Killing of African trypanosomes by antimicrobial peptides

Journal of Infectious Diseases

Volumn 188, Issue 1, 2003, Pages 146-152

  McGwire, Bradford S ^a,b   Olson, Cheryl L ^a   Tack, Brian F ^c   Engman, David M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; ANTIINFECTIVE AGENT; BETA DEFENSIN; CATHELICIDIN; NOVISPIRIN; OVISPIRIN; PROINTEGRIN 1; SMAP 29 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; INTRACELLULAR KILLING; MALE; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PARASITE SURVIVAL; PARASITE VECTOR; PARASITEMIA; PRIORITY JOURNAL; PROTEIN FAMILY; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS;

ALPHA-DEFENSINS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; CELL MEMBRANE; HUMANS; MICE; PARASITEMIA; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS;

EID: 0037560074     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/375747     Document Type: Article

References (42)

1. Martin E, Ganz T, Lehrer RI. Defensins and other endogenous peptide antibiotics of vertebrates. J Leukoc Biol 1995; 58:128-36.
2. Ganz T, Lehrer RI. Defensins. Curr Opin Immunol 1994; 6:584-9.
3. Lehrer RI, Ganz T. Antimicrobial peptides in mammalian and insect host defence. Curr Opin Immunol 1999; 11:23-7.
4. Ganz T, Selsted ME, Szklarek D, et al. Defensins: natural peptide antibiotics of human neutrophils. J Clin Invest 1985; 76:1427-35.
5. Sorensen OE, Follin P, Johnsen AH, et al. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 2001; 97:3951-9.
6. Zanetti M, Gennaro R, Romeo D. Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett 1995; 374:1-5.
7. Zanetti M, Gennaro R, Scocchi M, Skerlavaj B. Structure and biology of cathelicidins. Adv Exp Med Biol 2000; 479:203-18.
8. Lehrer RI, Barton A, Daher KA, Harwig SS, Ganz T, Selsted ME. Interaction of human defensins with Escherichia coli: mechanism of bactericidal activity. J Clin Invest 1989; 84:553-61.
9. World Health Organization (WHO). Control and surveillance of African trypanosomiasis: report of a WHO expert committee. World Health Organ Tech Rep Ser 1998; 881:1-114.
10. Hajduk S, Adler B, Bertrand K, et al. Molecular biology of African trypanosomes: development of new strategies to combat an old disease. Am J Med Sci 1992; 303:258-70.
11. Vickerman K. Antigenic variation in trypanosomes. Nature 1978; 273:613-7.
12. Dumas M, Bouteille B. Human African trypanosomiasis. C R Seances Soc Biol Fil 1996; 190:395-408.
13. Keiser J, Stich A, Burri C. New drugs for the treatment of human African trypanosomiasis: research and development. Trends Parasitol 2001; 17:42-9.
14. Brun R, Schonenberger. Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Acta Trop 1979; 36:289-92.
15. Hirumi H, Martin S, Hirumi K, et al. Short communication: cultivation of bloodstream forms of Trypanosoma brucei and T. evansi in a serum-free medium. Trop Med Int Health 1997; 2:240-4.
16. Kiderlen AF, Kaye PM. A modified colorimetric assay of macrophage activation for intracellular cytotoxicity against Leishmania parasites. J Immunol Methods 1990; 127:11-8.
17. Ouellette AJ, Darmoul D, Tran D, Huttner KM, Yuan J, Selsted ME. Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin. Infect Immun 1999; 67:6643-51.
18. Sawai MV, Jia HP, Liu L, et al. The NMR structure of human β-defensin-2 reveals a novel α-helical segment. Biochemistry 2001; 40:3810-6.
19. Schibli DJ, Hunter HN, Aseyev V, et al. The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. J Biol Chem 2002; 277:8279-89.
20. Steinstraesser L, Tack BF, Waring AJ, et al. Activity of novispirin G10 against Pseudomonas aeruginosa in vitro and in infected burns. Antimicrob Agents Chemother 2002; 46:1837-44.
21. Carreira MAC, Tibbetts RS, Olson CL, et al. TcDJ1, a putatitve mitochondrial DnaJ protein in Trypanosoma cruzi. FEMS Microbiol Lett 1998; 166:141-6.
22. Ouellette AJ, Satchell DP, Hsieh MM, Hagen SJ, Selsted ME. Characterization of luminal paneth cell alpha-defensins in mouse small intestine: attenuated antimicrobial activities of peptides with truncated amino termini. J Biol Chem 2000; 275:33969-73.
23. Jia HP, Wowk SA, Schutte BC, et al. A novel murine beta-defensin expressed in tongue, esophagus, and trachea. J Biol Chem 2000; 275:33314-20.
24. Travis SM, Anderson NN, Forsyth WR, et al. Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun 2000; 68:2748-55.
25. Zhao C, Liu L, Lehrer RI. Identification of a new member of the protegrin family by cDNA cloning. FEBS Lett 1994; 346:285-8.
26. Steinberg DA, Hurst MA, Fujii CA, et al. Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity. Antimicrob Agents Chemother 1997; 41:1738-42.
27. Lohner K, Latal A, Lehrer RI, Ganz T. Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems. Biochemistry 1997; 36:1525-31.
28. Roumestand C, Louis V, Aumelas A, Grassy G, Calas B, Chavanieu A. Oligomerization of protegrin-1 in the presence of DPC micelles: a proton high-resolution NMR study. FEBS Lett 1998; 421:263-7.
29. Miyakawa Y, Ratnakar P, Rao AG, et al. In vitro activity, of the antimicrobial peptides human and rabbit defensins and porcine leukocyte protegrin against Mycobacterium tuberculosis. Infect Immun 1996; 64:926-32.
30. Turner J, Cho Y, Dinh NN, Waring AJ, Lehrer RI. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob Agents Chemother 1998; 42:2206-14.
31. Yang L, Weiss TM, Lehrer RI, Huang HW. Crystallization of antimicrobial pores in membranes: magainin and protegrin. Biophys J 2000; 79:2002-9.
32. Cardoso de Almeida ML, Turner MJ. The membrane form of variant surface glycoproteins of Trypanosoma brucei. Nature 1983; 302:349-52.
33. Davitz MA, Gurnett AM, Low MG, Turner MJ, Nussenzweig V. Decay-accelerating factor (DAF) shares a common carbohydrate determinant with the variant surface glycoprotein (VSG) of the African Trypanosoma brucei. J Immunol 1987; 138:520-3.
34. Acosta-Serrano A, Cole RN, Mehlert A, Lee MG, Ferguson MA, Englund PT. The procyclin repertoire of Trypanosoma brucei: identification and structural characterization of the Glu-Pro-rich polypeptides. J Biol Chem 1999; 274:29763-71.
35. Mangoni ME, Aumelas A, Charnet P, et al. Change in membrane permeability induced by protegrin 1: implication of disulphide bridges for pore formation. FEBS Lett 1996; 383:93-8.
36. Field MC, Menon AK, Cross GA. Developmental variation of glycosylphosphatidylinositol membrane anchors in Trypanosoma brucei: in vitro biosynthesis of intermediates in the construction of the GPI anchor of the major procyclic surface glycoprotein. J Biol Chem 1992; 267:5324-9.
37. Homans SW, Edge CJ, Ferguson MA, Dwek RA, Rademacher TW. Solution structure of the glycosylphosphatidylinositol membrane anchor glycan of Trypanosoma brucei variant surface glycoprotein. Biochemistry 1989; 28:2881-7.
38. Paturiaux-Hanocq F, Zitzmann N, Hanocq-Quertier J, et al. Expression of a variant surface glycoprotein of Trypanosoma gambiense in procyclic forms of Trypanosoma brucei shows that the cell type dictates the nature of the glycosylphosphatidylinositol membrane anchor attached to the glycoprotein. Biochem J 1997; 324:885-95.
39. Guthmiller JM, Vargas KG, Srikantha R, et al. Susceptibilities of oral bacteria and yeast to mammalian cathelicidins. Antimicrob Agents Chemother 2001; 45:3216-9.
40. Brogden KA, Kalfa VC, Ackermann MR, Palmquist DE, McCray PB Jr, Tack BF. The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection. Antimicrob Agents Chemother 2001; 45:331-4.
41. Jacobs T, Bruhn H, Gaworski I, Fleischer B, Leippe M. NK-lysin and its shortened analog NK-2 exhibit potent activities against Trypanosoma cruzi. Antimicrob Agents Chemother 2003; 47:607-13.
42. Brand GD, Leite JR, Silva LP, et al. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: anti- Trypanosoma cruzi activity without cytotoxicity to mammalian cells. J Biol Chem 2002; 277:49332-40.