Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism

Psychological Medicine

Volumn 38, Issue 11, 2008, Pages 1651-1658

  Roussos, P ^a   Giakoumaki, S G ^a,b   Rogdaki, M ^a   Pavlakis, S ^a,c   Frangou, S ^a   Bitsios, P ^a,b  

^a UNIVERSITY OF CRETE   (Greece)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

COMT; Healthy; Prepulse inhibition; Val158Met polymorphism

Indexed keywords

CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE INHIBITOR; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; METHIONINE; VALINE;

ADULT; ARTICLE; ATTENTION; BRAIN; COGNITION; DOPAMINERGIC TRANSMISSION; ELECTROMYOGRAPHY; GENETIC POLYMORPHISM; HUMAN; HUMAN EXPERIMENT; INFORMATION PROCESSING; MALE; MENTAL DISEASE; NEUROTRANSMISSION; NORMAL HUMAN; PREFRONTAL CORTEX; PREPULSE INHIBITION; SCHIZOPHRENIA; STARTLE REFLEX;

ACOUSTIC STIMULATION; ADOLESCENT; ADULT; ALLELES; CATECHOL O-METHYLTRANSFERASE; DOPAMINE; GENOTYPE; HUMANS; MALE; NEURAL INHIBITION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PREFRONTAL CORTEX; REFERENCE VALUES; STARTLE REACTION; YOUNG ADULT;

EID: 46849120124     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291708002912     Document Type: Article

References (68)

1. Aasen I, Kolli L, Kumari V (2005). Sex effects in prepulse inhibition and facilitation of the acoustic startle response: implications for pharmacological and treatment studies. Journal of Psychopharmacology 19, 39-45.
2. Anokhin AP, Heath AC, Myers E, Ralano A, Wood S (2003). Genetic influences on prepulse inhibition of startle reflex in humans. Neuroscience Letters 353, 45-48.
3. Bertolino A, Caforio G, Blasi G, De Candia M, Latorre V, Petruzzella V, Altamura M, Nappi G, Papa S, Callicott JH, Mattay VS, Bellomo A, Scarabino T, Weinberger DR, Nardini M (2004). Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. American Journal of Psychiatry 161, 1798-1805.
4. Bilder RM, Volavka J, Czobor P, Malhotra AK, Kennedy JL, Ni X, Golgman RS, Hoptman MJ, Sheitman B, Lindenmayer JP, Citrome L, McEnvoy JP, Kunz M, Chakos M, Cooper TB, Lieberman JA (2002). Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biological Psychiatry 52, 701-707.
5. Bitsios P, Giakoumaki SG, Frangou S (2005). The effects of dopamine agonists on prepulse inhibition (PPI) in healthy males depend on baseline PPI values. Psychopharmacology 182, 144-152.
6. Bitsios P, Giakoumaki SG, Theou K, Frangou S (2006). Increased PPI is associated with better strategy formation and execution times in healthy males. Neuropsychologia 44, 2494-2499.
7. Braff DL, Geyer MA (1990). Sensorimotor gating and schizophrenia: human and animal model studies. Archives of General Psychiatry 47, 181-188.
8. Braff DL, Grillon C, Geyer MA (1992). Gating and habituation of the startle reflex in schizophrenic patients. Archives of General Psychiatry 49, 206-215.
9. Braff DL, Light GA (2005). The use of neurophysiological endophenotypes to understand the genetic basis of schizophrenia. Dialogues in Clinical Neuroscience 7, 125-135.
10. Braff DL, Stone C, Callaway E, Geyer MA, Glick I, Bali L (1978). Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15, 339-343.
11. Braff DL, Swerdlow NR, Geyer MA (1999). Symptom correlates of prepulse inhibition deficits in male schizophrenic patients. American Journal of Psychiatry 156, 596-602.
12. Broersen LM, Feldon J, Weiner I (1999). Dissociative effects of apomorphine infusions into the medial prefrontal cortex of rats on latent inhibition, prepulse inhibition and amphetamine-induced locomotion. Neuroscience 94, 39-46.
13. Bubser M, Koch M (1994). Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex. Psychopharmacology 113, 487-492.
14. Cadenhead KS, Swerdlow NR, Shafer KM, Diaz M, Braff DL (2000). Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits. American Journal of Psychiatry 157, 1660-1668.
15. Calkins ME, Dobie DJ, Cadenhead KS, Olincy A, Freedman R, Green MF, Greenwood TA, Gur RE, Gur RC, Light GA, Mintz J, Nuechterlein KH, Radant AD, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Braff DL (2007). The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration. Schizophrenia Bulletin 33, 33-48.
16. Campbell LE, Hughes M, Budd TW, Cooper G, Fulham WR, Karayanidis F, Hanlon MC, Stojanov W, Johnston P, Case V, Schall U (2007). Primary and secondary neural networks of auditory prepulse inhibition: a functional magnetic resonance imaging study of sensorimotor gating of the human acoustic startle response. European Journal of Neuroscience 26, 2327-2333.
17. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JF, Weinberger DR (2004). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. American Journal of Human Genetics 75, 807-821.
18. Csomor PA, Stadler RR, Feldon J, Yee BK, Geyer MA, Vollenweider FX (2008). Haloperidol diferentially modulates prepulse inhibition and p50 suppression in healthy humans stratified for low and high gating levels. Neuropsychopharmacology 33, 497-512.
19. Csomor PA, Yee BK, Quednowa BB, Stadler RS, Feldon J, Vollenweider FX (2006). The monotonic dependency of prepulse inhibition of the acoustic startle reflex on the intensity of the startle-eliciting stimulus. Behavioural Brain Research 174, 143-150.
20. Davis M, Mansbach RS, Swerdlow NR, Campeau S, Braff DL, Geyer MA (1990). Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulse in rats. Psychopharmacology 102, 1-4.
21. Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W (2005). Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Human Molecular Genetics 14, 135-143.
22. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR (2001). Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences USA 98, 6917-6922.
23. Ellenbroek BA, Budde S, Cools AR (1996). Prepulse inhibition and latent inhibition: the role of dopamine in the medial prefrontal cortex. Neuroscience 75, 535-542.
24. Gewirtz JC, Davis M (1995). Habituation of prepulse inhibition of the startle reflex using an auditory prepulse close to background noise. Behavioral Neuroscience 109, 388-395.
25. Geyer MA, Krebs-Thompson K, Braff DL, Swerdlow NR (2001). Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology 156, 117-154.
26. Giakoumaki SG, Bitsios P, Frangou S (2006). The level of PPI in healthy individuals may index cortical modulation of early information processing. Brain Research 1078, 168-170.
27. Graham FK (1975). The more or less startling effects of weak prestimulation. Psychophysiology 12, 238-248.
28. Harrison PJ, Weinberger DR (2005). Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Molecular Psychiatry 10, 40-68.
29. Hazlett EA, Buchsbaum MS, Haznedar MM, Singer MB, Germans MK, Schnur DB, Jimenez FA, Buchsbaum BR, Troyer BT (1998). Prefrontal cortex glucose metabolism and startle eyeblink modification abnormalities in unmedicated schizophrenia patients. Psychophysiology 35, 186-198.
30. Hazlett EA, Dawson ME, Schell AM, Nuechterlein KH (2001). Attentional stages of information processing during a continuous performance test: a startle modification analysis. Psychophysiology 38, 669-677.
31. Hong LE, Wonodi I, Stine OC, Mitchell BD, Thaker GK (2007). Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition. Biological Psychiatry 62, 546-548.
32. Japha K, Koch M (1999). Picrotoxin in the medial prefrontal cortex impairs sensorimotor gating in rats: reversal by haloperidol. Psychopharmacology 144, 347-354.
33. Koch M, Bubser M (1994). Deficient sensorimotor gating after 6-hydroxydopamine lesion of the rat medial prefrontal cortex is reversed by haloperidol. European Journal of Neuroscience 6, 1837-1845.
34. Koch M, Schnitzler HU (1997). The acoustic startle response, in rats - circuits mediating evocation, inhibition and potentiation. Behavioural Brain Research 89, 35-49.
35. Kumari V, Antonova E, Geyer MA, ffytche D, Williams SC, Sharma T (2007). A fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychotics. International Journal of Neuropsychopharmacology 10, 463-477.
36. Kumari V, Das M, Zachariah E, Ettinger U, Sharma T (2005). Reduced prepulse inhibition in unaffected siblings of schizophrenia patients. Psychophysiology 42, 588-594.
37. Kumari V, Gray JA, Geyer MA, ffytche D, Soni W, Mitterschiffthaler MT, Vythelingum GN, Simmons A, Williams SC, Sharma T (2003). Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjects. Psychiatry Research 122, 99-113.
38. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM (1996). Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6, 243-250.
39. Lacroix L, Spinelli S, White W, Feldon J (2000). The effects of ibotenic acid lesions of the medial and lateral prefrontal cortex on latent inhibition, prepulse inhibition and amphetamine-induced hyperlocomotion. Neuroscience 97, 459-468.
40. Lu BY, Martin KE, Edgar JC, Smith AK, Lewis SF, Escamilla MA, Miller GA, Cañive JM (2007). Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in schizophrenia. Biological Psychiatry 62, 822-825.
41. Malhotra AK, Kestler LJ, Mazzanti C, Bates JA, Goldberg T, Goldman D (2002). A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. American Journal of Psychiatry 159, 652-654.
42. Mansbach RS, Geyer MA, Braff DL (1988). Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology 94, 507-514.
43. Matsumoto M, Weickert CS, Akil M, Lipska BK, Hyde TM, Herman MM, Kleinman JE, Weinberger DR (2003). Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience 116, 127-137.
44. Mattay VS, Goldberg TE, Fera F, Hariri AR, Tessitore A, Egan MF (2003). Catechol O-methyltransferase Val158-Met genotype and individual variation in the brain response to amphetamine. Proceedings of the National Academy of Sciences USA 100, 6186-6191.
45. Meyer-Lindenberg A, Kohn PD, Kolachana B, Kippenhan S, McInerney-Leo A, Nussbaum R, Weinberger DR, Berman KF (2005). Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nature Neuroscience 8, 594-596.
46. Montag C, Hartmann P, Merz M, Burk C, Reuter M (2008). D2 receptor density and prepulse inhibition in humans: negative findings from a molecular genetic approach. Behavioural Brain Research 187, 428-432.
47. Nackley AG, Shabalina SA, Tchivileva IE, Satterffeld K, Korchynskyi O, Makarov SS, Maixner W, Diatchenko L (2006). Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 314, 1930-1933.
48. Postma P, Gray JA, Sharma T, Geyer M, Mehrotra R, Das M, Zachariah E, Hines M, Williams SC, Kumari V (2006). A behavioural and functional neuroimaging investigation into the effects of nicotine on sensorimotor gating in healthy subjects and persons with schizophrenia. Psychopharmacology 184, 589-599.
49. Raymond M, Rousset F (1995). An exact test for population differentiation. Evolution 49, 1280-1283.
50. Roussos P, Giakoumaki SG, Pavlakis S, Bitsios P (2007). Planning, decision making and the COMT rs4818 polymorphism in healthy males. Neuropsychologia. Published online 22 October 2007. doi:10.1016/j. neuropsychologia.2007.10.009.
51. Salama SA, Ho SL, Wang HQ, Tenhunen J, Tilgmann C, Al-Hendy A (2006). Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas. Fertility and Sterility 86, 259-262.
52. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 59, 22-33.
53. Swerdlow NR, Auerbach P, Monroe SM, Harston H, Geyer MA, Braff DL (1993). Men are more inhibited than women by weak prepulses. Biological Psychiatry 34, 253-260.
54. Swerdlow NR, Braff DL, Taaid N, Geyer MA (1994). Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Archives of General Psychiatry 51, 139-154.
55. Swerdlow NR, Caine SB, Braff DL, Geyer MA (1991). Neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications. Journal of Psychopharmacology 6, 176-190.
56. Swerdlow NR, Caine SB, Braff DL, Geyer MA (1992). Neural substrates of sensorimotor gating of the startle reflex: preclinical findings and their implications. Journal of Psychopharmacology 6, 176-190.
57. Swerdlow NR, Geyer MA, Braff DL (2001a). Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology 156, 194-215.
58. Swerdlow NR, Hartman PL, Auerbach PP (1997). Changes in sensorimotor inhibition across the menstrual cycle: implications for neuropsychiatric disorders. Biological Psychiatry 4, 452-460.
59. Swerdlow NR, Lipska BK, Weinberger DR, Braff DL, Jaskiw GE, Geyer MA (1995). Increased sensitivity to the gating-disruptive effects of apomorphine after lesions of the medial prefrontal cortex or ventral hippocampus in adult rats. Psychopharmacology 122, 27-34.
60. Swerdlow NR, Platten A, Shoemaker J, Pitcher L, Auerbach P (2001b). Effects of pergolide on sensorimotor gating of the startle reflex in rats. Psychopharmacology 158, 230-240.
61. Swerdlow NR, Stephany N, Shoemaker JM, Ross L, Wasserman LC, Talledo J, Auerbach PP (2002). Effects of amantadine and bromocriptine on startle and sensorimotor gating: parametric studies and cross-species comparisons. Psychopharmacology 164, 82-92.
62. Swerdlow NR, Stephany N, Wasserman LC, Talledo J, Shoemaker J, Auerbach PP (2003). Amphetamine effects on prepulse inhibition across-species: replication and parametric extension. Neuropsychopharmacology 28, 640-650.
63. Swerdlow NR, Taaid N, Oostwegel JL, Randolph E, Geyer MA (1998). Towards a cross-species pharmacology of sensorimotor gating: effects of amantadine, bromocriptine, pergolide and ropinirole on prepulse inhibition of acoustic startle in rats. Behavioral Pharmacology 9, 389-396.
64. Tunbridge EM, Harrison PJ, Weinberger DR (2006). Catechol-O-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biological Psychiatry 60, 141-151.
65. Winterer G, Egan MF, Kolachana BS, Goldberg TE, Coppola R, Weinberger DR (2006). Prefrontal electrophysiologic 'noise' and catechol-O-methyl transferase genotype in schizophrenia. Biological Psychiatry 60, 578-584.
66. Winterer G, Goldman D (2003). Genetics of human prefrontal function. Brain Research. Brain Research Reviews 43, 134-163.
67. Yee BK (2000). Cytotoxic lesion of the medial prefrontal cortex abolishes the partial reinforcement extinction effect, attenuates prepulse inhibition of the acoustic startle reflex and induces transient hyperlocomotion, while sparing spontaneous object recognition memory in the rat. Neuroscience 95, 675-689.
68. Zavitsanou K, Cranney J, Richardson R (1999). Dopamine antagonists in the orbital prefrontal cortex reduce prepulse inhibition of the acoustic startle response in rats. Pharmacology Biochemistry and Behavior 63, 55-61.