메뉴 건너뛰기




Volumn 22, Issue 2, 2012, Pages 144-153

The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC)

Author keywords

EBV; LMP1; LMP2; NPC

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; GLYCOGEN SYNTHASE KINASE 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; LATENT MEMBRANE PROTEIN 1; LATENT MEMBRANE PROTEIN 2; LATENT MEMBRANE PROTEIN 2A; LATENT MEMBRANE PROTEIN 2B; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; RANTES; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSCRIPTION FACTOR FKHRL1; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 84857790848     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2012.01.004     Document Type: Review
Times cited : (279)

References (159)
  • 2
    • 0036435166 scopus 로고    scopus 로고
    • Epstein-Barr virus in the pathogenesis of NPC
    • Raab-Traub N. Epstein-Barr virus in the pathogenesis of NPC. Semin Cancer Biol 2002, 12:431-441.
    • (2002) Semin Cancer Biol , vol.12 , pp. 431-441
    • Raab-Traub, N.1
  • 3
    • 0029051898 scopus 로고
    • Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma
    • Pathmanathan R., Prasad U., Sadler R., Flynn K., Raab-Traub N. Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma. N Engl J Med 1995, 333:693-698.
    • (1995) N Engl J Med , vol.333 , pp. 693-698
    • Pathmanathan, R.1    Prasad, U.2    Sadler, R.3    Flynn, K.4    Raab-Traub, N.5
  • 5
    • 0025325578 scopus 로고
    • Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6
    • Wilson J.B., Weinberg W., Johnson R., Yuspa S., Levine A.J. Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6. Cell 1990, 61:1315-1327.
    • (1990) Cell , vol.61 , pp. 1315-1327
    • Wilson, J.B.1    Weinberg, W.2    Johnson, R.3    Yuspa, S.4    Levine, A.J.5
  • 6
    • 56349087017 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes
    • Morris M.A., Dawson C.W., Wei W., O'Neil J.D., Stewart S.E., Jia J., et al. Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes. J Gen Virol 2008, 89:2806-2820.
    • (2008) J Gen Virol , vol.89 , pp. 2806-2820
    • Morris, M.A.1    Dawson, C.W.2    Wei, W.3    O'Neil, J.D.4    Stewart, S.E.5    Jia, J.6
  • 7
    • 0041422143 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1: structure and functions
    • Li H.P., Chang Y.S. Epstein-Barr virus latent membrane protein 1: structure and functions. J Biomed Sci 2003, 10:490-504.
    • (2003) J Biomed Sci , vol.10 , pp. 490-504
    • Li, H.P.1    Chang, Y.S.2
  • 8
    • 34548085155 scopus 로고    scopus 로고
    • Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma
    • Zheng H., Li L.L., Hu D.S., Deng X.Y., Cao Y. Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cell Mol Immunol 2007, 4:185-196.
    • (2007) Cell Mol Immunol , vol.4 , pp. 185-196
    • Zheng, H.1    Li, L.L.2    Hu, D.S.3    Deng, X.Y.4    Cao, Y.5
  • 9
    • 70349210826 scopus 로고    scopus 로고
    • Role of the Epstein-Barr virus-encoded latent membrane protein 1, LMP1, in the pathogenesis of nasopharyngeal carcinoma
    • Morris M.A., Dawson C.W., Young L.S. Role of the Epstein-Barr virus-encoded latent membrane protein 1, LMP1, in the pathogenesis of nasopharyngeal carcinoma. Future Oncol 2009, 5:811-825.
    • (2009) Future Oncol , vol.5 , pp. 811-825
    • Morris, M.A.1    Dawson, C.W.2    Young, L.S.3
  • 10
    • 42949162045 scopus 로고    scopus 로고
    • The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy
    • Lee D.Y., Sugden B. The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy. Oncogene 2008, 27:2833-2842.
    • (2008) Oncogene , vol.27 , pp. 2833-2842
    • Lee, D.Y.1    Sugden, B.2
  • 11
    • 0034732153 scopus 로고    scopus 로고
    • Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Ets1 and invasive growth
    • Kim K.R., Yoshizaki T., Miyamori H., Hasegawa K., Horikawa T., Furukawa M., et al. Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Ets1 and invasive growth. Oncogene 2000, 19:1764-1771.
    • (2000) Oncogene , vol.19 , pp. 1764-1771
    • Kim, K.R.1    Yoshizaki, T.2    Miyamori, H.3    Hasegawa, K.4    Horikawa, T.5    Furukawa, M.6
  • 12
    • 27144542052 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K
    • Mainou B.A., Everly D.N., Raab-Traub N. Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K. Oncogene 2005, 24:6917-6924.
    • (2005) Oncogene , vol.24 , pp. 6917-6924
    • Mainou, B.A.1    Everly, D.N.2    Raab-Traub, N.3
  • 13
    • 41149159605 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway
    • Dawson C.W., Laverick L., Morris M.A., Tramoutanis G., Young L.S. Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. J Virol 2008, 82:3654-3664.
    • (2008) J Virol , vol.82 , pp. 3654-3664
    • Dawson, C.W.1    Laverick, L.2    Morris, M.A.3    Tramoutanis, G.4    Young, L.S.5
  • 14
    • 49049103338 scopus 로고    scopus 로고
    • DNA tumour viruses promote tumour cell invasion and metastasis by deregulating the normal processes of cell adhesion and motility
    • Morris M.A., Young L.S., Dawson C.W. DNA tumour viruses promote tumour cell invasion and metastasis by deregulating the normal processes of cell adhesion and motility. Eur J Cell Biol 2008, 87:677-697.
    • (2008) Eur J Cell Biol , vol.87 , pp. 677-697
    • Morris, M.A.1    Young, L.S.2    Dawson, C.W.3
  • 15
    • 0033523115 scopus 로고    scopus 로고
    • Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein1 coregulates interleukin-6 and interleukin-8 production
    • Eliopoulos A.G., Gallagher N.J., Blake S.M., Dawson C.W., Young L.S. Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein1 coregulates interleukin-6 and interleukin-8 production. J Biol Chem 1999, 274:16085-16096.
    • (1999) J Biol Chem , vol.274 , pp. 16085-16096
    • Eliopoulos, A.G.1    Gallagher, N.J.2    Blake, S.M.3    Dawson, C.W.4    Young, L.S.5
  • 16
    • 0035202289 scopus 로고    scopus 로고
    • Intracellular signaling molecules activated by Epstein-Barr virus for induction of interferon regulatory factor 7
    • Zhang L., Wu L., Hong K., Pagano J.S. Intracellular signaling molecules activated by Epstein-Barr virus for induction of interferon regulatory factor 7. J Virol 2001, 75:12393-12401.
    • (2001) J Virol , vol.75 , pp. 12393-12401
    • Zhang, L.1    Wu, L.2    Hong, K.3    Pagano, J.S.4
  • 17
    • 0344441264 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-κB2 to p52 via an IKKγ/NEMO-independent signalling pathway
    • Eliopoulos A.G., Caamano J.H., Flavell J., Reynolds G.M., Murray P.G., Poyet J.L., et al. Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-κB2 to p52 via an IKKγ/NEMO-independent signalling pathway. Oncogene 2003, 22:7557-7569.
    • (2003) Oncogene , vol.22 , pp. 7557-7569
    • Eliopoulos, A.G.1    Caamano, J.H.2    Flavell, J.3    Reynolds, G.M.4    Murray, P.G.5    Poyet, J.L.6
  • 18
    • 0347719385 scopus 로고    scopus 로고
    • Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKKα-dependent non-canonical NF-κB activation
    • Luftig M., Yasui T., Soni V., Kang M.S., Jacobson N., Cahir-McFarland E., et al. Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKKα-dependent non-canonical NF-κB activation. Proc Natl Acad Sci U S A 2004, 101:141-146.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 141-146
    • Luftig, M.1    Yasui, T.2    Soni, V.3    Kang, M.S.4    Jacobson, N.5    Cahir-McFarland, E.6
  • 19
    • 36348930548 scopus 로고    scopus 로고
    • Induction of epidermal growth factor receptor expression by Epstein-Barr virus latent membrane protein 1 C-terminal-activating region 1 is mediated by NF-kB p50 homodimer/Bcl-3 complexes
    • Thornburg N.J., Raab-Traub N. Induction of epidermal growth factor receptor expression by Epstein-Barr virus latent membrane protein 1 C-terminal-activating region 1 is mediated by NF-kB p50 homodimer/Bcl-3 complexes. J Virol 2007, 81:12954-12961.
    • (2007) J Virol , vol.81 , pp. 12954-12961
    • Thornburg, N.J.1    Raab-Traub, N.2
  • 20
    • 77953313540 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 modulates distinctive NF-kB pathways through C-terminus-activating region 1 to regulate epidermal growth factor receptor expression
    • Kung C.P., Raab-Traub N. Epstein-Barr virus latent membrane protein 1 modulates distinctive NF-kB pathways through C-terminus-activating region 1 to regulate epidermal growth factor receptor expression. J Virol 2010, 84:6605-6614.
    • (2010) J Virol , vol.84 , pp. 6605-6614
    • Kung, C.P.1    Raab-Traub, N.2
  • 21
    • 0030815756 scopus 로고    scopus 로고
    • The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB
    • Izumi K.M., Kieff E.D. The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB. Proc Natl Acad Sci USA 1997, 94:12592-12597.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12592-12597
    • Izumi, K.M.1    Kieff, E.D.2
  • 22
    • 0032510393 scopus 로고    scopus 로고
    • Epstein-Barr virus: LMP1 masquerades as an active receptor
    • Eliopoulos A.G., Rickinson A.B. Epstein-Barr virus: LMP1 masquerades as an active receptor. Curr Biol 1998, 8:R196-R198.
    • (1998) Curr Biol , vol.8
    • Eliopoulos, A.G.1    Rickinson, A.B.2
  • 23
    • 0032473910 scopus 로고    scopus 로고
    • Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1)
    • Eliopoulos A.G., Young L.S. Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Oncogene 1998, 16:1731-1742.
    • (1998) Oncogene , vol.16 , pp. 1731-1742
    • Eliopoulos, A.G.1    Young, L.S.2
  • 24
    • 0030728946 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade
    • Kieser A., Kilger E., Gires O., Ueffing M., Kolch W., Hammerschmidt W. Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade. EMBO J 1997, 16:6478-6485.
    • (1997) EMBO J , vol.16 , pp. 6478-6485
    • Kieser, A.1    Kilger, E.2    Gires, O.3    Ueffing, M.4    Kolch, W.5    Hammerschmidt, W.6
  • 25
    • 0032901776 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2
    • Eliopoulos A.G., Blake S.M., Floettmann J.E., Rowe M., Young L.S. Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2. J Virol 1999, 73:1023-1035.
    • (1999) J Virol , vol.73 , pp. 1023-1035
    • Eliopoulos, A.G.1    Blake, S.M.2    Floettmann, J.E.3    Rowe, M.4    Young, L.S.5
  • 26
    • 0033522511 scopus 로고    scopus 로고
    • LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2
    • Kieser A., Kaiser C., Hammerschmidt W. LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2. EMBO J 1999, 18:2511-2521.
    • (1999) EMBO J , vol.18 , pp. 2511-2521
    • Kieser, A.1    Kaiser, C.2    Hammerschmidt, W.3
  • 27
    • 30644473609 scopus 로고    scopus 로고
    • BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway
    • Wan J., Zhang W., Wu L., Bai T., Zhang M., Lo K.W., et al. BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway. Mol Cell Biol 2006, 26:448-456.
    • (2006) Mol Cell Biol , vol.26 , pp. 448-456
    • Wan, J.1    Zhang, W.2    Wu, L.3    Bai, T.4    Zhang, M.5    Lo, K.W.6
  • 28
    • 0037423201 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodelling
    • Dawson C.W., Tramountanis G., Eliopoulos A.G., Young L.S. Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodelling. J Biol Chem 2003, 278:3694-3704.
    • (2003) J Biol Chem , vol.278 , pp. 3694-3704
    • Dawson, C.W.1    Tramountanis, G.2    Eliopoulos, A.G.3    Young, L.S.4
  • 29
    • 35348850792 scopus 로고    scopus 로고
    • Unique signaling properties of CTAR1 in LMP1-mediated transformation
    • Mainou B.A., Everly D.N., Raab-Traub N. Unique signaling properties of CTAR1 in LMP1-mediated transformation. J Virol 2007, 81:9680-9692.
    • (2007) J Virol , vol.81 , pp. 9680-9692
    • Mainou, B.A.1    Everly, D.N.2    Raab-Traub, N.3
  • 30
    • 43949130116 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor through effects on Bcl-3 and STAT3
    • Kung C.P., Raab-Traub N. Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor through effects on Bcl-3 and STAT3. J Virol 2008, 82:5486-5493.
    • (2008) J Virol , vol.82 , pp. 5486-5493
    • Kung, C.P.1    Raab-Traub, N.2
  • 31
    • 79955368240 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP1 activates EGFR, STAT3, and ERK through effects on PKCδ
    • Kung C.P., Meckes D.G., Raab-Traub N. Epstein-Barr virus LMP1 activates EGFR, STAT3, and ERK through effects on PKCδ. J Virol 2011, 85:4399-4408.
    • (2011) J Virol , vol.85 , pp. 4399-4408
    • Kung, C.P.1    Meckes, D.G.2    Raab-Traub, N.3
  • 32
    • 33845709575 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 mediates phosphorylation and nuclear translocation of annexin A2 by activating PKC pathway
    • Yan G., Luo W., Lu Z., Luo X., Li L., Liu S., et al. Epstein-Barr virus latent membrane protein 1 mediates phosphorylation and nuclear translocation of annexin A2 by activating PKC pathway. Cell Signal 2007, 19:341-348.
    • (2007) Cell Signal , vol.19 , pp. 341-348
    • Yan, G.1    Luo, W.2    Lu, Z.3    Luo, X.4    Li, L.5    Liu, S.6
  • 33
    • 80052284504 scopus 로고    scopus 로고
    • IRF7: activation, regulation, modification and function
    • Ning S., Pagano J.S., Barber G.N. IRF7: activation, regulation, modification and function. Genes Immun 2011, 12:399-414.
    • (2011) Genes Immun , vol.12 , pp. 399-414
    • Ning, S.1    Pagano, J.S.2    Barber, G.N.3
  • 34
    • 34147208226 scopus 로고    scopus 로고
    • Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination
    • Huye L.E., Ning S., Kelliher M., Pagano J.S. Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination. Mol Cell Biol 2007, 27:2910-2918.
    • (2007) Mol Cell Biol , vol.27 , pp. 2910-2918
    • Huye, L.E.1    Ning, S.2    Kelliher, M.3    Pagano, J.S.4
  • 35
    • 0041387416 scopus 로고    scopus 로고
    • Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit
    • Ning S., Hahn A.M., Huye L.E., Pagano J.S. Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit. J Virol 2003, 77:9359-9368.
    • (2003) J Virol , vol.77 , pp. 9359-9368
    • Ning, S.1    Hahn, A.M.2    Huye, L.E.3    Pagano, J.S.4
  • 36
    • 77952716624 scopus 로고    scopus 로고
    • The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7
    • Ning S., Pagano J.S. The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7. J Virol 2010, 84:6130-6138.
    • (2010) J Virol , vol.84 , pp. 6130-6138
    • Ning, S.1    Pagano, J.S.2
  • 37
    • 0037131171 scopus 로고    scopus 로고
    • Negative regulation of Epstein-Barr virus latent membrane protein 1-mediated functions by the bone morphogenetic protein receptor IA-binding protein
    • Chung P.J., Chang Y.S., Liang C.L., Meng C.L. Negative regulation of Epstein-Barr virus latent membrane protein 1-mediated functions by the bone morphogenetic protein receptor IA-binding protein. BRAM1 J Biol Chem 2002, 277:39850-43987.
    • (2002) BRAM1 J Biol Chem , vol.277 , pp. 39850-43987
    • Chung, P.J.1    Chang, Y.S.2    Liang, C.L.3    Meng, C.L.4
  • 38
    • 67349205539 scopus 로고    scopus 로고
    • BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1
    • Ikeda O., Sekine Y., Mizushima A., Oritani K., Yasui T., Fujimuro M., et al. BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1. FEBS Lett 2009, 583:1567-1574.
    • (2009) FEBS Lett , vol.583 , pp. 1567-1574
    • Ikeda, O.1    Sekine, Y.2    Mizushima, A.3    Oritani, K.4    Yasui, T.5    Fujimuro, M.6
  • 39
    • 76749123262 scopus 로고    scopus 로고
    • BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-κB activation
    • Ikeda O., Miyasaka Y., Yoshida R., Mizushima A., Oritani K., Sekine Y., et al. BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-κB activation. FEBS Lett 2010, 584:865-872.
    • (2010) FEBS Lett , vol.584 , pp. 865-872
    • Ikeda, O.1    Miyasaka, Y.2    Yoshida, R.3    Mizushima, A.4    Oritani, K.5    Sekine, Y.6
  • 40
    • 49449084104 scopus 로고    scopus 로고
    • STAP-2 negatively regulates both canonical and noncanonical NF-κB activation induced by Epstein-Barr virus-derived latent membrane protein 1
    • Ikeda O., Sekine Y., Yasui T., Oritani K., Sugiyma K., Muromoto R., et al. STAP-2 negatively regulates both canonical and noncanonical NF-κB activation induced by Epstein-Barr virus-derived latent membrane protein 1. Mol Cell Biol 2008, 28:5027-5042.
    • (2008) Mol Cell Biol , vol.28 , pp. 5027-5042
    • Ikeda, O.1    Sekine, Y.2    Yasui, T.3    Oritani, K.4    Sugiyma, K.5    Muromoto, R.6
  • 41
    • 0036433743 scopus 로고    scopus 로고
    • Genetic and epigenetic changes in nasopharyngeal carcinoma
    • Lo K., Huang D. Genetic and epigenetic changes in nasopharyngeal carcinoma. Sem Cancer Biol 2002, 12:451-462.
    • (2002) Sem Cancer Biol , vol.12 , pp. 451-462
    • Lo, K.1    Huang, D.2
  • 42
    • 34548631786 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments
    • Tao Q., Chan A.T. Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments. Expert Rev Mol Med 2007, 9:1-24.
    • (2007) Expert Rev Mol Med , vol.9 , pp. 1-24
    • Tao, Q.1    Chan, A.T.2
  • 44
    • 0034644195 scopus 로고    scopus 로고
    • High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?
    • Crook T., Nicholls J.M., Brooks L., O'Nions J., Allday M.J. High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?. Oncogene 2000, 19:3439-3444.
    • (2000) Oncogene , vol.19 , pp. 3439-3444
    • Crook, T.1    Nicholls, J.M.2    Brooks, L.3    O'Nions, J.4    Allday, M.J.5
  • 45
    • 0029914174 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene
    • Fries K.L., Miller W.E., Raab-Traub N. Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene. J Virol 1996, 70:8653-8659.
    • (1996) J Virol , vol.70 , pp. 8653-8659
    • Fries, K.L.1    Miller, W.E.2    Raab-Traub, N.3
  • 46
    • 34547965826 scopus 로고    scopus 로고
    • Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases
    • Li L., Guo L., Tao Y., Zhou S., Wang Z., Luo W., et al. Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases. Cancer Lett 2007, 255:219-231.
    • (2007) Cancer Lett , vol.255 , pp. 219-231
    • Li, L.1    Guo, L.2    Tao, Y.3    Zhou, S.4    Wang, Z.5    Luo, W.6
  • 47
    • 10044262203 scopus 로고    scopus 로고
    • MDM2 expression in EBV-infected nasopharyngeal carcinoma cells
    • Wu H.C., Lu T.Y., Lee J.J., Hwang J.K., Lin Y.J., Wang C.K., et al. MDM2 expression in EBV-infected nasopharyngeal carcinoma cells. Lab Invest 2004, 84:1547-1556.
    • (2004) Lab Invest , vol.84 , pp. 1547-1556
    • Wu, H.C.1    Lu, T.Y.2    Lee, J.J.3    Hwang, J.K.4    Lin, Y.J.5    Wang, C.K.6
  • 48
    • 3242703867 scopus 로고    scopus 로고
    • Cooperative interactions among p53, bcl-2 and Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma cells
    • Sheu L.F., Chen A., Lee H.S., Hsu H.Y., Yu D.S. Cooperative interactions among p53, bcl-2 and Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma cells. Pathol Int 2004, 54:475-485.
    • (2004) Pathol Int , vol.54 , pp. 475-485
    • Sheu, L.F.1    Chen, A.2    Lee, H.S.3    Hsu, H.Y.4    Yu, D.S.5
  • 49
    • 34248368436 scopus 로고    scopus 로고
    • Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells
    • Man C., Rosa J., Lee L.T., Lee V.H., Chow B.K., Lo K.W., et al. Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells. Oncogene 2007, 26:3069-3080.
    • (2007) Oncogene , vol.26 , pp. 3069-3080
    • Man, C.1    Rosa, J.2    Lee, L.T.3    Lee, V.H.4    Chow, B.K.5    Lo, K.W.6
  • 50
    • 0042168998 scopus 로고    scopus 로고
    • The latent membrane protein 1 of Epstein-Barr virus and loss of the INK4a locus: paradoxes resolve to cooperation in carcinogenesis in vivo
    • Macdiarmid J., Stevenson D., Campbell D.H., Wilson J.B. The latent membrane protein 1 of Epstein-Barr virus and loss of the INK4a locus: paradoxes resolve to cooperation in carcinogenesis in vivo. Carcinogenesis 2003, 24:1209-1218.
    • (2003) Carcinogenesis , vol.24 , pp. 1209-1218
    • Macdiarmid, J.1    Stevenson, D.2    Campbell, D.H.3    Wilson, J.B.4
  • 51
    • 0033986419 scopus 로고    scopus 로고
    • LMP1 of Epstein-Barr virus induces proliferation of primary mouse embryonic fibroblasts and cooperatively transforms the cells with a p16-insensitive CDK4 oncogene
    • Yang X., Sham J.S., Ng M.H., Tsao S.W., Zhang D., Lowe S.W., et al. LMP1 of Epstein-Barr virus induces proliferation of primary mouse embryonic fibroblasts and cooperatively transforms the cells with a p16-insensitive CDK4 oncogene. J Virol 2000, 74:883-889.
    • (2000) J Virol , vol.74 , pp. 883-889
    • Yang, X.1    Sham, J.S.2    Ng, M.H.3    Tsao, S.W.4    Zhang, D.5    Lowe, S.W.6
  • 52
    • 0034643382 scopus 로고    scopus 로고
    • LMP1 of Epstein-Barr virus suppresses cellular senescence associated with the inhibition ofp16INK4a expression
    • Yang X., He Z., Xin B., Cao L. LMP1 of Epstein-Barr virus suppresses cellular senescence associated with the inhibition ofp16INK4a expression. Oncogene 2000, 19:2002-2013.
    • (2000) Oncogene , vol.19 , pp. 2002-2013
    • Yang, X.1    He, Z.2    Xin, B.3    Cao, L.4
  • 53
    • 1542543327 scopus 로고    scopus 로고
    • Effects of two LMP1 variants on resistance of CNE1 cell strain to TGFβ1
    • Huang H., Huang P.C. Effects of two LMP1 variants on resistance of CNE1 cell strain to TGFβ1. Ai Zheng 2003, 22:1254-1259.
    • (2003) Ai Zheng , vol.22 , pp. 1254-1259
    • Huang, H.1    Huang, P.C.2
  • 54
    • 2442486341 scopus 로고    scopus 로고
    • Phenotypic alterations induced by the Hong Kong-prevalent Epstein-Barr virus-encoded LMP1 variant (2117-LMP1) in nasopharyngeal epithelial cells
    • Lo A.K., Huang D.P., Lo K.W., Chui Y.L., Li H.M., Pang J.C., et al. Phenotypic alterations induced by the Hong Kong-prevalent Epstein-Barr virus-encoded LMP1 variant (2117-LMP1) in nasopharyngeal epithelial cells. Int J Cancer 2004, 109:919-925.
    • (2004) Int J Cancer , vol.109 , pp. 919-925
    • Lo, A.K.1    Huang, D.P.2    Lo, K.W.3    Chui, Y.L.4    Li, H.M.5    Pang, J.C.6
  • 55
    • 0043174021 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5
    • Ohtani N., Brennan P., Gaubatz S., Sanij E., Hertzog P., Wolvetang E., et al. Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5. J Cell Biol 2003, 162:173-183.
    • (2003) J Cell Biol , vol.162 , pp. 173-183
    • Ohtani, N.1    Brennan, P.2    Gaubatz, S.3    Sanij, E.4    Hertzog, P.5    Wolvetang, E.6
  • 56
    • 10044221147 scopus 로고    scopus 로고
    • Induction of Id1 and Id3 by latent membrane protein 1 of Epstein-Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation
    • Everly D.N., Mainou B.A., Raab-Traub N. Induction of Id1 and Id3 by latent membrane protein 1 of Epstein-Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation. J Virol 2004, 78:13470-13478.
    • (2004) J Virol , vol.78 , pp. 13470-13478
    • Everly, D.N.1    Mainou, B.A.2    Raab-Traub, N.3
  • 57
    • 44649158187 scopus 로고    scopus 로고
    • The Id proteins contribute to the growth of rodent fibroblasts during LMP1-mediated transformation
    • Everly D.N., Mainou B.A., Raab-Traub N. The Id proteins contribute to the growth of rodent fibroblasts during LMP1-mediated transformation. Virology 2008, 376:258-269.
    • (2008) Virology , vol.376 , pp. 258-269
    • Everly, D.N.1    Mainou, B.A.2    Raab-Traub, N.3
  • 58
    • 3042532226 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells
    • Li H.M., Zhuang Z.H., Wang Q., Pang J.C., Wang X.H., Wong H.L., et al. Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells. Oncogene 2004, 23:4488-4494.
    • (2004) Oncogene , vol.23 , pp. 4488-4494
    • Li, H.M.1    Zhuang, Z.H.2    Wang, Q.3    Pang, J.C.4    Wang, X.H.5    Wong, H.L.6
  • 59
    • 77955124555 scopus 로고    scopus 로고
    • Upregulation of Id1 by Epstein-Barr virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition
    • Lo A.K., Dawson C.W., Lo K.W., Yu Y., Young L.S. Upregulation of Id1 by Epstein-Barr virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition. Mol Cancer 2010, 9:155.
    • (2010) Mol Cancer , vol.9 , pp. 155
    • Lo, A.K.1    Dawson, C.W.2    Lo, K.W.3    Yu, Y.4    Young, L.S.5
  • 61
    • 0033119034 scopus 로고    scopus 로고
    • Profile of cytokine expression in nasopharyngeal carcinomas: a distinct expression of interleukin 1 in tumor and CD4+ T cells
    • Huang Y.T., Sheen T.S., Chen C.L., Lu J., Chang Y., Chen J.Y., et al. Profile of cytokine expression in nasopharyngeal carcinomas: a distinct expression of interleukin 1 in tumor and CD4+ T cells. Cancer Res 1999, 59:1599-1605.
    • (1999) Cancer Res , vol.59 , pp. 1599-1605
    • Huang, Y.T.1    Sheen, T.S.2    Chen, C.L.3    Lu, J.4    Chang, Y.5    Chen, J.Y.6
  • 62
    • 0034994445 scopus 로고    scopus 로고
    • Expression of cytokine and chemokine genes in Epstein-Barr virus-associated nasopharyngeal carcinoma: comparison with Hodgkin's disease
    • Beck A., Päzolt D., Grabenbauer G.G., Nicholls J.M., Herbst H., Young L.S., et al. Expression of cytokine and chemokine genes in Epstein-Barr virus-associated nasopharyngeal carcinoma: comparison with Hodgkin's disease. J Pathol 2001, 194:145-151.
    • (2001) J Pathol , vol.194 , pp. 145-151
    • Beck, A.1    Päzolt, D.2    Grabenbauer, G.G.3    Nicholls, J.M.4    Herbst, H.5    Young, L.S.6
  • 63
    • 77954412016 scopus 로고    scopus 로고
    • Upregulation of interleukin-1 by Epstein-Barr virus latent membrane protein 1 and its possible role in nasopharyngeal carcinoma cell growth
    • Huang Y.T., Liu M.Y., Tsai C.H., Yeh T.H. Upregulation of interleukin-1 by Epstein-Barr virus latent membrane protein 1 and its possible role in nasopharyngeal carcinoma cell growth. Head Neck 2010, 32:869-876.
    • (2010) Head Neck , vol.32 , pp. 869-876
    • Huang, Y.T.1    Liu, M.Y.2    Tsai, C.H.3    Yeh, T.H.4
  • 64
    • 34547671041 scopus 로고    scopus 로고
    • The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: dominance of innate immune responses in psoriasis
    • Mee J.B., Johnson C.M., Morar N., Burslem F., Groves R.W. The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: dominance of innate immune responses in psoriasis. Am J Pathol 2007, 171:32-42.
    • (2007) Am J Pathol , vol.171 , pp. 32-42
    • Mee, J.B.1    Johnson, C.M.2    Morar, N.3    Burslem, F.4    Groves, R.W.5
  • 65
    • 0029063936 scopus 로고
    • The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor
    • Miller W.E., Earp H.S., Raab-Traub N. The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor. J Virol 1995, 69:4390-4398.
    • (1995) J Virol , vol.69 , pp. 4390-4398
    • Miller, W.E.1    Earp, H.S.2    Raab-Traub, N.3
  • 66
    • 0033378791 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded latent membrane protein 1 co-expresses with epidermal growth factor receptor in nasopharyngeal carcinoma
    • Sheen T.S., Huang Y.T., Chang Y.L., Ko J.Y., Wu C.S., Yu Y.C., et al. Epstein-Barr virus-encoded latent membrane protein 1 co-expresses with epidermal growth factor receptor in nasopharyngeal carcinoma. Jpn J Cancer Res 1999, 90:1285-1292.
    • (1999) Jpn J Cancer Res , vol.90 , pp. 1285-1292
    • Sheen, T.S.1    Huang, Y.T.2    Chang, Y.L.3    Ko, J.Y.4    Wu, C.S.5    Yu, Y.C.6
  • 67
    • 0033551802 scopus 로고    scopus 로고
    • Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
    • Chen R.H., Chang M.C., Su Y.H., Tsai Y.T., Kuo M.L. Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J Biol Chem 1999, 274:23013-32309.
    • (1999) J Biol Chem , vol.274 , pp. 23013-32309
    • Chen, R.H.1    Chang, M.C.2    Su, Y.H.3    Tsai, Y.T.4    Kuo, M.L.5
  • 68
    • 0032940579 scopus 로고    scopus 로고
    • Downregulation and abnormal expression of E-cadherin and beta-catenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis
    • Zheng Z., Pan J., Chu B., Wong Y.C., Cheung A.L., Tsao S.W. Downregulation and abnormal expression of E-cadherin and beta-catenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis. Hum Pathol 1999, 30:458-466.
    • (1999) Hum Pathol , vol.30 , pp. 458-466
    • Zheng, Z.1    Pan, J.2    Chu, B.3    Wong, Y.C.4    Cheung, A.L.5    Tsao, S.W.6
  • 69
    • 0026468337 scopus 로고
    • Decreased expression of E-cadherin and increased invasive capacity in EBV-LMP-transfected human epithelial and murine adenocarcinoma cells
    • Fåhraeus R., Chen W., Trivedi P., Klein G., Obrink B. Decreased expression of E-cadherin and increased invasive capacity in EBV-LMP-transfected human epithelial and murine adenocarcinoma cells. Int J Cancer 1992, 52(5):834-838.
    • (1992) Int J Cancer , vol.52 , Issue.5 , pp. 834-838
    • Fåhraeus, R.1    Chen, W.2    Trivedi, P.3    Klein, G.4    Obrink, B.5
  • 70
    • 0037162536 scopus 로고    scopus 로고
    • The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the down-regulation of E-cadherin gene expression via activation of DNA methyltransferases
    • Tsai C.N., Tsai C.L., Tse K.P., Chang H.Y., Chang Y.S. The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the down-regulation of E-cadherin gene expression via activation of DNA methyltransferases. Proc Natl Acad Sci U S A 2002, 99:10084-10089.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10084-10089
    • Tsai, C.N.1    Tsai, C.L.2    Tse, K.P.3    Chang, H.Y.4    Chang, Y.S.5
  • 71
    • 33947196379 scopus 로고    scopus 로고
    • Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma
    • Horikawa T., Yang J., Kondo S., Yoshizaki T., Joab I., Furukawa M., et al. Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res 2007, 67:1970-1978.
    • (2007) Cancer Res , vol.67 , pp. 1970-1978
    • Horikawa, T.1    Yang, J.2    Kondo, S.3    Yoshizaki, T.4    Joab, I.5    Furukawa, M.6
  • 72
    • 0032845761 scopus 로고    scopus 로고
    • Expression of Epstein-Barr virus latent membrane proteins leads to changes in keratinocyte cell adhesion
    • Farwell D.G., McDougall J.K., Coltrera M.D. Expression of Epstein-Barr virus latent membrane proteins leads to changes in keratinocyte cell adhesion. Ann Otol Rhinol Laryngol 1999, 108:851-859.
    • (1999) Ann Otol Rhinol Laryngol , vol.108 , pp. 851-859
    • Farwell, D.G.1    McDougall, J.K.2    Coltrera, M.D.3
  • 73
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: twist in development and metastasis
    • Kang Y., Massagué J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 2004, 118:277-927.
    • (2004) Cell , vol.118 , pp. 277-927
    • Kang, Y.1    Massagué, J.2
  • 74
    • 80051558446 scopus 로고    scopus 로고
    • The Epstein-Barr virus latent membrane protein 1 and transforming growth factor-β1 synergistically induce epithelial-mesenchymal transition in lung epithelial cells
    • Sides M.D., Klingsberg R.C., Shan B., Gordon K.A., Nguyen H.T., Lin Z., et al. The Epstein-Barr virus latent membrane protein 1 and transforming growth factor-β1 synergistically induce epithelial-mesenchymal transition in lung epithelial cells. Am J Respir Cell Mol Biol 2011, 44:852-862.
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 852-862
    • Sides, M.D.1    Klingsberg, R.C.2    Shan, B.3    Gordon, K.A.4    Nguyen, H.T.5    Lin, Z.6
  • 75
    • 79953166389 scopus 로고    scopus 로고
    • Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial-mesenchymal transition in metastatic nasopharyngeal carcinoma
    • Horikawa T., Yoshizaki T., Kondo S., Furukawa M., Kaizaki Y., Pagano J.S. Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial-mesenchymal transition in metastatic nasopharyngeal carcinoma. Brit J Cancer 2011, 104:1160-1167.
    • (2011) Brit J Cancer , vol.104 , pp. 1160-1167
    • Horikawa, T.1    Yoshizaki, T.2    Kondo, S.3    Furukawa, M.4    Kaizaki, Y.5    Pagano, J.S.6
  • 76
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak K., Weinberg R.A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009, 9:265-273.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 77
    • 80055113577 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines
    • Kondo S., Wakisaka N., Muramatsu M., Zen Y., Endo K., Murono S., et al. Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines. J Virol 2011, 85:11255-11264.
    • (2011) J Virol , vol.85 , pp. 11255-11264
    • Kondo, S.1    Wakisaka, N.2    Muramatsu, M.3    Zen, Y.4    Endo, K.5    Murono, S.6
  • 78
    • 0036063344 scopus 로고    scopus 로고
    • Promotion of metastasis in nasopharyngeal carcinoma by Epstein-Barr virus latent membrane protein-1
    • Yoshizaki T. Promotion of metastasis in nasopharyngeal carcinoma by Epstein-Barr virus latent membrane protein-1. Histol Histopathol 2002, 17:845-850.
    • (2002) Histol Histopathol , vol.17 , pp. 845-850
    • Yoshizaki, T.1
  • 79
    • 0141463795 scopus 로고    scopus 로고
    • Effects of Epstein-Barr virus latent membrane protein 1(EBV-LMP1) on related factors of metastasis of nasopharyngeal carcinoma cell line CNE1
    • Gou X.M., Chen Y., Chen X.Y., Arrand J.R. Effects of Epstein-Barr virus latent membrane protein 1(EBV-LMP1) on related factors of metastasis of nasopharyngeal carcinoma cell line CNE1. Ai Zheng 2003, 22:481-485.
    • (2003) Ai Zheng , vol.22 , pp. 481-485
    • Gou, X.M.1    Chen, Y.2    Chen, X.Y.3    Arrand, J.R.4
  • 80
    • 35348913957 scopus 로고    scopus 로고
    • Induction of matrix metalloproteinases by Epstein-Barr virus latent membrane protein 1 isolated from nasopharyngeal carcinoma
    • Lee D.C., Chua D.T., Wei W.I., Sham J.S., Lau A.S. Induction of matrix metalloproteinases by Epstein-Barr virus latent membrane protein 1 isolated from nasopharyngeal carcinoma. Biomed Pharmacother 2007, 61:520-526.
    • (2007) Biomed Pharmacother , vol.61 , pp. 520-526
    • Lee, D.C.1    Chua, D.T.2    Wei, W.I.3    Sham, J.S.4    Lau, A.S.5
  • 81
    • 0034663173 scopus 로고    scopus 로고
    • Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma
    • Horikawa T., Yoshizaki T., Sheen T.S., Lee S.Y., Furukawa M. Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma. Cancer 2000, 89:715-723.
    • (2000) Cancer , vol.89 , pp. 715-723
    • Horikawa, T.1    Yoshizaki, T.2    Sheen, T.S.3    Lee, S.Y.4    Furukawa, M.5
  • 82
    • 22144492282 scopus 로고    scopus 로고
    • EBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in North African nasopharyngeal carcinomas
    • Khabir A., Karray H., Rodriguez S., Rosé M., Daoud J., Frikha M., et al. EBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in North African nasopharyngeal carcinomas. Virol J 2005, 2:39.
    • (2005) Virol J , vol.2 , pp. 39
    • Khabir, A.1    Karray, H.2    Rodriguez, S.3    Rosé, M.4    Daoud, J.5    Frikha, M.6
  • 83
    • 0041805365 scopus 로고    scopus 로고
    • Epstein-Barr virus induces invasion and metastasis factors
    • Wakisaka N., Pagano J.S. Epstein-Barr virus induces invasion and metastasis factors. Anticancer Res 2003, 23:2133-2138.
    • (2003) Anticancer Res , vol.23 , pp. 2133-2138
    • Wakisaka, N.1    Pagano, J.S.2
  • 84
    • 67651187778 scopus 로고    scopus 로고
    • Impact of up-regulating Ezrin expression by Epstein-Barr virus latent membrane protein 1 on metastasis ability of nasopharyngeal carcinoma cells
    • Shen Z.H., Chen X.Y., Chen J. Impact of up-regulating Ezrin expression by Epstein-Barr virus latent membrane protein 1 on metastasis ability of nasopharyngeal carcinoma cells. Ai Zheng 2008, 27:165-169.
    • (2008) Ai Zheng , vol.27 , pp. 165-169
    • Shen, Z.H.1    Chen, X.Y.2    Chen, J.3
  • 85
    • 0344010693 scopus 로고    scopus 로고
    • RECK is a target of Epstein-Barr virus latent membrane protein 1
    • Liu L.T., Peng J.P., Chang H.C., Hung W.C. RECK is a target of Epstein-Barr virus latent membrane protein 1. Oncogene 2003, 22:8263-8270.
    • (2003) Oncogene , vol.22 , pp. 8263-8270
    • Liu, L.T.1    Peng, J.P.2    Chang, H.C.3    Hung, W.C.4
  • 86
    • 67651006731 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch
    • Shair K.H., Schnegg C.I., Raab-Traub N. Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch. Cancer Res 2009, 69:5734-5742.
    • (2009) Cancer Res , vol.69 , pp. 5734-5742
    • Shair, K.H.1    Schnegg, C.I.2    Raab-Traub, N.3
  • 87
    • 50049104766 scopus 로고    scopus 로고
    • Transcriptional repression of tissue inhibitor of metalloproteinase-3 by Epstein-Barr virus latent membrane protein 1 enhances invasiveness of nasopharyngeal carcinoma cells
    • Chang S.H., Chang H.C., Hung W.C. Transcriptional repression of tissue inhibitor of metalloproteinase-3 by Epstein-Barr virus latent membrane protein 1 enhances invasiveness of nasopharyngeal carcinoma cells. Oral Oncol 2008, 44:891-897.
    • (2008) Oral Oncol , vol.44 , pp. 891-897
    • Chang, S.H.1    Chang, H.C.2    Hung, W.C.3
  • 88
    • 18644368754 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma
    • Kondo S., Wakisaka N., Schell M.J., Horikawa T., Sheen T.S., Sato H., et al. Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma. Int J Cancer 2005, 115:368-376.
    • (2005) Int J Cancer , vol.115 , pp. 368-376
    • Kondo, S.1    Wakisaka, N.2    Schell, M.J.3    Horikawa, T.4    Sheen, T.S.5    Sato, H.6
  • 89
    • 34748907897 scopus 로고    scopus 로고
    • Cross-talk between c-Jun/Ets1 involved in EBV-encoded latent membrane protein 1 regulates expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma
    • Zeng L., Liu Y.P., Tao Y.G., Ai M.D., Zhao X.R., Cao Y. Cross-talk between c-Jun/Ets1 involved in EBV-encoded latent membrane protein 1 regulates expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma. Zhonghua Zhong Liu Za Zhi 2005, 27:204-208.
    • (2005) Zhonghua Zhong Liu Za Zhi , vol.27 , pp. 204-208
    • Zeng, L.1    Liu, Y.P.2    Tao, Y.G.3    Ai, M.D.4    Zhao, X.R.5    Cao, Y.6
  • 90
    • 0035403317 scopus 로고    scopus 로고
    • Induction of c-Met proto-oncogene by Epstein-Barr virus latent membrane protein-1 and the correlation with cervical lymph node metastasis of nasopharyngeal carcinoma
    • Horikawa T., Sheen T.S., Takeshita H., Sato H., Furukawa M., Yoshizaki T. Induction of c-Met proto-oncogene by Epstein-Barr virus latent membrane protein-1 and the correlation with cervical lymph node metastasis of nasopharyngeal carcinoma. Am J Pathol 2001, 159:27-33.
    • (2001) Am J Pathol , vol.159 , pp. 27-33
    • Horikawa, T.1    Sheen, T.S.2    Takeshita, H.3    Sato, H.4    Furukawa, M.5    Yoshizaki, T.6
  • 91
    • 67349134562 scopus 로고    scopus 로고
    • Expression and clinical significance of latent membrane protein-1, matrix metalloproteinase-1 and Ets-1 transcription factor in tunisian nasopharyngeal carcinoma patients
    • Ben Nasr H., Chahed K., Remadi S., Zakhama A., Chouchane L. Expression and clinical significance of latent membrane protein-1, matrix metalloproteinase-1 and Ets-1 transcription factor in tunisian nasopharyngeal carcinoma patients. Arch Med Res 2009, 40:196-203.
    • (2009) Arch Med Res , vol.40 , pp. 196-203
    • Ben Nasr, H.1    Chahed, K.2    Remadi, S.3    Zakhama, A.4    Chouchane, L.5
  • 92
    • 77958030259 scopus 로고    scopus 로고
    • Interleukins, laminin and Epstein-Barr virus latent membrane protein 1 (EBV-LMP1) promote metastatic phenotype in nasopharyngeal carcinoma
    • Chew M.M., Gan S.Y., Khoo A.S., Tan E.L. Interleukins, laminin and Epstein-Barr virus latent membrane protein 1 (EBV-LMP1) promote metastatic phenotype in nasopharyngeal carcinoma. BMC Cancer 2010, 10:574.
    • (2010) BMC Cancer , vol.10 , pp. 574
    • Chew, M.M.1    Gan, S.Y.2    Khoo, A.S.3    Tan, E.L.4
  • 93
    • 33846841171 scopus 로고    scopus 로고
    • MUC1 induced by Epstein-Barr virus latent membrane protein 1 causes dissociation of the cell-matrix interaction and cellular invasiveness via STAT signaling
    • Kondo S., Yoshizaki T., Wakisaka N., Horikawa T., Murono S., Jang K.L., et al. MUC1 induced by Epstein-Barr virus latent membrane protein 1 causes dissociation of the cell-matrix interaction and cellular invasiveness via STAT signaling. J Virol 2007, 81:1554-1562.
    • (2007) J Virol , vol.81 , pp. 1554-1562
    • Kondo, S.1    Yoshizaki, T.2    Wakisaka, N.3    Horikawa, T.4    Murono, S.5    Jang, K.L.6
  • 94
    • 2542443138 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1α
    • Wakisaka N., Kondo S., Yoshizaki T., Murono S., Furukawa M., Pagano J.S. Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1α. Mol Cell Biol 2004, 24:5223-5234.
    • (2004) Mol Cell Biol , vol.24 , pp. 5223-5234
    • Wakisaka, N.1    Kondo, S.2    Yoshizaki, T.3    Murono, S.4    Furukawa, M.5    Pagano, J.S.6
  • 95
    • 33750537081 scopus 로고    scopus 로고
    • EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells
    • Kondo S., Seo S.Y., Yoshizaki T., Wakisaka N., Furukawa M., Joab I., et al. EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells. Cancer Res 2006, 66:9870-9877.
    • (2006) Cancer Res , vol.66 , pp. 9870-9877
    • Kondo, S.1    Seo, S.Y.2    Yoshizaki, T.3    Wakisaka, N.4    Furukawa, M.5    Joab, I.6
  • 96
    • 0035811070 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells
    • Murono S., Inoue H., Tanabe T., Joab I., Yoshizaki T., Furukawa M., et al. Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells. Proc Natl Acad Sci U S A 2001, 98:6905-6910.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6905-6910
    • Murono, S.1    Inoue, H.2    Tanabe, T.3    Joab, I.4    Yoshizaki, T.5    Furukawa, M.6
  • 97
    • 0000391746 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
    • Bergers G. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000, 2:737-744.
    • (2000) Nat Cell Biol , vol.2 , pp. 737-744
    • Bergers, G.1
  • 98
    • 0034781792 scopus 로고    scopus 로고
    • Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma
    • Yoshizaki T., Horikawa T., Qing-Chun R., Wakisaka N., Takeshita H., Sheen T.S., et al. Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma. Clin Cancer Res 2001, 7:1946-1951.
    • (2001) Clin Cancer Res , vol.7 , pp. 1946-1951
    • Yoshizaki, T.1    Horikawa, T.2    Qing-Chun, R.3    Wakisaka, N.4    Takeshita, H.5    Sheen, T.S.6
  • 99
    • 2442511257 scopus 로고    scopus 로고
    • Epstein-Barr virus (EBV) latent membrane protein 1 induces interleukin-8 through the NF-κB signaling pathway in EBV-infected nasopharyngeal carcinoma cell line
    • Ren Q., Sato H., Murono S., Furukawa M., Yoshizaki T. Epstein-Barr virus (EBV) latent membrane protein 1 induces interleukin-8 through the NF-κB signaling pathway in EBV-infected nasopharyngeal carcinoma cell line. Laryngoscope 2004, 114:855-859.
    • (2004) Laryngoscope , vol.114 , pp. 855-859
    • Ren, Q.1    Sato, H.2    Murono, S.3    Furukawa, M.4    Yoshizaki, T.5
  • 100
    • 0033523115 scopus 로고    scopus 로고
    • Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 production
    • Eliopoulos A.G., Gallagher N.J., Blake S.M., Dawson C.W., Young L.S. Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 production. J Biol Chem 1999, 274:16085-16096.
    • (1999) J Biol Chem , vol.274 , pp. 16085-16096
    • Eliopoulos, A.G.1    Gallagher, N.J.2    Blake, S.M.3    Dawson, C.W.4    Young, L.S.5
  • 101
    • 53049087445 scopus 로고    scopus 로고
    • Induction of receptor for advanced glycation end products by EBV latent membrane protein 1 and its correlation with angiogenesis and cervical lymph node metastasis in nasopharyngeal carcinoma
    • Tsuji A., Wakisaka N., Kondo S., Murono S., Furukawa M., Yoshizaki T. Induction of receptor for advanced glycation end products by EBV latent membrane protein 1 and its correlation with angiogenesis and cervical lymph node metastasis in nasopharyngeal carcinoma. Clin Cancer Res 2008, 14:5368-5375.
    • (2008) Clin Cancer Res , vol.14 , pp. 5368-5375
    • Tsuji, A.1    Wakisaka, N.2    Kondo, S.3    Murono, S.4    Furukawa, M.5    Yoshizaki, T.6
  • 102
    • 62549160416 scopus 로고    scopus 로고
    • MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma
    • Chen H.C., Chen G.H., Chen Y.H., Liao W.L., Liu C.Y., Chang K.P., et al. MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer 2009, 100:1002-1011.
    • (2009) Br J Cancer , vol.100 , pp. 1002-1011
    • Chen, H.C.1    Chen, G.H.2    Chen, Y.H.3    Liao, W.L.4    Liu, C.Y.5    Chang, K.P.6
  • 103
    • 44449111693 scopus 로고    scopus 로고
    • MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
    • Sengupta S., den Boon J.A., Chen I.H., Newton M.A., Stanhope S.A., Cheng Y.J., et al. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc Natl Acad Sci U S A 2008, 105:5874-5878.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5874-5878
    • Sengupta, S.1    den Boon, J.A.2    Chen, I.H.3    Newton, M.A.4    Stanhope, S.A.5    Cheng, Y.J.6
  • 104
    • 77957930209 scopus 로고    scopus 로고
    • MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells
    • Li G., Wu Z., Peng Y., Liu X., Lu J., Wang L., et al. MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells. Cancer Lett 2010, 299:29-36.
    • (2010) Cancer Lett , vol.299 , pp. 29-36
    • Li, G.1    Wu, Z.2    Peng, Y.3    Liu, X.4    Lu, J.5    Wang, L.6
  • 105
    • 79955622634 scopus 로고    scopus 로고
    • Upregulation of MiR-155 in nasopharyngeal carcinoma is partly driven by LMP1 and LMP2A and downregulates a negative prognostic marker JMJD1A
    • Du Z.M., Hu L.F., Wang H.Y., Yan L.X., Zeng Y.X., Shao J.Y., et al. Upregulation of MiR-155 in nasopharyngeal carcinoma is partly driven by LMP1 and LMP2A and downregulates a negative prognostic marker JMJD1A. PLoS One 2011, 6:e19137.
    • (2011) PLoS One , vol.6
    • Du, Z.M.1    Hu, L.F.2    Wang, H.Y.3    Yan, L.X.4    Zeng, Y.X.5    Shao, J.Y.6
  • 106
    • 72949119530 scopus 로고    scopus 로고
    • MiR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion
    • Xia H., Ng S.S., Jiang S., Cheung W.K., Sze J., Bian X.W., et al. miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion. Biochem Biophys Res Commun 2010, 391:535-541.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 535-541
    • Xia, H.1    Ng, S.S.2    Jiang, S.3    Cheung, W.K.4    Sze, J.5    Bian, X.W.6
  • 107
    • 74949124647 scopus 로고    scopus 로고
    • MiRNA control of tumor cell invasion and metastasis
    • Baranwal S., Alahari S.K. miRNA control of tumor cell invasion and metastasis. Int J Cancer 2010, 126:1283-1290.
    • (2010) Int J Cancer , vol.126 , pp. 1283-1290
    • Baranwal, S.1    Alahari, S.K.2
  • 108
    • 0033567145 scopus 로고    scopus 로고
    • Signature amino acid changes in latent membrane protein 1 distinguish Epstein-Barr virus strains
    • Edwards R.H., Seillier-Moiseiwitsch F., Raab-Traub N. Signature amino acid changes in latent membrane protein 1 distinguish Epstein-Barr virus strains. Virology 1999, 261:79-95.
    • (1999) Virology , vol.261 , pp. 79-95
    • Edwards, R.H.1    Seillier-Moiseiwitsch, F.2    Raab-Traub, N.3
  • 109
    • 0026459769 scopus 로고
    • Cloning and characterization of the latent membrane protein (LMP) of a specific Epstein-Barr virus variant derived from the nasopharyngeal carcinoma in the Taiwanese population
    • Chen M.L., Tsai C.N., Liang C.L., Shu C.H., Huang C.R., Sulitzeanu D., et al. Cloning and characterization of the latent membrane protein (LMP) of a specific Epstein-Barr virus variant derived from the nasopharyngeal carcinoma in the Taiwanese population. Oncogene 1992, 7:2131-2140.
    • (1992) Oncogene , vol.7 , pp. 2131-2140
    • Chen, M.L.1    Tsai, C.N.2    Liang, C.L.3    Shu, C.H.4    Huang, C.R.5    Sulitzeanu, D.6
  • 110
    • 0025953468 scopus 로고
    • Isolation and sequencing of the Epstein-Barr virus BNLF-1 gene (LMP1) from a Chinese nasopharyngeal carcinoma
    • Hu L.F., Zabarovsky E.R., Chen F., Cao S.L., Ernberg I., Klein G., et al. Isolation and sequencing of the Epstein-Barr virus BNLF-1 gene (LMP1) from a Chinese nasopharyngeal carcinoma. J Gen Virol 1991, 72:2399-2409.
    • (1991) J Gen Virol , vol.72 , pp. 2399-2409
    • Hu, L.F.1    Zabarovsky, E.R.2    Chen, F.3    Cao, S.L.4    Ernberg, I.5    Klein, G.6
  • 111
    • 0027215533 scopus 로고
    • Clonability and tumorigenicity of human epithelial cells expressing the EBV encoded membraneprotein LMP1
    • Hu L.F., Chen F., Zheng X., Ernberg I., Cao S.L., Christensson B., et al. Clonability and tumorigenicity of human epithelial cells expressing the EBV encoded membraneprotein LMP1. Oncogene 1993, 8:1575-1583.
    • (1993) Oncogene , vol.8 , pp. 1575-1583
    • Hu, L.F.1    Chen, F.2    Zheng, X.3    Ernberg, I.4    Cao, S.L.5    Christensson, B.6
  • 112
    • 0032499227 scopus 로고    scopus 로고
    • The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa B and induction of the EGFR in epithelial cells
    • Miller W.E., Cheshire J., Baldwin A.S.J., Raab-Traub N. The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa B and induction of the EGFR in epithelial cells. Oncogene 1998, 16:1869-1877.
    • (1998) Oncogene , vol.16 , pp. 1869-1877
    • Miller, W.E.1    Cheshire, J.2    Baldwin, A.S.J.3    Raab-Traub, N.4
  • 113
    • 0034691192 scopus 로고    scopus 로고
    • Identification of functional differences between prototype Epstein-Barr virus-encoded LMP1 and a nasopharyngeal carcinoma-derived LMP1 in human epithelial cells
    • Dawson C.W., Eliopoulos A.G., Blake S.M., Barker R., Young L.S. Identification of functional differences between prototype Epstein-Barr virus-encoded LMP1 and a nasopharyngeal carcinoma-derived LMP1 in human epithelial cells. Virology 2000, 272:204-217.
    • (2000) Virology , vol.272 , pp. 204-217
    • Dawson, C.W.1    Eliopoulos, A.G.2    Blake, S.M.3    Barker, R.4    Young, L.S.5
  • 114
    • 0034847766 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP-1 natural sequence variants differ in their potential to activate cellular signaling pathways
    • Fielding C.A., Sandvej K., Mehl A., Brennan P., Jones M., Rowe M. Epstein-Barr virus LMP-1 natural sequence variants differ in their potential to activate cellular signaling pathways. J Virol 2001, 75:9129-9141.
    • (2001) J Virol , vol.75 , pp. 9129-9141
    • Fielding, C.A.1    Sandvej, K.2    Mehl, A.3    Brennan, P.4    Jones, M.5    Rowe, M.6
  • 115
    • 0029950177 scopus 로고    scopus 로고
    • Effect of a 10-amino acid deletion on the oncogenic activity of latent membrane protein 1 of Epstein-Barr virus
    • Li S.N., Chang Y.S., Liu S.T. Effect of a 10-amino acid deletion on the oncogenic activity of latent membrane protein 1 of Epstein-Barr virus. Oncogene 1996, 12:2129-2135.
    • (1996) Oncogene , vol.12 , pp. 2129-2135
    • Li, S.N.1    Chang, Y.S.2    Liu, S.T.3
  • 116
    • 0035836377 scopus 로고    scopus 로고
    • The transmembrane domains of the EBV-encoded latent membrane protein 1 (LMP1) variant CAO regulate enhanced signaling activity
    • Blake S.M., Eliopoulos A.G., Dawson C.W., Young L.S. The transmembrane domains of the EBV-encoded latent membrane protein 1 (LMP1) variant CAO regulate enhanced signaling activity. Virology 2001, 282:278-287.
    • (2001) Virology , vol.282 , pp. 278-287
    • Blake, S.M.1    Eliopoulos, A.G.2    Dawson, C.W.3    Young, L.S.4
  • 117
    • 2942687018 scopus 로고    scopus 로고
    • Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from Southeast Asia
    • Burrows J.M., Bromham L., Woolfit M., Piganeau G., Tellam J., Connolly G., et al. Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from Southeast Asia. J Virol 2004, 78:7131-7137.
    • (2004) J Virol , vol.78 , pp. 7131-7137
    • Burrows, J.M.1    Bromham, L.2    Woolfit, M.3    Piganeau, G.4    Tellam, J.5    Connolly, G.6
  • 118
    • 0026594257 scopus 로고
    • Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: co expression of EBNA1, LMP1, and LMP2 transcripts
    • Brooks L., Yao Q.Y., Rickinson A.B., Young L.S. Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: co expression of EBNA1, LMP1, and LMP2 transcripts. J Virol 1992, 66:2689-2697.
    • (1992) J Virol , vol.66 , pp. 2689-2697
    • Brooks, L.1    Yao, Q.Y.2    Rickinson, A.B.3    Young, L.S.4
  • 119
    • 0026582459 scopus 로고
    • Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma
    • Busson P., McCoy R., Sadler R., Gilligan K., Tursz T., Raab-Traub N. Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma. J Virol 1992, 66:3257-3262.
    • (1992) J Virol , vol.66 , pp. 3257-3262
    • Busson, P.1    McCoy, R.2    Sadler, R.3    Gilligan, K.4    Tursz, T.5    Raab-Traub, N.6
  • 120
    • 2642543245 scopus 로고    scopus 로고
    • Expression of the Epstein-Barr virus (EBV)-encoded latent membrane protein 2A (LMP2A) in EBV-associated nasopharyngeal carcinoma
    • Heussinger N., Büttner M., Ott G., Brachtel E., Pilch B.Z., Kremmer E., et al. Expression of the Epstein-Barr virus (EBV)-encoded latent membrane protein 2A (LMP2A) in EBV-associated nasopharyngeal carcinoma. J Pathol 2004, 203:696-699.
    • (2004) J Pathol , vol.203 , pp. 696-699
    • Heussinger, N.1    Büttner, M.2    Ott, G.3    Brachtel, E.4    Pilch, B.Z.5    Kremmer, E.6
  • 121
    • 77954687468 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma
    • Kong Q.L., Hu L.J., Cao J.Y., Huang Y.J., Xu L.H., Liang Y., et al. Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog 2010, 6:e1000940.
    • (2010) PLoS Pathog , vol.6
    • Kong, Q.L.1    Hu, L.J.2    Cao, J.Y.3    Huang, Y.J.4    Xu, L.H.5    Liang, Y.6
  • 122
    • 0024535280 scopus 로고
    • Two related Epstein-Barr virus membrane proteins are encoded by separate genes
    • Sample J., Liebowitz D., Kieff E. Two related Epstein-Barr virus membrane proteins are encoded by separate genes. J Virol 1989, 63:933-937.
    • (1989) J Virol , vol.63 , pp. 933-937
    • Sample, J.1    Liebowitz, D.2    Kieff, E.3
  • 123
    • 0033650989 scopus 로고    scopus 로고
    • Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
    • Longnecker R. Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?. Adv Cancer Res 2000, 79:175-200.
    • (2000) Adv Cancer Res , vol.79 , pp. 175-200
    • Longnecker, R.1
  • 124
    • 63449129734 scopus 로고    scopus 로고
    • The signaling pathways of Epstein-Barr virus-encoded latent membrane protein 2A (LMP2A) in latency and cancer
    • Pang M.F., Lin K.W., Peh S.C. The signaling pathways of Epstein-Barr virus-encoded latent membrane protein 2A (LMP2A) in latency and cancer. Cell Mol Biol Lett 2009, 14:222-247.
    • (2009) Cell Mol Biol Lett , vol.14 , pp. 222-247
    • Pang, M.F.1    Lin, K.W.2    Peh, S.C.3
  • 125
    • 33845729873 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity
    • Rovedo M., Longnecker R. Epstein-Barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity. J Virol 2007, 81:84-94.
    • (2007) J Virol , vol.81 , pp. 84-94
    • Rovedo, M.1    Longnecker, R.2
  • 126
    • 0025305417 scopus 로고
    • A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1
    • Longnecker R., Kieff E. A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1. J Virol 1990, 64:2319-2326.
    • (1990) J Virol , vol.64 , pp. 2319-2326
    • Longnecker, R.1    Kieff, E.2
  • 127
    • 0035950594 scopus 로고    scopus 로고
    • The Epstein-Barr virus encoded latent membrane protein 2A augments signaling from latent membrane protein 1
    • Dawson C.W., George J.H., Blake S.M., Longnecker R., Young L.S. The Epstein-Barr virus encoded latent membrane protein 2A augments signaling from latent membrane protein 1. Virology 2001, 289:192-207.
    • (2001) Virology , vol.289 , pp. 192-207
    • Dawson, C.W.1    George, J.H.2    Blake, S.M.3    Longnecker, R.4    Young, L.S.5
  • 128
    • 0036256243 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 2B (LMP2B) co-localizes with LMP2A in perinuclear regions in transiently transfected cells
    • Lynch D.T., Zimmerman J.S., Rowe D.T. Epstein-Barr virus latent membrane protein 2B (LMP2B) co-localizes with LMP2A in perinuclear regions in transiently transfected cells. J Gen Virol 2002, 83:1025-1035.
    • (2002) J Gen Virol , vol.83 , pp. 1025-1035
    • Lynch, D.T.1    Zimmerman, J.S.2    Rowe, D.T.3
  • 129
    • 34447647891 scopus 로고    scopus 로고
    • Minimal protein domain requirements for the intracellular localization and self-aggregation of Epstein-Barr virus latent membrane protein 2
    • Tomaszewski-Flick M.J., Rowe D.T. Minimal protein domain requirements for the intracellular localization and self-aggregation of Epstein-Barr virus latent membrane protein 2. Virus Genes 2007, 35:225-234.
    • (2007) Virus Genes , vol.35 , pp. 225-234
    • Tomaszewski-Flick, M.J.1    Rowe, D.T.2
  • 130
    • 0035836746 scopus 로고    scopus 로고
    • Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors
    • Higuchi M., Izumi K.M., Kieff E. Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors. Proc Natl Acad Sci U S A 2001, 98:4675-4680.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 4675-4680
    • Higuchi, M.1    Izumi, K.M.2    Kieff, E.3
  • 131
    • 33947599292 scopus 로고    scopus 로고
    • Cholesterol is critical for Epstein-Barr virus latent membrane protein 2A trafficking and protein stability
    • Ikeda M., Longnecker R. Cholesterol is critical for Epstein-Barr virus latent membrane protein 2A trafficking and protein stability. Virology 2007, 360:461-468.
    • (2007) Virology , vol.360 , pp. 461-468
    • Ikeda, M.1    Longnecker, R.2
  • 132
    • 4644236949 scopus 로고    scopus 로고
    • LMP2A does not require palmitoylation to localize to buoyant complexes or for function
    • Katzman R.B., Longnecker R. LMP2A does not require palmitoylation to localize to buoyant complexes or for function. J Virol 2004, 78:10878-10887.
    • (2004) J Virol , vol.78 , pp. 10878-10887
    • Katzman, R.B.1    Longnecker, R.2
  • 133
    • 0036482280 scopus 로고    scopus 로고
    • The LMP2A signalosome-a therapeutic target for Epstein-Barr virus latency and associated disease
    • Portis T., Cooper L., Dennis P., Longnecker R. The LMP2A signalosome-a therapeutic target for Epstein-Barr virus latency and associated disease. Front Biosci 2002, 7:d414-d426.
    • (2002) Front Biosci , vol.7
    • Portis, T.1    Cooper, L.2    Dennis, P.3    Longnecker, R.4
  • 134
    • 0034007009 scopus 로고    scopus 로고
    • The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases
    • Ikeda M., Ikeda A., Longan L.C., Longnecker R. The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases. Virology 2000, 268:178-191.
    • (2000) Virology , vol.268 , pp. 178-191
    • Ikeda, M.1    Ikeda, A.2    Longan, L.C.3    Longnecker, R.4
  • 135
    • 0033756590 scopus 로고    scopus 로고
    • Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases
    • Winberg G., Matskova L., Chen F., Plant P., Rotin D., Gish G., et al. Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. Mol Cell Biol 2000, 20:8526-8535.
    • (2000) Mol Cell Biol , vol.20 , pp. 8526-8535
    • Winberg, G.1    Matskova, L.2    Chen, F.3    Plant, P.4    Rotin, D.5    Gish, G.6
  • 136
    • 0037404527 scopus 로고    scopus 로고
    • Itchy, a Nedd4 ubiquitin ligase, downregulates latent membrane protein 2A activity in B-cell signaling
    • Ikeda A., Caldwell R.G., Longnecker R., Ikeda M. Itchy, a Nedd4 ubiquitin ligase, downregulates latent membrane protein 2A activity in B-cell signaling. J Virol 2003, 77:5529-5534.
    • (2003) J Virol , vol.77 , pp. 5529-5534
    • Ikeda, A.1    Caldwell, R.G.2    Longnecker, R.3    Ikeda, M.4
  • 137
    • 60349105595 scopus 로고    scopus 로고
    • The c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling
    • Ikeda M., Longnecker R. The c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling. Virology 2009, 385:183-191.
    • (2009) Virology , vol.385 , pp. 183-191
    • Ikeda, M.1    Longnecker, R.2
  • 138
    • 0030962177 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 2 associates with and is a substrate for mitogen-activated protein kinase
    • Panousis C.G., Rowe D.T. Epstein-Barr virus latent membrane protein 2 associates with and is a substrate for mitogen-activated protein kinase. J Virol 1997, 71:4752-4760.
    • (1997) J Virol , vol.71 , pp. 4752-4760
    • Panousis, C.G.1    Rowe, D.T.2
  • 139
    • 0032990723 scopus 로고    scopus 로고
    • Epithelial cell adhesion to extracellular matrix proteins induces tyrosine phosphorylation of the Epstein-Barr virus latent membrane protein 2: a role for C-terminal Src kinase
    • Scholle F., Longnecker R., Raab-Traub N. Epithelial cell adhesion to extracellular matrix proteins induces tyrosine phosphorylation of the Epstein-Barr virus latent membrane protein 2: a role for C-terminal Src kinase. J Virol 1999, 73:4767-4775.
    • (1999) J Virol , vol.73 , pp. 4767-4775
    • Scholle, F.1    Longnecker, R.2    Raab-Traub, N.3
  • 140
    • 0028088994 scopus 로고
    • An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking
    • Miller C.L., Lee J.H., Kieff E., Longnecker R. An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. Proc Natl Acad Sci U S A 1994, 91:772-776.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 772-776
    • Miller, C.L.1    Lee, J.H.2    Kieff, E.3    Longnecker, R.4
  • 141
    • 0028970289 scopus 로고
    • Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases
    • Miller C.L., Burkhardt A.L., Lee J.H., Stealey B., Longnecker R., Bolen J.B., et al. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Immunity 1995, 2:155-166.
    • (1995) Immunity , vol.2 , pp. 155-166
    • Miller, C.L.1    Burkhardt, A.L.2    Lee, J.H.3    Stealey, B.4    Longnecker, R.5    Bolen, J.B.6
  • 142
    • 0035126502 scopus 로고    scopus 로고
    • Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR
    • Dykstra M.L., Longnecker R., Pierce S.K. Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR. Immunity 2001, 14:57-67.
    • (2001) Immunity , vol.14 , pp. 57-67
    • Dykstra, M.L.1    Longnecker, R.2    Pierce, S.K.3
  • 143
    • 0038447031 scopus 로고    scopus 로고
    • Length of Epstein-Barr virus termini as a determinant of epithelial cell clonal emergence
    • Moody C.A., Scott R.S., Su T., Sixbey J.W. Length of Epstein-Barr virus termini as a determinant of epithelial cell clonal emergence. J Virol 2003, 77:8555-8561.
    • (2003) J Virol , vol.77 , pp. 8555-8561
    • Moody, C.A.1    Scott, R.S.2    Su, T.3    Sixbey, J.W.4
  • 144
    • 0033825005 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 2A has no growth-altering effects when expressed in differentiating epithelia
    • Longan L., Longnecker R. Epstein-Barr virus latent membrane protein 2A has no growth-altering effects when expressed in differentiating epithelia. J Gen Virol 2000, 81:2245-2252.
    • (2000) J Gen Virol , vol.81 , pp. 2245-2252
    • Longan, L.1    Longnecker, R.2
  • 145
    • 0033756107 scopus 로고    scopus 로고
    • Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates
    • Scholle F., Bendt K.M., Raab-Traub N. Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates. Akt J Virol 2000, 74:10681-10689.
    • (2000) Akt J Virol , vol.74 , pp. 10681-10689
    • Scholle, F.1    Bendt, K.M.2    Raab-Traub, N.3
  • 146
    • 13444254201 scopus 로고    scopus 로고
    • Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling
    • Morrison J.A., Raab-Traub N. Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling. J Virol 2005, 79:2375-2382.
    • (2005) J Virol , vol.79 , pp. 2375-2382
    • Morrison, J.A.1    Raab-Traub, N.2
  • 147
    • 34548156449 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt pathway
    • Fukuda M., Longnecker R. Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt pathway. J Virol 2007, 81:9299-9306.
    • (2007) J Virol , vol.81 , pp. 9299-9306
    • Fukuda, M.1    Longnecker, R.2
  • 148
    • 13744255187 scopus 로고    scopus 로고
    • The Epstein-Barr virus-encoded LMP2A and LMP2B proteins promote epithelial cell spreading and motility
    • Allen M.D., Young L.S., Dawson C.W. The Epstein-Barr virus-encoded LMP2A and LMP2B proteins promote epithelial cell spreading and motility. J Virol 2005, 79:1789-1802.
    • (2005) J Virol , vol.79 , pp. 1789-1802
    • Allen, M.D.1    Young, L.S.2    Dawson, C.W.3
  • 149
    • 33646847002 scopus 로고    scopus 로고
    • Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells
    • Lu J., Lin W.H., Chen S.Y., Longnecker R., Tsai S.C., Chen C.L., et al. Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells. J Biol Chem 2006, 281:8806-8814.
    • (2006) J Biol Chem , vol.281 , pp. 8806-8814
    • Lu, J.1    Lin, W.H.2    Chen, S.Y.3    Longnecker, R.4    Tsai, S.C.5    Chen, C.L.6
  • 150
    • 0842326032 scopus 로고    scopus 로고
    • Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway
    • Fukuda M., Longnecker R. Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway. J Virol 2004, 78:1697-1705.
    • (2004) J Virol , vol.78 , pp. 1697-1705
    • Fukuda, M.1    Longnecker, R.2
  • 151
    • 17444368316 scopus 로고    scopus 로고
    • Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A
    • Moody C.A., Scott R.S., Amirghahari N., Nathan C.O., Young L.S., Dawson C.W., et al. Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A. J Virol 2005, 79:5499-5506.
    • (2005) J Virol , vol.79 , pp. 5499-5506
    • Moody, C.A.1    Scott, R.S.2    Amirghahari, N.3    Nathan, C.O.4    Young, L.S.5    Dawson, C.W.6
  • 152
    • 77955172208 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein-2A-induced DNp63alpha expression is associated with impaired epithelial-cell differentiation
    • Fotheringham J.A., Mazzucca S., Raab-Traub N. Epstein-Barr virus latent membrane protein-2A-induced DNp63alpha expression is associated with impaired epithelial-cell differentiation. Oncogene 2010, 29:4287-4296.
    • (2010) Oncogene , vol.29 , pp. 4287-4296
    • Fotheringham, J.A.1    Mazzucca, S.2    Raab-Traub, N.3
  • 154
    • 29744450125 scopus 로고    scopus 로고
    • Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis
    • Pegtel D.M., Subramanian A., Sheen T.S., Tsai C.H., Golub T.R., Thorley-Lawson D.A. Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis. J Virol 2005, 79:15430-15442.
    • (2005) J Virol , vol.79 , pp. 15430-15442
    • Pegtel, D.M.1    Subramanian, A.2    Sheen, T.S.3    Tsai, C.H.4    Golub, T.R.5    Thorley-Lawson, D.A.6
  • 155
    • 38649117565 scopus 로고    scopus 로고
    • An auto-regulatory loop for EBV LMP2A involves activation of Notch
    • Anderson L.J., Longnecker R. An auto-regulatory loop for EBV LMP2A involves activation of Notch. Virology 2008, 371:257-266.
    • (2008) Virology , vol.371 , pp. 257-266
    • Anderson, L.J.1    Longnecker, R.2
  • 156
    • 84856057486 scopus 로고    scopus 로고
    • Inhibition of NOTCH3 signalling significantly enhances sensitivity to cisplatin in EBV-associated nasopharyngeal carcinoma;
    • doi:10.1002/path.2997.
    • Man CH, Wei-Man Lun S, Wai-Ying Hui J, To KF, Choy KW, Wing-Hung Chan A, et al. Inhibition of NOTCH3 signalling significantly enhances sensitivity to cisplatin in EBV-associated nasopharyngeal carcinoma; 2011. doi:10.1002/path.2997.
    • (2011)
    • Man, C.H.1    Wei-Man Lun, S.2    Wai-Ying Hui, J.3    To, K.F.4    Choy, K.W.5    Wing-Hung Chan A6
  • 157
    • 77954687468 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma
    • Kong Q.L, Hu L.J., Cao J.Y., Huang Y.J., Xu L.H., Liang Y., et al. Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog 2010, 6:e1000940.
    • (2010) PLoS Pathog , vol.6
    • Kong, Q.L.1    Hu, L.J.2    Cao, J.Y.3    Huang, Y.J.4    Xu, L.H.5    Liang, Y.6
  • 158
    • 70449110086 scopus 로고    scopus 로고
    • The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation
    • Shah K.M., Stewart S.E., Wei W., Woodman C.B., O'Neil J.D., Dawson C.W., et al. The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation. Oncogene 2009, 28:3903-3914.
    • (2009) Oncogene , vol.28 , pp. 3903-3914
    • Shah, K.M.1    Stewart, S.E.2    Wei, W.3    Woodman, C.B.4    O'Neil, J.D.5    Dawson, C.W.6
  • 159
    • 8144219717 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded LMP2A regulates viral and cellular gene expression by modulation of the NF-kappaB transcription factor pathway
    • Stewart S., Dawson C.W., Takada K., Curnow J., Moody C.A., Sixbey J.W., et al. Epstein-Barr virus-encoded LMP2A regulates viral and cellular gene expression by modulation of the NF-kappaB transcription factor pathway. Proc Natl Acad Sci U S A 2004, 101:15730-15735.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 15730-15735
    • Stewart, S.1    Dawson, C.W.2    Takada, K.3    Curnow, J.4    Moody, C.A.5    Sixbey, J.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.