Global diffuse distribution in the brain and efficient gene delivery to the dorsal root ganglia by intrathecal injection of adeno-associated viral vector serotype 1

Journal of Gene Medicine

Volumn 11, Issue 6, 2009, Pages 498-505

  Iwamoto, Naotaka ^a   Watanabe, Atsushi ^a   Yamamoto, Motoko ^a   Miyake, Noriko ^a   Kurai, Toshiyuki ^a   Teramoto, Akira ^a   Shimada, Takashi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Adeno associated viral vector serotype 1 (AAV1); Arylsulfatase A (ASA); Brain; Dorsal root ganglia; Intrathecal (IT) Injection; Metachromatic leukodystrophy (MLD)

Indexed keywords

CEREBROSIDE SULFATASE; GREEN FLUORESCENT PROTEIN; PARVOVIRUS VECTOR; SULFATIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG DISTRIBUTION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GENE TARGETING; GENETIC TRANSDUCTION; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; METACHROMATIC LEUKODYSTROPHY; MOUSE; NERVE FIBER; NON INVASIVE PROCEDURE; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROTYPE; SPINAL GANGLION; VIRAL GENE THERAPY; ANIMAL MODEL; CELLULAR DISTRIBUTION; FEASIBILITY STUDY; NERVE CELL; TISSUE DISTRIBUTION; VIRAL GENE DELIVERY SYSTEM;

MUS;

ANIMALS; BRAIN; CELLS, CULTURED; CEREBROSIDE-SULFATASE; DEPENDOVIRUS; GANGLIA, SPINAL; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; INJECTIONS, SPINAL; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE;

EID: 65949115945     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1325     Document Type: Article

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