An acidic amino acid transmembrane helix 10 residue conserved in the neurotransmitter:sodium:symporters is essential for the formation of the extracellular gate of the γ-aminobutyric acid (GABA) transporter GAT-1

Journal of Biological Chemistry

Volumn 287, Issue 10, 2012, Pages 7159-7168

  Ben Yona, Assaf ^a   Kanner, Baruch I ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC AMINO ACIDS; AMINOBUTYRIC ACIDS; ASPARTATE RESIDUE; BINDING POCKETS; CYSTEINE RESIDUES; EXTRACELLULAR; EXTRACELLULAR SPACE; GABAERGIC; MEMBRANE-IMPERMEANT; MODELING STUDIES; SODIUM BINDING; STATE-DEPENDENT; SULFHYDRYL; TRANS-MEMBRANE DOMAINS; TRANSIENT CURRENT; TRANSMEMBRANE HELICES; TRANSPORT ACTIVITY;

ACTIVATION ANALYSIS; CHLORINE COMPOUNDS; FACINGS; TRANSIENTS;

AMINO ACIDS;

4 AMINOBUTYRIC ACID CARRIER; ASPARTIC ACID; COTRANSPORTER; CYSTEINE; GAMMA AMINOBUTYRIC ACID TRANSPORTER 1; GLUTAMIC ACID; LEUCINE; NEUROTRANSMITTER SODIUM SYMPORTER; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL SURFACE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRIC POTENTIAL; EXTRACELLULAR SPACE; FEMALE; INHIBITION KINETICS; ION CURRENT; MOLECULAR DYNAMICS; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; RESIDUE ANALYSIS; SIGNAL TRANSDUCTION; STEADY STATE;

AMINO ACID SUBSTITUTION; ANIMALS; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; HELA CELLS; HUMANS; ION CHANNEL GATING; ION TRANSPORT; MUTATION, MISSENSE; NEUROTRANSMITTER AGENTS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SODIUM; XENOPUS LAEVIS;

BACTERIA (MICROORGANISMS);

EID: 84857716908     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.323634     Document Type: Article

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