COMT Val 158met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition

Biological Psychiatry

Volumn 71, Issue 6, 2012, Pages 538-544

  Farrell, Sarah M ^a   Tunbridge, Elizabeth M ^a   Braeutigam, Sven ^a   Harrison, Paul J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Catechol o methyltransferase; decision making; pharmacogenetics; polymorphism; tolcapone; working memory

Indexed keywords

CATECHOL METHYLTRANSFERASE; PLACEBO; TOLCAPONE;

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENOTYPE; HUMAN; MALE; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; TASK PERFORMANCE; WORKING MEMORY;

ADOLESCENT; ADULT; BENZOPHENONES; CATECHOL O-METHYLTRANSFERASE; COGNITION; DOUBLE-BLIND METHOD; GAMBLING; HUMANS; MALE; MEMORY, SHORT-TERM; METHIONINE; MIDDLE AGED; NEURAL INHIBITION; NEUROPSYCHOLOGICAL TESTS; NITROPHENOLS; POLYMORPHISM, GENETIC; TASK PERFORMANCE AND ANALYSIS; VALINE; YOUNG ADULT;

EID: 84857572587     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.12.023     Document Type: Article

References (62)

1. G.V. Williams, P.S. Goldman-Rakic Modulation of memory fields by dopamine D1 receptors in prefrontal cortex Nature 376 1995 572 575
2. A. Arnsten, T. Robbins Neurochemical modulation of prefrontal cortical function in humans and animals D.T. Stuss, R.T. Knight, Principles of Frontal Lobes Function 2002 Oxford University Press Oxford 51 84
3. T.W. Robbins, A.F.T. Arnsten The neuropsychopharmacology of fronto-executive function: Monoaminergic modulation Annu Rev Neurosci 32 2009 267 287
4. R. Cools, M. D'Esposito Inverted-U-shaped dopamine actions on human working memory and cognitive control Biol Psychiatry 69 2011 e113 e125
5. D.R. Weinberger, M.F. Egan, A. Bertolino, J.H. Callicott, V.S. Mattay, B.A. Lipska Prefrontal neurons and the genetics of schizophrenia Biol Psychiatry 50 2001 825 844 (Pubitemid 34020697)
6. R.M. Bilder, J. Volavka, H.M. Lachman, A.A. Grace The catechol-O-methyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes Neuropsychopharmacol 29 2004 1943 1961 (Pubitemid 39486546)
7. 158Met and beyond Biol Psychiatry 60 2006 141 151
8. D. Durstewitz, J.K. Seamans The dual-state theory of prefrontal cortex dopamine function with relevance to catechol-O-methyltransferase genotypes and schizophrenia Biol Psychiatry 64 2008 739 749
9. D. Dickinson, B. Elvevg Genes, cognition and brain through a COMT lens Neuroscience 164 2009 72 87
10. J.S. Chen, B.K. Lipska, N. Halim, Q.D. Ma, M. Matsumoto, S. Melhem Functional analysis of genetic variation in catechol-o-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain Am J Hum Genet 75 2004 807 821 (Pubitemid 39390488)
11. M. Slifstein, B. Kolachana, E.H. Simpson, P. Tabares, B. Cheng, M. Duvall COMT genotype predicts cortical-limbic D1 receptor availability measured with [C-11]NNC112 and PET Mol Psychiatry 13 2008 821 827 (Pubitemid 352032110)
12. 108/158 Met genotype on frontal lobe function and risk for schizophrenia Proc Natl Acad Sci U S A 98 2001 6917 6922 (Pubitemid 32538317)
13. D. Mier, P. Kirsch, A. Meyer-Lindenberg Neural substrates of pleiotropic action of genetic variation in COMT: A meta-analysis Mol Psychiatry 15 2009 918 927
14. C.M. Diaz-Asper, T.E. Goldberg, B.S. Kolachana, R.E. Straub, M.F. Egan, D.R. Weinberger Genetic variation in catechol-O-methyltransferase: Effects on working memory in schizophrenic patients, their siblings, and healthy controls Biol Psychiatry 63 2008 72 79 (Pubitemid 350234889)
15. J.H. Barnett, L. Scoriels, M.R. Munafo Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene val158/108met polymorphism Biol Psychiatry 64 2008 137 144
16. E.M. Tunbridge, D.M. Bannerman, T. Sharp, P.J. Harrison Catechol-O-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex J Neurosci 24 2004 5331 5335 (Pubitemid 38747674)
17. C.C. Lapish, S. Ahn, L.M. Evangelista, K. So, J.K. Seamans, A.G. Phillips Tolcapone enhances food-evoked dopamine efflux and executive memory processes mediated by the rat prefrontal cortex Psychopharmacol 202 2009 521 530
18. M. Gasparini, E. Fabrizio, V. Bonifati, G. Meco Cognitive improvement during tolcapone treatment in Parkinson's disease J Neural Transm 104 1997 887 894 (Pubitemid 27507335)
19. J.A. Apud, V. Mattay, J.S. Chen, B.S. Kolachana, J.H. Callicott, R. Rasetti Tolcapone improves cognition and cortical information processing in normal human subjects Neuropsychopharmacol 32 2007 1011 1020 (Pubitemid 46631983)
20. S.G. Giakoumaki, P. Roussos, P. Bitsios Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val(158)Met polymorphism Neuropsychopharmacol 33 2008 3058 3068
21. P. Roussos, S.G. Giakoumaki, P. Bitsios Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O- methyltransferase rs4818C/G polymorphism Biol Psychiatry 66 2009 997 1004
22. V.S. Mattay, T.E. Goldberg, F. Fera, A.R. Hariri, A. Tessitore, M.F. Egan Catechol O-methyltransferase val(158)-met genotype and individual variation in the brain response to amphetamine Proc Natl Acad Sci U S A 100 2003 6186 6191 (Pubitemid 36576952)
23. 108/158Met genotype predicts working memory response to antipsychotic medications Biol Psychiatry 56 2004 677 682 (Pubitemid 39446850)
24. E. Kereszturi, E. Tarnok, E. Bognar, K. Lakatos, L. Farkas, J. Gadoros Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children Am J Med Genet B Neuropsychiatr Genet 147B 2008 1431 1435
25. J. Dingemanse, K.M. Jorga, M. Schmitt, R. Gieschke, B. Fotteler, G. Zurcher Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans Clin Pharmacol Ther 57 1995 508 517
26. 18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson's disease Synapse 43 2002 201 207 (Pubitemid 34087675)
27. K.M. Jorga Pharmacokinetics, pharmacodynamics, and tolerability of tolcapone: A review of early studies in volunteers Neurology 50 suppl 1998 S31 S38
28. E.M. Tunbridge, P.W.J. Burnet, M.S. Sodhi, P.J. Harrison Catechol-o-methyltransferase and proline dehydrogenase messenger RNA in the prefrontal cortex in schizophrenia, bipolar disorder and major depression Synapse 51 2004 112 118 (Pubitemid 38018793)
29. J.H. Callicott, N.F. Ramsey, K. Tallent, A. Bertolino, M.B. Knable, R. Coppola Functional magnetic resonance imaging brain mapping in psychiatry: Methodological issues illustrated in a study of working memory in schizophrenia Neuropsychopharmacol 18 1998 186 196 (Pubitemid 28062582)
30. W.J. Gehring, A.R. Willoughby The medial frontal cortex and the rapid processing of monetary gains and losses Science 295 2002 2279 2282 (Pubitemid 34258845)
31. J. Marco-Pallars, D. Cucurell, T. Cunillera, U.M. Krmer, E. Cmara, W. Nager Genetic variability in the dopamine system (dopamine receptor D4, COMT) modulates neurophysiological responses to gains and losses Biol Psychiatry 66 2009 154 161
32. K. Schmack, F. Schlagenhauf, P. Sterzer, I. Puls, T. Sander, A. Heinz Catechol-O-methyltransferase val(158)met genotype influences neural processing of reward anticipation Neuroimage 42 2008 1631 1638
33. E. Camara, U.M. Kramer, T. Cunillera, J. Marco-Pallares, D. Cucurell, W. Nager The effects of COMT (Val108/158Met) and DRD4 (SNP-521) dopamine genotypes on brain activations related to valence and magnitude of rewards Cereb Cortex 20 2010 1985 1996
34. A. Meyer-Lindenberg, T. Nichols, J. Callicott, J. Ding, B. Kolachana, J. Buckholtz Impact of complex genetic variation on COMT on human brain function Mol Psychiatry 11 2006 867 877 (Pubitemid 44299108)
35. A.G. Nackley, S.A. Shabalania, I.E. Tchivileva, K. Satterfield, O. Korchynski, S.S. Makarov Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure Science 314 2006 1930 1933 (Pubitemid 46026115)
36. G. Ursini, V. Bollati, L. Fazio, A. Porcelli, L. Iacovelli, A. Catalani Stress-related methylation of the catechol-O-methyltransferase val(158) allele predicts human prefrontal cognition and activity J Neurosci 31 2011 6692 6698
37. A. Bertolino, G. Blasi, V. Latorre, V. Rubino, A. Rampino, L. Sinibaldi Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in humans J Neurosci 26 2006 3918 3922 (Pubitemid 44315411)
38. M.J. Frank, A.A. Moustafa, H.M. Haughley, T. Curran, K.E. Hutchison Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning Proc Natl Acad Sci U S A 104 2007 16311 16316 (Pubitemid 350099356)
39. D.P. Prata, A. Mechelli, C.H. Fu, M. Picchioni, T. Toulopoulou, E. Bramon Epistasis between the DAT 3′ UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia Proc Natl Acad Sci U S A 106 2009 13600 13605
40. T.E. Goldberg, M.F. Egan, T. Gscheidle, R. Coppola, T. Weickert, B.S. Kolachana Executive subprocesses in working memory: Relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia Arch Gen Psychiatry 60 2003 889 896 (Pubitemid 37122307)
41. M.M. Blanchard, S.R. Chamberlain, J. Roiser, T.W. Robbins, U. Muller Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers Psychol Med 41 2011 611 618
42. D. Goldman, D.R. Weinberger, A.K. Malhotra, T.E. Goldberg The role of COMT Val158Met in cognition Biol Psychiatry 65 2009 e1 e2
43. P.J. Harrison, E.M. Tunbridge Catechol-O-methyltransferase (COMT): A gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders Neuropsychopharmacol 33 2008 3037 3045
44. E. Jacobs, M. D'Esposito Estrogen shapes dopamine-dependent cognitive processes: Implications for women's health J Neurosci 31 2011 5286 5293
45. E.M. Tunbridge, C.S. Weickert, J.E. Kleinman, M.M. Herman, J. Chen, B.S. Kolachana Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan Cereb Cortex 17 2007 1206 1212 (Pubitemid 46598863)
46. I. Dumontheil, C. Roggeman, T. Ziermans, M. Peyrard-Janvid, H. Matsson, J. Kere Influence of the COMT genotype on working memory and brain activity changes during development Biol Psychiatry 70 2011 222 229
47. J. Yacubian, T. Sommer, K. Schroeder, J. Glascher, R. Kalisch, B. Leuenberger Gene-gene interaction associated with neural reward sensitivity Proc Natl Acad Sci U S A 104 2007 8125 8130 (Pubitemid 47185886)
48. L.K. Krugel, G. Biele, P.N.C. Mohr, S.C. Li, H.R. Heekeren Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions Proc Natl Acad Sci U S A 106 2009 17951 17956
49. M.J. Frank, J.A. Fossella Neurogenetics and pharmacology of learning, motivation, and cognition Neuropsychopharmacol 36 2011 133 152
50. Tunbridge EM, Huber A, Farrell SM, Stumpenhorst K, Harrison PJ, Walton M (in press): The role of catechol-O-methyltransferase (COMT) in reward processing and addiction. CNS Neurol Disord Drug Targets.
51. N.W. Simon, K.S. Montgomery, B.S. Beas, M.R. Mitchell, C.I. LaSarge, I.A. Mendez Dopaminergic modulation of risky decision-making J Neurosci 31 2011 17460 17470
52. G. Blasi, V.S. Mattay, A. Bertolino, B. Elvevg, J.H. Callicott, S. Das Effect of catechol-O-methyltransferase val158met genotype on attentional control J Neurosci 25 2005 5038 5045 (Pubitemid 40712847)
53. P. Roussos, S.G. Giakoumaki, M. Rogdaki, S. Pavlakis, S. Frangou, P. Bitios Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism Psychol Med 38 2008 1651 1658
54. 158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex J Neurosci 25 2005 836 842 (Pubitemid 40170998)
55. F. Papaleo, J.N. Crawley, J. Song, B.K. Lipska, J. Pickel, D.R. Weinberger, J. Chen Genetic dissection of the role of catechol-O- methyltransferase in cognition and stress reactivity in mice J Neurosci 28 2008 8709 8723
56. J.A. Apud, D.R. Weinberger Treatment of cognitive deficits associated with schizophrenia: Potential role of catechol-O-methyltransferase inhibitors CNS Drugs 21 2007 535 557 (Pubitemid 46984856)
57. P. Bitsios, P. Roussos Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia Pharmacogenomics 12 2011 559 566
58. J. Chen, J. Song, P. Yuan, Q. Tian, Y. Ji, R. Ren-Patterson Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons Implications for drug development J Biol Chem 286 2011 34752 34760
59. R. Cools, R.A. Barker, B.J. Sahakian, T.R. Robbins Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands Cereb Cortex 11 2001 1136 1143 (Pubitemid 33108240)
60. T. Foltynie, T. Goldberg, S. Lewis, A. Blackwell, D. Weinberger, T. Robbins Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism Mov Disord 19 2004 885 891 (Pubitemid 39199254)
61. D.P. Prata, A. Mechelli, C. Fu, M. Picchioni, F. Kane, S. Kalidindi Opposite effects of COMT Val158Met on cortical function in healthy subjects and patients with schizophrenia Biol Psychiatry 65 2009 473 480
62. M. Husain, M.A. Mehta Cognitive enhancement by drugs in health and disease Trends Cogn Sci 15 2011 28 36