MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Schlatter, Ivan D ^a   Meira, Maria ^a,c   Ueberschlag, Vanessa ^a   Hoepfner, Dominic ^b   Movva, Rao ^b   Hynes, Nancy E ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; MEDIATOR OF ERBB2 DRIVEN CELL MOTILITY PROTEIN; MEMO HOMOLOG 1 PROTEIN; PHOSPHOLIPASE C; UNCLASSIFIED DRUG; PLC1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ANIMAL CELL; ARTICLE; BACTERIAL STRAIN; BIOACCUMULATION; CELL INVASION; CELL MOTILITY; CELL NUCLEUS; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; EMBRYO; GENE; GENE EXPRESSION; MHO1 GENE; MOUSE; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEAR LOCALIZATION SIGNAL; PHENOTYPE; PLC1 GENE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; YEAST CELL; ACTIVE TRANSPORT; AMINO ACID SEQUENCE; GENE DELETION; GENETIC COMPLEMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; LETHAL GENE; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYLOGENY; SEQUENCE ALIGNMENT;

MAMMALIA;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; GENE DELETION; GENE EXPRESSION; GENES, LETHAL; GENETIC COMPLEMENTATION TEST; HUMANS; MOLECULAR SEQUENCE DATA; PHENOTYPE; PHYLOGENY; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; TYPE C PHOSPHOLIPASES;

EID: 84857819974     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032501     Document Type: Article

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