Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome

New England Journal of Medicine

Volumn 334, Issue 22, 1996, Pages 1417-1421

  Anzueto, Antonio ^a,j   Baughman, Robert P ^b   Guntupalli, Kalpalatha K ^c   Weg, John G ^d   Wiedemann, Herbert P ^e   Raventós, Antoni Artigas ^f   Lemaire, François ^g   Long, Walker ^h   Zaccardelli, David S ⁱ   Pattishall, Edward N ⁱ  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b OHIO UNIVERSITY   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^e LERNER RESEARCH INSTITUTE   (United States)

^f Consorci Hospitalari del Parc Tavli ^*  (Spain)

^g HENRI MONDOR HOSPITAL   (France)

^h UNIVERSITY OF NORTH CAROLINA   (United States)

ⁱ GLAXOSMITHKLINE   (United States)

^j SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DIPALMITOYLPHOSPHATIDYLCHOLINE; LUNG SURFACTANT; PLACEBO;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ARTICLE; ARTIFICIAL VENTILATION; CAUSE OF DEATH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INTENSIVE CARE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEPSIS; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; AEROSOLS; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FATTY ALCOHOLS; FEMALE; HUMANS; MALE; MIDDLE AGED; PHOSPHORYLCHOLINE; POLYETHYLENE GLYCOLS; PROSPECTIVE STUDIES; PULMONARY SURFACTANTS; RESPIRATORY DISTRESS SYNDROME, ADULT; SEPSIS; SURVIVAL RATE; TREATMENT FAILURE;

EID: 9344262898     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199605303342201     Document Type: Article

References (36)

1. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet 1967;2:319-23.
2. Petty TL, Reiss OK, Paul GW, Silvers GW, Elkins ND. Characteristics of pulmonary surfactant in adult respiratory syndrome associated with trauma and shock. Am Rev Respir Dis 1977;115:531-6.
3. Petty TL, Silvers GW, Paul GW, Stanford RE. Abnormalities in lung elastic properties and surfactant function in adult respiratory distress syndrome. Chest 1979;75:571-4.
4. Hallman M, Spragg R, Harrell JH, Moser KM, Gluck L. Evidence of lung surfactant abnormality in respiratory failure: study of bronchoalveolar lavage phospholipids, surface activity, phospholipase activity, and plasma myoinositol. J Clin Invest 1982;70:673-83.
5. Gregory TJ, Longmore WJ, Moxley MA, et al. Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. J Clin Invest 1991;88:1976-81.
6. Dreyfuss D, Soler P, Saumon G. Mechanical ventilation-induced pulmonary edema: interaction with previous lung alterations. Am J Respir Crit Care Med 1995;151:1568-75.
7. Dreyfuss D, Soler P, Basset G, Saumon G. High inflation pressure pulmonary edema: respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 1988;137:1159-64.
8. Richman PS, Spragg RG, Robertson B, Merritt TA, Curstedt T. The adult respiratory distress syndrome: first trials with surfactant replacement. Eur Respir J Suppl 1989;3:109-111.
9. Lachmann B. Animal models and clinical pilot studies of surfactant replacement in adult respiratory distress syndrome. Eur Respir J Suppl 1989;3:98-103.
10. Chan CYJ, Barton TL, Rasch DK. Colfosceril in an infant with adult respiratory distress syndrome. Clin Pharm 1992;11:880-2.
11. Weg JG, Balk RA, Tharratt RS, et al. Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome. JAMA 1994;272:1433-8.
12. Spragg RG, Gilliard N, Richman P, et al. Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome. Chest 1994;105:195-202.
13. Gregory TJ, Gadeck JE, Weiland JE, et al. Survanta supplementation in patients with acute respiratory distress syndrome (ARDS). Am J Respir Crit Care Med 1994;149:Suppl:A567. abstract.
14. Reines HD, Silverman H, Hurst J, et al. Effects of two concentrations of nebulized surfactant (Exosurf) in sepsis-induced adult respiratory distress syndrome (ARDS). Crit Care Med 1992;20:Suppl:S61. abstract.
15. Knaus WA, Wagner DP, Draper EA, et al. The APACHE III prognostic system: risk prediction of hospital mortality in critically ill hospitalized adults. Chest 1991;100:1619-36.
16. Hyers TM. Adult respiratory distress syndrome: definition, risk factors, and outcome. In: Zapol WM, Lemaire F, eds. Adult respiratory distress syndrome. Vol. 50 of Lung biology in health and disease. New York: Marcel Dekker, 1991:23-36.
17. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994;149:818-24.
18. Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA, Balk RA. Sepsis syndrome: a valid clinical entity. Crit Care Med 1989;17:389-93.
19. Durand DJ, Clyman RI, Heymann MA, et al. Effects of protein-free, synthetic surfactant on the survival and pulmonary function on preterm lambs. J Pediatr 1985;107:775-80.
20. 99mTc-pentetic acid (DTPA) and synthetic surfactant (Exosurf). Chest 1994;105:1765-9.
21. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719-48.
22. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
23. Petty TL. Acute respiratory distress syndrome (ARDS). Dis Mon 1990;36: 1-58.
24. MacIntyre NR, Coleman RE, Schuller FS, Zaccardelli D, Pattishall E. Efficiency of the delivery of aerosolized artificial surfactant in intubated patients with the adult respiratory distress syndrome. Am J Respir Crit Care Med 1994;149:Suppl:A125. abstract.
25. Lewis JF, McCaig L. Aerosolized versus instilled exogenous surfactant in a nonuniform pattern of lung injury. Am Rev Respir Dis 1993;148:1187-93.
26. Lewis J, Ikegami M, Higuchi R, Jobe A, Absolom D. Nebulized vs. instilled exogenous surfactant in an adult lung injury model. J Appl Physiol 1991;71: 1270-6.
27. Froese AB, McCulloch PR, Sugiura M, Vaclavik S, Possmayer F, Moller F. Optimizing alveolar expansion prolongs the effectiveness of exogenous surfactant therapy in the adult rabbit. Am Rev Respir Dis 1993;148:569-77.
28. Kobayashi T, Kataoka H, Ueda T, Murakami S, Takada Y, Kokubo M. Effects of surfactant supplement and end-expiratory pressure in lung-lavaged rabbits. J Appl Physiol 1984;57:995-1001.
29. Allen JN, Moore SA, Pope-Harman AL, Marsh CB, Wewers MD. Immunosuppressive properties of surfactant and plasma on alveolar macrophages. J Lab Clin Med 1995;125:356-69.
30. Thomassen MJ, Antal JM, Connors MJ, Meeker DP, Wiedemann HP. Characterization of Exosurf (surfactant)-mediated suppression of stimulated human alveolar macrophage cytokine responses. Am J Respir Cell Mol Biol 1994;10:399-404.
31. Roth MD, Pinto M, Golub SH, Shaw H. Pulmonary surfactant inhibits interleukin-2-induced proliferation and the generation of lymphokine-activated killer cells. Am J Respir Cell Mol Biol 1993;9:652-8.
32. Thomassen MJ, Meeker DP, Antal JM, Connors MJ, Wiedemann HP. Synthetic surfactant (Exosurf) inhibits endotoxin-stimulated cytokine secretion by human alveolar macrophages. Am J Respir Cell Mol Biol 1992;7: 257-60.
33. Suchyta MR, Clemmer TP, Elliott CG, Orme JF Jr, Weaver LK. The adult respiratory distress syndrome: a report of survival and modifying factors. Chest 1992;101:1074-9.
34. Sloane PJ, Gee MH, Gottlieb JE, et al. A multicenter registry of patients with acute respiratory distress syndrome: physiology and outcome. Am Rev Respir Dis 1992;146:419-26.
35. Mitchell DR, Milberg JA, Steinberg KP, Hudson LD. Trends in adult respiratory distress syndrome (ARDS) fatality rates from 1983-1992. Am Rev Respir Dis 1993;147:Suppl:A348. abstract.
36. Milberg JA, Davis DR, Steinberg KP, Hudson LD. Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993. JAMA 1995;273:306-9.