First report on development of quantitative interspecies structure-carcinogenicity relationship models and exploring discriminatory features for rodent carcinogenicity of diverse organic chemicals using OECD guidelines

Chemosphere

Volumn 87, Issue 4, 2012, Pages 339-355

  Kar, Supratik ^a   Roy, Kunal ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

Carcinogenicity; Chemicals; Interspecies correlation; Organization for Economic Cooperation and Development; Quantitative structure activity relationship

Indexed keywords

CHEMICAL CONTAMINATION; CHEMICALS; COMPUTATIONAL CHEMISTRY; DISCRIMINATORS; ECONOMIC AND SOCIAL EFFECTS; INDICATORS (CHEMICAL); INDUSTRIAL CHEMICALS; MOLECULAR GRAPHICS; RATS; STRUCTURES (BUILT OBJECTS); TOXICITY; UNCERTAINTY ANALYSIS;

BIOLOGICAL MECHANISMS; CARCINOGENIC POTENTIAL; CARCINOGENICITY; FOOD AND DRUG ADMINISTRATION; INTERSPECIES CORRELATIONS; ORGANIZATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS;

ORGANIC CHEMICALS;

1,1,1,2 TETRACHLOROETHANE; 1,2 DICHLOROPROPANE; AZATHIOPRINE; BENZALDEHYDE; CARBAZOLE DERIVATIVE; CHLORDANE; CHLOROBENZILATE; CRYSTAL VIOLET; CYCLOCHLOROTINE; DIBROMOCHLOROMETHANE; DICOFOL; DIMETHYLCARBAMOYL CHLORIDE; FUROSEMIDE; GRISEOFULVIN; HEPTACHLOR; LINDANE; MESYLIC ACID METHYL ESTER; NAPHTHALENE; NICOTINOHYDRAZIDE; ORGANIC COMPOUND; OXAZEPAM; PENTACHLOROETHANE; PIPERONYL SULPHOXIDE; STIROFOS; TRIAMTERENE; TRICHLOROETHYLENE; TRIFLURALIN; TRIMETHYL PHOSPHATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZEARALENONE;

CARCINOGEN; DISCRIMINANT ANALYSIS; ENVIRONMENTAL PROTECTION; ESTIMATION METHOD; FRAGMENTATION; HEALTH RISK; IDENTIFICATION METHOD; MOLECULAR ANALYSIS; NUMERICAL MODEL; OECD; POLLUTION EXPOSURE; QUANTITATIVE ANALYSIS; RODENT; SENSITIVITY ANALYSIS; UNCERTAINTY ANALYSIS;

ARTICLE; CARCINOGENICITY; MODEL; MOUSE; NONHUMAN; PREDICTION; QUANTITATIVE INTERSPECIE STRUCTURE CARCINOGENICITY CORRELATION MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

RATTUS; RODENTIA;

EID: 84857500640     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2011.12.019     Document Type: Article

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