Variations in insulin secretion in carriers of gene variants in IRS-1 and -2

Diabetes

Volumn 51, Issue 3, 2002, Pages 884-887

  'T Hart, Leen M ^a   Nijpels, Giel ^b   Dekker, Jacqueline M ^b   Antonie Maassen, J ^a,d   Heine, Robert J ^b   Van Haeften, Timon W ^c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC VARIABILITY; GENOTYPE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0036318131     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.3.884     Document Type: Article

References (25)

1. Aminoacid polymorfisms of insulin receptor substrate-1 in non insulin dependent diabetes mellitus
2. Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians
3. Prevalence of variants in candidate genes for type 2 diabetes mellitus in the Netherlands: The Rotterdam study and the Hoorn study
4. The common PPARgamma Pro 12A1a polymorphism is associated with decreased risk of type 2 diabetes
5. Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: Evaluation of their relation with alterations in insulin secretion and insulin sensitivity
6. Insulin resistance: Interactions between obesity and a common variant of insulin receptor substrate-1
7. Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes
8. The Gly(972)-> Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells
9. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
10. Insights into insulin resistance and type 2 diabetes from knockout mouse models
11. IRS proteins and beta-cell function
12. The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans
13. Genetic polymorphisms and disease
14. Relation of impaired fasting and postload glucose with incident type 2 diabetes in a Dutch population: The Hoorn Study
15. Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1
16. Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo
17. Determinants for the progression from impaired glucose tolerance to non-insulin-dependent diabetes mellitus
18. Relative contributions of beta-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia
19. Disruption of IRS-2 causes type 2 diabetes in mice
20. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
21. The prevalent gly1057asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion
22. Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects: Assessments using hyperglycemic glucose clamps and oral glucose tolerance tests
23. Hyperproinsulinaemia in impaired glucose tolerance is associated with a delayed insulin response to glucose
24. Simultaneous assessment of insulin secretion and insulin sensitivity using a hyperglycemic clamp