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Angewandte Chemie - International Edition

Volumn 43, Issue 8, 2004, Pages 1000-1003

Reactivity-based one-pot synthesis of oligomannoses: Defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody

(10) Lee, Hing Ken a Scanlan, Christopher N a Huang, Cheng Yuan a Chang, Aileen Y a Calarese, Daniel A a Dwek, Raymond A b Rudd, Pauline M b Burton, Dennis R a Wilson, Ian A a Wong, Chi Huey a

a SCRIPPS RESEARCH INSTITUTE (United States)

b UNIVERSITY OF OXFORD (United Kingdom)

Author keywords

Antibodies; Drug design; Oligosaccharides; Self condensation; Synthetic methods

Indexed keywords

ANTIBODIES; CHEMICAL COMPOUNDS; CONDENSATION; GLUCOSE; VACCINES;

EPITOPES; OLIGOMANNOSES; REACTIVITY;

ANTIGENS;

CARBOHYDRATE DERIVATIVE; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2G12; OLIGOMANNOSE; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ANTIGEN BINDING; ANTIGEN RECOGNITION; ANTIGEN STRUCTURE; ARTICLE; CARBOHYDRATE SYNTHESIS; CRYSTAL STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOGLOBULIN VARIABLE REGION; PROTEIN DOMAIN; VACCINE PRODUCTION;

ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; IMMUNOGLOBULIN FAB FRAGMENTS; MANNOSE; NEUTRALIZATION TESTS; OLIGOSACCHARIDES;

EID: 20844432534 PISSN: 14337851 EISSN: None Source Type: Journal
DOI: 10.1002/anie.200353105 Document Type: Article

Times cited : (126)

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