeast hexokinase. Genetics 86: 727-744.
32. Lodi, T., O' Connor, D., Goffrini, P., and Ferrero, I. (1994) Carbon catabolite repression in Kluyveromyces lactis: isolation and characterization of the KIDLD gene encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase. Mol Gen Genet 244: 622-629.
33. Luyten, K., de Koning, W., Tesseur, I., Ruiz, M.C., Ramos, J., Cobbaert, P., Thevelein, J.M., and Hohmann, S. (1993) Disruption of the Kluyveromyces tactis GGS1 gene causes inability to grow on glucose and fructose and is suppressed by mutations that reduce sugar uptake. Eur J Biochem 217: 701-713.
34. Maitra, P.K., and Lobo, Z. (1983) Genetics of yeast glucokinase. Genetics 105: 501-515.
35. Ménart, S. (1993) PhD Thesis, University of Paris.
36. Mulder, W. (1994) PhD Thesis, University of Amsterdam.
37. Neale, A.D., Scopes, R.K., Wettenhall, R.E.H., and Hoogenraad, N.J. (1987) Nucleotide sequence of the pyruvate decarboxylase gene from Zymomonas mobilis. Nucl Acids Res 15: 1753-1761.
38. Özcan, S., and Johnston, M. (1995) Three different regulatory mechanisms enable yeast hexose-transporter (HXT) genes to be induced by different levels of glucose. Mol Cell Biol 15: 1564-1572.
39. Peschke, V.M., and Sachs, M.M. (1993) Multiple pyruvate decarboxylase genes in maize are induced by hypoxia. Mol Gen Genet 240: 206-212.
40. Postma, E., Verduyn, C., Scheffers, W.A., and van Dijken, J.P. (1989) Enzymic analysis of the Crabtree effect in glucose-limited cultures of Saccharomyces cerevisiae. Appl Environ Microbiol 55: 486-477.
41. Prior, C. (1993) PhD Thesis, University of Paris.
42. Prior, C., Mamessier, P., Fukuhara, H., Chen, X.J., and Wésolowski-Louvel, M. (1993) The hexokinase gene is required for transcriptional regulation of the glucose transporter gene Rag1 in Kluyveromyces lactis. Mol Cell Biol 13: 3882-3889.
43. Pronk, J.T., Wenzel, T.J., Luttik, M.A.H., Klassen, C.M., Scheffers, W.A., Steensma, H.Y., and van Dijken, J.P. (1994) Energetic aspects of glucose metabolism in a pyruvate dehydrogenase-negative mutant of Saccharomyces cerevisiae. Microbiol 140: 601-610.
44. Raghuram, V., Lobo, Z., and Maitra, P.K. (1994) PDC2, a yeast gene essential for synthesis of pyruvate decarboxylase, encodes a novel transcription factor. J Genet 73: 17-32.
45. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual. 2nd edn. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
46. Sanchis, V., Vinas, I., Roberts, I.N., Jeenes, D.J., Watson, A.J., and Archer, D.B. (1994) A pyruvate decarboxylase gene from Aspergillus parasiticus. FEMS Microbiol Lett 117: 207-210.
47. Schaaff, I., Green, J.B.A., Gozalbo, D., and Hohmann, S. (1989) A deletion of the PDC1 gene for pyruvate decarboxylase of yeast causes a different phenotype than previously isolated point mutations. Curr Genet 15: 75-81.
48. Schmitt, H.D., and Zimmermann, F.K. (1982) Genetic analysis of pyruvate decarboxylase reaction in yeast glycolysis. J Bacteriol 151: 1146-1152.
49. Schmitt, H.D., Ciriacy, M., and Zimmermann, F.K. (1983) The synthesis of yeast pyruvate decarboxylase is regulated by large variations in the messenger RNA level. Mol Gen Genet 192: 247-252.
50. c mutants of Saccharomyces cerevisiae give evidence for an additional structural PDC gene: cloning of PDC5, a gene homologous to PDC1. J Bacteriol 172: 678-685.
51. Ullrich, J. (1970) Yeast pyruvate decarboxylase (2-oxoacid carboxy-lyase, EC 4.1.1.1) assay of thiamine pyrophosphate. In Methods in Enzymology, vol. 18. McCormick, D.B., and Wright, L.D. (eds). New York: Academic Press, pp. 109-115.
52. Wenzel, T.J., Luttik, M.A.H., van den Berg, J.A., and Steensma, H.Y. (1993) Regulation of the PDA1 gene encoding the E1α subunit of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae. Eur J Biochem 218: 405-411.
53. Wésolowski-Louvel, M., and Fukuhara, H. (1995) A map of the Kluyveromyces lactis genome. Yeast 11: 211-218.
54. Wésolowski, M., Algeri, A., Goffrini, P., and Fukuhara, H. (1982) Killer DNA plasmids of the yeast Kluyveromyces lactis. I. Mutations affecting the killer phenotype. Curr Gene 150: 137-140.
55. Wésolowski-Louvel, M., Tanguy-Rougeau, C., and Fukuhara, H. (1988) A nuclear gene required for the expression of the linear DNA associated killer system in the yeast Kluyveromyces lactis. Yeast 4: 71-81.
56. Wésolowski-Louvel, M., Goffrini, P., Ferrera, I., and Fukuhara, H. (1992a) Glucose transport in the yeast Kluyveromyces lactis. I. Properties of an inducible low-affinity glucose transporter gene. Mol Gen Genet 233: 89-96.
57. - mutations involved in glucose metabolism in yeast: isolation and genetic characterization. Yeast 8: 711-719.
58. Wright, A.P.H., Png H.-L., and Hartley, B.S. (1989) Identification, cloning and characterization of a new gene required for full pyruvate decarboxylase activity in Saccharomyces cerevisiae. Curr Genet 15: 171-175.