Ghrelin plasma levels are not altered in major depression

Neuropsychobiology

Volumn 59, Issue 4, 2009, Pages 199-204

  Kluge, Michael ^a   Schüssler, Petra ^a   Schmid, Dagmar ^a   Uhr, Manfred ^a   Kleyer, Sara ^a   Yassouridis, Alexander ^a   Steiger, Axel ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Ghrelin; Major depression; Secretion pattern

Indexed keywords

FLUOXETINE; GHRELIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HAMILTON SCALE; HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; MAJOR DEPRESSION; MALE; NIGHT; PRIORITY JOURNAL; SEX;

ADULT; AREA UNDER CURVE; DEPRESSIVE DISORDER, MAJOR; FEMALE; GHRELIN; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PHOTOPERIOD; SEVERITY OF ILLNESS INDEX; SEX CHARACTERISTICS; TIME FACTORS; YOUNG ADULT;

EID: 66749146659     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000223731     Document Type: Article

References (53)

1. Wittchen HU, Jacobi F: Size and burden of mental disorders in Europe - a critical review and appraisal of 27 studies. Eur Neuropsychopharmacol 2005;15:357-376.
2. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4 (text revision). Arlington, APA, 2000.
3. de Kloet ER, Joels M, Holsboer F: Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005;6:463-475.
4. Tichomirowa MA, Keck ME, Schneider HJ, Paez-Pereda M, Renner U, Holsboer F, et al: Endocrine disturbances in depression. J Endocrinol Invest 2005;28:89-99.
5. Scantamburlo G, Hansenne M, Fuchs S, Pitchot W, Marechal P, Pequeux C, et al: Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology 2007;32:407-410. (Pubitemid 46617779)
6. Heuser I, Deuschle M, Luppa P, Schweiger U, Standhardt H, Weber B: Increased diurnal plasma concentrations of dehydroepiandrosterone in depressed patients. J Clin Endocrinol Metab 1998;83:3130-3133. (Pubitemid 28500946)
7. Grambsch P, Young EA, Meller WH: Pulsatile luteinizing hormone disruption in depression. Psychoneuroendocrinology 2004;29:825-829. (Pubitemid 38716107)
8. Steiger A, von BU, Wiedemann K, Holsboer F: Sleep EEG and nocturnal secretion of testosterone and cortisol in patients with major endogenous depression during acute phase and after remission. J Psychiatr Res 1991;25:169-177.
9. Jarrett DB, Kupfer DJ, Miewald JM, Grochocinski VJ, Franz B: Sleep-related growth hormone secretion is persistently suppressed in women with recurrent depression: a preliminary longitudinal analysis. J Psychiatr Res 1994;28:211-223.
10. Steiger A, von Bardeleben U, Herth T, Holsboer F: Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery. J Affect Disord 1989;16:189-195. (Pubitemid 19062761)
11. Fountoulakis KN, Kantartzis S, Siamouli M, Panagiotidis P, Kaprinis S, Iacovides A, et al: Peripheral thyroid dysfunction in depression. World J Biol Psychiatry 2006;7:131-137.
12. Antonijevic IA, Murck H, Frieboes RM, Horn R, Brabant G, Steiger A: Elevated nocturnal profiles of serum leptin in patients with depression. J Psychiatr Res 1998;32:403-410. (Pubitemid 28491246)
13. Pasco JA, Jacka FN, Williams LJ, Henry MJ, Nicholson GC, Kotowicz MA, et al: Leptin in depressed women: cross-sectional and longitudinal data from an epidemiologic study. J Affect Disord 2008;107:221-225.
14. Kraus T, Haack M, Schuld A, Hinze-Selch D, Pollmächer T: Low leptin levels but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology 2001;73:243-247. (Pubitemid 32424518)
15. Jow GM, Yang TT, Chen CL: Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. J Affect Disord 2006;90:21-27.
16. Broglio F, Prodam F, Me E, Riganti F, Lucatello B, Granata R, et al: Ghrelin: endocrine, metabolic and cardiovascular actions. J Endocrinol Invest 2005;28:23-25. (Pubitemid 46211836)
17. Menyhert J, Wittmann G, Hrabovszky E, Szlavik N, Keller E, Tschop M, et al: Distribution of ghrelin-immunoreactive neuronal networks in the human hypothalamus. Brain Res 2006;1125:31-36. (Pubitemid 44838545)
18. Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJ, et al: Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 1997;48:23-29. (Pubitemid 27298124)
19. Kluge M, Schüssler P, Zuber V, Yassouridis A, Steiger A: Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep. Psychoneuroendocrinology 2007;32:287-292. (Pubitemid 46400281)
20. Kluge M, Schüssler P, Uhr M, Yassouridis A, Steiger A: Ghrelin suppresses secretion of luteinizing hormone in humans. J Clin Endocrinol Metab 2007;92:3202-3205. (Pubitemid 47236392)
21. Kluge M, Uhr M, Bleninger P, Yassouridis A, Steiger A: Ghrelin suppresses secretion of follicle stimulating hormone (FSH) in males. Clin Endocrinol (Oxf) 2009;70:920-923.
22. Kanehisa M, Akiyoshi J, Kitaichi T, Matsushita H, Tanaka E, Kodama K, et al: Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats. Prog Neuropsychopharmacol Biol Psychiatry 2006;30:1403-1407. (Pubitemid 44634944)
23. Lutter M, Sakata I, Osborne-Lawrence S, Rovinsky SA, Anderson JG, Jung S, et al: The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci 2008;11:752-753. (Pubitemid 351896679)
24. Nakashima K, Akiyoshi J, Hatano K, Hanada H, Tanaka Y, Tsuru J, et al: Ghrelin gene polymorphism is associated with depression, but not panic disorder. Psychiatr Genet 2008;18:257.
25. Schmid DA, Wichniak A, Uhr M, Ising M, Brunner H, Held K, et al: Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine. Neuropsychopharmacology 2006;31:832-844.
26. Schanze A, Reulbach U, Scheuchenzuber M, Groschl M, Kornhuber J, Kraus T: Ghrelin and eating disturbances in psychiatric disorders. Neuropsychobiology 2008;57:126-130.
27. Espelund U, Hansen TK, Hojlund K, Beck-Nielsen H, Clausen JT, Hansen BS, et al: Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects. J Clin Endocrinol Metab 2005;90:741-746. (Pubitemid 40279189)
28. Chan JL, Bullen J, Lee JH, Yiannakouris N, Mantzoros CS: Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects. J Clin Endocrinol Metab 2004;89:335-343. (Pubitemid 38183901)
29. Barkan AL, Dimaraki EV, Jessup SK, Symons KV, Ermolenko M, Jaffe CA: Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. J Clin Endocrinol Metab 2003;88:2180-2184. (Pubitemid 36549895)
30. Pinar M, Gulsun M, Tasci I, Erdil A, Bolu E, Acikel C, et al: Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:135-139.
31. Kluge M, Schüssler P, Bleninger P, Kleyer S, Uhr M, Weikel JC, et al: Ghrelin alone or coadministered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males. Psychoneuroendocrinology 2008;33:497-506.
32. Kluge M, Schüssler P, Zuber V, Kleyer S, Yassouridis A, Dresler M, et al: Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep. Psychoneuroendocrinology 2007;32:1079-1085. (Pubitemid 350086827)
33. Gröschl M, Uhr M, Kraus T: Evaluation of the comparability of commercial ghrelin assays. Clin Chem 2004;50:457-458. (Pubitemid 38156396)
34. Cummings DE: Ghrelin and the short- and long-term regulation of appetite and body weight. Physiol Behav 2006;89:71-84.
35. Purnell JQ, Weigle DS, Breen P, Cummings DE: Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans. J Clin Endocrinol Metab 2003;88:5747-5752. (Pubitemid 38033045)
36. Schur EA, Cummings DE, Callahan HS, Foster-Schubert KE: Association of cognitive restraint with ghrelin, leptin, and insulin levels in subjects who are not weight-reduced. Physiol Behav 2008;93:706-712.
37. Spiegel K, Tasali E, Penev P, Van CE: Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 2004;141:846-850. (Pubitemid 39601178)
38. Brunetti L, Recinella L, Orlando G, Michelotto B, Di Nisio C, Vacca M: Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus. Eur J Pharmacol 2002;454:189-192. (Pubitemid 35287478)
39. Carlini VP, Gaydou RC, Schioth HB, de Barioglio SR: Selective serotonin reuptake inhibitor (fluoxetine) decreases the effects of ghrelin on memory retention and food intake. Regul Pept 2007;140:65-73.
40. Nonogaki K, Ohashi-Nozue K, Oka Y: A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice. Biochem Biophys Res Commun 2006;341:703-707. (Pubitemid 43177546)
41. Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S, et al: Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin. Biol Psychiatry 2009;65:748-759.
42. Otto B, Cuntz U, Fruehauf E, Wawarta R, Folwaczny C, Riepl RL, et al: Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 2001;145:669-673.
43. Tanaka M, Naruo T, Yasuhara D, Tatebe Y, Nagai N, Shiiya T, et al: Fasting plasma ghrelin levels in subtypes of anorexia nervosa. Psychoneuroendocrinology 2003;28:829-835. (Pubitemid 36936794)
44. Tanaka M, Naruo T, Muranaga T, Yasuhara D, Shiiya T, Nakazato M, et al: Increased fasting plasma ghrelin levels in patients with bulimia nervosa. Eur J Endocrinol 2002;146:R1-R3. (Pubitemid 34705084)
45. Nakazato M, Hashimoto K, Shiina A, Koizumi H, Mitsumoti M, Imai M, et al: No changes in serum ghrelin levels in female patients with bulimia nervosa. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:1181-1184. (Pubitemid 40017635)
46. Emül HM, Serteser M, Kurt E, Ozbulut O, Guler O, Gecici O: Ghrelin and leptin levels in patients with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:1270-1274. (Pubitemid 47081315)
47. Kluge M, Schüssler P, Weikel J, Dresler M, Zuber V, Querfurt F, et al: Altered nocturnal growth hormone (GH) secretion in obsessive compulsive disorder. Psychoneuroendocrinology 2006;31:1098-1104. (Pubitemid 44485360)
48. Kluge M, Schüssler P, Künzel HE, Dresler M, Yassouridis A, Steiger A: Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder. J Psychiatr Res 2007;41:928-933. (Pubitemid 47259089)
49. Kraus T, Schanze A, Groschl M, Bayerlein K, Hillemacher T, Reulbach U, et al: Ghrelin levels are increased in alcoholism. Alcohol Clin Exp Res 2005;29:2154-2157. (Pubitemid 43042806)
50. Kim DJ, Yoon SJ, Choi B, Kim TS, Woo YS, Kim W, et al: Increased fasting plasma ghrelin levels during alcohol abstinence. Alcohol Alcohol 2005;40:76-79.
51. Sentissi O, Epelbaum J, Olie JP, Poirier MF: Leptin and ghrelin levels in patients with schizophrenia during different antipsychotics treatment: a review. Schizophr Bull 2008;34:1189-1199.
52. Carlini VP, Monzon ME, Varas MM, Cragnolini AB, Schioth HB, Scimonelli TN, et al: Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem Biophys Res Commun 2002;299:739-743.
53. Liu J, Prudom CE, Nass R, Pezzoli SS, Oliveri MC, Johnson ML, et al: Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men. J Clin Endocrinol Metab 2008;93:1980-1987. (Pubitemid 351656547)