EDD induces cell cycle arrest by increasing p53 levels

Cell Cycle

Volumn 11, Issue 4, 2012, Pages 715-720

  Smits, Veronique A J ^a  

^a HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

Author keywords

Cell cycle arrest; EDD; hHyd; p53; Senescence; UBR5

Indexed keywords

EDD PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GENE DELETION; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN STABILITY;

EID: 84857496778     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.11.4.19154     Document Type: Article

References (37)

1. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408:307-10; PMID:11099028; http://dx.doi.org/10.1038/35042675.
2. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991; 51:6304-11; PMID:1933891.
3. Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 2000; 275:8945-51; PMID:10722742; http://dx.doi. org/10.1074/jbc.275.12.8945.
4. Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997; 387:296-9; PMID:9153395; http://dx.doi.org/10.1038/387296a0.
5. Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 1997; 387:299-303; PMID:9153396; http://dx.doi.org/10.1038/387299a0.
6. Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O, et al. ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev 2001; 15:1067-77; PMID:11331603; http://dx.doi.org/10. 1101/gad.886901.
7. Shieh SY, Ikeda M, Taya Y, Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 1997; 91:325-34; PMID:9363941; http://dx.doi.org/10.1016/S0092-8674(00)80416-X.
8. Unger T, Juven-Gershon T, Moallem E, Berger M, Vogt Sionov R, Lozano G, et al. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J 1999; 18:1805-14; PMID:10202144; http://dx.doi.org/10.1093/emboj/ 18.7.1805.
9. Kruse JP, Gu W. SnapShot: p53 posttranslational modifications. Cell 2008; 133:930; PMID:18510935; http://dx.doi.org/10.1016/j.cell.2008.05.020.
10. Mansfield E, Hersperger E, Biggs J, Shearn A. Genetic and molecular analysis of hyperplastic discs, a gene whose product is required for regulation of cell proliferation in Drosophila melanogaster imaginal discs and germ cells. Dev Biol 1994; 165:507-26; PMID:7958417; http://dx.doi.org/10.1006/dbio.1994. 1271.
11. Saunders DN, Hird SL, Withington SL, Dunwoodie SL, Henderson MJ, Biben C, et al. Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. Mol Cell Biol 2004; 24:7225-34; PMID:15282321; http://dx.doi. org/10.1128/MCB.24.16.7225-34.2004.
12. Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J. Characterization of the interactome of the human MutL homologues MLH1, PMS1 and PMS2. J Biol Chem 2007; 282:2976-86; PMID:17148452; http://dx.doi.org/10.1074/jbc.M609989200.
13. Henderson MJ, Munoz MA, Saunders DN, Clancy JL, Russell AJ, Williams B, et al. EDD mediates DNA damage-induced activation of CHK2. J Biol Chem 2006; 281:39990-40000; PMID:17074762; http://dx.doi.org/10.1074/jbc.M602818200.
14. Munoz MA, Saunders DN, Henderson MJ, Clancy JL, Russell AJ, Lehrbach G, et al. The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints. Cell Cycle 2007; 6:3070-7; PMID:18073532; http://dx.doi.org/10. 4161/cc.6.24.5021.
15. Huibregtse JM, Scheffner M, Beaudenon S, Howley PM. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci USA 1995; 92:5249; PMID:7761480; http://dx.doi.org/10.1073/ pnas.92.11.5249a.
16. Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, et al. A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. Mol Cell Biol 2005; 25:7120-36; PMID:16055722; http://dx.doi.org/10.1128/MCB.25.16.7120-36.2005.
17. Honda Y, Tojo M, Matsuzaki K, Anan T, Matsumoto M, Ando M, et al. Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response. J Biol Chem 2002; 277:3599-605; PMID:11714696; http://dx.doi.org/10.1074/jbc.M104347200.
18. Clancy JL, Henderson MJ, Russell AJ, Anderson DW, Bova RJ, Campbell IG, et al. EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer. Oncogene 2003; 22:5070-81; PMID:12902990; http://dx.doi. org/10.1038/sj.onc.1206775.
19. Mori Y, Sato F, Selaru FM, Olaru A, Perry K, Kimos MC, et al. Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers. Cancer Res 2002; 62:3641-5; PMID:12097267.
20. Dulić V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, et al. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 1994; 76:1013-23; PMID:8137420; http://dx.doi.org/10.1016/0092-8674(94)90379-4.
21. Bringold F, Serrano M. Tumor suppressors and oncogenes in cellular senescence. Exp Gerontol 2000; 35:317-29; PMID:10832053; http://dx.doi. org/10.1016/S0531-5565(00)00083-8.
22. Demidenko ZN, Korotchkina LG, Gudkov AV, Blagosklonny MV. Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci USA 2010; 107:9660-4; PMID:20457898; http://dx.doi. org/10.1073/pnas.1002298107.
23. Korotchkina LG, Leontieva OV, Bukreeva EI, Demidenko ZN, Gudkov AV, Blagosklonny MV. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY) 2010; 2:344-52; PMID:20606252.
24. Leontieva OV, Gudkov AV, Blagosklonny MV. Weak p53 permits senescence during cell cycle arrest. Cell Cycle 2010; 9:4323-7; PMID:21051933; http://dx.doi.org/10.4161/cc.9.21.13584.
25. Ling S, Lin WC. EDD inhibits ATM-mediated phosphorylation of p53. J Biol Chem 2011; 286:14972- 82; PMID:21383020; http://dx.doi.org/10.1074/jbc. M110.182527.
26. Watts CK, Saunders DN. Effects of EDD on p53 function are context-specific. J Biol Chem 2011; 286:13-4; PMID:21757764; http://dx.doi.org/10.1074/jbc. L110.182527.
27. Henderson MJ, Russell AJ, Hird S, Muñoz M, Clancy JL, Lehrbach GM, et al. EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J Biol Chem 2002; 277:26468-78; PMID:12011095; http://dx.doi.org/10.1074/jbc. M203527200.
28. Yoshida M, Yoshida K, Kozlov G, Lim NS, De Crescenzo G, Pang Z, et al. Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. EMBO J 2006; 25:1934-44; PMID:16601676; http://dx.doi.org/10. 1038/sj.emboj.7601079.
29. Hu G, Wang X, Saunders DN, Henderson M, Russell AJ, Herring BP, et al. Modulation of myocardin function by the ubiquitin E3 ligase UBR5. J Biol Chem 2010; 285:11800-9; PMID:20167605; http://dx.doi. org/10.1074/jbc.M109.079384.
30. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992; 356:215-21; PMID:1552940; http://dx.doi.org/ 10.1038/356215a0.
31. Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, et al. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 2002; 416:648-53; PMID:11923872; http://dx.doi.org/10.1038/nature737.
32. Yuan J, Luo K, Zhang L, Cheville JC, Lou Z. USP10 regulates p53 localization and stability by deubiquitinating p53. Cell 2010; 140:384-96; PMID:20096447; http://dx.doi.org/10.1016/j.cell.2009.12.032.
33. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism and function. Cell 2004; 116:281-97; PMID:14744438; http://dx.doi.org/10.1016/S0092-8674(04)00045- 5.
34. Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, et al. MicroRNA-125b is a novel negative regulator of p53. Genes Dev 2009; 23:862-76; PMID:19293287; http://dx.doi.org/10.1101/gad.1767609.
35. Hu W, Chan CS, Wu R, Zhang C, Sun Y, Song JS, et al. Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell 2010; 38:689-99; PMID:20542001; http://dx.doi.org/10.1016/j.molcel. 2010.05.027.
36. Su H, Meng S, Lu Y, Trombly MI, Chen J, Lin C, et al. Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing. Mol Cell 2011; 43:97-109; PMID:21726813; http://dx.doi. org/10.1016/j.molcel.2011.06. 013.
37. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, 3rd, Hurov KE, Luo J, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007; 316:1160-6; PMID:17525332; http://dx.doi.org/10.1126/science. 1140321.