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Volumn 19, Issue 2, 2012, Pages 254-263

A bacterial lipooligosaccharide that naturally mimics the epitope of the HIV-neutralizing antibody 2G12 as a template for vaccine design

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL LIPOOLIGOSACCHARIDE; EPITOPE; GLYCOCONJUGATE; LIPOOLIGOSACCHARIDE; MANNOSE OLIGOSACCHARIDE; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VACCINE;

EID: 84857534559     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.12.019     Document Type: Article
Times cited : (30)

References (59)
  • 1
    • 78650062305 scopus 로고    scopus 로고
    • Yeast-elicited cross-reactive antibodies to HIV Env glycans efficiently neutralize virions expressing exclusively high-mannose N-linked glycans
    • C. Agrawal-Gamse, R.J. Luallen, B. Liu, H. Fu, F.-H. Lee, Y. Geng, and R.W. Doms Yeast-elicited cross-reactive antibodies to HIV Env glycans efficiently neutralize virions expressing exclusively high-mannose N-linked glycans J. Virol. 85 2011 470 480
    • (2011) J. Virol. , vol.85 , pp. 470-480
    • Agrawal-Gamse, C.1    Luallen, R.J.2    Liu, B.3    Fu, H.4    Lee, F.-H.5    Geng, Y.6    Doms, R.W.7
  • 2
    • 77950480397 scopus 로고    scopus 로고
    • Carbohydrate vaccines: Developing sweet solutions to sticky situations?
    • R.D. Astronomo, and D.R. Burton Carbohydrate vaccines: developing sweet solutions to sticky situations? Nat. Rev. Drug Discov. 9 2010 308 324
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 308-324
    • Astronomo, R.D.1    Burton, D.R.2
  • 3
    • 45749138808 scopus 로고    scopus 로고
    • A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120
    • DOI 10.1128/JVI.00293-08
    • R.D. Astronomo, H.-K. Lee, C.N. Scanlan, R. Pantophlet, C.-Y. Huang, I.A. Wilson, O. Blixt, R.A. Dwek, C.-H. Wong, and D.R. Burton A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120 J. Virol. 82 2008 6359 6368 (Pubitemid 351875114)
    • (2008) Journal of Virology , vol.82 , Issue.13 , pp. 6359-6368
    • Astronomo, R.D.1    Lee, H.-K.2    Scanlan, C.N.3    Pantophlet, R.4    Huang, C.-Y.5    Wilson, I.A.6    Blixt, O.7    Dwek, R.A.8    Wong, C.-H.9    Burton, D.R.10
  • 7
    • 79957604981 scopus 로고    scopus 로고
    • Long-term protection after immunization with protein-polysaccharide conjugate vaccines in infancy
    • G. Blanchard-Rohner, and A.J. Pollard Long-term protection after immunization with protein-polysaccharide conjugate vaccines in infancy Expert Rev. Vaccines 10 2011 673 684
    • (2011) Expert Rev. Vaccines , vol.10 , pp. 673-684
    • Blanchard-Rohner, G.1    Pollard, A.J.2
  • 8
    • 0028178461 scopus 로고
    • Cyclic beta-glucans of members of the family Rhizobiaceae
    • M.W. Breedveld, and K.J. Miller Cyclic beta-glucans of members of the family Rhizobiaceae Microbiol. Rev. 58 1994 145 161
    • (1994) Microbiol. Rev. , vol.58 , pp. 145-161
    • Breedveld, M.W.1    Miller, K.J.2
  • 12
    • 0033046030 scopus 로고    scopus 로고
    • Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system
    • DOI 10.1038/sj.gt.3300895
    • L.J. Chang, V. Urlacher, T. Iwakuma, Y. Cui, and J. Zucali Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system Gene Ther. 6 1999 715 728 (Pubitemid 29243643)
    • (1999) Gene Therapy , vol.6 , Issue.5 , pp. 715-728
    • Chang, L.-J.1    Urlacher, V.2    Iwakuma, T.3    Cui, Y.4    Zucali, J.5
  • 13
    • 0028842207 scopus 로고
    • Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes
    • R.I. Connor, B.K. Chen, S. Choe, and N.R. Landau Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes Virology 206 1995 935 944
    • (1995) Virology , vol.206 , pp. 935-944
    • Connor, R.I.1    Chen, B.K.2    Choe, S.3    Landau, N.R.4
  • 14
    • 0015826335 scopus 로고
    • Structural studies on the Klebsiella O group 3 lipopolysaccharide
    • M. Curvall, B. Lindberg, J. Lönngren, and W. Nimmich Structural studies on the Klebsiella O group 3 lipopolysaccharide Acta Chem. Scand. 27 1973 2645 2649
    • (1973) Acta Chem. Scand. , vol.27 , pp. 2645-2649
    • Curvall, M.1    Lindberg, B.2    Lönngren, J.3    Nimmich, W.4
  • 15
    • 45049088002 scopus 로고    scopus 로고
    • Lipopolysaccharide structures from Agrobacterium and Rhizobiaceae species
    • C. De Castro, A. Molinaro, R. Lanzetta, A. Silipo, and M. Parrilli Lipopolysaccharide structures from Agrobacterium and Rhizobiaceae species Carbohydr. Res. 343 2008 1924 1933
    • (2008) Carbohydr. Res. , vol.343 , pp. 1924-1933
    • De Castro, C.1    Molinaro, A.2    Lanzetta, R.3    Silipo, A.4    Parrilli, M.5
  • 16
    • 77956165575 scopus 로고    scopus 로고
    • Microbe-associated molecular patterns in innate immunity: Extraction and chemical analysis of gram-negative bacterial lipopolysaccharides
    • C. De Castro, M. Parrilli, O. Holst, and A. Molinaro Microbe-associated molecular patterns in innate immunity: extraction and chemical analysis of gram-negative bacterial lipopolysaccharides Methods Enzymol. 480 2010 89 115
    • (2010) Methods Enzymol. , vol.480 , pp. 89-115
    • De Castro, C.1    Parrilli, M.2    Holst, O.3    Molinaro, A.4
  • 18
    • 77957189612 scopus 로고    scopus 로고
    • Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged
    • K.J. Doores, Z. Fulton, M. Huber, I.A. Wilson, and D.R. Burton Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged J. Virol. 84 2010 10690 10699
    • (2010) J. Virol. , vol.84 , pp. 10690-10699
    • Doores, K.J.1    Fulton, Z.2    Huber, M.3    Wilson, I.A.4    Burton, D.R.5
  • 20
    • 77956366187 scopus 로고    scopus 로고
    • Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans
    • D.C. Dunlop, C. Bonomelli, F. Mansab, S. Vasiljevic, K.J. Doores, M.R. Wormald, A.S. Palma, T. Feizi, D.J. Harvey, and R.A. Dwek Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans Glycobiology 20 2010 812 823
    • (2010) Glycobiology , vol.20 , pp. 812-823
    • Dunlop, D.C.1    Bonomelli, C.2    Mansab, F.3    Vasiljevic, S.4    Doores, K.J.5    Wormald, M.R.6    Palma, A.S.7    Feizi, T.8    Harvey, D.J.9    Dwek, R.A.10
  • 21
    • 11244266086 scopus 로고    scopus 로고
    • Bacterial polysaccharide-protein conjugate vaccines
    • DOI 10.1093/bmb/ldh021
    • A. Finn Bacterial polysaccharide-protein conjugate vaccines Br. Med. Bull. 70 2004 1 14 (Pubitemid 40069369)
    • (2004) British Medical Bulletin , vol.70 , pp. 1-14
    • Finn, A.1
  • 22
    • 0014531184 scopus 로고
    • A new method for the extraction of R lipopolysaccharides
    • C. Galanos, O. Lüderitz, and O. Westphal A new method for the extraction of R lipopolysaccharides Eur. J. Biochem. 9 1969 245 249
    • (1969) Eur. J. Biochem. , vol.9 , pp. 245-249
    • Galanos, C.1    Lüderitz, O.2    Westphal, O.3
  • 23
    • 0028853961 scopus 로고
    • Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity
    • J. He, S. Choe, R. Walker, P. Di Marzio, D.O. Morgan, and N.R. Landau Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity J. Virol. 69 1995 6705 6711
    • (1995) J. Virol. , vol.69 , pp. 6705-6711
    • He, J.1    Choe, S.2    Walker, R.3    Di Marzio, P.4    Morgan, D.O.5    Landau, N.R.6
  • 24
    • 79957612221 scopus 로고    scopus 로고
    • An update on vaccination against group B streptococcus
    • P.T. Heath An update on vaccination against group B streptococcus Expert Rev. Vaccines 10 2011 685 694
    • (2011) Expert Rev. Vaccines , vol.10 , pp. 685-694
    • Heath, P.T.1
  • 25
    • 0020536197 scopus 로고
    • Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels
    • P.J. Hitchcock, and T.M. Brown Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels J. Bacteriol. 154 1983 269 277 (Pubitemid 13115445)
    • (1983) Journal of Bacteriology , vol.154 , Issue.1 , pp. 269-277
    • Hitchcock, P.J.1    Brown, T.M.2
  • 26
    • 0033657009 scopus 로고    scopus 로고
    • Deacylation of lipopolysaccharides and isolation of oligosaccharide phosphates
    • O. Holst Deacylation of lipopolysaccharides and isolation of oligosaccharide phosphates Methods Mol. Biol. 145 2000 345 353
    • (2000) Methods Mol. Biol. , vol.145 , pp. 345-353
    • Holst, O.1
  • 27
    • 0028919669 scopus 로고
    • The structures of oligosaccharide bisphosphates isolated from the lipopolysaccharide of a recombinant Escherichia coli strain expressing the gene gseA [3-deoxy-D-manno-octulopyranosonic acid (Kdo) transferase] of Chlamydia psittaci 6BC
    • O. Holst, K. Bock, L. Brade, and H. Brade The structures of oligosaccharide bisphosphates isolated from the lipopolysaccharide of a recombinant Escherichia coli strain expressing the gene gseA [3-deoxy-D-manno-octulopyranosonic acid (Kdo) transferase] of Chlamydia psittaci 6BC Eur. J. Biochem. 229 1995 194 200
    • (1995) Eur. J. Biochem. , vol.229 , pp. 194-200
    • Holst, O.1    Bock, K.2    Brade, L.3    Brade, H.4
  • 30
    • 50449090525 scopus 로고    scopus 로고
    • An HIV vaccine - Challenges and prospects
    • M.I. Johnston, and A.S. Fauci An HIV vaccine - challenges and prospects N. Engl. J. Med. 359 2008 888 890
    • (2008) N. Engl. J. Med. , vol.359 , pp. 888-890
    • Johnston, M.I.1    Fauci, A.S.2
  • 32
    • 0035027531 scopus 로고    scopus 로고
    • Structural and serological studies on Hafnia alvei O-specific polysaccharide of α-D-mannan type isolated from the lipopolysaccharide of strain PCM 1223
    • DOI 10.1016/S0928-8244(01)00226-7, PII S0928824401002267
    • E. Katzenellenbogen, N.A. Kocharova, G.V. Zatonsky, J. Kübler-Kiełb, A. Gamian, A.S. Shashkov, Y.A. Knirel, and E. Romanowska Structural and serological studies on Hafnia alvei O-specific polysaccharide of alpha-D-mannan type isolated from the lipopolysaccharide of strain PCM 1223 FEMS Immunol. Med. Microbiol. 30 2001 223 227 (Pubitemid 32373297)
    • (2001) FEMS Immunology and Medical Microbiology , vol.30 , Issue.3 , pp. 223-227
    • Katzenellenbogen, E.1    Kocharova, N.A.2    Zatonsky, G.V.3    Kubler-Kielb, J.4    Gamian, A.5    Shashkov, A.S.6    Knirel, Y.A.7    Romanowska, E.8
  • 33
    • 0027479474 scopus 로고
    • Sensitive silver-staining detection of bacterial lipopolysaccharides in polyacrylamide gels
    • DOI 10.1016/0165-022X(93)90024-I
    • R. Kittelberger, and F. Hilbink Sensitive silver-staining detection of bacterial lipopolysaccharides in polyacrylamide gels J. Biochem. Biophys. Methods 26 1993 81 86 (Pubitemid 23047958)
    • (1993) Journal of Biochemical and Biophysical Methods , vol.26 , Issue.1 , pp. 81-86
    • Kittelberger, R.1    Hilbink, F.2
  • 34
    • 0028673711 scopus 로고
    • Automated and semiautomated analysis of homo- and heteronuclear multidimensional nuclear magnetic resonance spectra of proteins: The program Pronto
    • M. Kjaer, K.V. Andersen, and F.M. Poulsen Automated and semiautomated analysis of homo- and heteronuclear multidimensional nuclear magnetic resonance spectra of proteins: the program Pronto Methods Enzymol. 239 1994 288 307
    • (1994) Methods Enzymol. , vol.239 , pp. 288-307
    • Kjaer, M.1    Andersen, K.V.2    Poulsen, F.M.3
  • 36
    • 1342302499 scopus 로고    scopus 로고
    • Design and synthesis of a template-assembled oligomannose cluster as an epitope mimic for human HIV-neutralizing antibody 2G12
    • H. Li, and L.X. Wang Design and synthesis of a template-assembled oligomannose cluster as an epitope mimic for human HIV-neutralizing antibody 2G12 Org. Biomol. Chem. 2 2004 483 488
    • (2004) Org. Biomol. Chem. , vol.2 , pp. 483-488
    • Li, H.1    Wang, L.X.2
  • 38
    • 0015443359 scopus 로고
    • Structural studies on Klebsiella O group 5 lipopolysaccharides
    • B. Lindberg, J. Lönngren, and W. Nimmich Structural studies on Klebsiella O group 5 lipopolysaccharides Acta Chem. Scand. 26 1972 2231 2236
    • (1972) Acta Chem. Scand. , vol.26 , pp. 2231-2236
    • Lindberg, B.1    Lönngren, J.2    Nimmich, W.3
  • 39
    • 45749122331 scopus 로고    scopus 로고
    • An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing human immunodeficiency virus type 1 antibody 2G12 and elicits mannose-specific gp120-binding antibodies
    • DOI 10.1128/JVI.00412-08
    • R.J. Luallen, J. Lin, H. Fu, K.K. Cai, C. Agrawal, I. Mboudjeka, F.-H. Lee, D. Montefiori, D.F. Smith, R.W. Doms, and Y. Geng An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing human immunodeficiency virus type 1 antibody 2G12 and elicits mannose-specific gp120-binding antibodies J. Virol. 82 2008 6447 6457 (Pubitemid 351875122)
    • (2008) Journal of Virology , vol.82 , Issue.13 , pp. 6447-6457
    • Luallen, R.J.1    Lin, J.2    Fu, H.3    Cai, K.K.4    Agrawal, C.5    Mboudjeka, I.6    Lee, F.-H.7    Montefiori, D.8    Smith, D.F.9    Doms, R.W.10    Geng, Y.11
  • 40
    • 77949907643 scopus 로고    scopus 로고
    • Antibodies against Manalpha1,2-Manalpha1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV strains
    • R.J. Luallen, C. Agrawal-Gamse, H. Fu, D.F. Smith, R.W. Doms, and Y. Geng Antibodies against Manalpha1,2-Manalpha1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV strains Glycobiology 20 2010 280 286
    • (2010) Glycobiology , vol.20 , pp. 280-286
    • Luallen, R.J.1    Agrawal-Gamse, C.2    Fu, H.3    Smith, D.F.4    Doms, R.W.5    Geng, Y.6
  • 42
    • 33645466248 scopus 로고    scopus 로고
    • Toward a carbohydrate-based HIV-1 vaccine: Synthesis and immunological studies of oligomannose-containing glycoconjugates
    • J. Ni, H. Song, Y. Wang, N.M. Stamatos, and L.-X. Wang Toward a carbohydrate-based HIV-1 vaccine: synthesis and immunological studies of oligomannose-containing glycoconjugates Bioconjug. Chem. 17 2006 493 500
    • (2006) Bioconjug. Chem. , vol.17 , pp. 493-500
    • Ni, J.1    Song, H.2    Wang, Y.3    Stamatos, N.M.4    Wang, L.-X.5
  • 43
    • 0031970118 scopus 로고    scopus 로고
    • Specificity of rabbit antisera against lipopolysaccharide of Acinetobacter
    • R. Pantophlet, L. Brade, L. Dijkshoorn, and H. Brade Specificity of rabbit antisera against lipopolysaccharide of Acinetobacter J. Clin. Microbiol. 36 1998 1245 1250 (Pubitemid 28208007)
    • (1998) Journal of Clinical Microbiology , vol.36 , Issue.5 , pp. 1245-1250
    • Pantophlet, R.1    Brade, L.2    Dijkshoorn, L.3    Brade, H.4
  • 44
    • 0037213247 scopus 로고    scopus 로고
    • Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120
    • DOI 10.1128/JVI.77.1.642-658.2003
    • R. Pantophlet, E. Ollmann Saphire, P. Poignard, P.W. Parren, I.A. Wilson, and D.R. Burton Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120 J. Virol. 77 2003 642 658 (Pubitemid 36005001)
    • (2003) Journal of Virology , vol.77 , Issue.1 , pp. 642-658
    • Pantophlet, R.1    Ollmann Saphire, E.2    Poignard, P.3    Parren, P.W.H.I.4    Wilson, I.A.5    Burton, D.R.6
  • 45
    • 0017073610 scopus 로고
    • The O9 antigen of Escherichia coli Structure of the polysaccharide chain
    • P. Prehm, B. Jann, and K. Jann The O9 antigen of Escherichia coli Structure of the polysaccharide chain Eur. J. Biochem. 67 1976 53 56
    • (1976) Eur. J. Biochem. , vol.67 , pp. 53-56
    • Prehm, P.1    Jann, B.2    Jann, K.3
  • 46
  • 50
    • 4444371143 scopus 로고    scopus 로고
    • Full structural characterization of the lipid A components from the Agrobacterium tumefaciens strain C58 lipopolysaccharide fraction
    • DOI 10.1093/glycob/cwh096
    • A. Silipo, C. De Castro, R. Lanzetta, A. Molinaro, and M. Parrilli Full structural characterization of the lipid A components from the Agrobacterium tumefaciens strain C58 lipopolysaccharide fraction Glycobiology 14 2004 805 815 (Pubitemid 39206883)
    • (2004) Glycobiology , vol.14 , Issue.9 , pp. 805-815
    • Silipo, A.1    De Castro, C.2    Lanzetta, R.3    Molinaro, A.4    Parrilli, M.5
  • 51
    • 77956047416 scopus 로고    scopus 로고
    • Fundamental difference in the content of high-mannose carbohydrate in the HIV-1 and HIV-2 lineages
    • E. Stansell, and R.C. Desrosiers Fundamental difference in the content of high-mannose carbohydrate in the HIV-1 and HIV-2 lineages J. Virol. 84 2010 8998 9009
    • (2010) J. Virol. , vol.84 , pp. 8998-9009
    • Stansell, E.1    Desrosiers, R.C.2
  • 53
    • 33646597300 scopus 로고    scopus 로고
    • Carbohydrate based vaccines
    • DOI 10.1016/j.febslet.2006.03.053, PII S0014579306003681
    • J.F.G. Vliegenthart Carbohydrate based vaccines FEBS Lett. 580 2006 2945 2950 (Pubitemid 43729166)
    • (2006) FEBS Letters , vol.580 , Issue.12 , pp. 2945-2950
    • Vliegenthart, J.F.G.1
  • 55
    • 1142306158 scopus 로고    scopus 로고
    • Binding of High-Mannose-Type Oligosaccharides and Synthetic Oligomannose Clusters to Human Antibody 2G12: Implications for HIV-1 Vaccine Design
    • DOI 10.1016/S1074-5521(03)00299-0
    • L.X. Wang, J. Ni, S. Singh, and H. Li Binding of high-mannose-type oligosaccharides and synthetic oligomannose clusters to human antibody 2G12: implications for HIV-1 vaccine design Chem. Biol. 11 2004 127 134 (Pubitemid 38203997)
    • (2004) Chemistry and Biology , vol.11 , Issue.1 , pp. 127-134
    • Wang, L.-X.1    Ni, J.2    Singh, S.3    Li, H.4
  • 56
    • 34250750826 scopus 로고    scopus 로고
    • Novel template-assembled oligosaccharide clusters as epitope mimics for HIV-neutralizing antibody 2G12. Design, synthesis, and antibody binding study
    • DOI 10.1039/b702961f
    • J. Wang, H. Li, G. Zou, and L.X. Wang Novel template-assembled oligosaccharide clusters as epitope mimics for HIV-neutralizing antibody 2G12. Design, synthesis, and antibody binding study Org. Biomol. Chem. 5 2007 1529 1540 (Pubitemid 46959421)
    • (2007) Organic and Biomolecular Chemistry , vol.5 , Issue.10 , pp. 1529-1540
    • Wang, J.1    Li, H.2    Zou, G.3    Wang, L.-X.4
  • 57
    • 0002447206 scopus 로고
    • Bacterial lipopolysaccharides: Extraction with phenol-water and further applications of the procedure
    • R.L. Whistler, Academic Press New York
    • O. Westphal, and K. Jann Bacterial lipopolysaccharides: extraction with phenol-water and further applications of the procedure R.L. Whistler, Methods in Carnohydrate Chemistry 1965 Academic Press New York 83 91
    • (1965) Methods in Carnohydrate Chemistry , pp. 83-91
    • Westphal, O.1    Jann, K.2
  • 59
    • 0035202616 scopus 로고    scopus 로고
    • Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies
    • DOI 10.1128/JVI.75.24.12198-12208.2001
    • M.B. Zwick, M. Wang, P. Poignard, G. Stiegler, H. Katinger, D.R. Burton, and P.W. Parren Neutralization synergy of human immunodeficiency virus type 1 primary isolates by cocktails of broadly neutralizing antibodies J. Virol. 75 2001 12198 12208 (Pubitemid 33115893)
    • (2001) Journal of Virology , vol.75 , Issue.24 , pp. 12198-12208
    • Zwick, M.B.1    Wang, M.2    Poignard, P.3    Stiegler, G.4    Katinger, H.5    Burton, D.R.6    Parren, P.W.H.I.7


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