메뉴 건너뛰기




Volumn 32, Issue 2, 2012, Pages 388-409

Recent advances in search of oral heparin therapeutics

Author keywords

Bioavailability; Heparin; Novel drug delivery systems; Oral delivery

Indexed keywords

18 BETA GLYCYRRHETINIC ACID; BLOOD CLOTTING FACTOR 10A; CHITOSAN; DECANOATE SODIUM; DEOXYCHOLIC ACID; ENOXAPARIN; FONDAPARINUX; GLUTATHIONE; HEPARIN; HEXAPEPTIDE; IDRAPARINUX; LOW MOLECULAR WEIGHT HEPARIN; N SULFONATO N, O CARBOXYMETHYLCHITOSAN; NANOSHELL; PENETRATION ENHANCING AGENT; POLYCAPROLACTONE; POLYGLACTIN; TRIOCTANOIN; UNCLASSIFIED DRUG; ZONULA OCCLUDENS TOXIN;

EID: 84857685980     PISSN: 01986325     EISSN: 10981128     Source Type: Journal    
DOI: 10.1002/med.20217     Document Type: Article
Times cited : (41)

References (74)
  • 2
    • 0036204925 scopus 로고    scopus 로고
    • Oral heparins
    • Hiebert LM. Oral heparins. Clin Lab 2002;48:111-116.
    • (2002) Clin Lab , vol.48 , pp. 111-116
    • Hiebert, L.M.1
  • 3
    • 0035998957 scopus 로고    scopus 로고
    • Nasal administration of low molecular weight heparin
    • Arnold J, Ahsan F, Meezan E, Pillion DJ. Nasal administration of low molecular weight heparin. J Pharm Sci 2002;91:1707-1714.
    • (2002) J Pharm Sci , vol.91 , pp. 1707-1714
    • Arnold, J.1    Ahsan, F.2    Meezan, E.3    Pillion, D.J.4
  • 4
    • 60049089372 scopus 로고    scopus 로고
    • Synthesis and evaluation of pegylated dendrimeric nanocarrier for pulmonary delivery of low molecular weight heparin
    • Bai S, Ahsan F. Synthesis and evaluation of pegylated dendrimeric nanocarrier for pulmonary delivery of low molecular weight heparin. Pharm Res 2009;26:539-548.
    • (2009) Pharm Res , vol.26 , pp. 539-548
    • Bai, S.1    Ahsan, F.2
  • 5
    • 0018477317 scopus 로고
    • Heparins: Anionic polyelectrolyte drugs
    • Jaques LB. Heparins: Anionic polyelectrolyte drugs. Pharmacol Rev 1979;31:99-166.
    • (1979) Pharmacol Rev , vol.31 , pp. 99-166
    • Jaques, L.B.1
  • 6
    • 0031758671 scopus 로고    scopus 로고
    • Heparin and low-molecular-weight-heparin: Mechanisms of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety
    • Hirsh J, Warkentin TE, Raschke R, Granger C, Ohman EM, Dalen JE. Heparin and low-molecular-weight-heparin: Mechanisms of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. Chest 1998;114:489S-510S.
    • (1998) Chest , vol.114
    • Hirsh, J.1    Warkentin, T.E.2    Raschke, R.3    Granger, C.4    Ohman, E.M.5    Dalen, J.E.6
  • 7
    • 0029144705 scopus 로고
    • Oral bioavailability of heparin using a novel delivery system
    • Dunn JM, Hollister AS. Oral bioavailability of heparin using a novel delivery system. Curr Ther Res 1995;56:738-745.
    • (1995) Curr Ther Res , vol.56 , pp. 738-745
    • Dunn, J.M.1    Hollister, A.S.2
  • 8
    • 0037275872 scopus 로고    scopus 로고
    • Microencapsulation of low molecular weight heparin into polymeric particles designed with biodegradable and nonbiodegradable polycationic polymers
    • Hoffart V, Ubrich N, Lamprecht A, Bachelier K, Vigneron C, Lecompte T, Hoffman M, Maincent P. Microencapsulation of low molecular weight heparin into polymeric particles designed with biodegradable and nonbiodegradable polycationic polymers. Drug Deliv 2003;10:1-7.
    • (2003) Drug Deliv , vol.10 , pp. 1-7
    • Hoffart, V.1    Ubrich, N.2    Lamprecht, A.3    Bachelier, K.4    Vigneron, C.5    Lecompte, T.6    Hoffman, M.7    Maincent, P.8
  • 10
    • 0033638463 scopus 로고    scopus 로고
    • Oral delivery of new heparin derivatives in rats
    • Lee Y, Kim SH, Byun Y. Oral delivery of new heparin derivatives in rats. Pharm Res 2000;17:1259-1264.
    • (2000) Pharm Res , vol.17 , pp. 1259-1264
    • Lee, Y.1    Kim, S.H.2    Byun, Y.3
  • 11
    • 0035910004 scopus 로고    scopus 로고
    • Conjugation of low-molecular-weight heparin and deoxycholic acid for the development of a new oral anticoagulant agent
    • Lee Y, Nam JH, Shin HC, Byun Y. Conjugation of low-molecular-weight heparin and deoxycholic acid for the development of a new oral anticoagulant agent. Circulation 2001;104:3116-3120.
    • (2001) Circulation , vol.104 , pp. 3116-3120
    • Lee, Y.1    Nam, J.H.2    Shin, H.C.3    Byun, Y.4
  • 12
    • 33645227760 scopus 로고    scopus 로고
    • Efficacy of orally active chemical conjugate of low molecular weight heparin and deoxycholic acid in rats, mice and monkeys
    • Lee YK, Kim SK, Lee DY, Lee S, Kim CY, Shin HC, Moon HT, Byun Y. Efficacy of orally active chemical conjugate of low molecular weight heparin and deoxycholic acid in rats, mice and monkeys. J Control Release 2006;111:290-298.
    • (2006) J Control Release , vol.111 , pp. 290-298
    • Lee, Y.K.1    Kim, S.K.2    Lee, D.Y.3    Lee, S.4    Kim, C.Y.5    Shin, H.C.6    Moon, H.T.7    Byun, Y.8
  • 13
    • 34548830808 scopus 로고    scopus 로고
    • Liphophilic complexation of heparin based on bile acid for oral delivery
    • Lee DY, Lee J, Lee S, Kim SK, Byun Y. Liphophilic complexation of heparin based on bile acid for oral delivery. J Control Release 2007;123:39-45.
    • (2007) J Control Release , vol.123 , pp. 39-45
    • Lee, D.Y.1    Lee, J.2    Lee, S.3    Kim, S.K.4    Byun, Y.5
  • 15
    • 0034243512 scopus 로고    scopus 로고
    • Synthesis and heparin-like biological activity of amino acid-based polymers
    • Bentolila A, Vlodavsky I, Haloun C, Domb AJ. Synthesis and heparin-like biological activity of amino acid-based polymers. Polym Adv Technol 2000;11:377-387.
    • (2000) Polym Adv Technol , vol.11 , pp. 377-387
    • Bentolila, A.1    Vlodavsky, I.2    Haloun, C.3    Domb, A.J.4
  • 17
    • 0035853111 scopus 로고    scopus 로고
    • Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis
    • Borsig L, Wong R, Feramisco J, Nadeau DR, Varki NM, Varki A. Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis. Proc Natl Acad Sci 2001;98:3352-3357.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 3352-3357
    • Borsig, L.1    Wong, R.2    Feramisco, J.3    Nadeau, D.R.4    Varki, N.M.5    Varki, A.6
  • 18
    • 18044368921 scopus 로고    scopus 로고
    • Selectins facilitate carcinoma metastasis and heparin can prevent them
    • Borsig L. Selectins facilitate carcinoma metastasis and heparin can prevent them. News Physiol Sci 2004;19:16-21.
    • (2004) News Physiol Sci , vol.19 , pp. 16-21
    • Borsig, L.1
  • 20
    • 2442483898 scopus 로고    scopus 로고
    • Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease
    • Bergamaschini L, Rossi E, Storini C, Pizzimenti S, Distaso M, Perego C, De Luigi A, Vergani C, De Simoni MG. Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease. J Neurosci 2004;24:4181-4186.
    • (2004) J Neurosci , vol.24 , pp. 4181-4186
    • Bergamaschini, L.1    Rossi, E.2    Storini, C.3    Pizzimenti, S.4    Distaso, M.5    Perego, C.6    De Luigi, A.7    Vergani, C.8    De Simoni, M.G.9
  • 21
    • 0034219846 scopus 로고    scopus 로고
    • Heparin and inflammation: A new use for an old GAG?
    • Perretti M, Page CP. Heparin and inflammation: A new use for an old GAG? Gut 2000;47:14-15.
    • (2000) Gut , vol.47 , pp. 14-15
    • Perretti, M.1    Page, C.P.2
  • 22
    • 1942509627 scopus 로고    scopus 로고
    • Heparin-induced cancer cell death
    • Linhardt RJ. Heparin-induced cancer cell death. Chem Biol 2004;11:420-422.
    • (2004) Chem Biol , vol.11 , pp. 420-422
    • Linhardt, R.J.1
  • 24
    • 0017044123 scopus 로고
    • Anticoagulant properties of heparin fractionated by affinity chromatography on matrix-bound antithrombin III and by gel filtration
    • Andersson LO, Barrowcliffe TW, Holmer E, Johnson EA, Sims GE. Anticoagulant properties of heparin fractionated by affinity chromatography on matrix-bound antithrombin III and by gel filtration. Thromb Res 1976;9:575-583.
    • (1976) Thromb Res , vol.9 , pp. 575-583
    • Andersson, L.O.1    Barrowcliffe, T.W.2    Holmer, E.3    Johnson, E.A.4    Sims, G.E.5
  • 25
    • 0020321012 scopus 로고
    • Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma
    • Tollefsen DM, Majerus DW, Blank MK. Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma. J Biol Chem 1982;257:2162-2169.
    • (1982) J Biol Chem , vol.257 , pp. 2162-2169
    • Tollefsen, D.M.1    Majerus, D.W.2    Blank, M.K.3
  • 27
    • 4544226466 scopus 로고    scopus 로고
    • New anticoagulants for treatment of venous thromboembolism
    • Weitz JI. New anticoagulants for treatment of venous thromboembolism. Circulation 2004;110:119-126.
    • (2004) Circulation , vol.110 , pp. 119-126
    • Weitz, J.I.1
  • 28
    • 2442545479 scopus 로고    scopus 로고
    • The use of bivalirudin to prevent subacute thrombosis during drug-eluting stent implantation
    • Medina RP, Foto D. The use of bivalirudin to prevent subacute thrombosis during drug-eluting stent implantation. J Invasive Cardiol 2004;16:236-239.
    • (2004) J Invasive Cardiol , vol.16 , pp. 236-239
    • Medina, R.P.1    Foto, D.2
  • 30
    • 0035979396 scopus 로고    scopus 로고
    • Edelman, physiological transport forces govern drug distribution for stent based delivery
    • Hwang CW, Wu DER. Edelman, physiological transport forces govern drug distribution for stent based delivery. Circulation 2001;104:600-605.
    • (2001) Circulation , vol.104 , pp. 600-605
    • Hwang, C.W.1    Wu, D.E.R.2
  • 32
    • 4043177078 scopus 로고    scopus 로고
    • Targeted delivery of heparin and LMWH using a fibrin antibody prevents restenosis
    • Thomas AC, Campbell JH. Targeted delivery of heparin and LMWH using a fibrin antibody prevents restenosis. Atherosclerosis 2004;176:73-81.
    • (2004) Atherosclerosis , vol.176 , pp. 73-81
    • Thomas, A.C.1    Campbell, J.H.2
  • 33
    • 0037428958 scopus 로고    scopus 로고
    • ATTEMPTS: A heparin/protamine-based triggered release system for the delivery of enzyme drugs without associated side-effects
    • Park YJ, Liang JF, Song H, Li YT, Naik S, Yang VC. ATTEMPTS: A heparin/protamine-based triggered release system for the delivery of enzyme drugs without associated side-effects. Adv Drug Deliv Rev 2003;55:251-265.
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 251-265
    • Park, Y.J.1    Liang, J.F.2    Song, H.3    Li, Y.T.4    Naik, S.5    Yang, V.C.6
  • 34
    • 33745274728 scopus 로고    scopus 로고
    • The quest for non-invasive delivery of bioactive macromolecules: A focus on heparins
    • Motlekar NA, Youan BB. The quest for non-invasive delivery of bioactive macromolecules: A focus on heparins. J Control Release 2006;113:91-101.
    • (2006) J Control Release , vol.113 , pp. 91-101
    • Motlekar, N.A.1    Youan, B.B.2
  • 35
    • 0003409027 scopus 로고
    • An investigation of routes of administration of heparin other than injection
    • Windsor E, Freeman L. An investigation of routes of administration of heparin other than injection. Am J Med 1964;37:408-416.
    • (1964) Am J Med , vol.37 , pp. 408-416
    • Windsor, E.1    Freeman, L.2
  • 36
    • 0036690723 scopus 로고    scopus 로고
    • Pathway of oral absorption of heparin with sodium N-[8-(2 hydroxybenzoyl) amino]caprylate
    • Malkov D, Huai-zhen W, Dinh S, Gomez-Orellana I. Pathway of oral absorption of heparin with sodium N-[8-(2 hydroxybenzoyl) amino]caprylate. Pharm Res 2002;19:1180-1184.
    • (2002) Pharm Res , vol.19 , pp. 1180-1184
    • Malkov, D.1    Huai-zhen, W.2    Dinh, S.3    Gomez-Orellana, I.4
  • 37
    • 21744442224 scopus 로고    scopus 로고
    • Gastrointestinal absorption of heparin by lipidization or coadministration with penetration enhancers
    • Ross BP, Toth I. Gastrointestinal absorption of heparin by lipidization or coadministration with penetration enhancers. Curr Drug Deliv 2005;2:277-287.
    • (2005) Curr Drug Deliv , vol.2 , pp. 277-287
    • Ross, B.P.1    Toth, I.2
  • 38
    • 0024427918 scopus 로고
    • New heparin complexes active by intestinal absorption: I. Multiple ion pairs with basic organic compounds
    • Dal Pozzo A, Acquasaliente M, Geron MR. New heparin complexes active by intestinal absorption: I. Multiple ion pairs with basic organic compounds. Thromb Res 1989;56:119-124.
    • (1989) Thromb Res , vol.56 , pp. 119-124
    • Dal Pozzo, A.1    Acquasaliente, M.2    Geron, M.R.3
  • 39
    • 0035038087 scopus 로고    scopus 로고
    • Development of oral heparin therapy for prophylaxis and treatment of deep venous thrombosis
    • Money SR, York JW. Development of oral heparin therapy for prophylaxis and treatment of deep venous thrombosis. Cardiovasc Surg 2001;9:211-218.
    • (2001) Cardiovasc Surg , vol.9 , pp. 211-218
    • Money, S.R.1    York, J.W.2
  • 40
    • 17644442033 scopus 로고    scopus 로고
    • Orally administered heparin for preventing deep venous thrombosis
    • Mark DG, Jeffrey DM, Andrea LB. Orally administered heparin for preventing deep venous thrombosis. Am J Surg 1998;176:176-178.
    • (1998) Am J Surg , vol.176 , pp. 176-178
    • Mark, D.G.1    Jeffrey, D.M.2    Andrea, L.B.3
  • 41
    • 0031404885 scopus 로고    scopus 로고
    • Oral delivery of heparin in combination with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate: Pharmacological considerations
    • Rivera TM, Leone-Bay A, Paton DR, Leipold HR, Baughman RA. Oral delivery of heparin in combination with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate: Pharmacological considerations. Pharm Res 1997;14:1830-1834.
    • (1997) Pharm Res , vol.14 , pp. 1830-1834
    • Rivera, T.M.1    Leone-Bay, A.2    Paton, D.R.3    Leipold, H.R.4    Baughman, R.A.5
  • 43
    • 0032874867 scopus 로고    scopus 로고
    • Oral low-molecular weight heparin and delivery agent prevents jugular venous thrombosis in the rat
    • 3rd
    • Salartash K, Gonze MD, Leone-Bay A, Baughman R, Sternbergh WC, 3rd, Money SR. Oral low-molecular weight heparin and delivery agent prevents jugular venous thrombosis in the rat. J Vasc Surg 1999;30:526-531.
    • (1999) J Vasc Surg , vol.30 , pp. 526-531
    • Salartash, K.1    Gonze, M.D.2    Leone-Bay, A.3    Baughman, R.4    Sternbergh, W.C.5    Money, S.R.6
  • 44
    • 0034038961 scopus 로고    scopus 로고
    • Treatment of experimentally induced caval thrombosis with oral low molecular weight heparin and delivery agent in a porcine model of deep venous thrombosis
    • 3rd
    • Salartash K, Lepore M, Gonze MD, Leone-Bay A, Baughman R, Sternbergh WC, 3rd, Bowen JC, Money SR. Treatment of experimentally induced caval thrombosis with oral low molecular weight heparin and delivery agent in a porcine model of deep venous thrombosis. Ann Surg 2000;231:789-794.
    • (2000) Ann Surg , vol.231 , pp. 789-794
    • Salartash, K.1    Lepore, M.2    Gonze, M.D.3    Leone-Bay, A.4    Baughman, R.5    Sternbergh, W.C.6    Bowen, J.C.7    Money, S.R.8
  • 47
    • 27744527586 scopus 로고    scopus 로고
    • Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin
    • Hayes PY, Ross BP, Thomas BG, Toth I. Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin. Bioorg Med Chem 2006;14:143-152.
    • (2006) Bioorg Med Chem , vol.14 , pp. 143-152
    • Hayes, P.Y.1    Ross, B.P.2    Thomas, B.G.3    Toth, I.4
  • 48
    • 0141551200 scopus 로고    scopus 로고
    • Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: Thiomer/GSH systems
    • Bernkop-Schnürch A, Kast CE, Guggi D. Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: Thiomer/GSH systems. J Control Release 2003;93:95-103.
    • (2003) J Control Release , vol.93 , pp. 95-103
    • Bernkop-Schnürch, A.1    Kast, C.E.2    Guggi, D.3
  • 50
    • 0038015493 scopus 로고    scopus 로고
    • Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil
    • Kast CE, Guggi D, Langoth N, Bernkop-Schnürch A. Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil. Pharm Res 2003;20:931-936.
    • (2003) Pharm Res , vol.20 , pp. 931-936
    • Kast, C.E.1    Guggi, D.2    Langoth, N.3    Bernkop-Schnürch, A.4
  • 51
    • 30844439844 scopus 로고    scopus 로고
    • Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels
    • Motlekar NA, Srivenugopal KS, Wachtel MS, Youan BB. Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels. J Drug Target 2005;13:573-583.
    • (2005) J Drug Target , vol.13 , pp. 573-583
    • Motlekar, N.A.1    Srivenugopal, K.S.2    Wachtel, M.S.3    Youan, B.B.4
  • 52
    • 33746790243 scopus 로고    scopus 로고
    • Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin
    • Motlekar NA, Fasano A, Wachtel MS, Youan BB. Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin. J Drug Target 2006;14:321-329.
    • (2006) J Drug Target , vol.14 , pp. 321-329
    • Motlekar, N.A.1    Fasano, A.2    Wachtel, M.S.3    Youan, B.B.4
  • 53
    • 33846550081 scopus 로고    scopus 로고
    • N-Sulfonato-N,O-carboxymethylchitosan: A novel polymeric absorption enhancer for the oral delivery of macromolecules
    • Thanou M, Henderson S, Kydonieus A, Elson C. N-Sulfonato-N, O-carboxymethylchitosan: A novel polymeric absorption enhancer for the oral delivery of macromolecules. J Control Release 2007;117:171-178.
    • (2007) J Control Release , vol.117 , pp. 171-178
    • Thanou, M.1    Henderson, S.2    Kydonieus, A.3    Elson, C.4
  • 54
    • 33745218070 scopus 로고    scopus 로고
    • Evaluation of the oral bioavailability of low molecular weight heparin formulated with glycyrrhetinic acid as permeation enhancer
    • Motlekar NA, Srivenugopal KS, Wachtel MS, Youan BB. Evaluation of the oral bioavailability of low molecular weight heparin formulated with glycyrrhetinic acid as permeation enhancer. Drug Dev Res 2006;67:166-174.
    • (2006) Drug Dev Res , vol.67 , pp. 166-174
    • Motlekar, N.A.1    Srivenugopal, K.S.2    Wachtel, M.S.3    Youan, B.B.4
  • 56
    • 0036273993 scopus 로고    scopus 로고
    • Delivery of LMW heparin via surface coated chitosan/peg-alginate microspheres prevents thrombosis
    • Chandy T, Rao GH, Wilson RF, Das GS. Delivery of LMW heparin via surface coated chitosan/peg-alginate microspheres prevents thrombosis. Drug Deliv 2002;9:87-96.
    • (2002) Drug Deliv , vol.9 , pp. 87-96
    • Chandy, T.1    Rao, G.H.2    Wilson, R.F.3    Das, G.S.4
  • 57
    • 20344385254 scopus 로고    scopus 로고
    • Oral heparin delivery: Design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system
    • Schmitz T, Leitner VM, Bernkop-Schnürch A. Oral heparin delivery: Design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system. J Pharm Sci 2005;94:966-973.
    • (2005) J Pharm Sci , vol.94 , pp. 966-973
    • Schmitz, T.1    Leitner, V.M.2    Bernkop-Schnürch, A.3
  • 59
    • 35348863173 scopus 로고    scopus 로고
    • Oral low molecular weight heparin delivery by microparticles from complex coacervation
    • Lamprecht A, Ubrich N, Maincent P. Oral low molecular weight heparin delivery by microparticles from complex coacervation. Eur J Pharm Biopharm 2007;67:632-638.
    • (2007) Eur J Pharm Biopharm , vol.67 , pp. 632-638
    • Lamprecht, A.1    Ubrich, N.2    Maincent, P.3
  • 60
    • 69749108382 scopus 로고    scopus 로고
    • Engineered chylomicron mimicking carrier emulsome for lymph targeted oral delivery of methotrexate
    • Paliwal R, Paliwal SR, Mishra N, Mehta A, Vyas SP. Engineered chylomicron mimicking carrier emulsome for lymph targeted oral delivery of methotrexate. Int J Pharm 2009;380:181-188.
    • (2009) Int J Pharm , vol.380 , pp. 181-188
    • Paliwal, R.1    Paliwal, S.R.2    Mishra, N.3    Mehta, A.4    Vyas, S.P.5
  • 62
    • 70849124071 scopus 로고    scopus 로고
    • Oral delivery of low molecular weight heparin microspheres prepared using biodegradable polymer matrix system
    • Lanke SS, Gayakwad SG, Strom JG, D'souza MJ. Oral delivery of low molecular weight heparin microspheres prepared using biodegradable polymer matrix system. J Microencapsul 2009;26:493-500.
    • (2009) J Microencapsul , vol.26 , pp. 493-500
    • Lanke, S.S.1    Gayakwad, S.G.2    Strom, J.G.3    D'souza, M.J.4
  • 63
    • 70349784917 scopus 로고    scopus 로고
    • The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin
    • Chen MC, Wong HS, Lin KJ, Chen HL, Wey SP, Sonaje K, Lin YH, Chu CY, Sung HW. The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin. Biomaterials 2009;30:6629-6637.
    • (2009) Biomaterials , vol.30 , pp. 6629-6637
    • Chen, M.C.1    Wong, H.S.2    Lin, K.J.3    Chen, H.L.4    Wey, S.P.5    Sonaje, K.6    Lin, Y.H.7    Chu, C.Y.8    Sung, H.W.9
  • 64
    • 33745200966 scopus 로고    scopus 로고
    • Preparation and evaluation of oral solid heparin using emulsifier and adsorbent for in vitro and in vivo studies
    • Ito Y, Kusawake T, Prasad YV, Sugioka N, Shibata N, Takada K. Preparation and evaluation of oral solid heparin using emulsifier and adsorbent for in vitro and in vivo studies. Int J Pharm 2006;317:114-119.
    • (2006) Int J Pharm , vol.317 , pp. 114-119
    • Ito, Y.1    Kusawake, T.2    Prasad, Y.V.3    Sugioka, N.4    Shibata, N.5    Takada, K.6
  • 65
    • 32044444307 scopus 로고    scopus 로고
    • Oral delivery of chemical conjugates of heparin and deoxycholic acid in aqueous formulation
    • Kim SK, Vaishali B, Lee E, Lee S, Lee YK, Kumar TS, Moon HT, Byun Y. Oral delivery of chemical conjugates of heparin and deoxycholic acid in aqueous formulation. Thromb Res 2006;117:419-427.
    • (2006) Thromb Res , vol.117 , pp. 419-427
    • Kim, S.K.1    Vaishali, B.2    Lee, E.3    Lee, S.4    Lee, Y.K.5    Kumar, T.S.6    Moon, H.T.7    Byun, Y.8
  • 66
    • 34249914210 scopus 로고    scopus 로고
    • Absorption study of deoxycholic acid-heparin conjugate as a new form of oral anti-coagulant
    • Kim SK, Lee DY, Lee E, Lee YK, Kim CY, Moon HT, Byun Y. Absorption study of deoxycholic acid-heparin conjugate as a new form of oral anti-coagulant. J Control Release 2007;120:4-10.
    • (2007) J Control Release , vol.120 , pp. 4-10
    • Kim, S.K.1    Lee, D.Y.2    Lee, E.3    Lee, Y.K.4    Kim, C.Y.5    Moon, H.T.6    Byun, Y.7
  • 67
    • 33748641168 scopus 로고    scopus 로고
    • Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET
    • Leonard TW, Lynch J, McKenna MJ, Brayden DJ. Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET. Expert Opin Drug Deliv 2006;3:685-692.
    • (2006) Expert Opin Drug Deliv , vol.3 , pp. 685-692
    • Leonard, T.W.1    Lynch, J.2    McKenna, M.J.3    Brayden, D.J.4
  • 68
    • 0034091858 scopus 로고    scopus 로고
    • The development of delivery agents that facilitate the oral absorption of macromolecular drugs
    • Leone-Bay A, Paton DR, Weidner JJ. The development of delivery agents that facilitate the oral absorption of macromolecular drugs. Med Res Rev 2000;20:169-186.
    • (2000) Med Res Rev , vol.20 , pp. 169-186
    • Leone-Bay, A.1    Paton, D.R.2    Weidner, J.J.3
  • 69
    • 0034816352 scopus 로고    scopus 로고
    • Orally active heparin and low-molecular-weight heparin
    • Pineo GF, Hull RD, Marder V. Orally active heparin and low-molecular-weight heparin. J Curr Opin Pulm Med 2001;7:344-348.
    • (2001) J Curr Opin Pulm Med , vol.7 , pp. 344-348
    • Pineo, G.F.1    Hull, R.D.2    Marder, V.3
  • 70
    • 0037393955 scopus 로고    scopus 로고
    • Challenges for the oral delivery of macromolecules
    • Goldberg M, Gomez-Orellana I. Challenges for the oral delivery of macromolecules. Nat Rev Drug Discov 2003;2:289-295.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 289-295
    • Goldberg, M.1    Gomez-Orellana, I.2
  • 71
    • 2942667700 scopus 로고    scopus 로고
    • Oral delivery of heparin: SNAC and related formulations
    • Pineo G, Hull R, Marder V. Oral delivery of heparin: SNAC and related formulations. Best Pract Res Clin Haematol 2004;17:153-160.
    • (2004) Best Pract Res Clin Haematol , vol.17 , pp. 153-160
    • Pineo, G.1    Hull, R.2    Marder, V.3
  • 72
    • 1842760484 scopus 로고    scopus 로고
    • Oral heparin administration with a novel drug delivery agent (SNAC) in healthy volunteers and patients undergoing elective total hip arthroplasty
    • Berkowitz SD, Marder VJ, Kosutic G, Baughman RA. Oral heparin administration with a novel drug delivery agent (SNAC) in healthy volunteers and patients undergoing elective total hip arthroplasty. J Thromb Haemost 2003;1:1914-1919.
    • (2003) J Thromb Haemost , vol.1 , pp. 1914-1919
    • Berkowitz, S.D.1    Marder, V.J.2    Kosutic, G.3    Baughman, R.A.4
  • 73
    • 34247275301 scopus 로고    scopus 로고
    • Epithelial heparin delivery via microspheres mitigates experimental colitis in mice
    • Pellequer Y, Meissner Y, Ubrich N, Lamprecht A. Epithelial heparin delivery via microspheres mitigates experimental colitis in mice. J Pharmacol Exp Ther 2007;321:726-733.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 726-733
    • Pellequer, Y.1    Meissner, Y.2    Ubrich, N.3    Lamprecht, A.4
  • 74
    • 1642579649 scopus 로고    scopus 로고
    • Study of the micellization behavior of different order amino block copolymers with heparin
    • Dufresne MH, Leroux JC. Study of the micellization behavior of different order amino block copolymers with heparin. Pharm Res 2004;21:160-169.
    • (2004) Pharm Res , vol.21 , pp. 160-169
    • Dufresne, M.H.1    Leroux, J.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.