An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors

Journal of Physiology

Volumn 588, Issue 10, 2010, Pages 1695-1707

  Stürzebecher, Annika S ^a   Hu, Jing ^b   Smith, Ewan St John ^b   Frahm, Silke ^a   Santos Torres, Julio ^a   Kampfrath, Branka ^a   Auer, Sebastian ^a   Lewin, Gary R ^b   Ibañez Tallon, Inés ^a  

^a Molecular Neurobiology group   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONOTOXIN; CONOTOXIN MRVIA; NEUROTOXIN; TETRODOTOXIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANALGESIA (SENSORY DYSFUNCTION); ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL TYPE; COLD SENSITIVITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; FEMALE; GENE MAPPING; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; ION CURRENT; MAMMAL; METHODOLOGY; MOUSE; NERVE FIBER; NEWBORN; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE CELL; TRANSGENIC MOUSE; UPREGULATION; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; BACTERIAL ARTIFICIAL CHROMOSOME; CELL FUNCTION; CELL MEMBRANE POTENTIAL; COLD; FIRING RATE; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOTOR COORDINATION; NERVE CELL; PAIN RECEPTOR; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SODIUM CURRENT; SOUTHERN BLOTTING; SPINAL GANGLION; TRANSGENICS; WHOLE CELL PATCH CLAMP; XENOPUS LAEVIS;

ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, SOUTHERN; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CONOTOXINS; DNA; ELECTROPHYSIOLOGY; FEMALE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; ION CHANNEL GATING; MICE; MICE, TRANSGENIC; NEURONS, AFFERENT; NOCICEPTORS; OOCYTES; PAIN; PATCH-CLAMP TECHNIQUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPINAL CORD; XENOPUS LAEVIS;

EID: 77953719599     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.187112     Document Type: Article

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