KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population

Cardiovascular Diabetology

Volumn 9, Issue , 2010, Pages

  Chen, Zhong ^a   Yin, Quanzhong ^b   Ma, Genshan ^a   Qian, Qi ^a  

^a AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

^b JIANGYIN PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POTASSIUM CHANNEL KCNQ1; TRIACYLGLYCEROL; KCNQ1 PROTEIN, HUMAN; LIPID;

ADULT; ANTHROPOMETRY; ARTICLE; CARDIOVASCULAR RISK; CHINESE; CHOLESTEROL BLOOD LEVEL; CONCENTRATION (PARAMETERS); CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; FEMALE; GENETIC ASSOCIATION; GENETIC MARKER; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; LIPID BLOOD LEVEL; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; ASIAN; BLOOD; CHINA; DYSLIPIDEMIA; ETHNOLOGY; GENETICS; HOMEOSTASIS; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; STATISTICS;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; DYSLIPIDEMIAS; FEMALE; GENOTYPE; HOMEOSTASIS; HUMANS; KCNQ1 POTASSIUM CHANNEL; LIPIDS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 77955365281     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-9-35     Document Type: Article

References (22)

1. Mori Y, Otabe S, Dina C, Yasuda K, Populaire C, Lecoeur C, Vatin V, Durand E, Hara K, Okada T, Tobe K, Boutin P, Kadowaki T, Froguel P. Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p. Diabetes 2002, 51:1247-1255. 10.2337/diabetes.51.4.1247, 11916952.
2. Nawata H, Shirasawa S, Nakashima N, Araki E, Hashiguchi J, Miyake S, Yamauchi T, Hamaguchi K, Yoshimatsu H, Takeda H, Fukushima H, Sasahara T, Yamaguchi K, Sonoda N, Sonoda T, Matsumoto M, Tanaka Y, Sugimoto H, Tsubouchi H, Inoguchi T, Yanase T, Wake N, Narazaki K, Eto T, Umeda F, Nakazaki M, Ono J, Asano T, Ito Y, Akazawa S, et al. Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese. J Hum Genet 2004, 49:629-634. 10.1007/s10038-004-0199-3, 15490285.
3. Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DP, Holmkvist J, Borch-Johnsen K, Jørgensen T, Sandbaek A, Lauritzen T, Hansen T, Nurbaya S, Tsunoda T, Kubo M, Babazono T, Hirose H, Hayashi M, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Tai ES, Pedersen O, Kamatani N, Kadowaki T, Kikkawa R, Nakamura Y, Maeda S. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008, 40:1098-1102. 10.1038/ng.208, 18711366.
4. Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008, 40:1092-1097. 10.1038/ng.207, 18711367.
5. Liu Y, Zhou DZ, Zhang D, Chen Z, Zhao T, Zhang Z, Ning M, Hu X, Yang YF, Zhang ZF, Yu L, He L, Xu H. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China. Diabetologia 2009, 52:1315-1321. 10.1007/s00125-009-1375-y, 2688614, 19448982.
6. Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Boström K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Råstam L, Speliotes EK, Taskinen MR, Tuomi T, et al. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT Lund University, and Novartis Institutes of BioMedical Research Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007, 316:1331-1336. 10.1126/science.1142358, 17463246, Diabetes Genetics Initiative of Broad Institute of Harvard and MIT Lund University, and Novartis Institutes of BioMedical Research.
7. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, , McCarthy MI, Hattersley AT. Wellcome Trust Case Control Consortium (WTCCC) Replication of genome-wide association signals in U.K. samples reveals risk loci for type 2 diabetes. Science 2007, 316:1336-1341. 10.1126/science.1142364, 17463249, Wellcome Trust Case Control Consortium (WTCCC).
8. Chen Z, Zhang X, Ma G, Qian Q, Yao Y. Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population. Mol Biol Rep 2010, 37:207-212. 10.1007/s11033-009-9597-0, 19575309.
9. Tan JT, Nurbaya S, Gardner D, Ye S, Tai ES, Ng DP. Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore. Diabetes 2009, 58:1445-1449. 10.2337/db08-1138, 2682664, 19252135.
10. Hu C, Wang C, Zhang R, Ma X, Wang J, Lu J, Qin W, Bao Y, Xiang K, Jia W. Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia 2009, 52:1322-1325. 10.1007/s00125-009-1335-6, 19308350.
11. Giuffrida FM, Furuzawa GK, Kasamatsu TS, Oliveira MM, Reis AF, Dib SA. HNF1A gene polymorphisms and cardiovascular risk factors in individuals with late-onset autosomal dominant diabetes: a cross-sectional study. Cardiovasc Diabetol 2009, 8:28. 10.1186/1475-2840-8-28, 2696421, 19490620.
12. Wan J, Xiong S, Chao S, Xiao J, Ma Y, Wang J, Roy S. PPARgamma gene C161T substitution alters lipid profile in Chinese patients with coronary artery disease and type 2 diabetes mellitus. Cardiovasc Diabetol 2010, 9:13. 10.1186/1475-2840-9-13, 2859850, 20334678.
13. Halvatsiotis I, Tsiotra PC, Ikonomidis I, Kollias A, Mitrou P, Maratou E, Boutati E, Lekakis J, Dimitriadis G, Economopoulos T, Kremastinos DT, Raptis SA. Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes. Cardiovasc Diabetol 2010, 9:10. 10.1186/1475-2840-9-10, 2846898, 20178558.
14. Kareinen A, Viitanen L, Halonen P, Lehto S, Laakso M. Cardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary artery disease. Arterioscler Thromb Vasc Biol 2001, 21:1346-1352. 10.1161/hq0801.093655, 11498464.
15. Chen Z, Ma G, Zhang X, Wang J. Lipoprotein lipase and premature coronary artery disease. Acta Cardiol 2009, 64:379-383. 10.2143/AC.64.3.2038025, 19593950.
16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419. 10.1007/BF00280883, 3899825.
17. Yasar AS, Turhan H, Basar N, Metin F, Erbay AR, Ilkay E, Sabah I. Comparison of major coronary risk factors in female and male patients with premature coronary artery disease. Acta Cardiol 2008, 63:19-25. 10.2143/AC.63.1.2025327, 18372576.
18. Hopkins PN, Wu LL, Hunt SC, Brinton EA. Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease. J Am Coll Cardiol 2005, 45:1003-1012. 10.1016/j.jacc.2004.11.062, 15808755.
19. Chen CY, Hwu CM, Lin MW, Tsai CH, Yeh HI. High triglyceride level is associated with severe coronary artery disease in hypertensive subjects. Scand Cardiovasc J 2008, 42:146-152. 10.1080/14017430701840325, 18365898.
20. Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease: the Framingham study. Am J Med 1977, 62:707-714. 10.1016/0002-9343(77)90874-9, 193398.
21. Assmann G, Schulte H, von Eckardstein A, Huang Y. High-density lipoprotein cholesterol as a predictor of coronary heart disease risk: the PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis 1996, 124(suppl):S11-20. 10.1016/0021-9150(96)05852-2, 8831911.
22. DeFaria Yeh D, Freeman MW, Meigs JB, Grant RW. Risk factors for coronary artery disease in patients with elevated high-density lipoprotein cholesterol. Am J Cardiol 2007, 99:1-4. 10.1016/j.amjcard.2006.07.053, 17196452.