Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis

Gut

Volumn 61, Issue 4, 2012, Pages 528-534

  Marquez L ^a,b   Shen, C ^a   Cleynen, I ^a   De Hertogh, G ^a   Van Steen, K ^c   Machiels, K ^a   Perrier, C ^a   Ballet, V ^a   Organe, S ^a   Ferrante, M ^a   Henckaerts, L ^a   Galicia, G ^a   Rutgeerts, P ^a   Ceuppens, J L ^a   Vermeire, Severine ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

HAPTOGLOBIN; INTERLEUKIN 17; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; ULCERATIVE COLITIS;

ADULT; ANIMALS; CHOLANGITIS, SCLEROSING; COLITIS; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPTOGLOBINS; HUMANS; INFLAMMATION MEDIATORS; INFLAMMATORY BOWEL DISEASES; MALE; MICE; MICE, KNOCKOUT; POLYMORPHISM, GENETIC; YOUNG ADULT;

EID: 84857800736     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2011.240978     Document Type: Article

References (50)

1. Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009;361:2066-78.
2. Sadrzadeh SM, Bozorgmehr J. Haptoglobin phenotypes in health and disorders. Am J Clin Pathol 2004;121(Suppl):S97-104.
3. Levy AP, Asleh R, Blum S, et al. Haptoglobin: basic and clinical aspects. Antioxid Redox Signal 2010;12:293-304.
4. Galicia G, Maes W, Verbinnen B, et al. Haptoglobin deficiency facilitates the development of autoimmune inflammation. Eur J Immunol 2009;39:3404-12.
5. Van Vlierberghe H, Langlois M, Delanghe J, et al. Haptoglobin polymorphisms and iron homeostasis in health and in disease. Clin Chim Acta 2004;345:35-42. (Pubitemid 38749169)
6. Maeda N, Yang F, Barnett DR, et al. Duplication within the haptoglobin Hp2 gene. Nature 1984;309:131-5. (Pubitemid 14142780)
7. Koch W, Latz W, Eichinger M, et al. Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR. Clin Chem 2002;48:1377-82. (Pubitemid 34925770)
8. Soejima M, Koda Y. TaqMan-based real-time PCR for genotyping common polymorphisms of haptoglobin (HP1 and HP2). Clin Chem 2008;54:1908-13.
9. Arredouani M, Matthys P, Kasran A, et al. Haptoglobin and the Th1/Th2 balance: hints from in vitro and in vivo studies. Redox Rep 2001;6:369-71. (Pubitemid 34134329)
10. Arredouani M, Matthijs P, Van Hoeyveld E, et al. Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release. Immunology 2003;108:144-51. (Pubitemid 36232863)
11. Guetta J, Strauss M, Levy NS, et al. Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin. Atherosclerosis 2007;191:48-53. (Pubitemid 46227428)
12. Dayan L, Levy AP, Blum S, et al. Haptoglobin genotype and endothelial function in diabetes mellitus: a pilot study. Eur J Appl Physiol 2009;106:639-44.
13. Langlois MR, Delanghe JR. Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem 1996;42:1589-600. (Pubitemid 26354735)
14. Pavon EJ, Munoz P, Lario A, et al. Proteomic analysis of plasma from patients with systemic lupus erythematosus: increased presence of haptoglobin alpha2 polypeptide chains over the alpha1 isoforms. Proteomics 2006;6(Suppl 1):S282-92.
15. Maza I, Miller-Lotan R, Levy AP, et al. The association of Haptoglobin polymorphism with Crohn's disease in Israel. J Crohns Colitis 2008;2:214-18.
16. Papp M, Lakatos PL, Palatka K, et al Hungarian IBD Study Group. Haptoglobin polymorphisms are associated with Crohn's disease, disease behavior, and extraintestinal manifestations in Hungarian patients. Dig Dis Sci 2007;52:1279-84. (Pubitemid 46626194)
17. Lim SK, Kim SH, Lim SK, et al. Increased susceptibility in Hp knockout mice during acute hemolysis. Blood 1998;92:1870-7. (Pubitemid 28446675)
18. Boirivant M, Fuss IJ, Chu A, et al. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 1998;188:1929-39. (Pubitemid 28536780)
19. Okayasu I, Hatakeyama S, Yamada M, et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990;98:694-702. (Pubitemid 20069706)
20. Satsangi J, Silverberg MS, Vermeire S, et al. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006;55:749-53. (Pubitemid 43764536)
21. Wiesner RH, LaRusso NF. Clinicopathologic features of the syndrome of primary sclerosing cholangitis. Gastroenterology 1980;79:200-6. (Pubitemid 10046359)
22. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
23. Mourelle M, Guarner F, Malagelada JR. Polyunsaturated phosphatidylcholine prevents stricture formation in a rat model of colitis. Gastroenterology 1996;110:1093-7. (Pubitemid 26113749)
24. Kojouharoff G, Hans W, Obermeier F, et al. Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice. Clin Exp Immunol 1997;107:353-8. (Pubitemid 27049264)
25. Shen C, Bullens D, Kasran A, et al. Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis. Int Immunopharmacol 2004;4:939-51. (Pubitemid 38739099)
26. Shen C, de HG, Bullens DM, et al. Remission-inducing effect of anti-TNF monoclonal antibody in TNBS colitis: mechanisms beyond neutralization? Inflamm Bowel Dis 2007;13:308-16.
27. Korn T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007;448:484-7. (Pubitemid 47123515)
28. Nurieva R, Yang XO, Martinez G, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007;448:480-3. (Pubitemid 47123514)
29. Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5. (Pubitemid 40202029)
30. Laird NM, Horvath S, Xu X. Implementing a unified approach to family-based tests of association. Genet Epidemiol 2000;19(Suppl 1):S36-42.
31. Purcell S, Sham P, Daly MJ. Parental phenotypes in family-based association analysis. Am J Hum Genet 2005;76:249-59. (Pubitemid 40129551)
32. Qian Y, Liu C, Hartupee J, et al. The adaptor Act1 is required for interleukin 17 dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol 2007;8:247-56. (Pubitemid 46745374)
33. Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 2006;116:1310-16.
34. Takedatsu H, Michelsen KS, Wei B, et al. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology 2008;135:552-67.
35. Kasvosve I, Speeckaert MM, Speeckaert R, et al. Haptoglobin polymorphism and infection. Adv Clin Chem 2010;50:23-46.
36. McGovern DP, Gardet A, Torkvist L, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet 2010;42:332-7.
37. Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008;40:955-62.
38. Silverberg MS, Cho JH, Rioux JD, et al. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet 2009;41:216-20.
39. Franke A, McGovern DP, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010;42:1118-25.
40. Cho JH, Nicolae DL, Gold LH, et al. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A 1998;95:7502-7. (Pubitemid 28293282)
41. Williams CN, Kocher K, Lander ES, et al. Using a genome-wide scan and meta-analysis to identify novel IBD locus and confirm previously identified IBD loci. Inflamm Bowel Dis 2002;8:375-81. (Pubitemid 36411023)
42. Van Heel DA, Fisher SA, Kirby A, et al Genome Scan Meta-Analysis Group of the IBD International Genetics Consortium. Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Hum Mol Genet 2004;13:763-70. (Pubitemid 38455963)
43. Van Rijn HJ, Van Der Wilt W, Stroes JW, et al. Is the turbidimetric immunoassay of haptoglobin phenotype-dependent? Clin Biochem 1987;20:245-8. (Pubitemid 17146446)
44. Arredouani MS, Kasran A, Vanoirbeek JA, et al. Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo. Immunology 2005;114:263-71. (Pubitemid 40208942)
45. Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003;52:65-70. (Pubitemid 36020767)
46. Fuss IJ, Becker C, Yang Z, et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis 2006;12:9-15. (Pubitemid 43032445)
47. Ito R, Kita M, Shin-Ya M, et al. Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice. Biochem Biophys Res Commun 2008;377:12-16.
48. Zhang Z, Zheng M, Bindas J, et al. Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm Bowel Dis 2006;12:382-8.
49. Veldhoen M, Hocking RJ, Atkins CJ, et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006;24:179-89. (Pubitemid 43214587)
50. Veldhoen M, Hocking RJ, Flavell RA, et al. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol 2006;7:1151-6. (Pubitemid 44594310)