Phospholipases and cationic peptides inhibit Cryptosporidium parvum sporozoite infectivity by parasiticidal and non-parasiticidal mechanisms

Journal of Parasitology

Volumn 98, Issue 1, 2012, Pages 199-204

  Carryn, Stéphane ^a,b   Schaefer, Deborah A ^a   Imboden, Michael ^a,c   Homan, E Jane ^a,c   Bremel, Robert D ^a,c   Riggs, Michael W ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

^c IoGenetics LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; BETA DEFENSIN 1; BETA DEFENSIN 2; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; INDOLICIDIN; LACTOFERRICIN B; LACTOFERRIN; LYSOZYME; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL LYASE; PHOSPHOLIPASE; PHOSPHOLIPASE A2; PROTEIN HYDROLYSATE;

ANTIMICROBIAL ACTIVITY; BIOLOGICAL INVASION; CATION; DIARRHEAL DISEASE; ENZYME ACTIVITY; IMMUNE SYSTEM; INFECTIVITY; INHIBITION; NEUTRALIZATION; PARASITOLOGY; PEPTIDE; PROTEIN; PROTOZOAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DRUG EFFECT; IN VITRO STUDY; MOUSE; NEWBORN; NONHUMAN; PARASITE CONTROL; PARASITE VIABILITY;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, MONOCLONAL; ANTIMICROBIAL CATIONIC PEPTIDES; CACO-2 CELLS; CATTLE; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; HUMANS; MALE; MICE; MICE, INBRED ICR; PHOSPHOLIPASES; SPECIFIC PATHOGEN-FREE ORGANISMS; SPOROZOITES;

BOS; CRYPTOSPORIDIUM PARVUM; PROTOZOA;

EID: 84857861698     PISSN: 00223395     EISSN: 19372345     Source Type: Journal    
DOI: 10.1645/GE-2822.1     Document Type: Article

References (48)

1. ARROWOOD, M. J., J. M. JAYNES, AND M. C. HEALEY. 1991. In vitro activities of lytic peptides against the sporozoites of Cryptosporidium parvum. Antimicrobial Agents and Chemotherapy 35: 224-227.
2. -, AND C. R. STERLING. 1987. Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic Percoll gradients. Journal of Parasitology 73: 314-319.
3. CUNLIFFE, R. N., AND Y. R. MAHIDA. 2004. Expression and regulation of antimicrobial peptides in the gastrointestinal tract. Journal of Leukocyte Biology 75: 49-58.
4. DAGAN, A., L. EFRON, L. GAIDUKOV, A.MOR, AND H. GINSBURG. 2002. In vitro antiplasmodium effects of dermaseptin S4 derivatives. Antimicrobial Agents and Chemotherapy 46: 1059-1066.
5. DANESI, R., S. SENESI, J. W. v. WOUT, J. T. v. DISSEL, A. LUPETTI, AND P. H. NIBBERING. 2002. Antimicrobial peptides: Therapeutic potential for the treatment of Candida infections. Expert Opinion on Investigational Drugs 11: 309-318.
6. FAYER, R., C. ANDREWS, B. L. UNGAR, AND B. BLAGBURN. 1989. Efficacy of hyperimmune bovine colostrum for prophylaxis of cryptosporidiosis in neonatal calves. Journal of Parasitology 75: 393-397.
7. -, C. A. SPEER, AND J. P. DUBEY. 1997. The general biology of Cryptosporidium. In Cryptosporidium and cryptosporidiosis, 1st edition, R. Fayer (ed.). CRC Press, Boca Raton, Florida, p. 1-42.
8. GANZ, T. 2004. Antimicrobial polypeptides. Journal of Leukocyte Biology 75: 34-38.
9. -, AND R. I. LEHRER. 1994. Defensins. Current Opinion in Immunology 6: 584-589.
10. GIACOMETTI, A., O. CIRIONI, F. BARCHIESI, F. ANCARANI, AND G. SCALISE. 2000. In vitro anti-cryptosporidial activity of cationic peptides alone and in combination with inhibitors of ion transport systems. Journal of Antimicrobial Chemotherapy 45: 651-654.
11. -, -, M. S. DEL PRETE, F. BARCHIESI, AND G. SCALISE. 2000. Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture. Antimicrobial Agents and Chemotherapy 44: 3473-3475.
12. -, -, -, B. SKERLAVAJ, R. CIRCO, M. ZANETTI, AND G. SCALISE. 2003. In vitro effect on Cryptosporidium parvum of shortterm exposure to cathelicidin peptides. Journal of Antimicrobial Chemotherapy 51: 843-847.
13. HANCOCK, R. E., AND D. S. CHAPPLE. 1999. Peptide antibiotics. Antimicrobial Agents and Chemotherapy 43: 1317-1323.
14. HEINE, J., J. F. L. POHLENZ, H. W. MOON, AND G. N. WOODE. 1984. Enteric lesions and diarrhea in gnotobiotic calves monoinfected with Cryptosporidium species. Journal of Infectious Diseases 150: 768-775.
15. HERNANDEZ, J. M., M. H. T. BUI, K. HAN, H. MUKOUYAMA, D. G. FREITAS, D. NGUYEN, R. CALILIW, P. I. SHINTAKU, S. H. PAIK, C.-L. TSO, ET AL. 2003. Novel kidney cancer immunotherapy based on the granulocyte-macrophage colony-stimulating factor and carbonic anhydrase IX fusion gene. Clinical Cancer Research 1906: 1906-1916.
16. IMBODEN, M., M. W. RIGGS, D. A. SCHAEFER, E. J. HOMAN, AND R. D. BREMEL. 2010. Antibodies fused to innate immune molecules reduce initiation of Cryptosporidium parvum infection in mice. Antimicrobial Agents and Chemotherapy 54: 1385-1392.
17. JACOBS, T., H. BRUHN, I. GAWORSKI, B. FLEISCHER, AND M. LEIPPE. 2003. NK-lysin and its shortened analog NK-2 exhibit potent activities against Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy 47: 607-613.
18. KANTHAWONG, S., J. G. M. BOLSHER, E. C. I. VEERMAN, J. VAN MARLE, K. NAZMI, S. WONGRATANACHEEWIN, AND S. TAWEECHAISUPAPONG. 2010. Antimicrobial activities of LL-37 and its truncated variants against Burkholderia thailandensis. International Journal of Antimicrobial Agents 36: 447-452.
19. KUHLS, T. L., D. A. MOSIER, AND D. L. CRAWFORD. 1991. Effects of carbohydrates and lectins on cryptosporidial sporozoite penetration of cultured cell monolayers. Journal of Protozoology 38: S74-S76.
20. LANGER, R. C., AND M. W. RIGGS. 1999. Cryptosporidium parvum apical complex glycoprotein CSL contains a sporozoite ligand for intestinal epithelial cells. Infection and Immunity 67: 5282-5291.
21. -, D. A. SCHAEFER, AND M. W. RIGGS. 2001. Characterization of an intestinal epithelial cell receptor recognized by the Cryptosporidium parvum sporozoite ligand CSL. Infection and Immunity 69: 1661-1670.
22. LEHRER, R. I., AND T. GANZ. 1999. Antimicrobial peptides in mammalian and insect host defence. Current Opinion in Immunology 11: 23-27.
23. MARTIN, E., T. GANZ, AND R. I. LEHRER. 1995. Defensins and other endogenous peptide antibiotics of vertebrates. Journal of Leukocyte Biology 58: 128-136.
24. MCDONALD, V. 2008. Immune responses. In Cryptosporidium and cryptosporidiosis, 2nd edition, R. Fayer, and L. Xiao (eds.). CRC Press, Boca Raton, Florida, p. 209-233.
25. MCGWIRE, B. S., C. L. OLSON, B. F. TACK, AND D. M. ENGMAN. 2003. Killing of African trypanosomes by antimicrobial peptides. Journal of Infectious Diseases 188: 146-152.
26. MITSCHLER, R. R., R. WELTI, AND S. J. UPTON. 1994. A comparative study of lipid compositions of Cryptosporidium parvum (Apicomplexa) and Madin-Darby bovine cells. Journal of Eukaryotic Microbiology 41: 8-12.
27. MURDOCK, C. A., AND K. R. MATTHEWS. 2002. Antibacterial activity of pepsin-digested lactoferrin on foodborne pathogens in buffered broth systems and ultra-high temperature milk with EDTA. Journal of Applied Microbiology 93: 850-856.
28. PELEGRINI, P. B., L. R. FARIAS, A. C. M. SAUDE, F. T. COSTA, C. BLOCH, L. P. SILVA, A. S. OLIVEIRA, C. E. M. GOMES, M. P. SALES, AND O. L. FRANCO. 2009. A novel antimicrobial peptide from Crotalaria pallida seeds with activity against human and phytopathogens. Current Microbiology 59: 400-404.
29. PERRYMAN, L. E., S. J. KAPIL, M. L. JONES, AND E. L. HUNT. 1999. Protection of calves against cryptosporidiosis with immune bovine colostrum induced by a Cryptosporidium parvum recombinant protein. Vaccine 17: 2142-2149.
30. PRIEST, J. W., A. MEHLERT, M. J. ARROWOOD, M.W. RIGGS, AND M. A. J. FERGUSON. 2003. Characterization of a low molecular weight glycolipid antigen from Cryptosporidium parvum. Journal of Biological Chemistry 278: 52212-52222.
31. QU, X.-D., AND R. I. LEHRER. 1998. Secretory phospholipase A2 is the principal bactericide for Staphylococci and other gram-positive bacteria in human tears. Infection and Immunity 66: 2791-2797.
32. RIGGS, M. W. 1997. Immunology: Host response and development of passive immunotherapy and vaccines. In Cryptosporidium and cryptosporidiosis, 1st edition, R. Fayer (ed.). CRC Press, Boca Raton, Florida, p. 129-161.
33. -. 2002. Recent advances in cryptosporidiosis: The immune response. Microbes and Infection 4: 1067-1080.
34. -, T. C. MCGUIRE, P. H. MASON, AND L. E. PERRYMAN. 1989. Neutralization-sensitive epitopes are exposed on the surface of infectious Cryptosporidium parvum sporozoites. Journal of Immunology 143: 1340-1345.
35. -, A. L. STONE, P. A. YOUNT, R. C. LANGER, M. J. ARROWOOD, AND D. L. BENTLEY. 1997. Protective monoclonal antibody defines a circumsporozoite-like glycoprotein exoantigen of Cryptosporidium parvum sporozoites and merozoites. Journal of Immunology 158: 1787-1795.
36. SCHAEFER, D. A., B. A. AUERBACH-DIXON, AND M. W. RIGGS. 2000. Characterization and formulation of multiple epitope-specific neutralizing monoclonal antibodies for passive immunization against cryptosporidiosis. Infection and Immunity 68: 2608-2616.
37. STOCKDALE, H. D., J. A. SPENCER, AND B. L. BLAGBURN. 2008. Prophylaxis and chemotherapy. In Cryptosporidium and cryptosporidiosis, 2nd edition, R. Fayer and L. Xiao (eds.). CRC Press, Boca Raton, Florida, p. 255-287.
38. TAKAKURA, N., H.WAKABAYASHI, H. ISHIBASHI, S. TERAGUCHI, Y. TAMURA, H. YAMAGUCHI, AND S. ABE. 2003. Oral lactoferrin treatment of experimental oral candidiasis in mice. Antimicrobial Agents and Chemotherapy 47: 2619-2623.
39. TANAKA, T., Y. OMATA, A. SAITO, K. SHIMAZAKI, K. YAMAUCHI, M. TAKASE, K. KAWASE, K. IGARASHI, AND N. SUZUKI. 1995. Toxoplasma gondii: Parasiticidal effects of bovine lactoferricin against parasites. Experimental Parasitology 81: 614-617.
40. TARVER, A. P., D. P. CLARK, G. DIAMOND, J. P. RUSSELL, H. ERDJUMENTBROMAGE, P. TEMPST, K. S. COHEN, D. E. JONES, R.W. SWEENEY, M. WINES, ET AL. 1998. Enteric beta-defensin: Molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection. Infection and Immunity 66: 1045-1056.
41. TZIPORI, S., AND G. WIDMER. 2008. Animal models. In Cryptosporidium and cryptosporidiosis, 2nd edition, R. Fayer and L. Xiao (eds.). CRC Press, Boca Raton, Florida, p. 485-497.
42. VERDON, R., G. T. KEUSCH, S. TZIPORI, S. A. GRUBMAN, D. M. JEFFERSON, AND H. D. WARD. 1997. An in vitro model of infection of human biliary epithelial cells by Cryptosporidium parvum. Journal of Infectious Diseases 175: 1268-1272.
43. WADE, D., A. BOMAN, B. WÅHLIN, C. M. DRAIN, D. ANDREU, H. G. BOMAN, AND R. B. MERRIFIELD. 1990. All-D amino acid-containing channel-forming antibiotic peptides. Proceedings of the National Academy of Sciences USA 87: 4761-4765.
44. WEHKAMP, J., J. SCHAUBER, AND E. F. STANGE. 2007. Defensins and cathelicidins in gastrointestinal infections. Current Opinion in Gastroenterology 23: 32-38.
45. WYATT, C. R., M. W. RIGGS, AND R. FAYER. 2010. Cryptosporidiosis in neonatal calves. In Veterinary clinics of North America food animal practice, vol. 26, S. Kapil, and D. S. McVey (eds.). Elsevier Saunders, Philadelphia, Pennsylvania, p. 89-103.
46. ZAALOUK, T. K., M. BAJAJ-ELLIOTT, J. T. GEORGE, AND V. MCDONALD. 2004. Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection. Infection and Immunity 72: 2772-2779.
47. ZAIOU, M., V. NIZET, AND R. L. GALLO. 2003. Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL37) prosequence. Journal of Investigative Dermatology 120: 810-816.
48. ZHU, G. 2008. Biochemistry. In Cryptosporidium and cryptosporidiosis, 2nd edition, R. Fayer and L. Xiao (eds.). CRC Press, Boca Raton, Florida, p. 57-77.