Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

Oncogene

Volumn 31, Issue 9, 2012, Pages 1176-1180

  Mao, J H ^a   Wu, D ^b   Kim, I J ^b   Kang, H C ^b   Wei, G ^c,d   Climent, J ^b   Kumar, A ^b   Pelorosso, F G ^b   Delrosario, R ^b   Huang, E J ^c   Balmain, A ^b  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Hipk2; p53; radiation; tumorigenesis

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CHROMOSOME 6; CONTROLLED STUDY; GAMMA RADIATION; GENETIC ASSOCIATION; HETEROZYGOSITY LOSS; HIPK 2 GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMUS LYMPHOMA; TUMOR SUPPRESSOR GENE;

ANIMALS; CARRIER PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, MAMMALIAN; GAMMA RAYS; GENE EXPRESSION REGULATION, NEOPLASTIC; LOSS OF HETEROZYGOSITY; LYMPHOMA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASMS, RADIATION-INDUCED; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; THYMUS NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 84857792739     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.306     Document Type: Article

References (17)

1. Cai WW, Mao JH, Chow CW, Damani S, Balmain A, Bradley A. (2002). Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays. Nat Biotechnol 20: 393-396.
2. Deshmukh H, Yeh TH, Yu J, Sharma MK, Perry A, Leonard JR et al. (2008). High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas. Oncogene 27: 4745-4751.
3. Di Stefano V, Blandino G, Sacchi A, Soddu S, D'Orazi G. (2004). HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. Oncogene 23: 5185-5192.
4. Dauth I, Krü ger J, Hofmann TG. (2007). Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM. Cancer Res 67: 2274-2279.
5. D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S et al. (2002). Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4: 11-19.
6. Hofmann TG, Mö ller A, Sirma H, Zentgraf H, Taya Y, Dröge W et al. (2002). Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 4: 1-10.
7. Kanei-Ishii C, Nomura T, Tanikawa J, Ichikawa-Iwata E, Ishii S. (2004). Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. J Biol Chem 279: 44582-44589.
8. Li XL, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S et al. (2007). Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1-and p53-mediated transcription. Oncogene 26: 7231-7239.
9. Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI et al. (2004). Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 432: 775-779.
10. Mao JH, Wu D, Perez-Losada J, Jiang T, Li Q, Neve RM et al. (2007). Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell 11: 161-173.
11. Mitelman F, Johansson B, Mertens F (eds). (2010). Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer. http://cgap.nci.nih.gov/ Chromosomes/Mitelman.
12. Pierantoni GM, Fedele M, Pentimalli F, Benvenuto G, Pero R, Viglietto G et al. (2001). High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth. Oncogene 20: 6132-6141.
13. Pierantoni GM, Rinaldo C, Mottolese M, Di Benedetto A, Esposito F, Soddu S et al. (2007). High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2. J Clin Invest 117: 693-702.
14. Pistritto G, Puca R, Nardinocchi L, Sacchi A, D'Orazi G. (2007). HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway. Cell Death Differ 14: 1837-1839.
15. Trapasso F, Aqeilan RI, Iuliano R, Visone R, Gaudio E, Ciuffini L et al. (2009). Targeted disruption of the murine homeodomaininteracting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro. DNA Cell Biol 28: 161-167.
16. Wei G, Ku S,Ma GK, Saito S, Tang AA, Zhang J et al. (2007). HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci USA 104: 13040-13045.
17. Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH. (2003). Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 115: 177-186.