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Volumn 13, Issue 2, 2012, Pages 120-128

A spectrum of susceptibility to rheumatoid arthritis within HLA-DRB1: Stratification by autoantibody status in a large UK population

Author keywords

genetic susceptibility; HLA DRB1; logistic regression; rheumatoid arthritis; shared epitope

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; EPITOPE; HLA DRB1 ANTIGEN; RHEUMATOID FACTOR; SHARED EPITOPE; UNCLASSIFIED DRUG;

EID: 84857781570     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2011.60     Document Type: Article
Times cited : (48)

References (64)
  • 1
    • 65249103342 scopus 로고    scopus 로고
    • Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis
    • van der Woude D, Houwing-Duisternaat JJ, Toes RE, Huizinga TW, Thomson W, Worthington J et al. Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis. Arthritis Rheum 2009; 60: 916-923.
    • (2009) Arthritis Rheum , vol.60 , pp. 916-923
    • Van Der Woude, D.1    Houwing-Duisternaat, J.J.2    Toes, R.E.3    Huizinga, T.W.4    Thomson, W.5    Worthington, J.6
  • 2
    • 0023500817 scopus 로고
    • The shared epitope hypothesis An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
    • Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30: 1205-1213.
    • (1987) Arthritis Rheum , vol.30 , pp. 1205-1213
    • Gregersen, P.K.1    Silver, J.2    Winchester, R.J.3
  • 3
    • 0038107566 scopus 로고    scopus 로고
    • Cutting edge: The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule
    • Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E et al. Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J Immunol 2003; 171: 538-541.
    • (2003) J Immunol , vol.171 , pp. 538-541
    • Hill, J.A.1    Southwood, S.2    Sette, A.3    Jevnikar, A.M.4    Bell, D.A.5    Cairns, E.6
  • 4
    • 0021022294 scopus 로고
    • Rheumatoid arthritis: Relationship with HLA-D
    • Stastny P. Rheumatoid arthritis: relationship with HLA-D. Am J Med 1983; 75: 9-15.
    • (1983) Am J Med , vol.75 , pp. 9-15
    • Stastny, P.1
  • 5
    • 0032960458 scopus 로고    scopus 로고
    • Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: Results from a large, population-based study
    • Thomson W, Harrison B, Ollier B, Wiles N, Payton T, Barrett J et al. Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: results from a large, population-based study. Arthritis Rheum 1999; 42: 757-762.
    • (1999) Arthritis Rheum , vol.42 , pp. 757-762
    • Thomson, W.1    Harrison, B.2    Ollier, B.3    Wiles, N.4    Payton, T.5    Barrett, J.6
  • 6
    • 3142769762 scopus 로고    scopus 로고
    • Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
    • van Gaalen FA, van AJ, Huizinga TW, Schreuder GM, Breedveld FC, Zanelli E et al. Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum 2004; 50: 2113-2121.
    • (2004) Arthritis Rheum , vol.50 , pp. 2113-2121
    • Van Gaalen, F.A.1    Van Aj Huizinga, T.W.2    Schreuder, G.M.3    Breedveld, F.C.4    Zanelli, E.5
  • 7
    • 33646348123 scopus 로고    scopus 로고
    • The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis
    • Van der Helm-van Mil AH, Verpoort KN, Breedveld FC, Huizinga TW, Toes RE, de Vries RR et al. The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. Arthritis Rheum 2006; 54: 1117-1121.
    • (2006) Arthritis Rheum , vol.54 , pp. 1117-1121
    • Van Der Helm-Van Mil, A.H.1    Verpoort, K.N.2    Breedveld, F.C.3    Huizinga, T.W.4    Toes, R.E.5    De Vries, R.R.6
  • 8
    • 57649166551 scopus 로고    scopus 로고
    • Anti-cyclic citrullinated peptide antibody is associated with radiographic erosion in rheumatoid arthritis independently of shared epitope status
    • Im CH, Kang EH, Ryu HJ, Lee JH, Lee EY, Lee YJ et al. Anti-cyclic citrullinated peptide antibody is associated with radiographic erosion in rheumatoid arthritis independently of shared epitope status. Rheumatol Int 2009; 29: 251-256.
    • (2009) Rheumatol Int , vol.29 , pp. 251-256
    • Im, C.H.1    Kang, E.H.2    Ryu, H.J.3    Lee, J.H.4    Lee, E.Y.5    Lee, Y.J.6
  • 9
    • 29144460980 scopus 로고    scopus 로고
    • Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: Contrasting effects of HLA-DR3 and the shared epitope alleles
    • Irigoyen P, Lee AT, Wener MH, Li W, Kern M, Batliwalla F et al. Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles. Arthritis Rheum 2005; 52: 3813-3818.
    • (2005) Arthritis Rheum , vol.52 , pp. 3813-3818
    • Irigoyen, P.1    Lee, A.T.2    Wener, M.H.3    Li, W.4    Kern, M.5    Batliwalla, F.6
  • 10
    • 41849103126 scopus 로고    scopus 로고
    • Associations between genetic factors, tobacco smoking and autoantibodies in familial and sporadic rheumatoid arthritis
    • Michou L, Teixeira VH, Pierlot C, Lasbleiz S, Bardin T, Dieudé P et al. Associations between genetic factors, tobacco smoking and autoantibodies in familial and sporadic rheumatoid arthritis. Ann Rheum Dis 2008; 67: 466-470.
    • (2008) Ann Rheum Dis , vol.67 , pp. 466-470
    • Michou, L.1    Teixeira, V.H.2    Pierlot, C.3    Lasbleiz, S.4    Bardin, T.5    Dieudé, P.6
  • 11
    • 54949088976 scopus 로고    scopus 로고
    • Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease
    • Ioan-Facsinay A, Willemze A, Robinson RB, Peschken CA, Markland J, van der Woude D et al. Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease. Arthritis Rheum 2008; 58: 3000-3008.
    • (2008) Arthritis Rheum , vol.58 , pp. 3000-3008
    • Ioan-Facsinay, A.1    Willemze, A.2    Robinson, R.B.3    Peschken, C.A.4    Markland, J.5    Van Der Woude, D.6
  • 12
    • 69449090215 scopus 로고    scopus 로고
    • Reevaluation of the interaction between HLA-DRB1 SE alleles, PTPN22 and smoking in determining the susceptibility to autoantibody positive and negative rheumatoid arthritis in a large UK Caucasian population
    • Yorkshire Early Arthritis Register Consortium, UK Rheumatoid Arthritis Genetics Consortium
    • Morgan AW, Thomson W, Martin SG, Carter AM, Erlich HA, Barton A, et al., Yorkshire Early Arthritis Register Consortium, UK Rheumatoid Arthritis Genetics Consortium. Reevaluation of the interaction between HLA-DRB1 SE alleles, PTPN22 and smoking in determining the susceptibility to autoantibody positive and negative rheumatoid arthritis in a large UK Caucasian population. Arthritis Rheum 2009; 60: 2565-2576.
    • (2009) Arthritis Rheum , vol.60 , pp. 2565-2576
    • Morgan, A.W.1    Thomson, W.2    Martin, S.G.3    Carter, A.M.4    Erlich, H.A.5    Barton, A.6
  • 13
    • 27744550413 scopus 로고    scopus 로고
    • Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins
    • Huizinga TW, Amos CI, van der Helm-van Mil AH, Chen W, van Gaalen FA, Jawaheer D et al. Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum 2005; 52: 3433-3438.
    • (2005) Arthritis Rheum , vol.52 , pp. 3433-3438
    • Huizinga, T.W.1    Amos, C.I.2    Van Der Helm-Van Mil, A.H.3    Chen, W.4    Van Gaalen, F.A.5    Jawaheer, D.6
  • 14
    • 34248587913 scopus 로고    scopus 로고
    • Strong combined gene-environment effects in anti-cyclic citrullinated peptide-positive rheumatoid arthritis: A nationwide case-control study in Denmark
    • Pedersen M, Jacobsen S, Garred P, Madsen HO, Klarlund M, Svejgaard A et al. Strong combined gene-environment effects in anti-cyclic citrullinated peptide-positive rheumatoid arthritis: a nationwide case-control study in Denmark. Arthritis Rheum 2007; 56: 1446-1453.
    • (2007) Arthritis Rheum , vol.56 , pp. 1446-1453
    • Pedersen, M.1    Jacobsen, S.2    Garred, P.3    Madsen, H.O.4    Klarlund, M.5    Svejgaard, A.6
  • 15
    • 34447509669 scopus 로고    scopus 로고
    • Interaction between smoking, the shared epitope, and anticyclic citrullinated peptide: A mixed picture in three large North American rheumatoid arthritis cohorts
    • Lee HS, Irigoyen P, Kern M, Lee A, Batliwalla F, Khalili H et al. Interaction between smoking, the shared epitope, and anticyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohorts. Arthritis Rheum 2007; 56: 1745-1753.
    • (2007) Arthritis Rheum , vol.56 , pp. 1745-1753
    • Lee, H.S.1    Irigoyen, P.2    Kern, M.3    Lee, A.4    Batliwalla, F.5    Khalili, H.6
  • 16
    • 67449104845 scopus 로고    scopus 로고
    • Shared epitope and anti-cyclic citrullinated peptide antibodies: Relationship with age at onset and duration of disease in rheumatoid arthritis
    • Varadé J, Loza-Santamaría E, Fernández-Arquero M, Lamas JR, de Los Angeles Figueredo M, Jover JA et al. Shared epitope and anti-cyclic citrullinated peptide antibodies: relationship with age at onset and duration of disease in rheumatoid arthritis. J Rheumatol 2009; 36: 1085-1086.
    • (2009) J Rheumatol , vol.36 , pp. 1085-1086
    • Varadé, J.1    Loza-Santamaría, E.2    Fernández-Arquero, M.3    Lamas, J.R.4    De Los Angeles Figueredo, M.5    Jover, J.A.6
  • 17
    • 75749143915 scopus 로고    scopus 로고
    • Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status
    • Bang SY, Lee KH, Cho SK, Lee HS, Lee KW, Bae SC et al. Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status. Arthritis Rheum 2010; 62: 369-377.
    • (2010) Arthritis Rheum , vol.62 , pp. 369-377
    • Bang, S.Y.1    Lee, K.H.2    Cho, S.K.3    Lee, H.S.4    Lee, K.W.5    Bae, S.C.6
  • 18
    • 20244385126 scopus 로고    scopus 로고
    • New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility
    • du Montcel ST, Michou L, Petit-Teixeira E, Osorio J, Lemaire I, Lasbleiz S et al. New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility. Arthritis Rheum 2005; 52: 1063-1068.
    • (2005) Arthritis Rheum , vol.52 , pp. 1063-1068
    • Du Montcel, S.T.1    Michou, L.2    Petit-Teixeira, E.3    Osorio, J.4    Lemaire, I.5    Lasbleiz, S.6
  • 20
    • 43949132125 scopus 로고    scopus 로고
    • The shared epitope hypothesis in rheumatoid arthritis: Evaluation of alternative classification criteria in a large UK Caucasian cohort
    • Morgan AW, Haroon-Rashid L, Martin SG, Gooi HC, Worthington J, Thomson W et al. The shared epitope hypothesis in rheumatoid arthritis: evaluation of alternative classification criteria in a large UK Caucasian cohort. Arthritis Rheum 2008; 58: 1275-1283.
    • (2008) Arthritis Rheum , vol.58 , pp. 1275-1283
    • Morgan, A.W.1    Haroon-Rashid, L.2    Martin, S.G.3    Gooi, H.C.4    Worthington, J.5    Thomson, W.6
  • 21
    • 0025918334 scopus 로고
    • Dw14(DRB1*0404) is a Dw4-dependent risk factor for rheumatoid arthritis. Rethinking the 'shared epitope' hypothesis
    • Nelson JL, Mickelson E, Masewicz S, Barrington R, Dugowson C, Koepsell Tet al. Dw14(DRB1*0404) is a Dw4-dependent risk factor for rheumatoid arthritis. Rethinking the 'shared epitope' hypothesis. Tissue Antigens 1991; 38: 145-151.
    • (1991) Tissue Antigens , vol.38 , pp. 145-151
    • Nelson, J.L.1    Mickelson, E.2    Masewicz, S.3    Barrington, R.4    Dugowson, C.5    Koepsell, T.6
  • 23
    • 0028061748 scopus 로고
    • Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome
    • Gough A, Faint J, Salmon M, Hassell A, Wordsworth P, Pilling D et al. Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome. Arthritis Rheum 1994; 37: 1166-1170.
    • (1994) Arthritis Rheum , vol.37 , pp. 1166-1170
    • Gough, A.1    Faint, J.2    Salmon, M.3    Hassell, A.4    Wordsworth, P.5    Pilling, D.6
  • 24
    • 0030804762 scopus 로고    scopus 로고
    • Compound heterozygosity for the shared epitope and the risk and severity of rheumatoid arthritis in extended pedigrees
    • McDonagh JE, Dunn A, Ollier WE, Walker DJ. Compound heterozygosity for the shared epitope and the risk and severity of rheumatoid arthritis in extended pedigrees. Br J Rheumatol 1997; 36: 322-327.
    • (1997) Br J Rheumatol , vol.36 , pp. 322-327
    • McDonagh, J.E.1    Dunn, A.2    Ollier, W.E.3    Walker, D.J.4
  • 25
    • 0032913384 scopus 로고    scopus 로고
    • HLA-DRB1 genotype influences risk for and severity of rheumatoid arthritis
    • Meyer JM, Evans TI, Small RE, Redford TW, Han J, Singh R et al. HLA-DRB1 genotype influences risk for and severity of rheumatoid arthritis. J Rheumatol 1999; 26: 1024-1034.
    • (1999) J Rheumatol , vol.26 , pp. 1024-1034
    • Meyer, J.M.1    Evans, T.I.2    Small, R.E.3    Redford, T.W.4    Han, J.5    Singh, R.6
  • 26
    • 8444232859 scopus 로고    scopus 로고
    • Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis
    • Gorman JD, David-Vaudey E, Pai M, Lum RF, Criswell LA. Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis. Arthritis Rheum 2004; 50: 3476-3484.
    • (2004) Arthritis Rheum , vol.50 , pp. 3476-3484
    • Gorman, J.D.1    David-Vaudey, E.2    Pai, M.3    Lum, R.F.4    Criswell, L.A.5
  • 27
    • 39749086221 scopus 로고    scopus 로고
    • Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis
    • Farragher TM, Goodson NJ, Naseem H, Silman AJ, Thomson W, Symmons D et al. Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis. Arthritis Rheum 2008; 58: 359-369.
    • (2008) Arthritis Rheum , vol.58 , pp. 359-369
    • Farragher, T.M.1    Goodson, N.J.2    Naseem, H.3    Silman, A.J.4    Thomson, W.5    Symmons, D.6
  • 29
    • 0035077075 scopus 로고    scopus 로고
    • Influence of shared epitope-negative HLADRB1 alleles on genetic susceptibility to rheumatoid arthritis
    • Reviron D, Perdriger A, Toussirot E, Wendling D, Balandraud N, Guis S et al. Influence of shared epitope-negative HLADRB1 alleles on genetic susceptibility to rheumatoid arthritis. Arthritis Rheum 2001; 44: 535-540.
    • (2001) Arthritis Rheum , vol.44 , pp. 535-540
    • Reviron, D.1    Perdriger, A.2    Toussirot, E.3    Wendling, D.4    Balandraud, N.5    Guis, S.6
  • 31
    • 54749155927 scopus 로고    scopus 로고
    • A majority of Brazilian patients with rheumatoid arthritis HLA-DRB1 alleles carry both the HLA-DRB1 shared epitope and anti-citrunillated peptide antibodies
    • Louzada-Junior P, Freitas MV, Oliveira RD, Deghaide NH, Conde RA, Bertolo MB et al. A majority of Brazilian patients with rheumatoid arthritis HLA-DRB1 alleles carry both the HLA-DRB1 shared epitope and anti-citrunillated peptide antibodies. Braz J Med Biol Res 2008; 41: 493-499.
    • (2008) Braz J Med Biol Res , vol.41 , pp. 493-499
    • Louzada-Junior, P.1    Freitas, M.V.2    Oliveira, R.D.3    Deghaide, N.H.4    Conde, R.A.5    Bertolo, M.B.6
  • 32
    • 0035112851 scopus 로고    scopus 로고
    • HLA-DRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis
    • Mattey DL, Dawes PT, Gonzalez-Gay MA, Garcia-Porrua C, Thomson W, Hajeer AH et al. HLA-DRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis. J Rheumatol 2001; 28: 232-239.
    • (2001) J Rheumatol , vol.28 , pp. 232-239
    • Mattey, D.L.1    Dawes, P.T.2    Gonzalez-Gay, M.A.3    Garcia-Porrua, C.4    Thomson, W.5    Hajeer, A.H.6
  • 33
    • 35648988077 scopus 로고    scopus 로고
    • Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis
    • Shadick NA, Heller JE, Weinblatt ME, Maher NE, Cui J, Ginsburg G et al. Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis. Ann Rheum Dis 2007; 66: 1497-1502.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1497-1502
    • Shadick, N.A.1    Heller, J.E.2    Weinblatt, M.E.3    Maher, N.E.4    Cui, J.5    Ginsburg, G.6
  • 34
    • 0036222676 scopus 로고    scopus 로고
    • Reshaping the shared epitope hypo thesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67-74 of the HLA-DRB1molecule
    • de Vries N, Tijssen H, van Riel PL, van de Putte LB. Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67-74 of the HLA-DRB1molecule. Arthritis Rheum 2002; 46: 921-928.
    • (2002) Arthritis Rheum , vol.46 , pp. 921-928
    • De Vries, N.1    Tijssen, H.2    Van Riel, P.L.3    Van De Putte, L.B.4
  • 35
    • 41049086360 scopus 로고    scopus 로고
    • New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: A combined analysis of worldwide samples
    • Barnetche T, Constantin A, Cantagrel A, Cambon-Thomsen A, Gourraud PA. New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples. Arthritis Res Ther 2008; 10: R26.
    • (2008) Arthritis Res Ther , vol.10
    • Barnetche, T.1    Constantin, A.2    Cantagrel, A.3    Cambon-Thomsen, A.4    Gourraud, P.A.5
  • 37
    • 51749101703 scopus 로고    scopus 로고
    • Balancing selection and heterogeneity across the classical human leukocyte antigen loci: A meta-analytic review of 497 population studies Supporting online material, accessed March 2009
    • Solberg OD, Mack SJ, Lancaster AK, Single RM, Tsai Y, Sanchez-Mazas A et al. Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies. Supporting online material, accessed March 2009. Hum Immunol 2008; 69: 443-464.
    • (2008) Hum Immunol , vol.69 , pp. 443-464
    • Solberg, O.D.1    MacK, S.J.2    Lancaster, A.K.3    Single, R.M.4    Tsai, Y.5    Sanchez-Mazas, A.6
  • 38
    • 52149095213 scopus 로고    scopus 로고
    • Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets
    • Van der Helm-van Mil AH, Huizinga TW. Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets. Arthritis Res Ther 2008; 10: 205.
    • (2008) Arthritis Res Ther , vol.10 , pp. 205
    • Van Der Helm-Van Mil, A.H.1    Huizinga, T.W.2
  • 39
    • 33847023027 scopus 로고    scopus 로고
    • The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide
    • van der Helm-van Mil AH, Verpoort KN, le Cessie S, Huizinga TW, de Vries RR, Toes RE et al. The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide. Arthritis Rheum 2007; 56: 425-432.
    • (2007) Arthritis Rheum , vol.56 , pp. 425-432
    • Van Der Helm-Van Mil, A.H.1    Verpoort, K.N.2    Le Cessie, S.3    Huizinga, T.W.4    De Vries, R.R.5    Toes, R.E.6
  • 40
    • 41149169614 scopus 로고    scopus 로고
    • Associations between serum anti-CCP antibody, rheumatoid factor levels and HLA-DR4 expression in Hungarian patients with rheumatoid arthritis
    • Kapitany A, Szabo Z, Lakos G, Aleksza M, Végvári A, Soós L et al. Associations between serum anti-CCP antibody, rheumatoid factor levels and HLA-DR4 expression in Hungarian patients with rheumatoid arthritis. Isr Med Assoc J 2008; 10: 32-36.
    • (2008) Isr Med Assoc J , vol.10 , pp. 32-36
    • Kapitany, A.1    Szabo, Z.2    Lakos, G.3    Aleksza, M.4    Végvári, A.5    Soós, L.6
  • 41
    • 66149124137 scopus 로고    scopus 로고
    • Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: Association with HLA-DRB1 alleles
    • Snir O, Widhe M, von Spee C, Lindberg J, Padyukov L, Lundberg K et al. Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles. Ann Rheum Dis 2009; 68: 736-743.
    • (2009) Ann Rheum Dis , vol.68 , pp. 736-743
    • Snir, O.1    Widhe, M.2    Von Spee, C.3    Lindberg, J.4    Padyukov, L.5    Lundberg, K.6
  • 42
    • 0033071595 scopus 로고    scopus 로고
    • A 'case control' study on the role of HLA DR4 in severe periodontitis and rapidly progressive periodontitis. Identification of types and subtypes using molecular biology (PCR.SSO)
    • Bonfil JJ, Dillier FL, Mercier P, Reviron D, Foti B, Sambuc R et al. A 'case control' study on the role of HLA DR4 in severe periodontitis and rapidly progressive periodontitis. Identification of types and subtypes using molecular biology (PCR.SSO). J Clin Periodontol. 1999; 26: 77-84.
    • (1999) J Clin Periodontol. , vol.26 , pp. 77-84
    • Bonfil, J.J.1    Dillier, F.L.2    Mercier, P.3    Reviron, D.4    Foti, B.5    Sambuc, R.6
  • 43
    • 34047200804 scopus 로고    scopus 로고
    • A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis
    • Gourraud PA, Dieude P, Boyer JF, Nogueira L, Cambon-Thomsen A, Mazières B et al. A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis. Arthritis Res Ther. 2007; 9: R27.
    • (2007) Arthritis Res Ther. , vol.9
    • Gourraud, P.A.1    Dieude, P.2    Boyer, J.F.3    Nogueira, L.4    Cambon-Thomsen, A.5    Mazières, B.6
  • 44
    • 46849101506 scopus 로고    scopus 로고
    • Association between radiographic severity of rheumatoid arthritis and shared epitope alleles: Differing mechanisms of susceptibility and protection
    • Mewar D, Marinou I, Coote AL, Moore DJ, Akil M, Smillie D et al. Association between radiographic severity of rheumatoid arthritis and shared epitope alleles: differing mechanisms of susceptibility and protection. Ann Rheum Dis. 2008; 67: 980-983.
    • (2008) Ann Rheum Dis. , vol.67 , pp. 980-983
    • Mewar, D.1    Marinou, I.2    Coote, A.L.3    Moore, D.J.4    Akil, M.5    Smillie, D.6
  • 45
    • 70649108632 scopus 로고    scopus 로고
    • Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis
    • Mahdi H, Fisher BA, Kallberg H, Plant D, Malmström V, Rönnelid J et al. Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis. Nat Genet 2009; 41: 1319-1324.
    • (2009) Nat Genet , vol.41 , pp. 1319-1324
    • Mahdi, H.1    Fisher, B.A.2    Kallberg, H.3    Plant, D.4    Malmström, V.5    Rönnelid, J.6
  • 46
    • 52749095695 scopus 로고    scopus 로고
    • HLA-DRB1*0404 is strongly associated with high titers of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis
    • Charpin C, Balandraud B, Guis S, Roudier C, Toussirot E, Rak J et al. HLA-DRB1*0404 is strongly associated with high titers of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis. Clin Exp Rheum 2008; 26: 627-631.
    • (2008) Clin Exp Rheum , vol.26 , pp. 627-631
    • Charpin, C.1    Balandraud, B.2    Guis, S.3    Roudier, C.4    Toussirot, E.5    Rak, J.6
  • 47
    • 77951731231 scopus 로고    scopus 로고
    • Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: A meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibodynegative rheumatoid arthritis in four European populations
    • van der Woude D, Lie BA, Lundstrom E, Balsa A, Feitsma AL, Houwing-Duistermaat JJ et al. Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: a meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibodynegative rheumatoid arthritis in four European populations. Arthritis Rheum 2010; 62: 1236-1245.
    • (2010) Arthritis Rheum , vol.62 , pp. 1236-1245
    • Van Der Woude, D.1    Lie, B.A.2    Lundstrom, E.3    Balsa, A.4    Feitsma, A.L.5    Houwing-Duistermaat, J.J.6
  • 48
    • 77950456388 scopus 로고    scopus 로고
    • Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort
    • Morgan AW, Robinson JI, Conaghan PG, Martin SG, Hensor EM, Morgan MD et al. Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. Arthritis Res Ther 2010; 12: R57.
    • (2010) Arthritis Res Ther , vol.12
    • Morgan, A.W.1    Robinson, J.I.2    Conaghan, P.G.3    Martin, S.G.4    Hensor, E.M.5    Morgan, M.D.6
  • 49
    • 0034939720 scopus 로고    scopus 로고
    • Independent association of rheumatoid factor and the HLA-DRB1 shared epitope with radiographic outcome in rheumatoid arthritis
    • Mattey DL, Hassell AB, Dawes PT, Cheung NT, Poulton KV, Thomson W et al. Independent association of rheumatoid factor and the HLA-DRB1 shared epitope with radiographic outcome in rheumatoid arthritis. Arthritis Rheum 2001; 44: 1529-1533.
    • (2001) Arthritis Rheum , vol.44 , pp. 1529-1533
    • Mattey, D.L.1    Hassell, A.B.2    Dawes, P.T.3    Cheung, N.T.4    Poulton, K.V.5    Thomson, W.6
  • 50
    • 68049104242 scopus 로고    scopus 로고
    • Value of anti-modified citrullinated vimentin and second-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis
    • van der Linden MP, van der Woude D, Ioan-Facsinay A, Levarht EW, Stoeken-Rijsbergen G, Huizinga TW et al. Value of anti-modified citrullinated vimentin and second-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis. Arthritis Rheum 2009; 60: 2232-2241.
    • (2009) Arthritis Rheum , vol.60 , pp. 2232-2241
    • Van Der Linden, M.P.1    Van Der Woude, D.2    Ioan-Facsinay, A.3    Levarht, E.W.4    Stoeken-Rijsbergen, G.5    Huizinga, T.W.6
  • 51
    • 50249108486 scopus 로고    scopus 로고
    • The role of the shared epitope in arthralgia with anti-cyclic citrullinated peptide antibodies (anti-CCP), and its effect on anti-CCP levels
    • Bos WH, Ursum J, de Vries N, Bartelds GM, Wolbink GJ, Nurmohamed MT et al. The role of the shared epitope in arthralgia with anti-cyclic citrullinated peptide antibodies (anti-CCP), and its effect on anti-CCP levels. Ann Rheum Dis. 2008; 67: 1347-1350.
    • (2008) Ann Rheum Dis. , vol.67 , pp. 1347-1350
    • Bos, W.H.1    Ursum, J.2    De Vries, N.3    Bartelds, G.M.4    Wolbink, G.J.5    Nurmohamed, M.T.6
  • 52
    • 39549114063 scopus 로고    scopus 로고
    • Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study
    • Karlson EW, Chibnik LB, Cui J, Plenge RM, Glass RJ, Maher NE et al. Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study. Ann Rheum Dis. 2008; 67: 358-363.
    • (2008) Ann Rheum Dis. , vol.67 , pp. 358-363
    • Karlson, E.W.1    Chibnik, L.B.2    Cui, J.3    Plenge, R.M.4    Glass, R.J.5    Maher, N.E.6
  • 54
    • 0024455974 scopus 로고
    • Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease
    • Payami H, Joe S, Farid NR, Stenszky V, Chan SH, Yeo PP et al. Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease. Am J Hum Genet. 1989; 45: 541-546.
    • (1989) Am J Hum Genet. , vol.45 , pp. 541-546
    • Payami, H.1    Joe, S.2    Farid, N.R.3    Stenszky, V.4    Chan, S.H.5    Yeo, P.P.6
  • 55
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls. Nature 2007; 447: 661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 56
    • 0036731956 scopus 로고    scopus 로고
    • HLA-DR/DQ haplotype in rheumatoid arthritis: Novel allelic associations in UK Caucasians
    • Milicic A, Lee D, Brown MA, Darke C, Wordsworth BP. HLA-DR/DQ haplotype in rheumatoid arthritis: novel allelic associations in UK Caucasians. J Rheumatol 2002; 29: 1821-1826.
    • (2002) J Rheumatol , vol.29 , pp. 1821-1826
    • Milicic, A.1    Lee, D.2    Brown, M.A.3    Darke, C.4    Wordsworth, B.P.5
  • 57
    • 0033376808 scopus 로고    scopus 로고
    • DQCAR 113 and DQCAR 115 in combination with HLA-DRB1 alleles are significant markers of susceptibility to rheumatoid arthritis in the Korean population
    • Kim TG, Choi HB, Park SH, Kim HY, Han H. DQCAR 113 and DQCAR 115 in combination with HLA-DRB1 alleles are significant markers of susceptibility to rheumatoid arthritis in the Korean population. Tissue Antigens 1999; 54: 552-559.
    • (1999) Tissue Antigens , vol.54 , pp. 552-559
    • Kim, T.G.1    Choi, H.B.2    Park, S.H.3    Kim, H.Y.4    Han, H.5
  • 58
    • 34249811529 scopus 로고    scopus 로고
    • Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide
    • Furuya T, Hakoda M, Ichikawa N, Higami K, Nanke Y, Yago T et al. Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide. Clin Exp Rheumatol 2007; 25: 219-224.
    • (2007) Clin Exp Rheumatol , vol.25 , pp. 219-224
    • Furuya, T.1    Hakoda, M.2    Ichikawa, N.3    Higami, K.4    Nanke, Y.5    Yago, T.6
  • 60
    • 58249104988 scopus 로고    scopus 로고
    • Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci
    • Vignal C, Bansal AT, Balding DJ, Binks MH, Dickson MC, Montgomery DS et al. Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci. Arthritis Rheum 2009; 60: 53-62.
    • (2009) Arthritis Rheum , vol.60 , pp. 53-62
    • Vignal, C.1    Bansal, A.T.2    Balding, D.J.3    Binks, M.H.4    Dickson, M.C.5    Montgomery, D.S.6
  • 61
    • 65249174519 scopus 로고    scopus 로고
    • Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibodynegative rheumatoid arthritis
    • Lundstrom E, Kallberg H, Smolnikova M, Ding B, Rönnelid J, Alfredsson L et al. Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibodynegative rheumatoid arthritis. Arthritis Rheum. 2009; 60: 924-930.
    • (2009) Arthritis Rheum. , vol.60 , pp. 924-930
    • Lundstrom, E.1    Kallberg, H.2    Smolnikova, M.3    Ding, B.4    Rönnelid, J.5    Alfredsson, L.6
  • 62
    • 58249097071 scopus 로고    scopus 로고
    • Different patterns of associations with anti-citrullinated protein antibody-positive and anticitrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region
    • Ding B, Padyukov L, Lundstrom E, Seielstad M, Plenge RM, Oksenberg JR et al. Different patterns of associations with anti-citrullinated protein antibody-positive and anticitrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region. Arthritis Rheum 2009; 60: 30-38.
    • (2009) Arthritis Rheum , vol.60 , pp. 30-38
    • Ding, B.1    Padyukov, L.2    Lundstrom, E.3    Seielstad, M.4    Plenge, R.M.5    Oksenberg, J.R.6
  • 63
    • 0023945481 scopus 로고
    • The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-324.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5    Cooper, N.S.6
  • 64
    • 0027953822 scopus 로고
    • A comparison of the performance of different methods of disease classification for rheumatoid arthritis. Results of an analysis from a nationwide twin study
    • Macgregor AJ, Bamber S, Silman AJ. A comparison of the performance of different methods of disease classification for rheumatoid arthritis. Results of an analysis from a nationwide twin study. J Rheumatol 1994; 21: 1420-1426.
    • (1994) J Rheumatol , vol.21 , pp. 1420-1426
    • MacGregor, A.J.1    Bamber, S.2    Silman, A.J.3


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