Treatment of brain metastases: Review of phase III randomized controlled trials

Radiotherapy and Oncology

Volumn 102, Issue 2, 2012, Pages 168-179

  Scoccianti, Silvia ^a   Ricardi, Umberto ^b  

^a CAREGGI UNIVERSITY HOSPITAL   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Brain metastases; Neurocognitive impairment; Quality of life; Radiosurgery; Radiotherapy; Whole brain radiation therapy

Indexed keywords

BRAIN METASTASIS; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; COGNITIVE DEFECT; HUMAN; NEUROTOXICITY; OVERALL SURVIVAL; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; QUALITY OF LIFE; RADIATION INJURY; RADIOSURGERY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW;

BRAIN NEOPLASMS; CLINICAL TRIALS, PHASE III AS TOPIC; COMBINED MODALITY THERAPY; CRANIAL IRRADIATION; HUMANS; QUALITY OF LIFE; RADIOSURGERY; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84857571028     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.08.041     Document Type: Review

References (56)

1. P.Y. Wen, P.M. Black, and J.S. Loeffler Metastatic brain cancer V. DeVita, S. Hellman, S.A. Rosenberg, Cancer: principles and practice of oncology 6th ed. 2001 Lippincott, Williams & Wilkins Philadelphia, PA 2655 2670
2. D.E. Weissman Glucocorticoid treatment for brain metastases and epidural spinal cord compression: a review J Clin Oncol 6 1988 543 551
3. F. Muller-Riemenschneider, A. Bockelbrink, and I. Ernst Stereotactic radiosurgery for the treatment of brain metastases Radiother Oncol 91 2009 67 74
4. L. Gaspar, C. Scott, and M. Rotman Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials Int J Radiat Oncol Biol Phys 37 1997 745 751
5. P.W. Sperduto, S.T. Chao, and P.K. Sneed Diagnosis specific prognostic factors, indexes and treatment outcomes for patients with newly diagnosed brain metastases: a multiinstitutional analysis of 4259 patients Int J Radiat Oncol Biol Phys 77 2010 655 661
6. D. Khuntia, P. Brown, J. Li, and M. Mehta Whole brain radiotherapy in the management of brain metastases J Clin Oncol 24 2006 1295 1304
7. J.S. Loeffler, and D. Shrieve An overview of radiotherapy trials for the treatment of brain metastases Oncology 9 1995 1212 1216
8. R.A. Patchell, P.A. Tibbs, and J.W. Walsh A randomized trial of surgery in the treatment of single metastases to the brain N Engl J Med 322 1990 494 500
9. C.J. Vecht, H. Haaxma-Reiche, and E.M. Noordijk Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol 33 1993 583 590
10. E.M. Noordijk, C.J. Vecht, and H. Haaxma-Reiche The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age Int J Radiat Oncol Biol Phys 29 1994 711 717
11. A.H. Mintz, J. Kestle, and M.P. Rathbone A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single brain metastasis Cancer 78 1996 1470 1476
12. D. Kondziolka, A. Patel, L.D. Lunsford, A. Kassam, and J.C. Flickinger Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases Int J Radiat Oncol Biol Phys 45 1999 427 434
13. D.W. Andrews, C.B. Scott, and P.W. Sperduto Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial Lancet 363 2004 1665 1672
14. R.A. Patchell, P.A. Tibbs, and W.F. Regine Postoperative radiotherapy in the treatment of single metastases to the brain. A randomized trial JAMA 280 1998 1485 1489
15. H. Aoyama, H. Shirato, and M. Tago Stereotactic radiosurgery plus whole brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases. A randomized controlled trial JAMA 295 2006 2483 2491
16. E.L. Chang, J.S. Wefel, and K.R. Hess Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole brain irradiation: a randomized controlled trial Lancet Oncol 10 2009 1037 1044
17. J.P. Knisely Focused attention on brain metastases Lancet Oncol 10 2009 1024
18. S.E. Weiss, and P.J. Kelly Neurocognitive function after WBRT plus SRS or SRS alone Lancet Oncol 11 2010 220 221
19. U. Mahmood, Y. Kwok, W.F. Regine, and R.A. Patchell Whole brain irradiation for patients with brain metastases: still the standard of care Lancet Oncol 11 2010 221 222
20. R.P. Mueller, R. Soffietti, and U. Abacioglu Adjuvant whole brain radiotherapy versus observation after radiosurgery or surgical resection of 1-3 cerebral metastases: Results of the EORTC 22952-26001 study J Clin Oncol 27 2009 15s
21. M. Kocher, R. Soffietti, and U. Abacioglu Adjuvant whole brain radiotherapy versus observation after radiosurgery or surgical resection of 1-3 cerebral metastases: Results of the EORTC 22952-26001 study J Clin Oncol 29 2011 134 141
22. D.E. Roos, A. Wirth, and B.H. Burmeister Whole brain irradiation following surgery or radiosurgery for solitary brain metastases: mature results of a prematurely closed randomized Trans-Tasman Radiation Oncology Group trial (TROG 98.05) Radiother Oncol 80 2006 318 322
23. A. Muacevic, B. Wowra, A. Siefert, J.C. Tonn, H.J. Steiger, and F.W. Kreth Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial J Neurooncol 87 2008 299 307
24. D.E. Roos, J.G. Smith, and S.W. Stephens Radiosurgery versus surgery, both with adjuvant whole brain radiotherapy, for solitary brain metastases: a randomized controlled trial Clinical Oncology 2011 doi:/10.1016/j.clon.2011.04. 009
25. B. Borgelt, R. Gelber, and S. Kramer The palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group Int J Radiat Oncol Biol Phys 6 1980 1 9
26. B. Borgelt, R. Gelber, M. Larson, F. Hendrickson, T. Griffin, and R. Roth Ultra-rapid high dose irradiation for the palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group Int J Radiat Oncol Biol Phys 7 1981 1633 1638
27. J.M. Kurtz, R. Gelber, L.W. Brady, R. Carella, and J.S. Cooper The palliation of brain metastases in a favorable patient population: a randomized clinical trial by the Radiation Therapy Oncology Group Int J Radiat Oncol Biol Phys 7 1981 891 895
28. L.T. Komarnicky, T.L. Phillips, K. Martz, S. Asbell, S. Isaacson, and R. Urtasun A randomized phase III protocol for the evaluation of misonidazole combined with radiation in the treatment of patients with brain metastases (RTOG-7916) Int J Radiat Oncol Biol Phys 20 1991 53 58
29. C. Haie-Meder, B. Pellae-Cosset, and A. Laplanche Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases Radiother Oncol 26 1993 111 116
30. T.J. Priestman, J. Dunn, M. Brada, R. Rampling, and P.G. Baker Final results of the Royal College of Radiologists' trial comparing two different radiotherapy schedules in the treatment of cerebral metastases Clin Oncol (R Coll Radiol) 8 1996 308 315
31. K.J. Murray, C. Scott, and H.M. Greenberg A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases: A report of the Radiation Therapy Oncology Group (RTOG) 9104 Int J Radiat Oncol Biol Phys 39 1997 571 574
32. P. Davey, D. Hoegler, M. Ennis, and J. Smith A phase III study of accelerated versus conventional hypofractionated whole brain irradiation in patients of good performance status with brain metastases not suitable for surgical excision Radiother Oncol 88 2008 173 176
33. P.H. Graham, J. Bucci, and L. Browne Randomized comparison of whole brain radiotherapy, 20 Gy in four daily fractions versus 40 Gy in 20 twice-daily fractions, for brain metastases Int J Radiat Oncol Biol Phys 77 2010 648 654
34. J.H. Suh, B. Stea, and A. Nabid Phase III study of Efaproxiral as an adjunct to whole brain radiation therapy for brain metastases J Clin Oncol 24 2006 106 114
35. M.P. Mehta, P. Rodrigus, and C.H.J. Terhaard Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole brain radiation therapy in brain metastases J Clin Oncol 21 2003 2529 2536
36. M.P. Mehta, W.R. Shapiro, and S.C. Phan Motexafin gadolinium combined with prompt whole brain radiotherapy prolong time to neurologic progression in non-small-lung cancer patients with brain metastases: results of a phase III trial Int J Radiat Oncol Biol Phys 73 2009 1069 1076
37. D. Antonadou, N. Coliarakis, and M. Paraskevaidis Whole brain radiotherapy alone or in combination with temozolomide for brain metastases. A phase III trial Int J Radiat Oncol Biol Phys 54 2002 93 94
38. M. Guerrieri, K. Wong, G. Ryan, M. Millward, G. Quong, and D.L. Ball A randomized phase III study of palliative radiation with concomitant carboplatin for brain metastases from non small cell carcinoma of the lung Lung cancer 46 2004 107 111
39. T. Neuhaus, Y. Ko, and R.P. Muller A phase III trial of topotecan and whole brain radiation therapy for patients with CNS metastases due to lung cancer Br J Cancer 100 2009 291 297
40. J.P.S. Knisely, B. Berkey, and A. Chakravarti A phase III study of conventional radiation therapy plus thalidomide versus conventional radiation therapy for multiple brain metastases (RTOG 0118) Int J Radiat Oncol Biol Phys 71 2008 79 86
41. W.F. Regine, C. Scott, K. Murray, and W. Curran Neurocognitive outcome in brain metastases patients treated with accelerated fractionation vs accelerated hyperfractionationated radiotherapy: an analysis from radiation therapy group study 91-04 Int J Radiat Oncol Biol Phys 51 2001 711 717
42. C.A. Meyers, J.A. Smith, and A. Bezjak Neurocognitive function and progression in patients with brain metastases treated with whole brain radiation and motexafin gadolinium: results of a randomized phase III trial J Clin Oncol 22 2004 157 165
43. C. Scott, J. Suh, B. Stea, A. Nabid, and J. Hackman Improved survival, quality of life and quality-adjusted survival in breast cancer patients treated with efaproxiral (Efaproxyn) plus whole radiation therapy for brain metastases Am J Clin Oncol 30 2007 580 587
44. B. Corn, J. Moughan, and P.S. Knisely Prospective evaluation of quality of life and neurocognitive effects in patients with multiple brain metastases receiving whole brain radiotherapy with or without thalidomide on Radiation Oncology Group (RTOG) trial 0118 Int J Radiat Oncol Biol Phys 71 2008 71 78
45. H. Aoyama, M. Tago, and N. Kato Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone Int J Radiat Oncol Biol Phys l 68 2007 1388 1395
46. R. Soffietti, M. Mueller, and S. Abacioglu Quality of life results of an EORTC phase III randomized trial of adjuvant whole brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases of solid tumors J Clin Oncol 28 2010 15s
47. C.A. Meyers, and J.S. Wefel The use of the mini-mental status examination to assess cognitive functioning in cancer trials: no ifs, ands, buts or sensitivity J Clin Oncol 21 2003 3557 3558
48. J. Li, S.M. Bentzen, and M. Renschler Regression after whole brain radiation therapy for brain metastases correlates with survival and improved neurocognitive function J Clin Oncol 25 2007 1260 1266
49. I.G. Barani, L.W. Cuttino, and S.H. Benedict Neural stem cell-preserving external-beam radiotherapy of central nervous system malignancies Int J Radiat Oncology Biol Phys 4 2007 978 985
50. V. Gondi, W.A. Tom, and M.P. Mehta Why avoid the hippocampus? A comprehensive review Radiother Oncol 97 2010 370 376
51. V. Gondi, W.A. Tom, and Marsh Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole brain radiotherapy: safety profile for RTOG 0933 Radiother Oncol 95 2010 327 331
52. R. Wiggenraad, A. Verbeek-de Kanter, H.B. Kal, M. Taphoorn, T. Vissers, and H. Struikmans Dose effect relation in stereotactic radiotherapy for brain metastases. A systematic review Radiother Oncol 98 2011 292 297
53. A. Ernst-Stecken, O. Ganslandt, U. Lambrecht, R. Sauer, and G. Grabenbauer Phase II trial of hypofractionated stereotactic radiotherapy for brain metastases: results and toxicity Radiother Oncol 81 2006 18 24
54. G. Rodrigues, W. Eppinga, and F. Lagerwaard A pooled analysis of arc-based image-guided simultaneous integrated boost radiation therapy for oligometastatic brain metastases Radiother Oncol 102 2012 180 186
55. N. Ramakrishna, F. Rosca, S. Friesen, E. Tezcanli, P. Zygmanszki, and F. Hacker A clinical comparison of patient setup and intra-fraction motion using frame-based radiosurgery versus a frameless image-guided radiosurgery system for intracranial lesions Radiother Oncol 95 2010 109 115
56. W. Verbakel, F.J. Lagerwaard, A.J.E. Verduin, S. Heukelom, B.J. Slotman, and J.P. Cuijpers The accuracy of frameless stereotactic intracranial radiosurgery Radiother Oncol 97 2010 390 394