Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: Possible role of peroxynitrite formation

Molecular and Cellular Biochemistry

Volumn 363, Issue 1-2, 2012, Pages 323-333

  Gan, Xiaohong Tracey ^a   Hunter, J Craig ^a,b   Huang, Cathy ^a   Xue, Jenny ^a   Rajapurohitam, Venkatesh ^a   Javadov, Sabzali ^a,c   Karmazyn, Morris ^a  

^a WESTERN UNIVERSITY   (Canada)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

Author keywords

Adult rat ventricular myocytes; Cytotoxicity; Hypertrophy; iNOS; Ouabain; Reactive oxygen species

Indexed keywords

ATRIAL NATRIURETIC FACTOR; GLYCOSIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) NITROARGININE METHYL ESTER; OUABAIN; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TRYPAN BLUE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL STRUCTURE; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; GENE EXPRESSION; HEART HYPERTROPHY; MALE; MUSCLE CELL; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANIMALS; CARDIOTONIC AGENTS; CELL SHAPE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HYPERTROPHY, LEFT VENTRICULAR; L-LACTATE DEHYDROGENASE; MALE; MYOCYTES, CARDIAC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OUABAIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXYNITROUS ACID; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPEROXIDES; TIME FACTORS; TYROSINE; UP-REGULATION;

RATTUS; STROPHANTHUS GRATUS;

EID: 84857906432     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-1185-7     Document Type: Article

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