Acute respiratory distress syndrome: Evaluation and management

Minerva Anestesiologica

Volumn 78, Issue 3, 2012, Pages 343-357

  Cortes I ^a   Penuelas O ^a   Esteban, A ^a  

^a HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

Author keywords

Adult; Artificial; Intensive care units; Respiration; Respiratory distress syndrome

Indexed keywords

ACTIVATED PROTEIN C; DIPALMITOYLPHOSPHATIDYLCHOLINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KETOCONAZOLE; LEUKOCYTE ELASTASE INHIBITOR; LIPOPROSTAGLANDIN E1; LISOFYLLINE; LUNG SURFACTANT; METHYLPREDNISOLONE; NEUROMUSCULAR BLOCKING AGENT; NITRIC OXIDE; OMEGA 3 FATTY ACID; PALIFERMIN; PLACEBO; SALBUTAMOL; SIVELESTAT;

ACUTE LUNG INJURY; ACUTE RESPIRATORY TRACT DISEASE; ADJUVANT THERAPY; ADULT RESPIRATORY DISTRESS SYNDROME; AIR CONDITIONING; ARTIFICIAL VENTILATION; BODY POSTURE; CELL THERAPY; COMORBIDITY; CONTINUOUS INFUSION; EXTRACORPOREAL OXYGENATION; HUMAN; HYPOXEMIA; INCIDENCE; INTENSIVE CARE UNIT; LUNG EDEMA; LUNG INFILTRATE; LUNG INJURY; LUNG WEDGE PRESSURE; MESENCHYMAL STEM CELL; MORBIDITY; MORTALITY; MULTIPLE ORGAN FAILURE; NONHUMAN; OBSERVATIONAL STUDY; POSITIVE END EXPIRATORY PRESSURE; REVIEW; RISK FACTOR; TIDAL VOLUME;

ACUTE LUNG INJURY; ADULT; ANIMALS; ANOXIA; CLINICAL TRIALS AS TOPIC; DISEASE MANAGEMENT; DRUG EVALUATION, PRECLINICAL; EXTRACORPOREAL MEMBRANE OXYGENATION; HUMANS; INTENSIVE CARE; LUNG; META-ANALYSIS AS TOPIC; MULTICENTER STUDIES AS TOPIC; MULTIPLE ORGAN FAILURE; PATIENT SELECTION; POSITIVE-PRESSURE RESPIRATION; PRONE POSITION; PULMONARY SURFACTANTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; TIDAL VOLUME;

EID: 84857564195     PISSN: 03759393     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (98)

1. Rubenfeld GD, Herridge MS. Epidemiology and outcomes of acute lung injury. Chest 2007; 131: 554-562.
2. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet 1967; 2: 319.
3. Brun-Buisson C, Minelli C, Bertollini G, Brazzi L, Pimentel J, Lewandowski K et al. Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study. Intensive Care Med 2004; 30: 51-61.
4. Arroliga AC, Ghamra ZW, Peéez-Trepichio A, Perez Trepichio P, Komara JJ Jr, Smith A et al. Incidence of ARDS in an adult population of Northeast Ohio. Chest 2002; 121: 1972-1976.
5. Bersten AD, Edibam C, Hunt T, Moran J; Australian and New Zealand Intensive Care Society Clinical Trials Group. Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian states. Am J Respir Crit Care Med 2002; 165: 443-448.
6. Estenssoro E, Dubin A, Laffaire E, Canales H, Sáenz G, Moseinco M et al. Incidence, clinical course, and outcomein 217 patients with acute respiratory distress syndrome. Crit Care Med 2002; 30: 2450-2456.
7. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342: 1334-1349.
8. Ventrice EA, Martísistac O, Gonzalvo R, Villagrá, A, Lóez-Aguilar J, Blanch L. Molecular and biophysical mechanisms and modulation of ventilator-induced lung injury. Med Intensiva 2007; 31: 73-82.
9. Lee WL, Downey GP. Neutrophil activation and acute lung injury. Curr Opin Crit Care 2001; 7: 1-7.
10. Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Resp Crit Care Med 2001; 163: 1376-1383.
11. Greene KE, Wright JR, Steinberg KP, Ruzinski JT, Caldwell E, Wong WB et al. Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Am J Respir Crit Care Med 1999; 160: 1843-1850.
12. Abraham E. Coagulation abnormalities in acute lung injury and sepsis. Am J Respir Cell Mol Biol 2000; 22: 401-404.
13. Villar J, Slutsky AS. The incidence of the adult respiratory distress syndrome. Am Rev Respir Dis 1989; 140: 814-816.
14. Lewandowski K, Metz J, Deutschmann C, Preiss H, Kuhlen R, Artigas A et al. Incidence, severity, and mortality of acute respiratory failure in Berlin. Germany. Am J Resp Crit Care Med 1995; 151: 1121-1155.
15. Luhr OR, Antonsen K, Karlsson M, Aardal S, Thorsteinsson A, Frostell CG et al. Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in Sweden, Denmark, and Iceland. The ARF Study Group. Am J Resp Crit Care Med 1999; 159: 1849-1861.
16. Thomsen GE, Morris AH Incidence of the adult respiratory distress syndrome in the State of Utah. Am J Resp Crit Care Med 1995; 152: 965-971.
17. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353: 1685.
18. Goss CH, Brower RG, Hudson LD, Rubenfeld GD; ARDS Network. Incidence of acute lung injury in the United States. Crit Care Med 2003; 31: 1607-1611.
19. Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L et al. VENTILA Group. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med 2008; 177: 170-177.
20. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308.
21. Zambon M, Vincent JL. Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest 2008; 133: 1120-1127.
22. Phua J, Badia JR, Adhikari NK, Friedrich JO, Fowler RA, Singh JM et al. Has mortality form acute respiratory distress syndrome decreased over time? Am J Respir Crit Care Med 2009; 179: 220-227.
23. Li G, Malinchoc M, Cartin-Ceba R, Venkata CV, Kor DJ, Peters SG et al. Eight-year trend of acute respiratory distress syndrome: a population-based study in Olmsted County, Minnesota. Am J Respir Crit Care Med 2011; 183: 59-66.
24. Stapleton RD, Wang BM, Hudson LD, Rubenfeld GD, Caldwell ES, Steinberg KP. Causes and timing of death in patients with ARDS. Chest 2005; 128: 525-532.
25. Phua J, Stewart TE, Ferguson ND. Acute respiratory distress syndrome 40 years later: Time to revisit its definition. Crit Care Med 2008; 36: 2912-2921.
26. Villar J, Blanco J, Kacmarek RM. Acute respiratory distress syndrome definition: do we need a change? Curr Opin Crit Care 2011; 17: 13-17.
27. Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am J Respir Crit Care Med 1988; 138: 720-723.
28. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149: 818-824.
29. Ferguson ND, Frutos-Vivar F, Esteban A, Fernández-Segoviano P, Aramburu JA, Näjera L et al. Acute respiratory distress syndrome: Underrecognition by clinicians and diagnostic accuracy of three clinical definitions. Crit Care Med 2005; 33: 2228-2234.
30. Meade MO, Cook RJ, Guyatt GH, Groll R, Kachura JR, Bedard M et al. Interobserver variation in interpreting chest radiographs for the diagnosis of acute respiratory distress syndrome. Am J Respir Crit Care Med 2000; 161: 85-90.
31. Wheeler AP, Bernard GR, Thompson BT, Schoenfeld D, Wiedemann HP, de Boisblanc B et al. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med 2006; 354: 2213-2224.
32. Rana R, Vlahakis NE, Daniels CE, Jaffe AS, Klee GG, Hubmayr RD et al. B-type natriuretic peptide in the assessment of acute lung injury and cardiogenic pulmonary edema. Crit Care Med 2006; 34: 1941-1946.
33. Levitt JE, Vinayak AG, Gehlbach BK, Pohlman A, Van Cleve W, Hall JB et al. Diagnostic utility of B-type natriuretic peptide in critically ill patients with pulmonary edema: a prospective cohort study. Crit Care 2008; R3.
34. Esteban A, Fernández-Segoviano P, Frutos-Vivar F, Aramburu JA, Näjera L, Ferguson ND et al. Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings. Ann Intern Med 2004; 41: 440-445.
35. Villar J, Pérz-Médez L, Lóez J, Belda J, Blanco J, Saralegui I, Suáez-Sipmann F et al.; HELP Network. An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2007; 176:795-804.
36. Dreyfuss D, Saumon G. Ventilator-induced lung injury: Lessons from experimental studies. Am J Respir Crit Care Med 1998; 157: 294-323.
37. Gattinoni L, Protti A, Caironi P, Carlesso E. Ventilator-induced lung injury: the anatomical and physiological framework. Crit Care Med 2010; 38: S539-S548.
38. Ventrice EA, Martí-Sistac O, Gonzalvo R, Villagrá A, Lóez-Aguilar J, Blanch L. Molecular and biophysical mechanisms and modulation of ventilator-induced lung injury. Med Intensiva 2007;31:73-82.
39. Esteban A, Alía I, Gordo F, de Pablo R, Suarez J, González G et al. Prospective randomized trial comparing pressurecontrolled ventilation and volume controlled ventilation in ARDS. Chest 2000;117:1690-1696.
40. Brochard L, Roudot-Thoraval F, Roupie E, Delclaux C, Chastre J, Fernandez-Mondéjar E et al. Tidal volume reduction for prevention of ventilator-induced lung injury in acute distress respiratory syndrome. Am J Respir Crit Care Med 1998;158:1831-1838.
41. Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998;338:347-354.
42. Stewart TE, Meade MO, Cook DJ, Granton JT, Hodder RV, Lapinsky SE et al. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome: Pressure- and Volume-Limited Ventilation Strategy Group. N Engl J Med 1998;338:355-361.
43. Brower RG, Shanholtz CB, Fessler HE, Shade DM, White P Jr, Wiener CM et al. Prospective, randomized controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 1999;27:1492-1498.
44. Villar J, Kacmarek RM, Pérz-Mérdez L, Aguirre-Jaime A. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acuterespiratory distress syndrome: a randomized, controlled trial. Crit Care Med 2006;34:1311-1318.
45. [No authors listed]. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000;342:1301-1308.
46. Eichacker PQ, Gerstenberger EP, Banks SM, Cui X, Natanson C. Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes. Am J Respir Crit Care Med 2002;166:1510-1514.
47. Putensen C, Theuerkauf N, Zinserling J, Wrigge H, Pelosi P. Meta-analysis: ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury. Ann Intern Med 2009;151:566-576.
48. Moran JL, Bersten AD, Solomon PJ. Meta-analysis of controlled trials of ventilator therapy in acute lung injury and acute respiratory distress syndrome: an alternative perspective. Intensive Care Med 2005;31:227-235.
49. Gattinoni L, Chiumello D, Russo R. Reduced tidal volumes and lung protective ventilatory strategies: where do we go from here? Curr Opin Crit Care 2002;8:45-50.
50. Yilmaz M, Keegan MT, Iscimen R, Afessa B, Buck CF, Hubmayr RD et al. Toward the prevention of acute lung injury: protocol-guided limitation of large tidal volume ventilation and inappropriate transfusion. Crit Care Med 2007;35:1660-1666.
51. Esteban A, Anzueto A, Alía I, Gordo F, Apezteguía C, Pálizas F et al. How is mechanical ventilation employed in the intensive care unit? An international utilization review. Am J Respir Crit Care Med 2000;161:1450-1458.
52. Gattinoni L, Pesenti A, Avalli L, Rossi F, Bombino M. Pressure-volume curve of total respiratory system in acute respiratory failure. Computed tomographic scan study. Am Rev Respir Dis 1987;136:730-736.
53. Gattinoni L, Caironi P, Cressoni M, Chiumello D, Ranieri VM, Quintel M et al. Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med 2006;354:1775-1786.
54. Gattinoni L, Pesenti A. The concept of "baby lung". Intensive Care Med 2005; 31: 776-784.
55. Guerin C. The preventive role of higher PEEP in treating severely hypoxemic ARDS. Minerva Anestesiol 2011;77:835-845.
56. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M et al.; National Heart, Lung and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressure in patients with the acute respiratory distress syndrome. N Engl J Med 2004;351:327-336.
57. Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ et al.; Lung Open Ventilation Study Investigators. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008;299:637-645.
58. Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL et al.; Expiratory Pressure (Express) Study Group. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008;299:646-655.
59. Briel M, Meade M, Mercat A, Brower RG, Talmor D, Walter SD et al. Higher vs. Lower Positive End-Expiratory Pressure in Patients with Acute Lung Injury and Acute Respiratory Distress Syndrome. Systematic Review and Metaanalysis. JAMA 2010;303:865-873.
60. Gattinoni L, Tognoni G, Pesenti A, Taccone P, Mascheroni D, Labarta V et al. Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med 2001;345:568-573.
61. Guerin C, Gaillard S, Lemasson S, Ayzac L, Girard R, Beuret P et al. Effects of systematic prone positioning in hypoxemic acute respiratory failure: a randomized controlled trial. JAMA 2004;292:2379-2387.
62. Mancebo J, Fernández R, Blanch L, Rialp G, Gordo F, Ferrer M et al. A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med 2006;173:1233-1239.
63. Taccone P, Pesenti A, Latini R, Polli F, Vagginelli F, Mietto C et al. Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA 2009;302:1977-1984.
64. Gattinoni L, Carlesso E, Taccone P, Polli F, Guérin C, Mancebo J. Prone positioning improves survival in severe ARDS: a pathophysiologic review and individual patient meta-analysis. Minerva Anestesiol 2010;76:448-454.
65. Sud S, Friedrich JO, Taccone P, Polli F, Adhikari NK, Latini R et al. Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med 2010;36:585-589.
66. Gattinoni L, Carlesso E, Taccone P, Polli F, Guérin C, Mancebo J. Prone positioning improves survival in severe ARDS: a pathophysiologic review and individual patient meta-analysis. Minerva Anestesiol 2010;76:448-454.
67. Downar J, Mehta S. Bench-to-bedside review: high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome. Crit Care 2006;10:240.
68. Slutsky AS, Drazen JM. Ventilation with small tidal volumes. N Engl J Med 2002;347:630-631.
69. Derdak S, Mehta S, Stewart TE, Smith T, Rogers M, Buchman TG et al. High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults: A randomized controlled trial. Am J Respir Crit Care Med 2002;166:80180-8.
70. Bollen CW, van Well GT, Sherry T, Beale RJ, Shah S, Findlay G et al. High-frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: A randomized controlled trial. Crit Care 2005;9:R430-R439.
71. Hirschl RB, Croce M, Gore D, Wiedemann H, Davis K, Zwischenberger J, Bartlett RH. Prospective, randomized, controlled pilot study of partial liquid ventilation in adult acute respiratory distress syndrome. Am J Respir Crit Care Med 2002;165:781-787.
72. Kacmarek RM, Wiedemann HP, Lavin PT, Wedel MK, Tütüncü AS, Slutsky AS. Partial liquid ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2006;173:882-889.
73. Peek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Thalanany MM et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): A multicentre randomized controlled trial. Lancet 2009;374:1351-1363.
74. Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A et al.; ACURASYS Study Investigators. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010;363:1107-1116.
75. Luce JM, Montgomery AB, Marks JD, Turner J, Metz CA, Murria JF. Inefectiveness of high-dose methylprednisolone in preventing parenchymal lung injury and improving mortality in patients with septic shock. Am Rev Respir Dis 1988;138:62-68.
76. Meduri GU, Headley AS, Golden E, Carson SJ, Umberger RA, Kelso T et al. Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial. JAMA 1998;280:159-165.
77. Meduri GU, Golden E, Freire AX, Taylor E, Zaman M, Carson SJ et al. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 2007;131:954-963.
78. Tang BM, Craig JC, Eslick GD, Seppelt I, McLean AS. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med 2009;37:1594-1603.
79. Kor DJ, Iscimen R, Yilmaz M, Brown MJ, Brown DR, Gajic O. Statin administration did not influence the progression of lung injury or associated organ failures in a cohort of patients with acute lung injury. Intensive Care Med 2009; 5:1039-1046.
80. Anzueto A, Baughman RP, Guntupalli KK, Weg JG, Wiedemann HP, Raventó AA et al. Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. N Engl J Med 1996;334:1417-1421.
81. Spragg RG, Lewis JF, Walmrath HD, Johannigman J, Bellingan G, Laterre PF et al. Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. N Engl J Med 2004;351:884-892.
82. Dellinger RP, Zimmerman JL, Taylor RW, Straube RC, Hauser DL, Criner GJ et al. Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Crit Care Med 1998;26:15-23.
83. Lundin S, Mang H, Smithies M, Stenquvist O, Frostell C. Inhalation of nitric oxide in acute lung injury: results of a European multicentre study. Intensive Care Med 1999;25:911-919.
84. Taylor RW, Zimmerman JL, Dellinger RP, Straube RC, Criner GJ, Davis K Jr et al. Low dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA 2004;291:1603-1609.
85. Abraham E, Baughman R, Fletcher E, Heard S, Lamberti J, Levy H et al. Liposomal prostaglandin E1 (TLC-C53) in acute respiratory distress syndrome: a controlled, randomized, double-blind, multicenter clinical trial. Crit Care Med 1999;27:1478-1485.
86. The Acute Respiratory Distress Syndrome Network. Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2000;283:1995-2002.
87. [No authors listed]. Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. Crit Care Med 2002;30:1-6.
88. Zeiher BG, Artigas A, Vincent JL, Dmitrienko A, Jackson K, Thompson BT et al.; STRIVE Study Group. Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit Care Med 2004;32:1695-1702.
89. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A et al.; Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699-709.
90. Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J et al. Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med 2008;178:618-623.
91. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D et al.; The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Randomized, Placebo- Controlled Clinical Trial of an Aerosolized Beta-2 Agonist for Treatment of Acute Lung Injury. Am J Respir Crit Care Med 2011.
92. Perkins GD, McAuley DF, Thickett DR, Gao F. The beta- agonist lung injury trial (BALTI): a randomized placebo- controlled clinical trial. Am J Respir Crit Care Med 2006;173:281-287.
93. Stapleton RD, Martin TR, Weiss NS, Crowley JJ, Gundel SJ, Nathens AB et al. A phase II randomized placebo-con-trolled trial of omega-3 fatty acids for the treatment of acute lung injury. Crit Care Med 2011;39:1655-62.
94. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A 2009;106:16357-16362.
95. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 2007;179:1855-1863.
96. Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J et al. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005;33:145-152.
97. Ortiz LA, Dutreil M, Fattman C, Pandey AC, Torres G, Go K et al. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci U S A 2007;104:11002-11007.
98. Chen L, Brizel DM, Rabbani ZN, Samulski TV, Farrell CL, Larrier N et al. The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats. Int J Radiat Oncol Biol Phys 2004;60:1520-15209.