Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions

Science Translational Medicine

Volumn 4, Issue 122, 2012, Pages

  Solyom, Szilvia ^a,h   Aressy, Bernadette ^b   Pylkäs, Katri ^a   Patterson Fortin, Jeffrey ^b,c   Hartikainen, Jaana M ^d,e   Kallioniemi, Anne ^f   Kauppila, Saila ^a   Nikkilä, Jenni ^a   Kosma, Veli Matti ^d,e   Mannermaa, Arto ^d,e   Greenberg, Roger A ^b,g   Winqvist, Robert ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

^e KUOPIO UNIVERSITY HOSPITAL   (Finland)

^f TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; CARRIER PROTEIN; FAM175A PROTEIN, HUMAN;

ABRAXAS GENE; ADULT; ARTICLE; BREAST CANCER; CANCER PATIENT; CANCER SUSCEPTIBILITY; COHORT ANALYSIS; CONTROLLED STUDY; DNA DAMAGE; DNA SPLICING; FAMILIAL CANCER; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENETIC CODE; GENETIC CONSERVATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NUCLEAR LOCALIZATION SIGNAL; ONCOGENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BREAST TUMOR; CELL NUCLEUS; CHEMISTRY; DOUBLE STRANDED DNA BREAK; FINLAND; GENETIC SCREENING; GENETICS; HETEROZYGOTE; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PEDIGREE; PROTEIN TRANSPORT; TUMOR CELL LINE;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; BREAST NEOPLASMS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; FEMALE; FINLAND; GENETIC TESTING; HETEROZYGOTE; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; PEDIGREE; PROTEIN TRANSPORT;

EID: 84857488162     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003223     Document Type: Article

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