Characterization and formulation of multiple epitope-specific neutralizing monoclonal antibodies for passive immunization against cryptosporidiosis

Infection and Immunity

Volumn 68, Issue 5, 2000, Pages 2608-2616

  Schaefer, Deborah A ^a   Auerbach Dixon, Beth A ^a   Riggs, Michael W ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOSPORIDIUM VACCINE; EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1E10; MONOCLONAL ANTIBODY 3E2; MONOCLONAL ANTIBODY 3H2; NEUTRALIZING ANTIBODY; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ANTIGEN SPECIFICITY; ARTICLE; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DRUG EFFICACY; DRUG FORMULATION; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CHROMATOGRAPHY, AFFINITY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; EPITOPES, B-LYMPHOCYTE; FEMALE; GLYCOPROTEINS; IMMUNIZATION, PASSIVE; MICE; MICE, INBRED BALB C; NEUTRALIZATION TESTS; PROTOZOAN PROTEINS; PROTOZOAN VACCINES;

EID: 0034063263     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.5.2608-2616.2000     Document Type: Article

References (59)

1. Arrowood, M. J., J. R. Mead, J. L. Mahrt, and C. R. Sterling. 1989. Effects of immune colostrum and orally administered antisporozoite monoclonal antibodies on the outcome of Cryptosporidium parvum infections in neonatal mice. Infect. Immun. 57:2283-2288.
2. Arrowood, M. J., and C. R. Sterling. 1987. Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic Percoll gradients. J. Parasitol. 73:314-319.
3. Arrowood, M. J., C. R. Sterling, and M. C. Healey. 1991. Immunofluorescent microscopic visualization of trails left by gliding Cryptosporidium parvum sporozoites. J. Parasitol. 77:315-317.
4. Blagburn, B. L., and R. Soave. 1997. Prophylaxis and chemotherapy: human and animal, p. 111-128. In R. Fayer (ed.), Cryptosporidium and cryptosporidiosis. CRC Press, Boca Raton, Fla.
5. Carruthers, V. B., and L. D. Sibley. 1997. Sequential protein secretion from three distinct organelles of Toxoplasma gandii accompanies invasion of human fibroblasts. Eur. J. Cell Biol. 73:114-123.
6. Casadevall, A. 1999. Passive antibody therapies: progress and continuing challenges. Clin. Immunol. 93:5-15.
7. Cochrane, A., H. M. Aikawa, M. Jeng, and R. S. Nussenzweig. 1976. Antibody-induced ultrastructural changes of malarial sporozoites. J. Immunol. 116:859-867.
8. Crabb, J. H. 1998. Antibody-based immunotherapy of cryptosporidiosis. Adv. Parasitol. 40:121-149.
9. Dubremetz, J. F. 1993. Apical organelles (rhoptries, micronemes, dense granules) and host cell invasion by Coccidia: what do we know now?, p. 3-9. In J. R. Barta and M. A. Fernando (ed.), Proceedings of tbe VIth International Coccidiosis Conference, vol. 6. Moffit Print Craft, Ltd., Guelph, Ontario, Canada.
10. Enriquez, F. J., and M. W. Riggs. 1998. Role of immunoglobulin A monoclonal antibodies against P23 in controlling murine Cryptosporidium parvum infection. Infect. Immun. 66:4469-4473.
11. Fayer, R., A. Guidry, and B. L. Blagburn. 1990. Immunotherapeutic efficacy of bovine colostral immunoglobulins from a hyperimmunized cow against cryptosporidiosis in neonatal mice. Infect. Immun. 58:2962-2965.
12. Fayer, R., L. E. Perryman, and M. W. Riggs. 1989. Hyperimmune bovine colostrum neutralizes Cryptosporidium sporozoites and protects mice against oocyst challenge. J. Parasitol. 75:151-153.
13. Fayer, R., C. A. Speer, and J. P. Dubey. 1947. The general biology of Cryptosporidium, p. 1-42. In R. Fayer (ed.), Cryptosporidium and cryptosporidiosis. CRC Press, Boca Raton, Fla.
14. Freedman, D. J., C. O. Tacket, A. Delehanty, D. R. Maneval, J. Nataro, and J. H. Crabb. 1998. Milk immunoglobulin with specific activity against purified colonization factor antigens can protect against oral challenge with cnterotoxigenic Escherichia coli. J. Infect. Dis. 177:662-667.
15. Griffiths, J. K., R. Balakrishnan, G. Widmer, and S. Tzipori. 1998. Paromomycin and geneticin inhibit intracellular Cryptospordium parvum without trafficking through the host cell cytoplasm: implications for drug delivery. Infect. Immun. 66:3874-3883.
16. Heine, J., J. F. L. Pohlenz, H. W. Moon, and G. N. Woode. 1984. Enteric lesions and diarrhea in gnotobiotic calves monoinfected with Cryptosporidium species. J. Infect. Dis. 150:768-775.
17. Jenkins, M. C., C. O'Brien, J. Trout, A. Guidry, and R. Fayer. 1998. Hyperimmune bovine colostrum specific for recombinant Cryptosporidium parvum antigen confers partial protection against cryptosporidiosis in immunosuppressed adult mice. Vaccine 17:2453-2460.
18. Lamm, M. E. 1997. Interaction of antigens and antibodies at mucosal surfaces. Annu. Rev. Microbiol. 51:311-340.
19. Langer, R. C., and M. W. Riggs. 1999. Cryptosporidium parvum apical complex glycoprotein CSL contains a sporozoite ligand fur intestinal epithelial cells. Infect. Immun. 67:5282-5291.
20. Luft, B. J., D. Payne, D. Woodmansee, and C. W. Kim. 1987. Characterization of the Cryptosporidium antigens from sporulated oocysts of Cryptosporidium parvum. Infect. Immun. 55:2436-2441.
21. Lumb, R., K. Smith, P. J. O'Donoghue, and J. A. Lanser. 1988. Ultrastructure of the attachment of Cryptosporidium sporozoites to tissue culture cells. Parasitol. Res. 74:531-536.
22. Mazier, D., S. Mellouk, R. L. Beaudoin, B. Texier, P. Druilhe, W. Hockmeyer, J. Trosper, C. Paul, Y. Charoenvit, J. Young, F. Miltgen, L. Chedid, J. P. Chigot, B. Galley, O. Brandicourt, and M. Gentilini. 1986. Effect of antibodies to recombinant and synthetic peptides on P. falciparum sporozoites in vitro. Science 231:156-159.
23. Mead, J. R., M. J. Arrowood, and C. R. Sterling. 1988. Antigens of Cryptosporidiurn sporozoites recognized by immune sera of infected animals and humans. J. Parasitol. 74:135-143.
24. Mineo, J. R., I. A. Kahn, and L. H. Kasper. 1994. Toxoplasma gandii: a monoclonal antibody that inhibits intracellular replication. Exp. Parasitol. 79:351-361.
25. Mitschler, R. R., R. Welti, and S. J. Upton. 1994. A comparative study of lipid compositions of Cryptosporidium parvum (Apicomplexa) and Madin-Darby bovine kidney cells. J. Eukaryot. Microbiol. 41:8-12.
26. Mukherjee, J., T. R. Kozel, and A. Casadevall. 1998. Monoclonal antibodies reveal additional epitopes of serotype D Cryptococcus neoformans capsular glucuronoxylomannan that elicit protective antibodies. J. Immunol. 161: 3557-3568.
27. Nord, J., P. Ma, D. DiJohn, S. Tzipori, and C. O. Tacket. 1990. Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patients. AIDS 4:581-584.
28. Nudelman, S., L. Renia, Y. Charoenvit, L. Yuan, F. Miltgen, R. L. Beaudoin, and D. Mazier. 1989. Dual action of anti-sporozoite antibodies in vitro. J. Immunol. 143:996-1000.
29. Okhuysen, P. C., C. L. Chappell, J. Crabb, L. M. Valdez, E. T. Douglass, and H. L. DuPont. 1998. Prophylactic effect of bovine anti-Cryptosporidium hyperimmune colostrum immunoglobulin in healthy volunteers challenged with Cryptosporidium parvum. Clin. Infect. Dis. 26:1324-1329.
30. Perkins, M. E., Y. A. Riojas, T. W. Wu, and S. M. Le Blancq. 1999. CpABC, a Cryptosporidium parvum ATP-binding cassette protein at the host-parasite boundary in intracellular stages. Proc. Natl. Acad. Sci. USA 96:5734-5739.
31. Perryman, L. E., D. P. Jasmer, M. W. Riggs, S. G. Bohnet, T. C. McGuire, and M. J. Arrowood. 1996. A cloned gene of Cryptosporidium parvum encodes neutralization-sensitive epitopes. Mol. Biochem. Parasitol. 80:137-147.
32. Perryman, L. E., S. J. Kapil, M. L. Jones, and E. L. Hunt. 1999. Protection of calves against cryptosporidiosis with immune bovine colostrum induced by a Cryptosporidium parvum recombinant protein. Vaccine 17:2142-2149.
33. Perryman, L. E., M. W. Riggs, P. H. Mason, and R. H. Fayer. 1990. Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal antibodies, immune bovine serum, and immune bovine colostrum. Infect. Immun. 58:257-259.
34. r Cryptosporidium parvum sporozoite glycoprotein recognized by protective hyperimmune bovine colostral immunoglobulin. Infect. Immun. 60:5132-5138.
35. Riggs, M. W. 1997. Immunology: host response and development of passive immunotherapy and vaccines, p. 129-161. In R. Fayer (ed.), Cryptosporidium and cryptosporidiosis. CRC Press, Boca Raton, Fla.
36. Riggs, M. W., V. A. Cama, H. L. Leary, Jr., and C. R. Sterling. 1994. Bovine antibody against Cryptosporidium parvum elicits a circumsporozoite precipitate-like reaction and has immunotherapeutic effect against persistent cryptosporidiosis in SCID mice. Infect. Immun. 62:1927-1939.
37. Riggs, M. W., T. C. McGuire, P. H. Mason, and L. E. Perryman. 1989. Neutralization-sensitive epitopes are exposed on the surface of infectious Cryptosporidium parvum sporozoites. J. Immunol. 143:1340-1345.
38. Riggs, M. W., M. R. McNeil, L. E. Perryman, A. L. Stone, M. S. Scherman, and R. M. O'Connor. 1999. Cryptosporidium parvum sporozoite pellicle antigen recognized by a neutralizing monoclonal antibody is a β-mannosylated glycolipid. Infect. Immun. 67:1317-1322.
39. Riggs, M. W., A. L. Stone, P. A. Yount, R. C. Langer, M. J. Arrowood, and D. L. Bentley. 1997. Protective monoclonal antibody defines a circumsporozoite-like glycoprotein exoantigen of Cryptosporidium parvum sporozoites and merozoites. J. Immunol. 158:1787-1795.
40. Riggs, M. W., P. A. Yount, A. L. Stone, and R. C. Langer. 1996. Protective monoclonal antibodies define a distinct, conserved epitope on an apical complex exoantigen of Cryptosporidium parvum sporozoites. J. Eukaryot. Microbiol. 43:74S-75S.
41. Sagodira, S., D. Buzoni-Gatel, S. Iochmann, M. Naciri, and D. Bout. 1999. Protection of kids against Cryptosporidium parvum infection after immunization of dams with CP15-DNA. Vaccine 17:2346-2355.
42. Schaefer, D. A. 1999. M.S. thesis. University of Arizona, Tucson.
43. Stahli, C., V. Miggiano, J. Stocker, T. Staehelin, P. Haring, and B. Takacs. 1983. Distinction of epitopes by monoclonal antibodies. Methods Enzymol. 92:242-253.
44. Stewart, M. J., and J. P. Vanderberg. 1988. Malaria sporozoites leave behind trails of circumsporozoite protein during gliding motility. J. Protozool. 35: 389-393.
45. Stewart, M. J., and J. P. Vanderberg. 1991. Malaria sporozoites release circumsporozoite protein from their apical end and translocate it along their surface. J. Protozool. 38:411-421.
46. Tacket, C. O., S. B. Binion, E. Bostwick, G. Losonsky, M. J. Roy, and R. Edelman. 1992. Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge. Am. J. Trop. Med. Hyg. 47:275-283.
47. Tacket, C. O., G. Losonsky, H. Link, Y. Hoang, P. Guesry, H. Hilpert, and M. M. Levine. 1988. Protection by milk immunoglobulin concentrate against oral challenge with enterotoxigenic Escherichia coli. New Engl. J. Med. 318:1240-1243.
48. Tilley, M., M. T. Eggleston, and S. J. Upton. 1993. Multiple oral inoculations with Cryptosporidium parvum as a means of immunization for production of monoclonal antibodies. FEMS Microbiol. Lett. 113:235-240.
49. Tilley, M., S. J. Upton, R. Fayer, J. R. Barta, C. E. Chrisp, P. S. Freed, B. L. Blagburn, B. C. Anderson, and S. M. Barnard. 1991. Identification of a 15-kilodalton surface glycoprotein on sporozoites of Cryptosporidium parvum. Infect. Immun. 59:1002-1007.
50. Tzipori, S. 1998. Cryptosporidiosis: laboratory investigations and chemotherapy. Adv. Parasitol. 40:186-221.
51. Tzipori, S., W. Rand, J. Griffiths, G. Widmer, and J. Crabb. 1994. Evaluation of an animal model system for cryptosporidiosis: therapeutic efficacy of paromomycin and hyperimmune bovine colostrum-immunoglobulin. Clin. Diagn. Lab. Immunol. 1:450-463.
52. Tzipori, S., D. Roberton, D. A. Cooper, and L. White. 1987. Chronic cryptosporidial diarrhoea and hyperimmune cow colostrum. Lancet ii:344-345.
53. Ungar, B. L. P., D. J. Ward, R. Fayer, and C. A. Quinn. 1990. Cessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum. Gastroenterology 98:486-489.
54. Upton, S. J., M. Tilley, and D. B. Brillhart. 1994. Comparative development of Cryptosporidium parvum (Apicomplexa) in 11 continuous host cell lines. FEMS Microbiol. Lett. 118:233-236.
55. Upton, S. J., M. Tilley, and D. B. Brillhart. 1995. Effects of select medium supplements on in vitro development of Cryptosporidium parvum in HCT-8 cells. J. Clin. Microbiol. 33:371-375.
56. Villacorta, I., D. deGraaf, G. Charlier, and J. E. Peeters. 1996. Complete development of Cryptosporidium parvum in MDBK cells. FEMS Microbiol. Lett. 142:129-132.
57. Ward, H., and A. M. Cevallos. 1998. Cryptosporidium: molecular basis of host-parasite interaction. Adv. Parasitol. 40:151-185.
58. Woodward, M. P., W. W. Young, Jr., and R. A. Bloodgood. 1985. Detection of monoclonal antibodies specific for carbohydrate epitopes using periodate oxidation. J. Immunol. Methods 78:143-153.
59. Zeitlin, L., R. A. Cone, and K. J. Whaley. 1999. Using monoclonal antibodies to prevent mucosal transmission of epidemic infectious diseases. Emerg. Infect. Dis. 5:54-64.