Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: Results from a large, population-based study

Arthritis and Rheumatism

Volumn 42, Issue 4, 1999, Pages 757-762

  Thomson, Wendy ^a   Harrison, Beverley ^a   Ollier, Bill ^a   Wiles, Nicola ^a   Payton, Tony ^a   Barrett, Jennifer ^a   Symmons, Deborah ^a   Silman, Alan ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN;

ADULT; ALLELE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INFLAMMATORY DISEASE; MAJOR CLINICAL STUDY; MALE; POLYARTHRITIS; POPULATION RESEARCH; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ALLELES; ARTHRITIS; COHORT STUDIES; DISEASE SUSCEPTIBILITY; EPITOPES; FEMALE; HLA-DR ANTIGENS; HUMANS; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; PHENOTYPE;

EID: 0032960458     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199904)42:4<757::AID-ANR20>3.0.CO;2-X     Document Type: Article

References (32)

1. Stastny P. Association of the B cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 1978;298:869-71.
2. Ollier W, Thomson W. Population genetics of rheumatoid arthritis. Rheum Dis Clin North Am 1992;18:741-59.
3. Ollier WER, Carthy D, Cutbush S, Okoye R, Fielder A, Silman A. HLA DR4 associated types in rheumatoid arthritis. Tissue Antigens 1989;33:30-7.
4. Woodrow JC, Nichol FE, Zaphiropoulos G. DR antigens and rheumatoid arthritis: a study of two populations. BMJ 1981;283: 1287-8.
5. Ollier WER, Stephens C, Awad J, Carthy D, Gupta A, Perry D, et al. Is rheumatoid arthritis in Indians associated with HLA antigens sharing a DRβ1 epitope? Ann Rheum Dis 1991;50:295-7.
6. Willkens RF, Hansen JA, Malmgren JA, Nisperos B, Mickelson EM, Watson MA. HLA antigens in Yakima Indians with rheumatoid arthritis: lack of association with HLA-Dw4 and HLA-DR4. Arthritis Rheum 1982;25:1435-9.
7. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30: 1205-13.
8. Wakitani S, Murata N, Toda Y, Ogawa R, Kaneshige T, Nishimura Y, et al. The relationship between HLA-DRB1 alleles and disease subsets of rheumatoid arthritis in Japanese. Br J Rheumatol 1997;36:630-6.
9. Hakala M, Silvennoinen-Kassinen S, Ikaheimo I, Isosomppi J, Tiilikainen A. HLA markers in a community-based rheumatoid arthritis series. Ann Med 1997;29:291-6.
10. McDonagh JE, Dunn A, Ollier WER, Walker DJ. Compound heterozygosity for the shared epitope and the risk and severity of rheumatoid arthritis in extended pedigrees. Br J Rheumatol 1997;36:322-7.
11. Gonzalez A, Nicovani S, Massardo L, Aguirre V, Cervilla V, Lanchbury JS, et al. Influence of the HLA-DRβ shared epitope on susceptibility to and clinical expression of rheumatoid arthritis in Chilean patients. Ann Rheum Dis 1997;56:191-3.
12. Jawaheer D, Thomson W, MacGregor AJ, Carthy D, Davidson J, Dyer PA, et al. "Homozygosity" for the HLA-DR shared epitope contributes the highest risk for rheumatoid arthritis concordance in identical twins. Arthritis Rheum 1994;37:681-6.
13. De Jongh BM, van Romunde LKJ, Valkenburg HA, de Lange GG. Epidemiological study of HLA and GM in rheumatoid arthritis and related symptoms in an open Dutch population. Ann Rheum Dis 1984;43:613-9.
14. Wordsworth P, Pile KD, Buckely JD, Lanchbury JS, Ollier B, Lathrop M, et al. HLA heterozygosity contributes to susceptibility to rheumatoid arthritis. Am J Hum Genet 1992;51:585-91.
15. Weyand CM, Hicok KC, Conn DL, Goronzy JJ. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 1992;117:801-6.
16. Benazet JF, Reviron D, Mercier P, Roux H, Roudier J. HLA-DRB1 alleles associated with rheumatoid arthritis in Southern France: absence of extraarticular disease despite expression of the shared epitope. J Rheumatol 1995;22:607-10.
17. Seitz M, Perler M, Pichler W. Only weak association between disease severity and HLA-DRB1 genes in a Swiss population of rheumatoid arthritis patients. Rheumatol Int 1996;16:9-13.
18. Hall FC, Weeks DE, Camilleri JP, Williams LA, Amos N, Darke C, et al. Influence of the HLA-DRB1 locus on susceptibility and severity in rheumatoid arthritis. QJM 1996;89:821-9.
19. Jaraquemada D, Ollier W, Awad J, Young A, Silman A, Roitt M, et al. HLA and rheumatoid arthritis: a combined analysis of 440 British patients. Ann Rheum Dis 1986;45:627-36.
20. MacGregor A, Ollier W, Thomson W, Jawaheer D, Silman AJ. HLA-DRB1*0401/0404 genotype and rheumatoid arthritis: increased association in men, young age at onset, and disease severity. J Rheumatol 1995;22:1032-6.
21. Hazes JMW, Dijkmans BAC, Hoevers JM, Janson JJM, de Vries RRP, Vandenbroucke JP, et al. DR4 prevalence related to the age at disease onset in female patients with rheumatoid arthritis. Ann Rheum Dis 1989;48:406-8.
22. Symmons DPM, Barrett EM, Bankhead CR, Scott DGI, Silman AJ. The incidence of rheumatoid arthritis in the United Kingdom: results from the Norfolk Arthritis Register. Br J Rheumatol 1994;33:735-9.
23. Thomson W, Pepper L, Payton A, Carthy D, Scott D, Ollier W, et al. Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community. Ann Rheum Dis 1993;52:539-41.
24. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
25. Symmons DPM, Bankhead CR, Harrison BJ, Brennan P, Barrett EM, Scott DGI, et al. Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: results from a primary care-based incident case-control study in Norfolk, England. Arthritis Rheum 1997;40:1955-61.
26. Lathrop MG. Estimating genotype relative risks. Tissue Antigens 1983;22:160-6.
27. Brennan P, Harrison B, Barrett E, Chakravarty K, Scott D, Silman A, et al. A simple algorithm to predict the development of radiological erosions in patients with early rheumatoid arthritis: a prospective cohort study. BMJ 1996;313:471-6.
28. Harrison BJ, Symmons DPM, Brennan P, Bankhead CR, Barrett EM, Scott DGI, et al. Inflammatory polyarthritis in the community is not a benign disease: predicting functional disability one year after presentation. J Rheumatol 1996;23:1326-31.
29. Harrison BJ, Symmons DPM, Brennan P, Barrett EM, Silman AJ. Natural remission in inflammatory polyarthritis: issues of definition and prediction. Br J Rheumatol 1996;35:1096-100.
30. Wilson AG, Symons JA, McDowell TL, di Giovine FS, Duff GW. Effects of a tumour necrosis factor promoter base transition on transcriptional activity [abstract]. Br J Rheumatol 1994;33 Suppl 1:89.
31. Pociot F, Briant L, Jongeneel CV, Molvig J, Worsaae H, Abbal M, et al. Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-α and TNF-β by human mononuclear cells: a possible link to insulin dependent diabetes mellitus. Eur J Immunol 1993;23:224-31.
32. Hajeer AH, Worthington J, Silman AJ, Ollier WER. Association of tumor necrosis factor microsatellite polymorphisms with HLA-DRB1*04-bearing haplotypes in rheumatoid arthritis patients. Arthritis Rheum 1996;39:1109-14.