Upregulation of interleukin-1 by Epstein-Barr virus latent membrane protein 1 and its possible role in nasopharyngeal carcinoma cell growth

Head and Neck

Volumn 32, Issue 7, 2010, Pages 869-876

  Huang, Yu Tzu ^a,b   Liu, Mei Ying ^c   Tsai, Ching Hwa ^b   Yeh, Te Huei ^d  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIPEI UNIVERSITY OF NURSING AND HEALTH SCIENCES   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cell growth; Epstein Barr virus; Interleukin 1; Latent membrane protein 1; Nasopharyngeal carcinoma

Indexed keywords

INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; LATENT MEMBRANE PROTEIN 1; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; KERATINOCYTE; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

CARCINOMA; CELL CULTURE TECHNIQUES; CELL LINE; CELL PROLIFERATION; EPITHELIAL CELLS; HERPESVIRUS 4, HUMAN; HUMANS; INTERLEUKIN-1; NASOPHARYNGEAL NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VIRAL MATRIX PROTEINS;

EID: 77954412016     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.21270     Document Type: Article

References (41)

1. Weiss LM, Movahed LA, Warnke RA, Sklar J. Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease. N Engl J Med 1989;320:502-506.
2. Kawa-Ha K, Ishihara S, Ninomiya T, et al. CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr viral DNA. J Clin Invest 1989;84:51-55.
3. + T cells. Cancer Res 1999;59:1599-1605.
4. Hsu SM, Waldron JWJ, Hsu PL, Hough AJJ. Cytokines in malignant lymphomas: review and prospective evaluation. Hum Pathol 1993;24:1040-1057.
5. Skinnider BF, Mak TW. The role of cytokines in classical Hodgkin lymphoma. Blood 2002;99:4283-4297.
6. Bani MR, Garofalo A, Scanziani E, Giavazzi R. Effect of interleukin-1-beta on metastasis formation in different tumor systems. J Natl Cancer Inst 1991;83:119-123.
7. Ito R, Kitadai Y, Kyo E, et al. Interleukin 1 alpha acts as an autocrine growth stimulator for human gastric carcinoma cells. Cancer Res 1993;53:4102-4106.
8. Kurtzman SH, Anderson KH, Wang Y, et al. Cytokines in human breast cancer: IL-1alpha and IL-1beta expression. Oncol Rep 1999;6:65-70.
9. Matanic D, Beg-Zec Z, Stojanovic D, Matakoric N, Flego V, Milevoj-Ribic F. Cytokines in patients with lung cancer. Scand J Immunol 2003;57:173-178.
10. Wolf JS, Chen Z, Dong G, et al. IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas. Clin Cancer Res 2001;7:1812-1820.
11. D'Addario M, Ahmad A, Xu JW, Menezes J. Epstein-Barr virus envelope glycoprotein gp350 induces NF-kappaB activation and IL-1beta synthesis in human monocytes-macrophages involving PKC and PI3-K. FASEB J 1999;13:2203-2213.
12. Roberge CJ, Poubelle PE, Beaulieu AD, Heitz D, Gosselin J. The IL-1 and IL-1 receptor antagonist (IL-1Ra) response of human neutrophils to EBV stimulation. Preponderance of IL-Ra detection. J Immunol 1996;156:4884-4891. (Pubitemid 26174476)
13. Eliopoulos AG, Stack M, Dawson CW, et al. Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-κB pathway involving TNF receptor-associated factors. Oncogene 1997;14:2899-2916.
14. Nakagomi H, Dolcetti R, Bejarano MT, Pisa P, Kiessling R, Masucci MG. The Epstein-Barr virus latent membrane protein-1 (LMP1) induces interleukin-10 production in Burkitt lymphoma lines. Int J Cancer 1994;57:240-244. (Pubitemid 24144215)
15. Yoshizaki T, Horikawa T, Qing-Chun R, et al. Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma. Clin Cancer Res 2001;7:1946-1951. (Pubitemid 32994829)
16. Lu J, Chen SY, Chua HH, et al. Upregulation of tyrosine kinase TKT by the Epstein-Barr virus transactivator Zta. J Virol 2000;74:7391-7399.
17. Lin CT, Chan WY, Chen W, et al. Characterization of seven newly established nasopharyngeal carcinoma cell lines. Lab Invest 1993;68:716-727.
18. Lu JJ, Chen JY, Hsu TY, Yu WC, Su IJ, Yang CS. Induction of apoptosis in epithelial cells by Epstein-Barr virus latent membrane protein 1. J Gen Virol 1996;77:1883-1892.
19. Chen SY, Lu J, Shih YC, Tsai CH. Epstein-Barr virus latent membrane protein 2A regulates c-Jun protein through extracellular signal-regulated kinase. J Virol 2002;76:9556-9561.
20. Brooks L, Yao QY, Rickinson AB, Young LS. Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcripts. J Virol 1992;66:2689-2697.
21. Acres RB, Larsen A, Gillis S, Conlon PJ. Production of IL-1 alpha and IL-1 beta by clones of EBV transformed, human B cells. Mol Immunol 1987;24:479-485.
22. Gosselin J, Flamand L, D'Addario M, et al. Modulatory effects of Epstein-Barr, herpes simplex, and human herpes-6 viral infections and coinfections on cytokine synthesis. A comparative study. J Immunol 1992;149:181-187.
23. Ma N, Kawanishi M, Hiraku Y, et al. Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: the relation to STAT3 activation and EGFR expression. Int J Cancer 2008;122:2517-2525.
24. Kaspar RL, Gehrke L. Peripheral blood mononuclear cells stimulated with C5a or lipopolysaccharide to synthesize equivalent levels of IL-1 beta mRNA show unequal IL-1 beta protein accumulation but similar polyribosome profiles. J Immunol 1994;153:277-286. (Pubitemid 24186541)
25. Turner M, Chantry D, Buchan G, Barrett K, Feldmann M. Regulation of expression of human IL-1 alpha and IL-1 beta genes. J Immunol 1989;143:3556-3561. (Pubitemid 20007020)
26. Shirakawa F, Saito K, Bonagura CA, et al. The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction. Mol Cell Biol 1993;13:1332-1344.
27. Dalton BJ, Connor JR, Johnson WJ. Interleukin-1 induces interleukin-1 alpha and interleukin-1 beta gene expression in synovial fibroblasts and peripheral blood monocytes. Arthritis Rheum 1989;32:279-287.
28. Hurme M. Modulation of interleukin-1 beta production by cyclic AMP in human monocytes. FEBS Lett 1990;263:35-37.
29. Cogswell JP, Godlevski MM, Wisely GB, et al. NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site. J Immunol 1994;153:712-723.
30. Tocci MJ. Structure and function of interleukin-1 beta converting enzyme. Vitam Horm 1997;53:27-63.
31. Huang TT, Vinci JM, Lan L, Jeffrey JJ, Wilcox BD. Serotonin-inducible transcription of interleukin-1alpha in uterine smooth muscle cells requires an AP-1 site: cloning and partial characterization of the rat IL-1alpha promoter. Mol Cell Endocrinol 1999;152:21-35.
32. Miller WE, Earp HS, Raab-Traub N. The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor. J Virol 1995;69:4390-4398.
33. Devergne O, Cahir-McFarland ED, Mosialos G, Izumi KM, Ware CF, Kieff E. Role of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expression. J Virol 1998;72:7900-7908.
34. Farrell PJ. Signal transduction from the Epstein-Barr virus LMP1 transforming protein. Trends Microbiol 1998;6:175-177; discussion 177-178.
35. Song YJ, Jen KvY, Soni V, Kieff E, Cahir-McFarland E. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-jB activation. Proc Natl Acad Sci U S A 2006;103:2689-2694.
36. Martin MU, Falk W. The interleukin-1 receptor complex and interleukin-1 signal transduction. Eur Cytokine Netw 1997;8:5-17. (Pubitemid 27189850)
37. Woods KV, Adler-Storthz K, Clayman GL, Francis GM, Grimm EA. Interleukin-1 regulates interleukin-6 secretion in human oral squamous cell carcinoma in vitro: possible influence of p53 but not human papillomavirus E6/E7. Cancer Res 1998;58:3142-3149. (Pubitemid 28335098)
38. Chong JM, Sakuma K, Sudo M, et al. Interleukin-1b expression in human gastric carcinoma with Epstein-Barr virus infection. J Virol 2002;76:6825-6831. (Pubitemid 34633548)
39. Greten FR, Eckmann L, Greten TF, et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004;118:285-296.
40. Pikarsky E, Porat RM, Stein I, et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004;431:461-466.
41. Morris MA, Dawson CW, Wei W, et al. Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes. J Gen Virol 2008;89:2806-2820.