In vivo gene knockdown in rat dorsal root ganglia mediated by self-complementary adeno-associated virus serotype 5 following intrathecal delivery

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Xu, Qinghao ^a   Chou, Beverly ^a   Fitzsimmons, Bethany ^a   Miyanohara, Atsushi ^b   Shubayev, Veronica ^a   Santucci, Camila ^a   Hefferan, Michael ^a   Marsala, Martin ^a,c   Hua, Xiao Ying ^a  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PARVOVIRUS VECTOR; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE;

ADENO ASSOCIATED VIRUS; ADENOVIRUS 5; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG TARGETING; GENE EXPRESSION; GENE SILENCING; IMMUNOHISTOCHEMISTRY; IN VIVO GENE TRANSFER; IN VIVO STUDY; MALE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MYELINATED NERVE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RNA SEQUENCE; SIGNAL TRANSDUCTION; SPINAL GANGLION; VIRAL TROPISM; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DRUG EFFECT; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; NERVE CELL; NOCICEPTION; SPRAGUE DAWLEY RAT; VIROLOGY;

ADENO-ASSOCIATED VIRUS; MAMMALIA; RATTUS;

ANIMALS; DEPENDOVIRUS; GANGLIA, SPINAL; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; INJECTIONS, SPINAL; MALE; NEURONS; NOCICEPTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; TOR SERINE-THREONINE KINASES; TRANSDUCTION, GENETIC;

EID: 84857708773     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032581     Document Type: Article

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