Hepatic mitochondrial DNA depletion after an alcohol binge in mice: Probable role of peroxynitrite and modulation by manganese superoxide dismutase

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 3, 2010, Pages 886-897

  Larosche, Isabelle ^a   Lettéron, Philippe ^a,b   Berson, Alain ^a,b   Fromenty, Bernard ^a,b   Huang, Ting Ting ^c   Moreau, Richard ^a,b   Pessayre, Dominique ^a,b   Mansouri, Abdellah ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) NITROARGININE METHYL ESTER; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SCAVENGER; TEMPOL; URIC ACID;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; HETEROZYGOSITY; KNOCKOUT MOUSE; LIVER; MALE; MITOCHONDRIAL DNA DEPLETION; MOUSE; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; CASPASE 3; CYCLIC N-OXIDES; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; ELECTRON TRANSPORT COMPLEX I; ETHANOL; FREE RADICAL SCAVENGERS; GLUTATHIONE PEROXIDASE; HIGH MOBILITY GROUP PROTEINS; IRON; LIVER; MICE; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE II; PEROXYNITROUS ACID; REACTIVE OXYGEN SPECIES; SPIN LABELS; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS; URIC ACID;

EID: 77249134288     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.160879     Document Type: Article

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