Statin administration did not influence the progression of lung injury or associated organ failures in a cohort of patients with acute lung injury

Intensive Care Medicine

Volumn 35, Issue 6, 2009, Pages 1039-1046

  Kor, Daryl J ^a   Iscimen, Remzi ^b   Yilmaz, Murat ^c   Brown, Michael J ^a   Brown, Daniel R ^a   Gajic, Ognjen ^a  

^a Mayo Clinic   (United States)

^b ULUDAG UNIVERSITY   (Turkey)

^c AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; HMG CoA reductase inhibitors; Multi organ failure; Statins

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; OXYGEN;

ACCIDENT PREVENTION; ACUTE LUNG INJURY; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; FEMALE; HOSPITALIZATION; HUMAN; INTENSIVE CARE; MALE; MORTALITY; MULTIPLE ORGAN FAILURE; OXYGEN TENSION; SCORING SYSTEM; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; TREATMENT OUTCOME;

ACUTE LUNG INJURY; AGED; COHORT STUDIES; CONFIDENCE INTERVALS; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; ODDS RATIO; OUTCOME ASSESSMENT (HEALTH CARE); RETROSPECTIVE STUDIES;

EID: 67349235035     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-009-1421-8     Document Type: Article

References (36)

1. GR Bernard A Artigas KL Brigham J Carlet K Falke L Hudson M Lamy JR Legall A Morris R Spragg 1994 The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination Am J Respir Crit Care Med 149 818 824 (Pubitemid 24082248)
2. The Acute Respiratory Distress Syndrome Network 2000 Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome N Engl J Med 342 1301 1308
3. HP Wiedemann AP Wheeler GR Bernard BT Thompson D Hayden B deBoisblanc AF Connors Jr RD Hite AL Harabin 2006 Comparison of two fluid-management strategies in acute lung injury N Engl J Med 354 2564 2575 (Pubitemid 43882352)
4. M Epstein VM Campese 2005 Pleiotropic effects of 3-hydroxy-3- methylglutaryl coenzyme a reductase inhibitors on renal function Am J Kidney Dis 45 2 14 (Pubitemid 40038040)
5. BV Naidu SM Woolley AS Farivar R Thomas C Fraga MS Mulligan 2003 Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion J Thorac Cardiovasc Surg 126 482 489 (Pubitemid 37048516)
6. A Pirat P Zeyneloglu D Aldemir M Yucel O Ozen S Candan G Arslan 2006 Pretreatment with simvastatin reduces lung injury related to intestinal ischemia-reperfusion in rats Anesth Analg 102 225 232 (Pubitemid 43038312)
7. R Jain A DalNogare 2006 Pharmacological therapy for acute respiratory distress syndrome Mayo Clin Proc 81 205 212 (Pubitemid 43205775)
8. JR Jacobson JW Barnard DN Grigoryev S-F Ma RM Tuder JGN Garcia 2005 Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury Am J Physiol Lung Cell Mol Physiol 288 L1026 L1032
9. HW Yao LG Mao JP Zhu 2006 Protective effects of pravastatin in murine lipopolysaccharide-induced acute lung injury Clin Exp Pharmacol Physiol 33 793 797
10. Y Le Manach P Coriat CD Collard B Riedel 2008 Statin therapy within the perioperative period Anesthesiology 108 1141 1146
11. D Poldermans JJ Bax MD Kertai B Krenning CM Westerhout AFL Schinkel IR Thomson PJ Lansberg LA Fleisher J Klein H van Urk JRTC Roelandt E Boersma 2003 Statins are associated with a reduced incidence of perioperative mortality in patients undergoing major noncardiac vascular surgery Circulation 107 1848 1851 (Pubitemid 36444123)
12. PK Lindenauer P Pekow K Wang B Gutierrez EM Benjamin 2004 Lipid-lowering therapy and in-hospital mortality following major noncardiac surgery JAMA 291 2092 2099 (Pubitemid 38580152)
13. AES Durazzo FS Machado DT Ikeoka C De Bernoche MC Monachini P Puech-Leao B Caramelli 2004 Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial J Vasc Surg 39 967 975
14. K O'Neil-Callahan G Katsimaglis MR Tepper J Ryan C Mosby JP Ioannidis PG Danias 2005 Statins decrease perioperative cardiac complications in patients undergoing noncardiac vascular surgery: The Statins for Risk Reduction in Surgery (StaRRS) study J Am Coll Cardiol 45 336 342 (Pubitemid 40186781)
15. R Sukhija Z Bursac P Kakar L Fink C Fort S Satwani WS Aronow D Bansal JL Mehta 2008 Effect of statins on the development of renal dysfunction Am J Cardiol 101 975 979
16. O Schouten NFM Kok E Boersma JJ Bax HHH Feringa R Vidakovic RG Statius van Eps MRHM van Sambeek D Poldermans 2006 Effects of statins on renal function after aortic cross clamping during major vascular surgery Am J Cardiol 97 1383 1385
17. D Pruefer J Makowski M Schnell U Buerke M Dahm H Oelert U Sibelius U Grandel F Grimminger W Seeger J Meyer H Darius M Buerke 2002 Simvastatin inhibits inflammatory properties of Staphylococcus aureus α-toxin Circulation 106 2104 2110 (Pubitemid 35192817)
18. H Yasuda PS Yuen X Hu H Zhou RA Star 2006 Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects Kidney Int 69 1535 1542
19. Y Almog 2003 Statins, inflammation, and sepsis: hypothesis Chest 124 740 743 (Pubitemid 37000158)
20. Y Almog A Shefer V Novack N Maimon L Barski M Eizinger M Friger L Zeller A Danon 2004 Prior statin therapy is associated with a decreased rate of severe sepsis Circulation 110 880 885 (Pubitemid 39096018)
21. DG Hackam M Mamdani P Li DA Redelmeier 2006 Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis Lancet 367 413 418 (Pubitemid 43184262)
22. P Kruger K Fitzsimmons D Cook M Jones G Nimmo 2006 Statin therapy is associated with fewer deaths in patients with bacteraemia Intensive Care Med 32 75 79 (Pubitemid 43039379)
23. MW Merx EA Liehn U Janssens R Lütticken J Schrader P Hanrath C Weber 2004 HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis Circulation 109 2560 2565 (Pubitemid 38720557)
24. F Gao L Linhartova Johnston A McD DR Thickett 2008 Statins and sepsis Br J Anaesth 100 288 298
25. M-Y Tseng M Czosnyka H Richards JD Pickard PJ Kirkpatrick 2005 Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial Stroke 36 1627 1632 (Pubitemid 41098752)
26. A Nassief JD Marsh 2008 Statin therapy for stroke prevention Stroke 39 1042 1048
27. RD Stapleton BM Wang LD Hudson GD Rubenfeld ES Caldwell KP Steinberg 2005 Causes and timing of death in patients with ARDS Chest 128 525 532 (Pubitemid 41140476)
28. AB Montgomery MA Stager CJ Carrico LD Hudson 1985 Causes of mortality in patients with the adult respiratory distress syndrome Am Rev Respir Dis 132 485 489 (Pubitemid 15247959)
29. M Yilmaz R Iscimen MT Keegan NE Vlahakis B Afessa RD Hubmayr O Gajic 2007 Six-month survival of patients with acute lung injury: prospective cohort study Crit Care Med 35 2303 2307
30. FL Ferreira DP Bota A Bross C Melot J-L Vincent 2001 Serial evaluation of the SOFA score to predict outcome in critically ill patients JAMA 286 1754 1758 (Pubitemid 33010262)
31. WA Knaus DP Wagner EA Draper JE Zimmerman M Bergner PG Bastos CA Sirio DJ Murphy T Lotring A Damiano 1991 The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults Chest 100 1619 1636
32. F Gueler S Rong JK Park A Fiebeler J Menne M Elger DN Mueller F Hampich R Dechend U Kunter FC Luft H Haller 2002 Postischemic acute renal failure is reduced by short-term statin treatment in a rat model J Am Soc Nephrol 13 2288 2298
33. N Yokota M O'Donnell F Daniels M Burne-Taney W Keane B Kasiske H Rabb 2003 Protective effect of HMG-CoA reductase inhibitor on experimental renal ischemia-reperfusion injury Am J Nephrol 23 13 17 (Pubitemid 35316759)
34. U Laufs JK Liao 1998 Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase J Biol Chem 273 24266 24271 (Pubitemid 28435775)
35. JR Jacobson SM Dudek PA Singleton IA Kolosova AD Verin JGN Garcia 2006 Endothelial cell barrier enhancement by ATP is mediated by the small GTPase Rac and cortactin Am J Physiol Lung Cell Mol Physiol 291 L289 L295
36. R Fernandez VJ De Pedro A Artigas 2006 Statin therapy prior to ICU admission: protection against infection or a severity marker? Intensive Care Med 32 160 164 (Pubitemid 43039392)