Tethering toxins and peptide ligands for modulation of neuronal function

Current Opinion in Neurobiology

Volumn 22, Issue 1, 2012, Pages 72-78

  Ibañez Tallon, Inés ^a   Nitabach, Michael N ^b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGATOXIN; ALPHA BUNGAROTOXIN; AMPA RECEPTOR; CALCIUM CHANNEL; CONOTOXIN; GLYCOSYLPHOSPHATIDYLINOSITOL; LYNX1 TOXIN; NEUROPEPTIDE; NEUROTOXIN; NICOTINIC RECEPTOR; TETRODOTOXIN; TOXIN; UNCLASSIFIED DRUG;

CALCIUM CURRENT; GENE EXPRESSION SYSTEM; NERVE CELL NETWORK; NERVE CONDUCTION; NERVE FUNCTION; NEUROANATOMY; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SODIUM CURRENT; TOXIN ANALYSIS; TOXIN STRUCTURE; TOXIN SYNTHESIS; TRANSGENICS;

ANIMALS; LIGANDS; NEUROPEPTIDES; NEUROSCIENCES; NEUROTOXINS; PROTEIN ENGINEERING; RECEPTORS, NICOTINIC;

EID: 84857686980     PISSN: 09594388     EISSN: 18736882     Source Type: Journal    
DOI: 10.1016/j.conb.2011.11.003     Document Type: Review

References (31)

1. Miwa J.M., Ibanez-Tallon I., Crabtree G.W., Sanchez R., Sali A., Role L.W., Heintz N. lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS. Neuron 1999, 23:105-114.
2. Ibanez-Tallon I., Miwa J.M., Wang H.L., Adams N.C., Crabtree G.W., Sine S.M., Heintz N. Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron 2002, 33:893-903.
3. Wu M.N., Joiner W.J., Dean T., Yue Z., Smith C.J., Chen D., Hoshi T., Sehgal A., Koh K. SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker. Nat Neurosci 2010, 13:69-75.
4. von Engelhardt J., Mack V., Sprengel R., Kavenstock N., Li K.W., Stern-Bach Y., Smit A.B., Seeburg P.H., Monyer H. CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus. Science 2010, 327:1518-1522.
5. Heinemann S.H., Leipold E. Conotoxins of the O-superfamily affecting voltage-gated sodium channels. Cell Mol Life Sci 2007, 64:1329-1340.
6. Walker C.S., Jensen S., Ellison M., Matta J.A., Lee W.Y., Imperial J.S., Duclos N., Brockie P.J., Madsen D.M., Isaac J.T., et al. A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. Curr Biol 2009, 19:900-908.
7. Ibanez-Tallon I., Wen H., Miwa J.M., Xing J., Tekinay A.B., Ono F., Brehm P., Heintz N. Tethering naturally occurring peptide toxins for cell-autonomous modulation of ion channels and receptors in vivo. Neuron 2004, 43:305-311.
8. Holford M., Auer S., Laqua M., Ibanez-Tallon I. Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators. Front Mol Neurosci 2009, 2:21.
9. Auer S., Sturzebecher A.S., Juttner R., Santos-Torres J., Hanack C., Frahm S., Liehl B., Ibanez-Tallon I. Silencing neurotransmission with membrane-tethered toxins. Nat Methods 2010, 7:229-236.
10. Fortin J.P., Zhu Y., Choi C., Beinborn M., Nitabach M.N., Kopin A.S. Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function. Proc Natl Acad Sci USA 2009, 106:8049-8054.
11. Hruska M., Ibanez-Tallon I., Nishi R. Cell-autonomous inhibition of alpha 7-containing nicotinic acetylcholine receptors prevents death of parasympathetic neurons during development. J Neurosci 2007, 27:11501-11509.
12. Sturzebecher A.S., Hu J., Smith E.S., Frahm S., Santos-Torres J., Kampfrath B., Auer S., Lewin G.R., Ibanez-Tallon I. An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors. J Physiol 2010, 588:1695-1707.
13. Wu Y., Cao G., Pavlicek B., Luo X., Nitabach M.N. Phase coupling of a circadian neuropeptide with rest/activity rhythms detected using a membrane-tethered spider toxin. PLoS Biol 2008, 6:e273.
14. Auer S., Ibanez-Tallon I. " The King is dead": checkmating ion channels with tethered toxins. Toxicon 2010, 56:1293-1298.
15. Choi C., Fortin J.P., McCarthy E., Oksman L., Kopin A.S., Nitabach M.N. Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands. Curr Biol 2009, 19:1167-1175.
16. Nitabach M.N., Taghert P.H. Organization of the Drosophila circadian control circuit. Curr Biol 2008, 18:R84-R93.
17. Nielsen S.M., Nielsen L.Z., Hjorth S.A., Perrin M.H., Vale W.W. Constitutive activation of tethered-peptide/corticotropin-releasing factor receptor chimeras. Proc Natl Acad Sci USA 2000, 97:10277-10281.
18. Renn S.C., Park J.H., Rosbash M., Hall J.C., Taghert P.H. A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell 1999, 99:791-802.
19. Akopian A.N., Souslova V., England S., Okuse K., Ogata N., Ure J., Smith A., Kerr B.J., McMahon S.B., Boyce S., et al. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci 1999, 2:541-548.
20. Drago J., McColl C.D., Horne M.K., Finkelstein D.I., Ross S.A. Neuronal nicotinic receptors: insights gained from gene knockout and knockin mutant mice. Cell Mol Life Sci 2003, 60:1267-1280.
21. Nirthanan S., Gwee M.C. Three-finger alpha-neurotoxins and the nicotinic acetylcholine receptor, forty years on. J Pharmacol Sci 2004, 94:1-17.
22. Chang C.C., Lee C.Y. Isolation of neurotoxins from the venom of Bungarus multicinctus and their modes of neuromuscular blocking action. Arch Int Pharmacodyn Ther 1963, 144:241-257.
23. Chiappinelli V.A. Kappa-bungarotoxin: a probe for the neuronal nicotinic receptor in the avian ciliary ganglion. Brain Res 1983, 277:9-22.
24. Dessaud E., Salaun D., Gayet O., Chabbert M., deLapeyriere O. Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development. Mol Cell Neurosci 2006, 31:232-242.
25. Tekinay A.B., Nong Y., Miwa J.M., Lieberam I., Ibanez-Tallon I., Greengard P., Heintz N. A role for LYNX2 in anxiety-related behavior. Proc Natl Acad Sci USA 2009, 106:4477-4482.
26. Chimienti F., Hogg R.C., Plantard L., Lehmann C., Brakch N., Fischer J., Huber M., Bertrand D., Hohl D. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. Hum Mol Genet 2003, 12:3017-3024.
27. Arredondo J., Chernyavsky A.I., Jolkovsky D.L., Webber R.J., Grando S.A. SLURP-2: a novel cholinergic signaling peptide in human mucocutaneous epithelium. J Cell Physiol 2006, 208:238-245.
28. Choo Y.M., Lee B.H., Lee K.S., Kim B.Y., Li J., Kim J.G., Lee J.H., Sohn H.D., Nah S.Y., Jin B.R. Pr-lynx1, a modulator of nicotinic acetylcholine receptors in the insect. Mol Cell Neurosci 2008, 38:224-235.
29. Yang B., Yao X., Gu S., Zhang Y., Liu Z. Selectivity of lynx proteins on insect nicotinic acetylcholine receptors in the brown planthopper, Nilaparvata lugens. Insect Mol Biol 2010, 19:283-289.
30. Liu Z., Cao G., Li J., Bao H., Zhang Y. Identification of two Lynx proteins in Nilaparvata lugens and the modulation on insect nicotinic acetylcholine receptors. J Neurochem 2009, 110:1707-1714.
31. Hruska M., Keefe J., Wert D., Tekinay A.B., Hulce J.J., Ibanez-Tallon I., Nishi R. Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons. J Neurosci 2009, 29:14847-14854.