Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: Safety profile for RTOG 0933

Radiotherapy and Oncology

Volumn 95, Issue 3, 2010, Pages 327-331

  Gondi, Vinai ^a   Tome, Wolfgang A ^a   Marsh, James ^b   Struck, Aaron ^a   Ghia, Amol ^a   Turian, Julius V ^b   Bentzen, Søren M ^a   Kuo, John S ^a   Khuntia, Deepak ^a   Mehta, Minesh P ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Brain metastases; Hippocampal avoidance; Neurocognitive function; RTOG 0933; Whole brain radiotherapy

Indexed keywords

ADULT; ARTICLE; BRAIN METASTASIS; CANCER RADIOTHERAPY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HUMAN; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MELANOMA; METASTASIS POTENTIAL; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; TREATMENT PLANNING; TUMOR LOCALIZATION; WHOLE BRAIN RADIOTHERAPY;

ADULT; AGED; BRAIN NEOPLASMS; COGNITION; CRANIAL IRRADIATION; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED;

EID: 77952585016     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2010.02.030     Document Type: Article

References (7)

1. Mehta M.P., Rodrigus P., Terhaard C.H., et al. Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases. J Clin Oncol 21 (2003) 2529-2536
2. Mehta M.P., Shapiro W.R., Glantz M.J., et al. Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points. J Clin Oncol 20 (2002) 3445-3453
3. Gutierrez A.N., Westerly D.C., Tome W.A., et al. Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases boost: a planning study. Int J Radiat Oncol Biol Phys 69 (2007) 589-597
4. Gondi V, Tolakanahalli R, Mehta M, et al. Hippocampal-sparing whole-brain radiotherapy: a "how-to" technique, utilizing helical tomotherapy and LINAC-based intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys 2010; doi:10.1016/j.ijrobp.2010.01.039.
5. Gaspar L., Scott C., Rotman M., et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 37 (1997) 745-751
6. Ghia A., Tome W.A., Thomas S., et al. Distribution of brain metastases in relation to the hippocampus: implications for neurocognitive functional preservation. Int J Radiat Oncol Biol Phys 68 (2007) 971-977
7. Khuntia D., Brown P., Li J., and Mehta M.P. Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol 24 (2006) 1295-1304