-
1
-
-
42149181885
-
Structural diversity of G protein-coupled receptors and significance for drug discovery
-
Lagerstrom MC, Schioth HB (2008) Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 7:339-357.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 339-357
-
-
Lagerstrom, M.C.1
Schioth, H.B.2
-
2
-
-
16244383540
-
Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors
-
DOI 10.1016/S1359-6446(05)03370-2, PII S1359644604033702
-
Hoare SR (2005) Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors. Drug Discov Today 10:417-427. (Pubitemid 40450272)
-
(2005)
Drug Discovery Today
, vol.10
, Issue.6
, pp. 417-427
-
-
Hoare, S.R.J.1
-
3
-
-
42449160533
-
Molecular recognition of parathyroid hormone by its G protein-coupled receptor
-
Pioszak AA, Xu HE (2008) Molecular recognition of parathyroid hormone by its G protein-coupled receptor. Proc Natl Acad Sci USA 105:5034-5039.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 5034-5039
-
-
Pioszak, A.A.1
Xu, H.E.2
-
4
-
-
57749102733
-
Molecular recognition of corticotropin- Releasing factor by its G-protein-coupled receptor CRFR1
-
Pioszak AA, Parker NR, Suino-Powell K, Xu HE (2008) Molecular recognition of corticotropin- releasing factor by its G-protein-coupled receptor CRFR1. J Biol Chem 283:32900-32912.
-
(2008)
J Biol Chem
, vol.283
, pp. 32900-32912
-
-
Pioszak, A.A.1
Parker, N.R.2
Suino-Powell, K.3
Xu, H.E.4
-
5
-
-
35348845217
-
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor
-
DOI 10.1073/pnas.0706404104
-
Parthier C, et al. (2007) Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor. Proc Natl Acad Sci USA 104:13942-13947. (Pubitemid 350003317)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.35
, pp. 13942-13947
-
-
Parthier, C.1
Kleinschmidt, M.2
Neumann, P.3
Rudolph, R.4
Manhart, S.5
Schlenzig, D.6
Fanghanel, J.7
Rahfeld, J.-U.8
Demuth, H.-U.9
Stubbs, M.T.10
-
6
-
-
45549086826
-
Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain
-
Runge S, Thogersen H, Madsen K, Lau J, Rudolph R (2008) Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem 283:11340-11347.
-
(2008)
J Biol Chem
, vol.283
, pp. 11340-11347
-
-
Runge, S.1
Thogersen, H.2
Madsen, K.3
Lau, J.4
Rudolph, R.5
-
7
-
-
36548999220
-
Incretin hormone mimetics and analogues in diabetes therapeutics
-
DOI 10.1016/j.beem.2007.09.003, PII S1521690X07000863, New Therapies for Diabetes
-
Green BD, Flatt PR (2007) Incretin hormone mimetics and analogues in diabetes therapeutics. Best Pract Res Clin Endocrinol Metab 21:497-516. (Pubitemid 350177567)
-
(2007)
Best Practice and Research in Clinical Endocrinology and Metabolism
, vol.21
, Issue.4
, pp. 497-516
-
-
Green, B.D.1
Flatt, P.R.2
-
8
-
-
35648995321
-
CGRP antagonists: Unravelling the role of CGRP in migraine
-
DOI 10.1016/j.tips.2007.10.005, PII S0165614707002301
-
Doods H, Arndt K, Rudolf K, Just S (2007) CGRP antagonists: Unravelling the role of CGRP in migraine. Trends Pharmacol Sci 28:580-587. (Pubitemid 350026615)
-
(2007)
Trends in Pharmacological Sciences
, vol.28
, Issue.11
, pp. 580-587
-
-
Doods, H.1
Arndt, K.2
Rudolf, K.3
Just, S.4
-
9
-
-
45749084872
-
Teduglutide in intestinal adaptation and repair: Light at the end of the tunnel
-
Mardini HE, de Villiers WJ (2008) Teduglutide in intestinal adaptation and repair: Light at the end of the tunnel. Expert Opin Investig Drugs 17:945-951.
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 945-951
-
-
Mardini, H.E.1
De Villiers, W.J.2
-
10
-
-
33646180349
-
Neuropeptide mimetics and antagonists in the treatment of inflammatory disease: Focus on VIP and PACAP
-
Abad C, Gomariz RP, Waschek JA (2006) Neuropeptide mimetics and antagonists in the treatment of inflammatory disease: Focus on VIP and PACAP. Curr Top Med Chem 6:151-163.
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 151-163
-
-
Abad, C.1
Gomariz, R.P.2
Waschek, J.A.3
-
11
-
-
33748575313
-
CRF signaling: Molecular specificity for drug targeting in the CNS
-
DOI 10.1016/j.tips.2006.08.007, PII S0165614706002033
-
Arzt E, Holsboer F (2006) CRF signaling: Molecular specificity for drug targeting in the CNS. Trends Pharmacol Sci 27:531-538. (Pubitemid 44374761)
-
(2006)
Trends in Pharmacological Sciences
, vol.27
, Issue.10
, pp. 531-538
-
-
Arzt, E.1
Holsboer, F.2
-
12
-
-
0032910566
-
Prediction of membrane protein types and subcellular locations
-
DOI 10.1002/(SICI)1097-0134(19990101)34:1<137::AID-PROT11>3.0.CO;2- O
-
Chou KC, Elrod DW (1999) Prediction of membrane protein types and subcellular locations. Proteins 34:137-153. (Pubitemid 29019537)
-
(1999)
Proteins: Structure, Function and Genetics
, vol.34
, Issue.1
, pp. 137-153
-
-
Chou, K.-C.1
Elrod, D.W.2
-
13
-
-
0034730191
-
Constitutive activation of tethered-peptide/corticotropin-releasing factor receptor chimeras
-
Nielsen SM, Nielsen LZ, Hjorth SA, Perrin MH, Vale WW (2000) Constitutive activation of tethered-peptide/corticotropin-releasing factor receptor chimeras. Proc Natl Acad Sci USA 97:10277-10281.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10277-10281
-
-
Nielsen, S.M.1
Nielsen, L.Z.2
Hjorth, S.A.3
Perrin, M.H.4
Vale, W.W.5
-
14
-
-
46149098623
-
Class-B GPCR activation: Is ligand helix-capping the key?
-
Neumann JM, et al. (2008) Class-B GPCR activation: Is ligand helix-capping the key? Trends Biochem Sci 33:314-319.
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 314-319
-
-
Neumann, J.M.1
-
15
-
-
0036083481
-
Ligand-regulated secretion of recombinant annexin V from cultured thyroid epithelial cells
-
Wang X, Kaetzel MA, Yoo SE, Kim PS, Dedman JR (2002) Ligand-regulated secretion of recombinant annexin V from cultured thyroid epithelial cells. Am J Physiol Cell Physiol 282:C1313-C1321. (Pubitemid 34663080)
-
(2002)
American Journal of Physiology - Cell Physiology
, vol.282
, Issue.6
-
-
Wang, X.1
Kaetzel, M.A.2
Yoo, S.E.3
Kim, P.S.4
Dedman, J.R.5
-
16
-
-
33947375922
-
Identification of amino acid determinants of dopamine 2 receptor synthetic agonist function
-
DOI 10.1124/jpet.106.116384
-
Al-Fulaij MA, Ren Y, Beinborn M, Kopin AS (2007) Identification of amino acid determinants of dopamine 2 receptor synthetic agonist function. J Pharmacol Exp Ther 321:298-307. (Pubitemid 46456991)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.321
, Issue.1
, pp. 298-307
-
-
Al-Fulaij, M.A.1
Ren, Y.2
Beinborn, M.3
Kopin, A.S.4
-
17
-
-
0035101820
-
Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
-
Ferguson SS (2001) Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling. Pharmacol Rev 53:1-24. (Pubitemid 32173106)
-
(2001)
Pharmacological Reviews
, vol.53
, Issue.1
, pp. 1-24
-
-
Ferguson, S.S.G.1
-
18
-
-
34248223285
-
Biology of Incretins: GLP-1 and GIP
-
DOI 10.1053/j.gastro.2007.03.054, PII S001650850700580X
-
Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131-2157. (Pubitemid 46711096)
-
(2007)
Gastroenterology
, vol.132
, Issue.6
, pp. 2131-2157
-
-
Baggio, L.L.1
Drucker, D.J.2
-
19
-
-
0035814935
-
Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo
-
DOI 10.1021/bi0014498
-
Xiao Q, et al. (2001) Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo. Biochemistry 40:2860-2869. (Pubitemid 32198288)
-
(2001)
Biochemistry
, vol.40
, Issue.9
, pp. 2860-2869
-
-
Xiao, Q.1
Giguere, J.2
Parisien, M.3
Jeng, W.4
St Pierre, S.A.5
Brubaker, P.L.6
Wheeler, M.B.7
-
20
-
-
0028198851
-
Structure-activity studies of glucagon-like peptide-1
-
Adelhorst K, Hedegaard BB, Knudsen LB, Kirk O (1994) Structure-activity studies of glucagon-like peptide-1. J Biol Chem 269:6275-6278. (Pubitemid 24190992)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.9
, pp. 6275-6278
-
-
Adelhorst, K.1
Hedegaard, B.B.2
Knudsen, L.B.3
Kirk, O.4
-
21
-
-
4043168530
-
In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide
-
DOI 10.1016/j.lfs.2004.03.024, PII S0024320504004904
-
Hinke SA, et al. (2004) In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide. Life Sci 75:1857-1870. (Pubitemid 39070498)
-
(2004)
Life Sciences
, vol.75
, Issue.15
, pp. 1857-1870
-
-
Hinke, S.A.1
Manhart, S.2
Speck, M.3
Pederson, R.A.4
Demuth, H.-U.5
McIntosh, C.H.S.6
-
22
-
-
2142703828
-
2 adrenergic receptor
-
DOI 10.1124/mol.65.5.1181
-
Liapakis G, Chan WC, Papadokostaki M, Javitch JA (2004) Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor. Mol Pharmacol 65:1181-1190. (Pubitemid 38543488)
-
(2004)
Molecular Pharmacology
, vol.65
, Issue.5
, pp. 1181-1190
-
-
Liapakis, G.1
Chan, W.C.2
Papadokostaki, M.3
Javitch, J.A.4
-
23
-
-
0030779816
-
High potency antagonists of the pancreatic glucagon-like peptide-1 receptor
-
DOI 10.1074/jbc.272.34.21201
-
Montrose-Rafizadeh C, et al. (1997) High potency antagonists of the pancreatic glucagon-like peptide-1 receptor. J Biol Chem 272:21201-21206. (Pubitemid 27373982)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.34
, pp. 21201-21206
-
-
Montrose-Rafizadeh, C.1
Yang, H.2
Rodgers, B.D.3
Beday, A.4
Pritchette, L.A.5
Eng, J.6
-
24
-
-
0033304631
-
The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors
-
Luck MD, Carter PH, Gardella TJ (1999) The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors. Mol Endocrinol 13:670-680. (Pubitemid 30645321)
-
(1999)
Molecular Endocrinology
, vol.13
, Issue.5
, pp. 670-680
-
-
Luck, M.D.1
Carter, P.H.2
Gardella, T.J.3
-
25
-
-
0027460624
-
A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists
-
DOI 10.1038/362348a0
-
Beinborn M, Lee YM, McBride EW, Quinn SM, Kopin AS (1993) A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists. Nature 362:348-350. (Pubitemid 23101307)
-
(1993)
Nature
, vol.362
, Issue.6418
, pp. 348-350
-
-
Beinborn, M.1
Lee, Y.-M.2
McBride, E.W.3
Quinn, S.M.4
Kopin, A.S.5
-
26
-
-
0031785214
-
Mutations within the cholecystokinin-B/gastrin receptor ligand 'pocket' interconvert the functions of nonpeptide agonists and antagonists
-
Blaker M, et al. (1998) Mutations within the cholecystokinin-B/gastrin receptor ligand 'pocket' interconvert the functions of nonpeptide agonists and antagonists. Mol Pharmacol 54:857-863.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 857-863
-
-
Blaker, M.1
-
27
-
-
0027194751
-
Basis for selective incorporation of glycoproteins into the influenza virus envelope
-
Naim HY, Roth MG (1993) Basis for selective incorporation of glycoproteins into the influenza virus envelope. J Virol 67:4831-4841. (Pubitemid 23215964)
-
(1993)
Journal of Virology
, vol.67
, Issue.8
, pp. 4831-4841
-
-
Naim, H.Y.1
Roth, M.G.2
-
28
-
-
0036266044
-
International Union of Pharmacology. XXXII. the mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
-
DOI 10.1124/pr.54.2.233
-
Poyner DR, et al. (2002) International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 54:233-246. (Pubitemid 34575714)
-
(2002)
Pharmacological Reviews
, vol.54
, Issue.2
, pp. 233-246
-
-
Poyner, D.R.1
Sexton, P.M.2
Marshall, I.3
Smith, D.M.4
Quirion, R.5
Born, W.6
Muff, R.7
Fischer, J.A.8
Foord, S.M.9
-
29
-
-
0035851103
-
A Small Molecule Ligand of the Glucagon-like Peptide 1 Receptor Targets its Amino-terminal Hormone Binding Domain
-
Tibaduiza EC, Chen C, Beinborn M (2001) A small molecule ligand of the glucagon-like peptide 1 receptor targets its amino-terminal hormone binding domain. J Biol Chem 276:37787-37793. (Pubitemid 37384022)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.41
, pp. 37787-37793
-
-
Tibaduiza, E.C.1
Chen, C.2
Beinborn, M.3
-
30
-
-
0037195185
-
A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants
-
DOI 10.1073/pnas.202498299
-
Hearn MG, et al. (2002) A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants. Proc Natl Acad Sci USA 99:14554-14559. (Pubitemid 35257709)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.22
, pp. 14554-14559
-
-
Hearn, M.G.1
Ren, Y.2
McBride, E.W.3
Reveillaud, I.4
Beinborn, M.5
Kopin, A.S.6
-
31
-
-
0037387146
-
Regulation of melanocortin-4 receptor signaling: Agonist-mediated desensitization and internalization
-
DOI 10.1210/en.2002-220931
-
Shinyama H, Masuzaki H, Fang H, Flier JS (2003) Regulation of melanocortin-4 receptor signaling: Agonist-mediated desensitization and internalization. Endocrinology 144:1301-1314. (Pubitemid 36428472)
-
(2003)
Endocrinology
, vol.144
, Issue.4
, pp. 1301-1314
-
-
Shinyama, H.1
Masuzaki, H.2
Fang, H.3
Flier, J.S.4
|