Platelet count and prothrombin time help distinguish thrombotic thrombocytopenic purpura-hemolytic uremic syndrome from disseminated intravascular coagulation in adults

American Journal of Clinical Pathology

Volumn 133, Issue 3, 2010, Pages 460-465

  Park, Yara A ^a   Waldrum, Michael R ^b   Marques, Marisa B ^c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

Disseminated intravascular coagulation; Hemolytic uremic syndrome; Prothrombin time; Thrombocytopenia; Thrombotic thrombocytopenic purpura

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; FEMALE; HEMOLYTIC UREMIC SYNDROME; HUMAN; LABORATORY TEST; MALE; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; STANDARD; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; CASE CONTROL STUDY; DIFFERENTIAL DIAGNOSIS; REGRESSION ANALYSIS; RETROSPECTIVE STUDY;

ADULT; CASE-CONTROL STUDIES; DIAGNOSIS, DIFFERENTIAL; DISSEMINATED INTRAVASCULAR COAGULATION; HEMOLYTIC-UREMIC SYNDROME; HUMANS; PLATELET COUNT; PROTHROMBIN TIME; PURPURA, THROMBOTIC THROMBOCYTOPENIC; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES;

EID: 77949391746     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/AJCPPNF63FLIORCI     Document Type: Article

References (24)

1. Moschcowitz E. Hyaline thrombosis of the terminal arterioles and capillaries: a hitherto undescribed disease. Proc N Y Pathol Soc. 1924;24:21-24.
2. Rock G, Shumak KH, Buskard NA, et al. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. N Engl J Med. 1991;325:393-397.
3. Lara PN, Coe TL, Zhou H, et al. Improved survival with plasma exchange in patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Am J Med. 1999;107:572-579.
4. George JN. How I treat patients with thrombotic thrombocytopenic purpura - hemolytic uremic syndrome. Blood. 2000;96:1223-1229.
5. Tuncer HH, Oster RA, Huang ST, et al. Predictors of response and relapse in a cohort of adults with thrombotic thrombocytopenic purpura - hemolytic uremic syndrome: a single-institution experience. Transfusion. 2007;47:107-114.
6. Fakhouri F, Frémeaux-Bacchi V. Does hemolytic uremic syndrome differ from thrombotic thrombocytopenic purpura? Nat Clin Pract Nephrol. 2007;3:679-687.
7. Furlan M, Robles R, Galbusera M, et al. Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. N Engl J Med. 1998;339:1578-1584. (Pubitemid 28536132)
8. Tsai HM, Lian EC. Antibodies to von Willebrand factor - cleaving protease in acute thrombotic thrombocytopenic purpura. N Engl J Med. 1998;339:1585-1594.
9. Lämmle B, Kremer Hovinga JA, Alberio L. Thrombotic thrombocytopenic purpura. J Thromb Haemost. 2005;3:1663-1675.
10. Hosler GA, Cusumano AM, Hutchins GM. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities: a review of 56 autopsy cases. Arch Pathol Lab Med. 2003;127:834-839.
11. Jaffe EA, Nachman RL, Merskey C. Thrombotic thrombocytopenic purpura: coagulation parameters in twelve patients. Blood. 1973;42:499-507.
12. Neame PB, Hirsh J, Browman G, et al. Thrombotic thrombocytopenic purpura: a syndrome of intravascular platelet consumption. Can Med Assoc J. 1976;114:1108-1112.
13. Kakishita E, Koyama T, Higuchi M, et al. Fibrinogenolysis in thrombotic thrombocytopenic purpura. Am J Hematol. 1989;32:14-19.
14. Monteagudo J, Pereira A, Reverter JC, et al. Thrombin generation and fibrinolysis in the thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. Thromb Haemost. 1991;66:515-519.
15. Sagripanti A, Carpi A, Baicchi U, et al. Plasmatic parameters of coagulation activation in thrombotic microangiopathy. Biomed Pharmacother. 1996;50:357-362.
16. Gerritsen HE, Turecek PL, Schwarz HP, et al. Assay of von Willebrand factor (vWF)-cleaving protease based on decreased collagen binding affinity of degraded vWF: a tool for the diagnosis of thrombotic thrombocytopenic purpura (TTP). Thromb Haemost. 1999;82:1386-1389.
17. Staropoli JF, Stowell CP, Tuncer HH, et al. An inquiry into the relationship between ABO blood group and thrombotic thrombocytopenic purpura. Vox Sang. 2009;96:344-348.
18. Takahashi H, Takakuwa E, Yoshino N, et al. Protein C levels in disseminated intravascular coagulation and thrombotic thrombocytopenic purpura: its correlation with other coagulation parameters. Thromb Haemost. 1985;54:445-449.
19. Takahashi H, Tatewaki W, Nakamura T, et al. Coagulation studies in thrombotic thrombocytopenic purpura, with special reference to von Willebrand factor and protein S. Am J Hematol. 1989;30:14-21.
20. Takahashi H, Tatewaki W, Wada K, et al. Thrombin generation in patients with thrombotic thrombocytopenic purpura. Am J Hematol. 1989;32:255-257. (Pubitemid 20006484)
21. Kobayashi M, Wada H, Wakita Y, et al. Decreased plasma tissue factor pathway inhibitor levels in patients with thrombotic thrombocytopenic purpura. Thromb Haemost. 1995;73:10-14.
22. Watanabe R, Wada H, Miura Y, et al. Plasma levels of total plasminogen activator inhibitor-I (PAI-I) and tPA/ PAI-1 complex in patients with disseminated intravascular coagulation and thrombotic thrombocytopenic purpura. Clin Appl Thromb Hemost. 2001;7:229-233.
23. Howard MA, Williams LA, Terrell DR, et al. Complications of plasma exchange in patients treated for clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Transfusion. 2006;46:154-156.
24. Vesely SK, George JN, Lämmle B, et al. ADAMTS13 activity in thrombotic thrombocytopenic purpura - hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. Blood. 2003;102:60-68.