The structural basis of the kinetic mechanism of a gap-filling X-family DNA polymerase that binds Mg2+-dNTP before binding to DNA

Journal of Molecular Biology

Volumn 417, Issue 3, 2012, Pages 179-196

  Nakane, Shuhei ^a   Ishikawa, Hirohito ^a,c,d   Nakagawa, Noriko ^a,b   Kuramitsu, Seiki ^a,b   Masui, Ryoji ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b RIKEN SPring 8 Center ^*  (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

crystal structure; dNTP binding; substrate binding order; syn and anti conformations of dGTP; Theorell Chance mechanism

Indexed keywords

DEOXYGUANOSINE TRIPHOSPHATE; DNA; DNA POLYMERASE; GUANOSINE; LYSINE; MAGNESIUM ION; NUCLEOTIDE; PARATHION; UNCLASSIFIED DRUG; X FAMILY DNA POLYMERASE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; ENZYME ACTIVITY; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; THERMUS THERMOPHILUS;

THERMUS THERMOPHILUS;

EID: 84857640580     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2012.01.025     Document Type: Article

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