Intact working memory in the absence of forebrain neuronal glycine transporter 1

Behavioural Brain Research

Volumn 230, Issue 1, 2012, Pages 208-214

  Dubroqua, Sylvain ^a   Serrano, Lucas ^a,c   Boison, Detlev ^b   Feldon, Joram ^a   Gargiulo, Pascual A ^c   Yee, Benjamin K ^a  

^a ETH ZURICH   (Switzerland)

^b LEGACY RESEARCH   (United States)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Cheeseboard maze; GlyT1; Learning; NMDA receptor; Radial arm maze; Water maze

Indexed keywords

GLYCINE TRANSPORTER 1;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; BRAIN VENTRICLE; CELL DISRUPTION; CELL SPECIFICITY; COGNITION; CONTROLLED STUDY; FEMALE; FOREBRAIN; GLIA CELL; HABITUATION; HIPPOCAMPUS; MALE; MAZE TEST; MENTAL PERFORMANCE; MOUSE; MUTANT; NEUROMODULATION; NONHUMAN; OUTCOME ASSESSMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TASK PERFORMANCE; WORKING MEMORY;

ANALYSIS OF VARIANCE; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CUES; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; HABITUATION, PSYCHOPHYSIOLOGIC; MALE; MAZE LEARNING; MEMORY, SHORT-TERM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PROSENCEPHALON; TIME FACTORS;

EID: 84857762194     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.01.061     Document Type: Article

References (31)

1. Morris R.G., Anderson E., Lynch G.S., Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-d-aspartate receptor antagonist, AP5. Nature 1986, 319(6056):774-776.
2. Morris R.G. Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-d-aspartate receptor antagonist AP5. J Neurosci 1989, 9(9):3040-3057.
3. Martin S.J., Grimwood P.D., Morris R.G. Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci 2000, 23:649-711.
4. Wood P.L. The co-agonist concept: is the NMDA-associated glycine receptor saturated in vivo?. Life Sci 1995, 57(4):301-310.
5. Danysz W., Parsons C.G. Glycine and N-methyl-d-aspartate receptors: physiological significance and possible therapeutic applications. Pharmacol Rev 1998, 50(4):597-664.
6. Aragon C., Lopez-Corcuera B. Glycine transporters: crucial roles of pharmacological interest revealed by gene deletion. Trends Pharmacol Sci 2005, 26(6):283-286.
7. Eulenburg V., Armsen W., Betz H., Gomeza J. Glycine transporters: essential regulators of neurotransmission. Trends Biochem Sci 2005, 30(6):325-333.
8. Bergeron R., Meyer T.M., Coyle J.T., Greene R.W. Modulation of N-methyl-d-aspartate receptor function by glycine transport. Proc Natl Acad Sci U S A 1998, 95(26):15730-15734.
9. Depoortère R., Dargazanli G., Estenne-Bouhtou G., Coste A., Lanneau C., Desvignes C., et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology 2005, 30(11):1963-1985.
10. Singer P., Feldon J., Yee B.K. The glycine transporter 1 inhibitor SSR504734 enhances working memory performance in a continuous delayed alternation task in C57BL/6 mice. Psychopharmacology (Berl) 2009, 202(1-3):371-384.
11. Tsai G., Ralph-Williams R.J., Martina M., Bergeron R., Berger-Sweeney J., Dunham K.S., et al. Gene knockout of glycine transporter 1: characterization of the behavioral phenotype. Proc Natl Acad Sci U S A 2004, 101(22):8485-8490.
12. Gabernet L., Pauly-Evers M., Schwerdel C., Lentz M., Bluethmann H., Vogt K., et al. Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression. Neurosci Lett 2005, 373(1):79-84.
13. Yee B.K., Balic E., Singer P., Schwerdel C., Grampp T., Gabernet L., et al. Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile. J Neurosci 2006, 26(12):3169-3181.
14. Singer P., Boison D., Möhler H., Feldon J., Yee B.K. Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: enhanced cognitive adaptability?. Behav Neurosci 2009, 123(5):1012-1027.
15. Singer P., Boison D., Möhler H., Feldon J., Yee B.K. Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons. Behav Neurosci 2007, 121:815-825.
16. Singer P., Yee B.K., Feldon J., Iwasato T., Itohara S., Grampp T., et al. Altered mnemonic functions and resistance to N-methyl-d-aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1. Neuroscience 2009, 161(2):635-654.
17. Llano Lopez L., Hauser J., Feldon J., Gargiulo P.A., Yee B.K. Evaluating spatial memory function in mice: a within-subjects comparison between the water maze test and its adaptation to dry land. Behav Brain Res 2010, 209(1):85-92.
18. Olton D.S., Samuelson R.J. Remembrance of places passed - spatial memory in rats. Journal of Experimental Psychology-Animal Behavior Processes 1976, 2(2):97-116.
19. Lund F.H. The psychology of belief IV: the law of primacy in persuasion. Journal of Abnormal Psychology and Social Psychology 1925, 20(2):183-191.
20. Möhler H., Boison D., Singer P., Feldon J., Pauly-Evers M., Yee B.K. Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: evidence from genetically modified mouse models and pharmacological inhibition. Biochem Pharmacol 2011, 81(9):1065-1077.
21. Bannerman D.M., Good M.A., Butcher S.P., Ramsay M., Morris R.G. Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature 1995, 378(6553):182-186.
22. Gomeza J., Ohno K., Betz H. Glycine transporter isoforms in the mammalian central nervous system: structures, functions and therapeutic promises. Curr Opin Drug Discov Devel 2003, 6(5):675-682.
23. Gomeza J., Armsen W., Betz H., Eulenburg V. Lessons from the knocked-out glycine transporters. Handb Exp Pharmacol 2006, 175:457-483.
24. Zhang L.H., Gong N., Fei D., Xu L., Xu T.L. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology 2008, 33(3):701-711.
25. Möhler H., Rudolph U., Boison D., Singer P., Feldon J., Yee B.K. Regulation of cognition and symptoms of psychosis: focus on GABA(A) receptors and glycine transporter 1. Pharmacol Biochem Behav 2008, 90(1):58-64.
26. Collinson N., Kuenzi F.M., Jarolimek W., Maubach K.A., Cothliff R., Sur C., et al. Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor. J Neurosci 2002, 22(13):5572-5580.
27. Yee B.K., Hauser J., Dolgov V.V., Keist R., Möhler H., Rudolph U., et al. GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear. Eur J Neurosci 2004, 20(7):1928-1936.
28. Xu T.L., Gong N. Glycine and glycine receptor signaling in hippocampal neurons: diversity, function and regulation. Prog Neurobiol 2010, 91(4):349-361.
29. Eulenburg V., Retiounskaia M., Papadopoulos T., Gomeza J., Betz H. Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice. Glia 2010, 58(9):1066-1073.
30. Iwasato T., Nomura R., Ando R., Ikeda T., Tanaka M., Itohara S. Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis 2004, 38(3):130-138.
31. Dragatsis I., Zeitlin S. CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain. Genesis 2000, 26(2):133-135.