Analyzing thioflavin t binding to amyloid fibrils by an equilibrium microdialysis-based technique

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Kuznetsova, Irina M ^a   Sulatskaya, Anna I ^a   Uversky, Vladimir N ^b,c   Turoverov, Konstantin K ^a  

^a INSTITUTE OF CYTOLOGY   (Russian Federation)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c INSTITUTE FOR BIOLOGICAL INSTRUMENTATION   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; THIOFLAVINE; BENZOTHIAZOLE DERIVATIVE; COLORING AGENT; FLUORESCENT DYE; INSULIN; LIGAND; THIAZOLE DERIVATIVE;

ABSORPTION SPECTROSCOPY; ARTICLE; BINDING ASSAY; CONCENTRATION PROCESS; CONTROLLED STUDY; EQUILIBRIUM MICRODIALYSIS; FLUORESCENCE ANALYSIS; MICRODIALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; QUANTUM YIELD; RECEPTOR BINDING; STOICHIOMETRY; BINDING SITE; CHEMISTRY; HUMAN; KINETICS; METHODOLOGY; REGRESSION ANALYSIS; SPECTROFLUOROMETRY; SPECTROPHOTOMETRY; STATISTICAL MODEL; TIME;

AMYLOID; BENZOTHIAZOLES; BINDING SITES; COLORING AGENTS; FLUORESCENT DYES; HUMANS; INSULIN; KINETICS; LIGANDS; MICRODIALYSIS; MODELS, STATISTICAL; PROTEIN BINDING; REGRESSION ANALYSIS; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY; THIAZOLES; TIME FACTORS;

EID: 84857510553     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030724     Document Type: Article

References (31)

1. LeVine H 3rd, (1993) Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci 2: 404-410.
2. LeVine H 3rd, (1999) Quantification of beta-sheet amyloid fibril structures with thioflavin T. Methods Enzymol 309: 274-284.
3. De Ferrari GV, Mallender WD, Inestrosa NC, Rosenberry TL, (2001) Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites. J Biol Chem 276: 23282-23287.
4. Sen P, Fatima S, Ahmad B, Khan RH, (2009) Interactions of thioflavin T with serum albumins: spectroscopic analyses. Spectrochim Acta A Mol Biomol Spectrosc 74: 94-99.
5. Maskevich AA, Stsiapura VI, Kuzmitsky VA, Kuznetsova IM, Povarova OI, et al. (2007) Spectral properties of thioflavin T in solvents with different dielectric properties and in a fibril-incorporated form. J Proteome Res 6: 1392-1401.
6. Voropay ES, Samtsov MP, Kaplevsky KN, Maskevich AA, Stepuro VI, et al. (2003) Spectral properties of Thioflavin T and its complexes with amyloid fibrils. J Appl Spectrosc 70: 868-874.
7. Turoverov KK, Kuznetsova IM, Maskevich AA, Stepuro VI, Kuzmitsky VA, et al. (2007) Tht as an instrument for testing and investigation of amyloid and amyloid-like fibrils. Proc of SPIE 6733: 1-7.
8. Sulatskaya AI, Kuznetsova IM, Maskevich AA, Uversky VN, Turoverov KK, (2010) Non-radiative deactivation of the excited state of thioflavin T: Dependence on solvent viscosity and temperature. PLoS ONE 5: e15385.
9. Stsiapura VI, Maskevich AA, Kuzmitsky VA, Turoverov KK, Kuznetsova IM, (2007) Computational study of thioflavin T torsional relaxation in the excited state. J Phys Chem A 111: 4829-4835.
10. Krebs MR, Bromley EH, Donald AM, (2005) The binding of thioflavin-T to amyloid fibrils: localisation and implications. J Struct Biol 149: 30-37.
11. Loksztejn A, Dzwolak W, (2008) Chiral bifurcation in aggregating insulin: an induced circular dichroism study. J Mol Biol 379: 9-16.
12. Tycko R, (2004) Progress towards a molecular-level structural understanding of amyloid fibrils. Curr Opin Struct Biol 14: 96-103.
13. Qiang W, Yau WM, Tycko R, (2011) Structural evolution of Iowa mutant beta-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth. J Am Chem Soc 133: 4018-4029.
14. Tycko R, (2011) Solid-state NMR studies of amyloid fibril structure. Annu Rev Phys Chem 62: 279-299.
15. Wu C, Biancalana M, Koide S, Shea JE, (2009) Binding Modes of Thioflavin-T to the Single-Layer beta-Sheet of the Peptide Self-Assembly Mimics. J Mol Biol 394: 627-633.
16. Biancalana M, Makabe K, Koide A, Koide S, (2009) Molecular mechanism of thioflavin-T binding to the surface of beta-rich peptide self-assemblies. J Mol Biol 385: 1052-1063.
17. Biancalana M, Koide S, (2010) Molecular mechanism of Thioflavin-T binding to amyloid fibrils. Biochim Biophys Acta 1804: 1405-1412.
18. Groenning M, (2009) Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils-current status. J Chem Biol 3: 1-18.
19. Morimoto K, Kawabata K, Kunii S, Hamano K, Saito T, et al. (2009) Characterization of type I collagen fibril formation using thioflavin T fluorescent dye. J Biochem 145: 677-684.
20. Sabate R, Lascu I, Saupe SJ, (2008) On the binding of Thioflavin-T to HET-s amyloid fibrils assembled at pH 2. J Struct Biol 162: 387-396.
21. Ye L, Velasco A, Fraser G, Beach TG, Sue L, et al. (2008) In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain. J Neurochem 105: 1428-1437.
22. Sutharsan J, Dakanali M, Capule CC, Haidekker MA, Yang J, et al. (2010) Rational design of amyloid binding agents based on the molecular rotor motif. ChemMedChem 5: 56-60.
23. Dzwolak W, Pecul M, (2005) Chiral bias of amyloid fibrils revealed by the twisted conformation of Thioflavin T: an induced circular dichroism/DFT study. FEBS Lett 579: 6601-6603.
24. Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, et al. (2003) The binding of 2-(4′-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci 23: 2086-2092.
25. Mathis CA, Wang Y, Holt DP, Huang GF, Debnath ML, et al. (2003) Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem 46: 2740-2754.
26. Lockhart A, Ye L, Judd DB, Merritt AT, Lowe PN, et al. (2005) Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils. J Biol Chem 280: 7677-7684.
27. Henriksen G, Hauser AI, Westwell AD, Yousefi BH, Schwaiger M, et al. (2007) Metabolically stabilized benzothiazoles for imaging of amyloid plaques. J Med Chem 50: 1087-1089.
28. Ono M, (2009) Development of positron-emission tomography/single-photon emission computed tomography imaging probes for in vivo detection of beta-amyloid plaques in Alzheimer's brains. Chem Pharm Bull (Tokyo) 57: 1029-1039.
29. Goers J, Permyakov SE, Permyakov EA, Uversky VN, Fink AL, (2002) Conformational prerequisites for alpha-lactalbumin fibrillation. Biochemistry 41: 12546-12551.
30. Turoverov KK, Biktashev AG, Dorofeiuk AV, Kuznetsova IM, (1998) [A complex of apparatus and programs for the measurement of spectral, polarization and kinetic characteristics of fluorescence in solution]. Tsitologiia 40: 806-817.
31. Sulatskaya AI, Kuznetsova IM, Turoverov KK, (2011) Interaction of thioflavin T with amyloid fibrils: stoichiometry and affinity of dye binding, absorption spectra of bound dye. J Phys Chem B 115: 11519-11524.