Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: A comparative glucose tracer study with the fatty acid synthase inhibitor C75

Metabolomics

Volumn 8, Issue 2, 2012, Pages 201-210

  Harris, Diane M ^a   Li, Luyi ^a   Chen, Monica ^a   Lagunero, F Tracy ^b   Go, Vay Liang W ^a   Boros, Laszlo G ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SIDMAP LLC   (United States)

^c HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

C75; Fatty acid synthase; Lipogenesis; Luteolin; Metabolic profile; Pancreatic cancer; Phytochemicals; Quercetin; Resveratrol

Indexed keywords

C 75; CARBON 13; CHOLESTEROL; DIMETHYL SULFOXIDE; FATTY ACID SYNTHASE INHIBITOR; GLUCOSE; GLUTAMIC ACID; GLYCOGEN; LACTIC ACID; LUTEOLIN; NUCLEOTIDE; PALMITIC ACID; PENTOSE; QUERCETIN; RESVERATROL; RIBONUCLEOTIDE RIBOSE; RIBOSE; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CHOLESTEROL SYNTHESIS; CITRIC ACID CYCLE; CONTROLLED STUDY; CULTURE MEDIUM; FATTY ACID SYNTHESIS; GLUCOSE OXIDATION; GLYCOGEN SYNTHESIS; HUMAN; HUMAN CELL; ISOTOPE LABELING; MASS FRAGMENTOGRAPHY; NUCLEIC ACID SYNTHESIS; NUCLEOTIDE METABOLISM; PANCREAS ADENOCARCINOMA;

AGOUTI PACA;

EID: 84857782245     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-011-0300-9     Document Type: Article

References (31)

1. Alo, P. L., Amini, M., Piro, F., Pizzuti, L., Sebastiani, V., Botti, C., et al. (2007). Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma. Anticancer Research, 27(4B), 2523-2527.
2. Alo, P. L., Visca, P., Marci, A., Mangoni, A., Botti, C., & Di, T. U. (1996). Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer, 77(3), 474-482.
3. 2]-d-glucose profiles of the serum, liver, pancreas, and DMBA-induced pancreatic tumors of rats. Pancreas, 31(4), 337-343.
4. Brusselmans, K., Vrolix, R., Verhoeven, G., & Swinnen, J. V. (2005). Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. Journal of Biological Chemistry, 280(7), 5636-5645.
5. Crick, D. C., & Carroll, K. K. (1987). Extraction and quantitation of total cholesterol, dolichol and dolichyl phosphate from mammalian liver. Lipids, 22(12), 1045-1048.
6. Go, V. L., Nguyen, C. T., Harris, D. M., & Lee, W. N. (2005). Nutrient-gene interaction: Metabolic genotype-phenotype relationship. Journal of Nutrition, 135(12 Suppl), 3016S-3020S.
7. Harris, D. M., Besselink, E., Henning, S. M., Go, V. L., & Heber, D. (2005). Phytoestrogens induce differential estrogen receptor alpha- or beta-mediated responses in transfected breast cancer cells. Experimental Biology and Medicine (Maywood), 230(8), 558-568.
8. Harris, D. M., & Go, V. L. (2006). How dietary components protect from cancer. In A. B. Awad & P. G. Bradford (Eds.), Nutrition and cancer prevention (pp. 27-58). Boca Raton, FL: CRC Press.
9. Hussein, D., & Mo, H. (2009). d-Delta-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells. Pancreas, 38(4), e124-e136.
10. Jensen, V., Ladekarl, M., Holm-Nielsen, P., Melsen, F., & Soerensen, F. B. (1995). The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer. Journal of Pathology, 176(4), 343-352.
11. Kuhajda, F. P. (2000). Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology. Nutrition, 16(3), 202-208.
12. Kuhajda, F. P. (2006). Fatty acid synthase and cancer: New application of an old pathway. Cancer Research, 66(12), 5977-5980.
13. Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., et al. (1994). Fatty acid synthesis: A potential selective target for antineoplastic therapy. Proceedings of the National Academy of Sciences of the United States of America, 91(14), 6379-6383.
14. Kuhajda, F. P., Pizer, E. S., Li, J. N., Mani, N. S., Frehywot, G. L., & Townsend, C. A. (2000). Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proceedings of the National Academy of Sciences of the United States of America, 97(7), 3450-3454.
15. Lee, W. N. (1996). Stable isotopes and mass isotopomer study of fatty acid and cholesterol synthesis. A review of the MIDA approach. Advances in Experimental Medicine and Biology, 399, 95-114.
16. 2]glucose. American Journal of Physiology, 274(5 Pt 1), E843-E851.
17. Lee, W. N., Guo, P., Lim, S., Bassilian, S., Lee, S. T., Boren, J., et al. (2004). Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment. British Journal of Cancer, 91(12), 2094-2100.
18. Lee, W. N., Lim, S., Bassilian, S., Bergner, E. A., & Edmond, J. (1998b). Fatty acid cycling in human hepatoma cells and the effects of troglitazone. Journal of Biological Chemistry, 273(33), 20929-20934.
19. Lin, Y., Shi, R., Wang, X., & Shen, H. M. (2008). Luteolin, a flavonoid with potential for cancer prevention and therapy. Current Cancer Drug Targets, 8(7), 634-646.
20. Manach, C., Scalbert, A., Morand, C., Remesy, C., & Jimenez, L. (2004). Polyphenols: Food sources and bioavailability. American Journal of Clinical Nutrition, 79(5), 727-747.
21. 13C isotopic tracers for metabolic flux analysis in mammalian cells. Journal of Biotechnology, 144(3), 167-174.
22. Pizer, E. S., Jackisch, C., Wood, F. D., Pasternack, G. R., Davidson, N. E., & Kuhajda, F. P. (1996). Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. Cancer Research, 56(12), 2745-2747.
23. Pizer, E. S., Pflug, B. R., Bova, G. S., Han, W. F., Udan, M. S., & Nelson, J. B. (2001). Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression. Prostate, 47(2), 102-110.
24. Pizer, E. S., Thupari, J., Han, W. F., Pinn, M. L., Chrest, F. J., Frehywot, G. L., et al. (2000). Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Research, 60(2), 213-218.
25. Powell, N., Smith, K., & Fiander, A. (2006). Recovery of human papillomavirus nucleic acids from liquid-based cytology media. Journal of Virological Methods, 137(1), 58-62.
26. Sarkar, F. H., Li, Y., Wang, Z., & Kong, D. (2009). Cellular signaling perturbation by natural products. Cellular Signalling, 21(11), 1541-1547.
27. Swinnen, J. V., Brusselmans, K., & Verhoeven, G. (2006). Increased lipogenesis in cancer cells: New players, novel targets. Current Opinion in Clinical Nutrition & Metabolic Care, 9(4), 358-365.
28. Tian, W. X. (2006). Inhibition of fatty acid synthase by polyphenols. Current Medicinal Chemistry, 13(8), 967-977.
29. Witkiewicz, A. K., Nguyen, K. H., Dasgupta, A., Kennedy, E. P., Yeo, C. J., Lisanti, M. P., et al. (2008). Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: Implications for tumor progression and clinical outcome. Cell Cycle, 7(19), 3021-3025.
30. Yoo, H., Antoniewicz, M. R., Stephanopoulos, G., & Kelleher, J. K. (2008). Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. Journal of Biological Chemistry, 283(30), 20621-20627.
31. Zhou, W., Simpson, P. J., McFadden, J. M., Townsend, C. A., Medghalchi, S. M., Vadlamudi, A., et al. (2003). Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Research, 63(21), 7330-7337.