Carbohydrate moieties as vaccine candidates: Meeting summary

Vaccine

Volumn 28, Issue 4, 2010, Pages 1121-1131

  Lucas, A H ^a   Rittenhouse Olson, K ^b   Kronenberg, M ^c   Apicella, M A ^d   Wang, D ^e   Schreiber, J R ^f   Taylor, C E ^g  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e STANFORD UNIVERSITY   (United States)

^f TUFTS MEDICAL CENTER   (United States)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Adjuvant; Carbohydrate; Immunity; Tumor; Vaccine

Indexed keywords

CARBOHYDRATE ANTIGEN; GLYCAN; GLYCOLIPID; GLYCOPROTEIN; OLIGOSACCHARIDE;

ALGORITHM; ARTICLE; B LYMPHOCYTE; CARBOHYDRATE ANALYSIS; IMMUNE RESPONSE; MICROORGANISM; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; T LYMPHOCYTE;

CARBOHYDRATES; HUMANS; VACCINES;

EID: 73949116773     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.05.055     Document Type: Article

References (109)

1. Lucas A.H., and Reason D.C. Polysaccharide vaccines as probes of antibody repertoires in man. Immunol Rev 171 (1999) 89-104
2. Cobb B.A., and Kasper D.L. Zwitterionic capsularpolysaccharides: the new MHCII-dependent antigens. Cell Microbiol 7 (2005) 1398-1403
3. Duan J., Avci F.Y., and Kasper D.L. Microbial carbohydrate depolymerization by antigen-presenting cells: deamination prior to presentation by the MHCII pathway. Proc Nat Acad Sci USA 105 (2008) 5183-5188
4. Chattopadhyay G., Khan A.Q., Sen G., Colino J., DuBois W., Rubtsov A., et al. Transgenic expression of Bcl-xl or Bcl-2 by murine B cells enhances the in vivo antipolysaccharide, but not antiprotein, response to intact Streptococcus pneumoniae. J Immunol 179 (2007) 7523-7534
5. Ng L.G., Sutherland A.P., Newton R., Qian F., Cachero T.G., Scott M.L., et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 173 (2004) 807-817
6. von Bulow G.U., van Deursen J.M., and Bram R.J. Regulation of the T-independent humoral response by TACI. Immunity 14 (2001) 573-582
7. Moody D.B. The surprising diversity of lipid antigens for CD1-restricted T cells. Adv Immunol 89 (2006) 87-139
8. Giaccone G., Punt C.J., Ando Y., Ruijter R., Nishi N., Peters M., et al. A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors. Clin Cancer Res 8 (2002) 3702-3709
9. Gonzalez-Aseguinolaza G., Van Kaer L., Bergmann C.C., Wilson J.M., Schmieg J., Kronenberg M., et al. Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J Exp Med 195 (2002) 617-624
10. Tupin E., Kinjo Y., and Kronenberg M. The unique role of natural killer T cells in the response to microorganisms. Nat Rev Microbiol 5 (2007) 405-417
11. Kinjo Y., Wu D., Kim G., Xing G.W., Poles M.A., Ho D.D., et al. Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434 (2005) 520-525
12. Mattner J., Debord K.L., Ismail N., Goff R.D., Cantu III C., Zhou D., et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434 (2005) 525-529
13. Sriram V., Du W., Gervay-Hague J., and Brutkiewicz R.R. Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur J Immunol 35 (2005) 1692-1701
14. Kinjo Y., Tupin E., Wu D., Fujio M., Garcia-Navarro R., Benhnia M.R., et al. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol 7 (2006) 978-986
15. Rogers M.E., Ilg T., Nikolaev A.V., Ferguson M.A., and Bates P.A. Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. Nature 430 (2004) 463-467
16. Rogers M.E., Sizova O.V., Ferguson M.A., Nikolaev A.V., and Bates P.A. Synthetic glycovaccine protects against the bite of leishmania-infected sand flies. J Infect Dis 194 (2006) 512-518
17. MacGill T.C., MacGill R.S., and Kozel T.R. Capsular reactions of Cryptococcus neoformans with polyspecific and oligospecific polyclonal anticapsular antibodies. Infect Immun 69 February (2) (2001) 1189-1191
18. Buchanan K.L., and Murphy J.W. What makes Cryptococcus neoformans a pathogen?. Emerg Infect Dis 4 (1998) 71-83
19. Lucas A.H. IgM memory B cells: origin, mutation, and mobilization by polysaccharide vaccination. Blood 104 (2004) 3417-3418
20. Weller S., Braun M.C., Tan B.K., Rosenwald A., Cordier C., Conley M.E., et al. Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 104 December 1 (12) (2004) 3647-3654
21. Zhong Z., and Pirofski L.A. Antifungal activity of a human antiglucuronoxylomannan antibody. Clin Diag Lab Immunol 5 January (1) (1998) 58-64
22. Subramaniam K., French N., and Pirofski L.A. Cryptococcus neoformans-reactive and total immunoglobulin profiles of human immunodeficiency virus-infected and un-infected Ugandans. Cli Diag Lab Immunol 12 (2005) 1168-1176
23. FleuridorR, Lyles R.H., and Pirofski L.A. Quantitative and qualitative differences in the serum antibody profiles of human immunodeficiency virus-infected persons with and without Cryptococcus neoformans meningitis. J Infect Dis 180 (1999) 1526-1535
24. Datta K., and Pirofski L.A. Towards a vaccine for Cryptococcus neoformans: principles and caveats. FEMS Yeast Res. 6 June (4) (2006) 525-536 [Review]
25. Heimburg J., Yan J., Morey S., Glinskii O.V., Huxley V.H., Wild L., et al. Inhibition of spontaneous breast cancer metastasis by anti-Thomsen-Friedenreich antigen monoclonal antibody JAA-F11. Neoplasia 8 11 (2006) 939-948
26. Miller G.M., Andres M.L., and Gridley D.S. NK cell depletion results in accelerated tumor growth and attenuates the antitumor effect of total body irradiation. Int J Oncol 23 (2003) 1585-1592
27. Chaturvedi R, Yan J, Heimburg S, Koury M Sajjad, Rittenhouse-Olson K. Immuno-PET and biodistribution using Iodine-124 labeled anti-Thomsen-Friedenreich-antigen monoclonal antibody JAA-F11, Appl Radiat Isotopes (2007). http://www.sciencedirect.com/dx.doi.org/10.1016/j.apradiso.2007.07.029.
28. Monzavi-Karbassi B., Pashov A., Jousheghany F., Artaud C., and Kieber-Emmons T. Evaluating strategies to enhance the anti-tumor immune response to a carbohydrate mimetic peptide vaccine. Int J Mol Med 17 (2006) 1045
29. Han Y., Riesselman M.H., and Cutler J.E. Protection against candidiasis by an immunoglobulin G3 (IgG3) monoclonal antibody specific for the same mannotriose as an IgM protective antibody. Infect Immun 68 (2009) 1649-1654
30. Nitz M., Ling C., Otter A., Cutler J.E., and Bundle D.R. The unique solution structure and immunochemistry of the Candida albicans β-1,2-mannopyranan cell wall antigens. J Biol Chem 277 (2002) 3440-3446
31. Nikrad P.V., Beirerbeck H., and Lemieux R.U. Molecular recognition. X. A novel procedure for the detection of the intermolecular hydrogen bonds present in a protein oligosaccharide complex. Can J Chem 70 (1992) 241-253
32. Pashine A., Valiante N.M., and Ulmer J.B. Targeting the innate immune response with improved vaccine adjuvants. Nat Med 11 (2005) S63-68
33. Valiante N.M., O'Hagan D.T., and Ulmer J.B. Innate immunity and biodefense vaccines. Cell Microbiol 5 (2003) 755-760
34. Dupuis M., McDonald D.M., and Ott G. Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in mice. Vaccine 18 (1999) 434-439
35. Hemmi H., Kaisho T., Takeuchi O., Sato S., Sanjo H., Hoshino K., et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3 (2002) 196-200
36. Finne J., Leinonen M., and Makela P.H. Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis. Lancet 2 (1983) 355-357
37. Nedelec J., Boucraut J., Garnier J.M., Bernard D., and Rougon G. Evidence for autoimmune antibodies directed against embryonic neural cell adhesion molecules (N-CAM) in patients with group B meningitis. J Neuroimmunol 29 (1990) 49-56
38. Krug L.M., Ragupathi G., Ng K.K., Hood C., Jennings H.J., Guo Z., et al. Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin. Clin Cancer Res 10 (2004) 916-923
39. Moe G.R., Dave A., and Granoff D.M. Epitopes recognized by a nonautoreactive murine anti-N-propionyl meningococcal group B polysaccharide. Infect Immun 73 (2005) 2123-2128
40. Moe G.R., Dave A., and Granoff D.M. Molecular analysis of anti-N-propionyl Neisseria meningitidis group B polysaccharide monoclonal antibodies. Mol Immunol 43 (2006) 1424-1431
41. Li H., Li B., Song H., Breydo L., Baskakov I.V., and Wang L.X. Chemoenzymatic synthesis of HIV-1 V3 glycopeptides carrying two N-glycans and effects of glycosylation on the peptide domain. J Org Chem 70 (2005) 9990-9996
42. Li H., Singh S., Zeng Y., Song H., and Wang L.X. Chemoenzymatic synthesis of CD52 glycoproteins carrying native N-glycans. Bioorg Med Chem Lett 15 (2005) 895-898
43. Wang L.X., Song H., Liu S., Lu H., Jiang S., Ni J., et al. Chemoenzymatic synthesis of HIV-1 gp41 glycopeptides: effects of glycosylation on the anti-HIV activity and alpha-helix bundle-forming ability of peptide C34. Chem Biochem 6 (2005) 1068-1174
44. Livingston P.O., and Ragupathi G. Cancer vaccines targeting carbohydrate antigens. Hum Vac 2 (2006) 137-143
45. Zou W., Borrelli S., Gilbert M., Liu T., Pon R.A., and Jennings H.J. Bioengineering of surface GD3 ganglioside for immunotargeting human melanoma cells. J Biol Chem 279 (2004) 25390-25399
46. Feizi T. The antigens Ii, SSEA-1 and ABH are in interrelated system of carbohydrate differentiation antigens expressed on glycosphingolipids and glycoproteins. Adv Exp Med Biol 152 (1982) 167-177
47. Hakomori S. Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspectives. Cancer Res 45 6 (1985) 2405-2414
48. Focarelli R., La Sala G.B., Balasini M., and Rosati F. Carbohydrate-mediated sperm-egg interaction and species specificity: a clue from the Unio elongatulus model. Cells Tissues Organs 168 1/2 (2001) 76-81
49. Crocker P.R., and Feizi T. Carbohydrate recognition systems: functional triads in cell-cell interactions. Curr Opin Struct Biol 6 5 (1996) 679-691
50. Heidelberger M., and Avery O.T. The soluble specific substance of pneumococcus. J Exp Med 38 (1923) 73-80
51. Dochez A.R., and Avery O.T. The elaboration of specific soluble substance by pneumococcus during growth. J Exp Med 26 (1917) 477-493
52. Ezzell Jr. J.W., Abshire T.G., Little S.F., Lidgerding B.C., and Brown C. Identification of Bacillus anthracis by using monoclonal antibody to cell wall galactose-N-acetylglucosamine polysaccharide. J Clin Microbiol 28 2 (1990) 223-231
53. Robbins J.B., and Schneerson R. Polysaccharide-protein conjugates: a new generation of vaccines. J Infect Dis 161 (1990) 821-832
54. Mond J.J., Lees A., and Snapper C.M. T cell-independent antigens type 2. Annu Rev Immunol (1995) 655-692
55. Wang D., and Kabat E.A. Carbohydrate antigens (polysaccharides). In: Regenmortal M.H.V.V. (Ed). Structure of Antigens (1996), CRC Press, Boca Raton/New York/London/Tokyo 247-276
56. Wang D., Liu S., Trummer B.J., Deng C., and Wang A. Carbohydrate microarrays for the recognition of cross-reactive molecular markers of microbes and host cells. Nat Biotechnol 20 3 (2002) 275-281
57. Willats W.G., Rasmussen S.E., Kristensen T., Mikkelsen J.D., and Knox J.P. Sugar-coated microarrays: a novel slide surface for the high-throughput analysis of glycans. Proteomics 2 December (12) (2002) 1666-1671
58. Fazio F., Bryan M.C., Blixt O., Paulson J.C., and Wong C.H. Synthesis of sugar arrays in microtiter plate. J Am Chem Soc 124 December 4 (48) (2002) 14397-14402
59. Fukui S., Feizi T., Galustian C., Lawson A.M., and Chai W. Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions. Nat Biotechnol 20 October (10) (2002) 1011-1017
60. Houseman B.T., and Mrksich M. Carbohydrate arrays for the evaluation of protein binding and enzymatic modification. Chem Biol 9 April (4) (2002) 443-454
61. Park S., and Shin I. Fabrication of carbohydrate chips for studying protein-carbohydrate interactions. Angew Chem Int Ed Engl 41 September 2 (17) (2002) 3180-3182
62. Adams E.W., Ratner D.M., Bokesch H.R., McMahon J.B., O'Keefe B.R., and Seeberger P.H. Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology: glycan-dependent gp120/protein interactions. Chem Biol 11 June (6) (2004) 875-881
63. Wang D., and Lu J. Glycan arrays lead to the discovery of autoimmunogenic activity of SARS-CoV. Physiol Genomics 18 July 8 (2) (2004) 245-248
64. Wang D., Carroll G.T., Turro N.J., Koberstein J.T., Kovac P., Saksena R., et al. Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium. Proteomics 7 January (2) (2007) 180-184
65. Zhou X., and Zhou J. Oligosaccharide microarrays fabricated on aminooxyacetyl functionalized glass surface for characterization of carbohydrate-protein interaction. Biosens Bioelectron 21 8 (2006) 1451-1458
66. Ekins R., Chu F., and Biggart E. Multispot, multianalyte, immunoassay. Ann Biol Clin 48 9 (1990) 655-666
67. Wang D. Carbohydrate microarrays. Proteomics 3 (2003) 2167-2175
68. Wang D. Carbohydrate antigens. In: Meyers R.A. (Ed). Encyclopedia of Molecular Cell Biology and Molecular Medicine, II (2004) 277-301
69. Heidelberger M., Davie J.M., and Krause R.M. Cross-reactions of the group-specific polysaccharides of streptococcal groups B and G in anti-pneumococcal sera with especial reference to type 23 and its determinants. J Immunol 99 4 (1967) 794-796
70. Daubenspeck J.M., Zeng H., Chen P., Dong S., Steichen C.T., Krishna N.R., et al. Novel oligosaccharide side chains of the collagen-like region of BclA, the major glycoprotein of the Bacillus anthracis exosporium. J Biol Chem 279 July 23 (30) (2004) 30945-30953
71. Sylvestre P., Couture-Tosi E., and Mock M. A collagen-like surface glycoprotein is a structural component of the Bacillus anthracis exosporium. Mol Microbiol 45 July (1) (2002) 169-178
72. Saksena R., Adamo R., and Kovac P. Studies toward a conjugate vaccine for anthrax. Synthesis and characterization of anthrose [4,6-dideoxy-4-(3-hydroxy-3-methylbutanamido)-2-O-methyl-d-glucopyranose] and its methyl glycosides. Carbohydr Res 340 July 4 (9) (2005) 1591-1600
73. Adamo R., Saksena R., and Kovac P. Synthesis of the beta anomer of the spacer-equipped tetrasaccharide side chain of the major glycoprotein of the Bacillus anthracis exosporium. Carbohydr Res 340 December 12 (17) (2005) 2579-2582
74. Saksena R., Adamo R., and Kovac P. Synthesis of the tetrasaccharide side chain of the major glycoprotein of the Bacillus anthracis exosporium. Bioorg Med Chem Lett 16 February (3) (2006) 615-617
75. Tamborrini M., Werz D.B., Frey J., Pluschke G., and Seeberger P.H. Anti-carbohydrate antibodies for the detection of anthrax spores. Angew Chem Int Ed Engl 45 October 6 (39) (2006) 6581-6582
76. Werz D.B., and Seeberger P.H. Total synthesis of antigen Bacillus anthracis tetrasaccharide-creation of an anthrax vaccine candidate. Angew Chem Int Ed Engl 44 October 7 (39) (2005) 6315-6318
77. Mehta A.S., Saile E., Zhong W., Buskas T., Carlson R., Kannenberg E., et al. Synthesis and antigenic analysis of the BclA glycoprotein oligosaccharide from the Bacillus anthracis exosporium. Chemistry (Weinheim an der Bergstrasse, Germany) 12 December 13 (36) (2006) 9136-9149
78. Love K.R., and Seeberger P.H. Carbohydrate arrays as tools for glycomics. Angew Chem Int Ed Engl 41 October 4 (19) (2002) 3583-3586 13
79. Disney M.D., and Seeberger P.H. Aminoglycoside microarrays to explore interactions of antibiotics with RNAs and proteins. Chemistry (Weinheim an der Bergstrasse, Germany) 10 July 5 (13) (2004) 3308-3314
80. Horlacher T., and Seeberger P.H. The utility of carbohydrate microarrays in glycomics. Omics 10 Winter (4) (2006) 490-498
81. Seeberger P.H., and Werz D.B. Synthesis and medical applications of oligosaccharides. Nature 446 April 26 (7139) (2007) 1046-1051
82. Case D.A., Cheatham III T., Darden T., Gohlke H., Luo R., Merz K.M., et al. The Amber biomolecular simulation program. J Comput Chem 26 (2005) 1668-1688
83. Kirschner K.N., Yongye A.B., Gonzalez-Outeirino J., Tschampel S.M., Daniels C.R., Foley B.L., et al. GLYCAM06: a generalizable biomolecular force field. Carbohydr J Comput Chem 29 (2008) 622-655
84. Okur A., Wickstrom L., Layten M., Geney R., Song K., Hornak V., et al. Chem Theory Comput 2 (2006) 420-433
85. Brisson J.R., Baumann H., Imberty A., Perez S., and Jennings H.J. Helical epitope of the group B meningococcal alpha(208)-linked sialic acid polysaccharide. Biochemistry 31 (1992) 4996-5004
86. Michon F., Brisson J.R., and Jennings H.J. Conformational differences between linear alpha(2-8)-linked homosialooligosaccharides and the epitope of the group B meningococcal polysaccharide. Biochemistry 26 (1987) 8399-8405
87. Vyas N.K., Vyas M.N., Chervenak M.C., Johnson M.A., Pinto B.M., Bundle D.R., et al. Molecular recognition of oligosaccharide epitopes by a monoclonal Fab specific for Shigella flexneri Y lipooligosaccharide: X-ray crystal structures and thermodynamics. Biochemistry 41 (2002) 13575-13586
88. Morris, G.M., Goodsell, D.S., Huey, R., Hart, W.E., Halliday, R.S., Belew, R.K., Olson, A.J. Autodock 3.0.5. The Scripps Research Institute, CA, USA, 2001.
89. Petrovsky N. Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity. Vaccine 24 April 12 (Suppl. 2) (2006) S2-26-9 [Review]
90. Silva D.G., Cooper P.D., and Petrovsky N. Inulin-derived adjuvants efficiently promote both Th1 and Th2 immune responses. Immunol Cell Biol 82 December (6) (2004) 611-616 [Review]
91. Taper H.S., and Roberfroid M.B. Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice. Vaccine 25 December 17 (52) (2007) 8707-8717
92. Taper H.S., and Roberfroid M.B. Non-toxic potentiation of cancer radiotherapy by dietary oligofructose or inulin. Anticancer Res 22 November/December (6A) (2002) 3319-3323
93. Korbelik M., and Cooper P.D. Potentiation of photodynamic therapy of cancer by complement: the effect of gamma-inulin. Br J Cancer 96 January 15 (1) (2007) 67-72
94. Taper H.S., and Roberfroid M.B. Possible adjuvant cancer therapy by two prebiotics-inulin or oligofructose. In Vivo 19 January/February (1) (2005) 201-204
95. Li J., Cox A.D., Hood D.W., Schweda E.K., Moxon E.R., and Richards J.C. Electrophoretic and mass spectrometric strategies for profiling bacterial lipopolysaccharides. Mol Biosyst 1 May (1) (2005) 46-52
96. Logan S.M., Chen W., Aubry A., Gidney M.A., Lacelle S., St. Michael F., et al. Production of a d-glycero-d-manno-heptosyltransferase mutant of Mannheimia haemolytica displaying a veterinary pathogen specific conserved LPS structure; development and functionality of antibodies to this LPS structure. Vet Microbiol 116 August 25 (1-3) (2006) 175-186
97. St Michael F., Inzana T.J., and Cox A.D. Structural analysis of the lipooligosaccharide-derived oligosaccharide of Histophilus somni (Haemophilus somnus) strain 8025. Carbohydr Res 341 February 6 (2) (2006) 281-284
98. Griffin R., Cox A.D., Makepeace K., Richards J.C., Moxon E.R., and Hood D.W. Elucidation of the monoclonal antibody 5G8-reactive, virulence-associated lipopolysaccharide epitope of Haemophilus influenzae and its role in bacterial resistance to complement-mediated killing. Infect Immun 73 April (4) (2005) 2213-2221
99. Thomas P.G., and Harn Jr. D.A. Immune biasing by helminth glycans. Cell Microbiol 6 January (1) (2004) 13-22 [Review]
100. Birmann B.M., Mueller N.E., Okayama A., Hsieh C.C., Tsubouchi H., Harn D., et al. LNFPIII/LeX-stimulated macrophages activate natural killer cells via CD40-CD40L interaction. Clin Diagn Lab Immunol 12 September (9) (2005) 1041-1049
101. Da'Dara A.A., Lautsch N., Dudek T., Novitsky V., Lee T.H., Essex M., et al. Helminth infection suppresses T-cell immune response to HIV-DNA-based vaccine in mice. Vaccine 24 June 12 (24) (2006) 5211-5219
102. Thomas P.G., Carter M.R., Da'dara A.A., DeSimone T.M., and Harn D.A. A helminth glycan induces APC maturation via alternative NF-kappa B activation independent of I kappa B alpha degradation. J Immunol 175 August 15 (4) (2005) 2082-2090
103. Atochina O., and Harn D. Prevention of psoriasis-like lesions development in fsn/fsn mice by helminth glycans. Exp Dermatol 15 June (6) (2006) 461-468
104. Awomoyi A.A., Rallabhandi P., Pollin T.I., Lorenz E., Sztein M.B., Boukhvalova M.S., et al. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J Immunol 179 September 1 (5) (2007) 3171-3177
105. Castigli E., Scott S., Dedoglu F., Bryce P., Jabara H., Bhan A.K., et al. Impaired class switching in APRIL-deficient mice. Proc Natl Acad Sci USA 16 (2004) 3903-3908
106. Schneider P., MacKay F., Steiner V., Hofmann K., Bodmer J.L., Holler N., et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 189 (1999) 1747-1756
107. Castigli E., Wilson S.A., Garibyan L., Rachid R., Bonilla F., Schneider L., et al. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet 37 (2005) 829-834
108. Kaur K., Chowdhury S., Greenspan N.S., and Schreiber J.R. Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates. Blood 110 October 15 (8) (2007) 2948-2954
109. Katsenelson N., Kanswal S., Puig M., Mostowski H., Verthelyi D., and Akkoyunlu M. Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion. Eur J Immunol 37 July (7) (2007) 1785-1795