Expression of Epstein-Barr virus latent membrane proteins leads to changes in keratinocyte cell adhesion

Annals of Otology, Rhinology and Laryngology

Volumn 108, Issue 9 I, 1999, Pages 851-859

  Farwell, D Greg ^a   McDougall, James K ^b   Coltrera, Marc D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Cell adhesion molecules; Epstein Barr virus; Immunocytochemistry; Latent membrane proteins

Indexed keywords

DESMOPLAKIN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; KALININ; LATENT MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; UVOMORULIN; VIRUS PROTEIN;

ARTICLE; CELL ADHESION; CELL STRUCTURE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE EXPRESSION REGULATION; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; KERATINOCYTE; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0032845761     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348949910800906     Document Type: Article

References (61)

1. Young L, Alfieri C, Hennessy K, et al. Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. N Engl J Med 1989;321:1080-5.
2. Liebowitz D. Nasopharyngeal carcinoma: the Epstein-Barr virus association. Semin Oncol 1994;21:376-81.
3. Hennessy K, Fennewald S, Hummel M, Cole T, Kieff E. A membrane protein encoded by Epstein-Barr virus in latent growth-transforming infection. Proc Natl Acad Sci U S A 1984; 81:7207-11.
4. Longnecker R, Kieff E. A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and localizes with LMP1. J Virol 1990;64:2319-26.
5. Wang D, Liebowitz D, Kieff E. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 1985;43:831-40.
6. Baichwal VR, Sugden B. Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus. Oncogene 1988;2:461-7.
7. Peng M, Lundgren E. Transient expression of the Epstein-Barr virus LMP1 gene in human primary B cells induces cellular activation and DNA synthesis. Oncogene 1992;7:1775-82.
8. Wang F, Gregory C, Sample C, et al. Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. J Virol 1990;64:2309-18.
9. Wang F, Tsang SF, Kurilla MG, Cohen JI, Kieff E, Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1. J Virol 1990;64:3407-16.
10. Arvanitakis L, Yaseen N, Sharma S. Latent membrane protein-1 induces cyclin D2 expression, pRb hyperphosphorylation, and loss of TGF-beta 1-mediated growth inhibition in EBV-positive B cells. J Immunol 1995;155:1047-56.
11. Longnecker R. Biochemical and genetic studies of Epstein-Barr virus latent membrane protein 2. Leukemia 1994;1: S46-S50.
12. Longnecker R, Druker B, Roberts TM, Kieff E. An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase. J Virol 1991;65:3681-92.
13. Miller CL, Lee JH, Kieff E, Burkhardt AL, Bolen JB, Longnecker R. Epstein-Barr virus protein LMP2A regulates reactivation from latency by negatively regulating tyrosine kinases involved in sIg-mediated signal transduction. Infect Agents Dis 1994;3:128-36.
14. Laux G, Economou A, Farrell PJ. The terminal protein gene 2 of Epstein-Barr virus is transcribed from a bidirectional latent promoter region. J Gen Virol 1989;70:3079-84.
15. Winberg G, McDougall JK, Coltrera MD. Expression of Epstein-Barr virus membrane proteins LMP1, LMP2a, and LMP2b in human keratinocytes. Assoc Res Otolaryngol 1996; 19:52.
16. Kaur P, McDougall JK. HPV-18 immortalization of human keratinocytes. Virology 1989;173:302-10.
17. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques 1989;7:980-2.
18. Lennette ET, Winberg G, Yadav M, Enblad G, Klein G. Antibodies to LMP2A/2B in EBV-carrying malignancies. Eur J Cancer 1995;11:1875-8.
19. Blanton RA, Perez Reyes N, Merrick DT, McDougall JK. Epithelial cells immortalized by human papillomaviruses have premalignant characteristics in organotypic culture. Am J Pathol 1991;138:673-85.
20. Asselineau D, Bernhard B, Bailly C, Darmon M. Epidermal morphogenesis and induction of the 67 kd keratin polypeptide by culture of human keratinocytes at the liquid-air interface. Exp Cell Res 1985;159:536-9.
21. Lehr HA, Hansen KD, Coltrera MD, Russ JC, Gown AM. Photoshop-based image analysis for the semi-automated assessment of Ki-67-defined proliferative activity in the routine diagnosis of breast cancer. Appl Immunohistochem 1996;4:117-27.
22. Frech B, Zimber Strobl U, Suentzenich KO, et al. Identification of Epstein-Barr virus terminal protein 1 (TP1) in extracts of four lymphoid cell lines, expression in insect cells, and detection of antibodies in human sera. J Virol 1990;64:2759-67.
23. Frech B, Zimber Strobl U, Yip TT, Lau WH, Mueller Lantzsch N. Characterization of the antibody response to the latent infection terminal proteins of Epstein-Barr virus in patients with nasopharyngeal carcinoma. J Gen Virol 1993;74:811-8.
24. Niedobitek G, Young LS, Sam CK, Brooks L, Prasad U, Rickinson AB. Expression of Epstein-Barr virus genes and of lymphocyte activation molecules in undifferentiated nasopharyngeal carcinomas. Am J Pathol 1992;140:879-87.
25. Raab Traub N, Flynn K. The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell 1986;47:883-9.
26. Brooks L, Yao QY, Rickinson AB, Young LS. Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcripts. J Virol 1992;66:2689-97.
27. Fahraeus R, Fu HL, Ernberg I, et al. Expression of Epstein-Barr virus-encoded proteins in nasopharyngeal carcinoma. Int J Cancer 1988;42:329-38.
28. Young LS, Dawson CW, Clark D, et al. Epstein-Barr virus gene expression in nasopharyngeal carcinoma. J Gen Virol 1988;69:1051-65.
29. Busson P, McCoy R, Sadler R, Gilligan K, Tursz T, Raab Traub N. Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma. J Virol 1992;66:3257-62.
30. Longnecker R, Miller CL, Miao XQ, Tomkinson B, Kieff E. The last seven transmembrane and carboxy-terminal cytoplasmic domains of Epstein-Barr virus latent membrane protein 2 (LMP2) are dispensable for lymphocyte infection and growth transformation in vitro. J Virol 1993;67:2006-13.
31. Kaye KM, Izumi KM, Kieff E. Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc Natl Acad Sci U S A 1993;90:9150-4.
32. Salcedo R, Fuerstenberg SM, Patarroyo M, Winberg G. The Epstein-Barr virus BNLF-1 membrane protein LMP1 induces homotypic adhesion mediated by CD11a/CD18 in a murine B-cell line, mimicking the action of phorbol ester. J Virol 1991;65:5558-63.
33. Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 1995;80:389-99.
34. Fahraeus R, Rymo L, Rhim JS, Klein G. Morphological transformation of human keratinocytes expressing the LMP gene of Epstein-Barr virus. Nature 1990;345:447-9.
35. Dawson CW, Rickinson AB, Young LS. Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation. Nature 1990;344:777-80.
36. Rowe M, Peng Pilon M, Huen DS, et al. Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers. J Virol 1994;68:5602-12.
37. Mosialos G, Hanissian SH, Jawahar S, Vara L, Kieff E, Chatila TA. A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. J Virol 1994;68:1697-705.
38. Wayner EA, Carter WG. Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits. J Cell Biol 1987;105:1873-84.
39. Peltonen J, Larjava H, Jaakkola S, et al. Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas. J Clin Invest 1989;84:1916-23.
40. Carter WG, Ryan MC, Gahr PJ. Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Cell 1991;65:599-610.
41. Carter WG, Wayner EA, Bouchard TS, Kaur P. The role of integrins alpha 2 beta 1 and alpha 3 beta 1 in cell-cell and cell-substrate adhesion of human epidermal cells. J Cell Biol 1990;110:1387-404.
42. Hodivala KJ, Watt FM. Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation. J Cell Biol 1994; 124:589-600.
43. Van Waes C, Surh DM, Chen Z, et al. Increase in suprabasilar integrin adhesion molecule expression in human epidermal neoplasms accompanies increased proliferation occurring with immortalization and tumor progression. Cancer Res 1995; 55:5434-44.
44. Ruco LP, Stoppacciaro A, Uccini S, et al. Expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in undifferentiated nasopharyngeal carcinoma (lymphoepithelioma) and in malignant epithelial tumors. Hum Pathol 1994;25:924-8.
45. Busson P, Zhang Q, Guillon JM, et al. Elevated expression of ICAM1 (CD54) and minimal expression of LFA3 (CD58) in Epstein-Barr-virus-positive nasopharyngeal carcinoma cells. Int J Cancer 1992;50:863-7.
46. Van Waes C, Kozarsky KF, Warren AB, et al. The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin alpha 6 beta 4. Cancer Res 1991;51:2395-402.
47. Jones J, Sugiyama M, Watt FM, Speight PM. Integrin expression in normal, hyperplastic, dysplastic, and malignant oral epithelium. J Pathol 1993;169:235-43.
48. Voraberger G, Schafer R, Stralowa C. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region. Induction by cytokines and phorbol ester. J Immunol 1991;147:2777-86.
49. van Kooten C, Rensink I, Aarden L, van Oers R. TNF-alpha induces spreading of B-CLL via the CD11c/CD18 molecule. Am J Hematol 1993;44:221-8.
50. Felch ME, Willis RA, Penney DP, Keng PC, Phipps RP. Expression of alpha 6 beta 1 integrin, the laminin receptor, on subsets of normal murine lung fibroblasts and its upregulation by the inflammatory cytokines IFN-gamma and TNF-alpha. Reg Immunol 1992;4:363-70.
51. Santala P, Heino J. Regulation of integrin-type cell adhesion receptors by cytokines. J Biol Chem 1991;266:23505-9.
52. Ioffreda MD, Whitaker D, Murphy GF. Mast cell degranulation upregulates alpha 6 integrins on epidermal Langerhans cells. J Invest Dermatol 1993;101:150-4.
53. Malejczyk J, Malejczyk M, Kock A, et al. Autocrine growth limitation of human papillomavirus type 16-harboring keratinocytes by constitutively released tumor necrosis factor-alpha. J Immunol 1992;149:2702-8.
54. Gregory CD, Murray RJ, Edwards CF, Rickinson AB. Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance. J Exp Med 1988;167:1811-24.
55. Zong YS, Lin H, Choy DT, et al. Nasopharyngeal carcinoma and lymphoinfiltration. Oncology 1991;48:290-6.
56. Peng M, Lundgren E. Transient expression of the Epstein-Barr virus LMP1 gene in B-cell chronic lymphocytic leukemia cells, T cells, and hematopoietic cell lines: cell-type-independent induction of CD23, CD21, and ICAM-1. Leukemia 1993; 7:104-12.
57. Fandi A, Altun M, AzIi N, Armand JP, Cvitkovic E. Nasopharyngeal cancer: epidemiology, staging, and treatment. Semin Oncol 1994;21:382-97.
58. Wolf GT, Carey TE. Tumor antigen phenotype, biologic staging, and prognosis in head and neck squamous carcinoma. Monogr Natl Cancer Inst 1992;13:67-74.
59. Van Waes C, Carey TE. Overexpression of the A9 antigen/alpha 6 beta 4 integrin in head and neck cancer. Otolaryngol Clin North Am 1992;25:1117-39.
60. Liebert M, Washington R, Wedemeyer G, Carey TE, Grossman HB. Loss of co-localization of alpha 6 beta 4 integrin and collagen VII in bladder cancer. Am J Pathol 1994;144:787-95.
61. Savoia P, Trusolino L, Pepino E, Cremona O, Marchisio PC. Expression and topography of integrins and basement membrane proteins in epidermal carcinomas: basal but not squamous cell carcinomas display loss of alpha 6 beta 4 and BM-600/ nicein. J Invest Dermatol 1993;101:352-8.