CKAMP44: A brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus

Science

Volumn 327, Issue 5972, 2010, Pages 1518-1522

  Von Engelhardt, Jakob ^a   Mack, Volker ^a,b   Sprengel, Rolf ^c   Kavenstock, Netta ^d   Li, Ka Wan ^b   Stern Bach, Yael ^d   Smit, August B ^b   Seeburg, Peter H ^c   Monyer, Hannah ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^d HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BRAIN PROTEIN; CKAMP44 PROTEIN; KAINIC ACID; MEMBRANE PROTEIN; N METHYL DEXTRO ASPARTIC ACID; UNCLASSIFIED DRUG;

BRAIN; CELL ORGANELLE; DEVELOPMENTAL BIOLOGY; GENE EXPRESSION; PLASTICITY; PROTEIN;

ARTICLE; DENTATE GYRUS; DESENSITIZATION; EXCITATORY POSTSYNAPTIC POTENTIAL; GRANULE CELL; MEMBRANE CURRENT; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; OOCYTE; PERFORANT NERVE TRACT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; PYRAMIDAL NERVE CELL; STEADY STATE; XENOPUS;

ANIMALS; CA1 REGION, HIPPOCAMPAL; CALCIUM CHANNELS; DENDRITIC SPINES; DENTATE GYRUS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MINIATURE POSTSYNAPTIC POTENTIALS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEURAL INHIBITION; NEURONAL PLASTICITY; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PERFORANT PATHWAY; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN ISOFORMS; PROTEOMICS; PYRAMIDAL CELLS; RECEPTORS, AMPA; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNAPSES; SYNAPTIC TRANSMISSION; XENOPUS LAEVIS;

EID: 77949828149     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1184178     Document Type: Article

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22. We thank M. K. Schwarz for recombinant adenoassociated virus delivery into the brains of mouse pups, A. Zivkovich for electrophysiological experiments during the initial stages of this project, L. Layer and S. Giese for help with molecular cloning, R. van der Schors for his contribution to the mass spectrometry, and R. HinzHerkommer, I. Preugschat-Gumprecht, and R. Zilberstein for technical assistance. Supported by the Schilling Foundation (H.M.); EU-Synapse LSHM-CT-2005-019055 (H.M., P.H.S., Y.S.B.); SFB636 (R.S.P.) and Nationales Genomforschungsnetz (NGFN) (R.S.P.); the Center for Medical Systems Biology (K.W.L. and A.B.S.); and the Max Planck Society (R.S.P. and P.H.S.). The experimentally verified cDNA CKAMP44 sequences are annotated at the National Center for Biotechnology Information under the accession numbers GU479981 (CKAMP44a) and GU479982 (CKAMP44b).