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Volumn 3, Issue 5, 2011, Pages 255-266

Novel treatments for systemic lupus erythematosus

Author keywords

anticytokine therapies; B cells; biologics; lupus; systemic lupus erythematosus

Indexed keywords

ABATACEPT; AIN 457; ALPHA INTERFERON; AMG 811; ATACICEPT; AZATHIOPRINE; BELIMUMAB; CD40 LIGAND MONOCLONAL ANTIBODY; CYTOKINE ANTIBODY; EPRATUZUMAB; ETANERCEPT; INDUCIBLE T CELL COSTIMULATOR LIGAND; INFLIXIMAB; INTERFERON ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 6; IXEKIZUMAB; JANUS KINASE 3; METHOTREXATE; MONOCLONAL ANTIBODY; OCRELIZUMAB; PLACEBO; RAPAMYCIN; RONTALIZUMAB; SIFALIMUMAB; TOCILIZUMAB; TOFACITINIB; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84857469048     PISSN: 1759720X     EISSN: 17597218     Source Type: Journal    
DOI: 10.1177/1759720X11415456     Document Type: Review
Times cited : (16)

References (76)
  • 2
    • 79953294697 scopus 로고    scopus 로고
    • Immunologic reconstitution after rituximab in systemic lupus erythematosus: why should we care?
    • Anolik J. (2011) Immunologic reconstitution after rituximab in systemic lupus erythematosus: why should we care? J Rheumatol 38: 587–589.
    • (2011) J Rheumatol , vol.38 , pp. 587-589
    • Anolik, J.1
  • 3
    • 5644258326 scopus 로고    scopus 로고
    • Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study
    • Aringer M. Graninger W.B. Steiner G. Smolen J.S. (2004) Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study. Arthritis Rheum 50: 3161–3169.
    • (2004) Arthritis Rheum , vol.50 , pp. 3161-3169
    • Aringer, M.1    Graninger, W.B.2    Steiner, G.3    Smolen, J.S.4
  • 4
    • 73349117550 scopus 로고    scopus 로고
    • Adverse events and efficacy of TNF-alpha blockade with infliximab in patients with systemic lupus erythematosus: long-term follow-up of 13 patients
    • Aringer M. Houssiau F. Gordon C. Graninger W.B. Voll R.E. Rath E. et al (2009) Adverse events and efficacy of TNF-alpha blockade with infliximab in patients with systemic lupus erythematosus: long-term follow-up of 13 patients. Rheumatology (Oxford) 48: 1451–1454.
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 1451-1454
    • Aringer, M.1    Houssiau, F.2    Gordon, C.3    Graninger, W.B.4    Voll, R.E.5    Rath, E.6
  • 5
    • 13444266045 scopus 로고    scopus 로고
    • Cytokine expression in lupus kidneys
    • Aringer M. Smolen J.S. (2005) Cytokine expression in lupus kidneys. Lupus 14: 189–191.
    • (2005) Lupus , vol.14 , pp. 189-191
    • Aringer, M.1    Smolen, J.S.2
  • 7
    • 43949092440 scopus 로고    scopus 로고
    • An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus
    • Bahjat F.R. Pine P.R. Reitsma A. Cassafer G. Baluom M. Grillo S. et al (2008) An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum 58: 1433–1444.
    • (2008) Arthritis Rheum , vol.58 , pp. 1433-1444
    • Bahjat, F.R.1    Pine, P.R.2    Reitsma, A.3    Cassafer, G.4    Baluom, M.5    Grillo, S.6
  • 8
    • 0034533825 scopus 로고    scopus 로고
    • Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
    • Bengtsson A. Sturfelt G. Truedsson L. Blomberg J. Alm G. Vallin H. et al (2000) Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus 9: 664–671.
    • (2000) Lupus , vol.9 , pp. 664-671
    • Bengtsson, A.1    Sturfelt, G.2    Truedsson, L.3    Blomberg, J.4    Alm, G.5    Vallin, H.6
  • 9
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Erratum J AM: Med Assoc 295: 2482
    • Bongartz T. Sutton A.J. Sweeting M.J. Buchan I. Matteson E.L. Montori V. (2006) Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. J Am Med Assoc 295: 2275–2285. Erratum J AM Med Assoc 295: 2482.
    • (2006) J Am Med Assoc , vol.295 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 11
    • 0037333857 scopus 로고    scopus 로고
    • A short course of BG 9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    • Boumpas D.T. Furie R. Manzi S. Illei G.G. Wallace D.J. Balow J.E. et al (2003) A short course of BG 9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum 48: 719–727.
    • (2003) Arthritis Rheum , vol.48 , pp. 719-727
    • Boumpas, D.T.1    Furie, R.2    Manzi, S.3    Illei, G.G.4    Wallace, D.J.5    Balow, J.E.6
  • 12
    • 0024330731 scopus 로고
    • Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury
    • Brennan D. Yui M. Wuthrich R. Kelley V. (1989) Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury. J Immunol 143: 3470–3475.
    • (1989) J Immunol , vol.143 , pp. 3470-3475
    • Brennan, D.1    Yui, M.2    Wuthrich, R.3    Kelley, V.4
  • 13
    • 43949122717 scopus 로고    scopus 로고
    • R935788: a phase II, single center, open label, efficacy and safety, ascending dose, pilot study for the treatment of adult immune thrombocytopenic purpura (ITP) [abstract]
    • Bussel J.B. Schindler A.M. Grossbard E.B. (2007) R935788: a phase II, single center, open label, efficacy and safety, ascending dose, pilot study for the treatment of adult immune thrombocytopenic purpura (ITP) [abstract]. Blood 110: 1310–1310.
    • (2007) Blood , vol.110 , pp. 1310
    • Bussel, J.B.1    Schindler, A.M.2    Grossbard, E.B.3
  • 14
    • 79952481036 scopus 로고    scopus 로고
    • Targeting B cells for the treatment of SLE: the beginning of the end or the end of the beginning?
    • Calero I. Sanz I. (2010) Targeting B cells for the treatment of SLE: the beginning of the end or the end of the beginning? Discov Med 10: 416–424.
    • (2010) Discov Med , vol.10 , pp. 416-424
    • Calero, I.1    Sanz, I.2
  • 15
    • 0036776168 scopus 로고    scopus 로고
    • A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling
    • Chen J. Fang Y. (2002) A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling. Biochem Pharmacol 64: 1071–1077.
    • (2002) Biochem Pharmacol , vol.64 , pp. 1071-1077
    • Chen, J.1    Fang, Y.2
  • 16
    • 34548223736 scopus 로고    scopus 로고
    • Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus
    • Chun H.Y. Chung J.W. Kim H.A. Yun J.M. Jeon J.Y. Ye Y.M. et al (2007) Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J Clin Immunol 27: 461–466.
    • (2007) J Clin Immunol , vol.27 , pp. 461-466
    • Chun, H.Y.1    Chung, J.W.2    Kim, H.A.3    Yun, J.M.4    Jeon, J.Y.5    Ye, Y.M.6
  • 17
    • 84857475922 scopus 로고    scopus 로고
    • Rituximab infusion-related adverse event rates are lower in patients with systemic lupus erythematosus than in those with rheumatoid arthritis
    • [ePub ahead of print]
    • Conti F. Ceccarelli F. Perricone C. Alessandri C. Conti V. Massaro L. et al (2011) Rituximab infusion-related adverse event rates are lower in patients with systemic lupus erythematosus than in those with rheumatoid arthritis. Rheumatology (Oxford) [ePub ahead of print].
    • (2011) Rheumatology (Oxford)
    • Conti, F.1    Ceccarelli, F.2    Perricone, C.3    Alessandri, C.4    Conti, V.5    Massaro, L.6
  • 18
    • 77954229590 scopus 로고    scopus 로고
    • Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice
    • Deng G. Liu L. Bahjat F.R. Pine P.R. Tsokos G.C. (2010) Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice. Arthritis Rheum 62: 2086–2092.
    • (2010) Arthritis Rheum , vol.62 , pp. 2086-2092
    • Deng, G.1    Liu, L.2    Bahjat, F.R.3    Pine, P.R.4    Tsokos, G.C.5
  • 19
    • 33747008410 scopus 로고    scopus 로고
    • British Society for Rheumatology Biologics Register Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: result from the British Society for Rheumatology Biologics Register
    • Dixon W.G. Watson K. Lunt M. Hyrich K.L. Silman A.J. Symmons D.P. (2006) British Society for Rheumatology Biologics Register Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: result from the British Society for Rheumatology Biologics Register. Arthritis Rheum 54: 2368–2376.
    • (2006) Arthritis Rheum , vol.54 , pp. 2368-2376
    • Dixon, W.G.1    Watson, K.2    Lunt, M.3    Hyrich, K.L.4    Silman, A.J.5    Symmons, D.P.6
  • 20
    • 0038281377 scopus 로고    scopus 로고
    • IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients
    • Dong G. Ye R. Shi W. Liu S. Wang T. Yang X. et al (2003) IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients. Chin Med J 116: 543–548.
    • (2003) Chin Med J , vol.116 , pp. 543-548
    • Dong, G.1    Ye, R.2    Shi, W.3    Liu, S.4    Wang, T.5    Yang, X.6
  • 21
    • 0030586573 scopus 로고    scopus 로고
    • Inhibition of superantigen-induced proinflammatory cytokine production and inflammatory arthritis in MRL-lpr/lpr mice by a transcriptional inhibitor of TNF-a
    • Edwards C.K. Zhou T. Zhang J. Baker T.J. De M. Long R.E. et al (1996) Inhibition of superantigen-induced proinflammatory cytokine production and inflammatory arthritis in MRL-lpr/lpr mice by a transcriptional inhibitor of TNF-a. J Immunol 157: 1758–1772.
    • (1996) J Immunol , vol.157 , pp. 1758-1772
    • Edwards, C.K.1    Zhou, T.2    Zhang, J.3    Baker, T.J.4    De, M.5    Long, R.E.6
  • 23
    • 33749345289 scopus 로고    scopus 로고
    • Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus
    • Fernandez D. Bonilla E. Mirza N. Niland B. Perlet A. (2006) Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus. Arthritis Rheum 54: 2983–2988.
    • (2006) Arthritis Rheum , vol.54 , pp. 2983-2988
    • Fernandez, D.1    Bonilla, E.2    Mirza, N.3    Niland, B.4    Perlet, A.5
  • 24
    • 75149150898 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in subjects with active proliferative lupus nephritis: results from the randomized, double-blind phase III LUNAR study
    • Abstract 1149
    • Furie, R., Looney, R.J., Rovin, B., Latinis, Kevin M., Appel, G., Sanchez-Guerrero, J., et al. (2009) Efficacy and safety of rituximab in subjects with active proliferative lupus nephritis: results from the randomized, double-blind phase III LUNAR study. Arthritis Rheum 60(suppl 1): S429. Abstract 1149.
    • (2009) Arthritis Rheum , vol.60 , Issue.1 , pp. S429
    • Furie, R.1    Looney, R.J.2    Rovin, B.3    Latinis, K.M.4    Appel, G.5    Sanchez-Guerrero, J.6
  • 25
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study
    • Genovese M.C. Van den Bosch F. Roberson S.A. Bojin S. Biagini I.M. Ryan P. et al (2010) LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum 62: 929–939.
    • (2010) Arthritis Rheum , vol.62 , pp. 929-939
    • Genovese, M.C.1    Van den Bosch, F.2    Roberson, S.A.3    Bojin, S.4    Biagini, I.M.5    Ryan, P.6
  • 26
    • 0032522778 scopus 로고    scopus 로고
    • receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW) F1 mice
    • Haas C. Ryffel B. Le Hir M. (1998) IFN-γ receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW)F1 mice. J Immunol 160: 3713–3718.
    • (1998) J Immunol , vol.160 , pp. 3713-3718
    • Haas, C.1    Ryffel, B.2    Le Hir, M.3
  • 27
    • 79953002735 scopus 로고    scopus 로고
    • Targeted therapies in systemic lupus erythematosus: successes, failures and future
    • Hahn B.H. (2011) Targeted therapies in systemic lupus erythematosus: successes, failures and future. Ann Rheum Dis 70(Suppl. 1): i64–i66.
    • (2011) Ann Rheum Dis , vol.70 , Issue.Suppl. 1 , pp. i64-i66
    • Hahn, B.H.1
  • 28
    • 49649119208 scopus 로고    scopus 로고
    • Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B
    • Harigai M. Kawamoto M. Hara M. Kubota T. Kamatani N. Miyasaka N. (2008) Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B. J Immunol 181: 2211–2219.
    • (2008) J Immunol , vol.181 , pp. 2211-2219
    • Harigai, M.1    Kawamoto, M.2    Hara, M.3    Kubota, T.4    Kamatani, N.5    Miyasaka, N.6
  • 30
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    • Hueber W. Patel D.D. Dryja T. Wright A.M. Koroleva I. Bruin G. et al (2010) Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med 6(2, 52): 52–72.
    • (2010) Sci Transl Med , vol.6 , Issue.2, 52 , pp. 52-72
    • Hueber, W.1    Patel, D.D.2    Dryja, T.3    Wright, A.M.4    Koroleva, I.5    Bruin, G.6
  • 31
    • 75749113331 scopus 로고    scopus 로고
    • Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study
    • Illei G.G. Shirota Y. Yarboro C.H. Daruwalla J. Tackey E. Takada K. et al (2010) Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study. Arthritis Rheum 62: 542–552.
    • (2010) Arthritis Rheum , vol.62 , pp. 542-552
    • Illei, G.G.1    Shirota, Y.2    Yarboro, C.H.3    Daruwalla, J.4    Tackey, E.5    Takada, K.6
  • 32
    • 0028081880 scopus 로고
    • Continuous administration of anti-interleukin 10 antibody delays onset of autoimmunity in NZB/W F1 mice
    • Ishida H. Muchamuel T. Sakaguchi S. Andrade S. Menon S. Howard M. (1994) Continuous administration of anti-interleukin 10 antibody delays onset of autoimmunity in NZB/W F1 mice. J Exp Med 179: 305–310.
    • (1994) J Exp Med , vol.179 , pp. 305-310
    • Ishida, H.1    Muchamuel, T.2    Sakaguchi, S.3    Andrade, S.4    Menon, S.5    Howard, M.6
  • 33
    • 0041331737 scopus 로고    scopus 로고
    • Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis
    • Iwai H. Abe M. Hirose S. Tsushima F. Tezuka K. Akiba H. et al (2003) Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 171: 2848–2854.
    • (2003) J Immunol , vol.171 , pp. 2848-2854
    • Iwai, H.1    Abe, M.2    Hirose, S.3    Tsushima, F.4    Tezuka, K.5    Akiba, H.6
  • 34
    • 0037991063 scopus 로고    scopus 로고
    • Correlation between circulating CD27 high plasma cells and disease activity in patients with systemic lupus erythematosus
    • Jacobi A.M. Odendahl M. Reiter K. Bruns A. Burmester G.R. Radbruch A. et al (2003) Correlation between circulating CD27 high plasma cells and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 48: 1332–1342.
    • (2003) Arthritis Rheum , vol.48 , pp. 1332-1342
    • Jacobi, A.M.1    Odendahl, M.2    Reiter, K.3    Bruns, A.4    Burmester, G.R.5    Radbruch, A.6
  • 35
    • 0036899589 scopus 로고    scopus 로고
    • Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial
    • Kalunian K.C. Davis J.C. Merrill J.T. Totoritis M.C. Wofsy D. (2002) Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 46: 3251–3258.
    • (2002) Arthritis Rheum , vol.46 , pp. 3251-3258
    • Kalunian, K.C.1    Davis, J.C.2    Merrill, J.T.3    Totoritis, M.C.4    Wofsy, D.5
  • 36
    • 34247551065 scopus 로고    scopus 로고
    • Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-γ and anti-double-stranded DNA antibody production
    • Kawamoto M. Harigai M. Masako Hara M. Kawaguchi Y. Tezuka K. Tanaka M. et al (2006) Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-γ and anti-double-stranded DNA antibody production. Arthritis Res Ther 8: R62–R62.
    • (2006) Arthritis Res Ther , vol.8 , pp. R62-R62
    • Kawamoto, M.1    Harigai, M.2    Masako Hara, M.3    Kawaguchi, Y.4    Tezuka, K.5    Tanaka, M.6
  • 37
    • 0028301958 scopus 로고
    • Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes
    • Kawamura M. McVicar D.W. Johnston J.A. Blake T.B. Chen Y.Q. Lal B.K. et al (1994) Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc Natl Acad Sci U S A 91: 6374–6378.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6374-6378
    • Kawamura, M.1    McVicar, D.W.2    Johnston, J.A.3    Blake, T.B.4    Chen, Y.Q.5    Lal, B.K.6
  • 38
    • 67650093218 scopus 로고    scopus 로고
    • The Safety and Efficacy of a JAK Inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
    • Kremer J.M. Bloom B.J. Breedveld F.C. Coombs J.H. Fletcher M.P. Gruben D. et al (2009) The Safety and Efficacy of a JAK Inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. Arthritis Rheum 60: 1895–1905.
    • (2009) Arthritis Rheum , vol.60 , pp. 1895-1905
    • Kremer, J.M.1    Bloom, B.J.2    Breedveld, F.C.3    Coombs, J.H.4    Fletcher, M.P.5    Gruben, D.6
  • 39
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
    • Kremer J.M. Westhovens R. Leon M. Di Giorgio E. Alten R. Steinfeld S. et al (2003) Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 349: 1907–1915.
    • (2003) N Engl J Med , vol.349 , pp. 1907-1915
    • Kremer, J.M.1    Westhovens, R.2    Leon, M.3    Di Giorgio, E.4    Alten, R.5    Steinfeld, S.6
  • 40
    • 71849102938 scopus 로고    scopus 로고
    • Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells
    • Krishnan S. Juang Y.T. Chowdhury B. Magilavy A. Fisher C.U. Nguyen H. et al (2008) Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells. J Immunol 181: 8145–8152.
    • (2008) J Immunol , vol.181 , pp. 8145-8152
    • Krishnan, S.1    Juang, Y.T.2    Chowdhury, B.3    Magilavy, A.4    Fisher, C.U.5    Nguyen, H.6
  • 41
    • 77958465072 scopus 로고    scopus 로고
    • Targeting B cells with biologics in systemic lupus erythematosus
    • La Cava A. (2010) Targeting B cells with biologics in systemic lupus erythematosus. Expert Opin Biol Ther 10: 1555–1561.
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 1555-1561
    • La Cava, A.1
  • 43
    • 67549117204 scopus 로고    scopus 로고
    • The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events
    • Leombruno J.P. Einarson T.R. Keystone E.C. (2009) The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events. Ann Rheum Dis 68: 1136–1145.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1136-1145
    • Leombruno, J.P.1    Einarson, T.R.2    Keystone, E.C.3
  • 44
    • 33750011260 scopus 로고    scopus 로고
    • Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus
    • Liang B. Gardner D.B. Griswold D.E. Bugelski P.J. Song X.Y. (2006) Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus. Immunology 119: 296–305.
    • (2006) Immunology , vol.119 , pp. 296-305
    • Liang, B.1    Gardner, D.B.2    Griswold, D.E.3    Bugelski, P.J.4    Song, X.Y.5
  • 45
    • 0033883903 scopus 로고    scopus 로고
    • Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus
    • Llorente L. Richaud-Patin Y. Garcia-Padilla C. Claret E. Jakez-Ocampo J. Cardiel M.H. (2000) Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus. Arthritis Rheum 43: 1790–1800.
    • (2000) Arthritis Rheum , vol.43 , pp. 1790-1800
    • Llorente, L.1    Richaud-Patin, Y.2    Garcia-Padilla, C.3    Claret, E.4    Jakez-Ocampo, J.5    Cardiel, M.H.6
  • 46
    • 67651149869 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor therapy in patients with difficult-to-treat lupus nephritis: a prospective series of nine patients
    • Matsumura R. Umemiya K. Sugiyama T. Sueishi M. Umibe T. Ichikawa K. et al (2009) Anti-tumor necrosis factor therapy in patients with difficult-to-treat lupus nephritis: a prospective series of nine patients. Clin Exp Rheumatol 27: 416–421.
    • (2009) Clin Exp Rheumatol , vol.27 , pp. 416-421
    • Matsumura, R.1    Umemiya, K.2    Sugiyama, T.3    Sueishi, M.4    Umibe, T.5    Ichikawa, K.6
  • 47
    • 0034327808 scopus 로고    scopus 로고
    • Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells
    • McAdam A.J. Chang T.T. Lumelsky A.E. Greenfield E.A. Boussiotis V.A. Duke-Cohan J.S. et al (2000) Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol 165: 5035–5040.
    • (2000) J Immunol , vol.165 , pp. 5035-5040
    • McAdam, A.J.1    Chang, T.T.2    Lumelsky, A.E.3    Greenfield, E.A.4    Boussiotis, V.A.5    Duke-Cohan, J.S.6
  • 48
    • 79957617387 scopus 로고    scopus 로고
    • Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER)
    • [ePub ahead of print]
    • Merrill J.T. Buyon J.P. Furie R.A. Latinis K.M. Gordon C. Hsieh H.J. et al (2011) Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER). Lupus [ePub ahead of print].
    • (2011) Lupus
    • Merrill, J.T.1    Buyon, J.P.2    Furie, R.A.3    Latinis, K.M.4    Gordon, C.5    Hsieh, H.J.6
  • 49
    • 0033932756 scopus 로고    scopus 로고
    • CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus
    • Mihara M. Tan I. Chuzhin Y. Reddy B. Budhai L. Holzer A. et al (2000) CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus. J Clin Invest 106: 91–101.
    • (2000) J Clin Invest , vol.106 , pp. 91-101
    • Mihara, M.1    Tan, I.2    Chuzhin, Y.3    Reddy, B.4    Budhai, L.5    Holzer, A.6
  • 50
    • 79951531576 scopus 로고    scopus 로고
    • FDA to act on benlysta, rare new drug for lupus
    • Morrow T. (2011) FDA to act on benlysta, rare new drug for lupus. Manag Care 20: 43–44.
    • (2011) Manag Care , vol.20 , pp. 43-44
    • Morrow, T.1
  • 51
    • 0037370324 scopus 로고    scopus 로고
    • Inducible costimulator is essential for collagen-induced arthritis
    • Nurieva R.I. Treuting P. Duong J. Flavell R.A. Dong C. (2003) Inducible costimulator is essential for collagen-induced arthritis. J Clin Invest 111: 701–706.
    • (2003) J Clin Invest , vol.111 , pp. 701-706
    • Nurieva, R.I.1    Treuting, P.2    Duong, J.3    Flavell, R.A.4    Dong, C.5
  • 52
    • 77958120721 scopus 로고    scopus 로고
    • Regulation of the B cell receptor repertoire and self-reactivity by BAFF
    • Ota M. Duong B.H. Torkamani A. Doyle C.M. Gavin A.L. Ota T. et al (2010) Regulation of the B cell receptor repertoire and self-reactivity by BAFF. J Immunol 185: 4128–4136.
    • (2010) J Immunol , vol.185 , pp. 4128-4136
    • Ota, M.1    Duong, B.H.2    Torkamani, A.3    Doyle, C.M.4    Gavin, A.L.5    Ota, T.6
  • 55
    • 0034922160 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE
    • Rottman J.B. Smith T. Tonra J.R. Ganley K. Bloom T. Silva R. et al (2001) The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat Immunol 2: 605–611.
    • (2001) Nat Immunol , vol.2 , pp. 605-611
    • Rottman, J.B.1    Smith, T.2    Tonra, J.R.3    Ganley, K.4    Bloom, T.5    Silva, R.6
  • 59
    • 33745027354 scopus 로고    scopus 로고
    • Anti–interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study
    • Straub R.H. Harle P. Yamana S. Matsuda T. Takasugi K. Kishimoto T. et al (2006) Anti–interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. Arthritis Rheum 54: 1778–1785.
    • (2006) Arthritis Rheum , vol.54 , pp. 1778-1785
    • Straub, R.H.1    Harle, P.2    Yamana, S.3    Matsuda, T.4    Takasugi, K.5    Kishimoto, T.6
  • 60
    • 0027480306 scopus 로고
    • Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal
    • Suzuki H. Yasukawa K. Saito T. Narazaki M. Hasegawa A. Taga T. et al (1993) Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal. Eur J Immunol 23: 1078–1082.
    • (1993) Eur J Immunol , vol.23 , pp. 1078-1082
    • Suzuki, H.1    Yasukawa, K.2    Saito, T.3    Narazaki, M.4    Hasegawa, A.5    Taga, T.6
  • 61
    • 0032725836 scopus 로고    scopus 로고
    • Tumour necrosis factor and other cytokines in murine lupus
    • Theofilopoulos A.N. Lawson B.R. (1999) Tumour necrosis factor and other cytokines in murine lupus. Ann Rheum Dis 58(Suppl. 1): I49–I55.
    • (1999) Ann Rheum Dis , vol.58 , Issue.Suppl. 1 , pp. I49-I55
    • Theofilopoulos, A.N.1    Lawson, B.R.2
  • 62
    • 0033623775 scopus 로고    scopus 로고
    • Increased excretions of β-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm–Horsfall glycoprotein in urine of patients with active lupus nephritis
    • Tsai C.Y. Wu T.H. Yu C.L. Lu J.Y. Tsai Y.Y. (2000) Increased excretions of β-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm–Horsfall glycoprotein in urine of patients with active lupus nephritis. Nephron 85: 207–214.
    • (2000) Nephron , vol.85 , pp. 207-214
    • Tsai, C.Y.1    Wu, T.H.2    Yu, C.L.3    Lu, J.Y.4    Tsai, Y.Y.5
  • 63
    • 0141504367 scopus 로고    scopus 로고
    • Cytokine balance in kidney tissue from lupus nephritis patients
    • Uhm W.S. Na K. Song G.W. Jung S.S. Lee T. Park M.H. et al (2003) Cytokine balance in kidney tissue from lupus nephritis patients. Rheumatology 42: 935–938.
    • (2003) Rheumatology , vol.42 , pp. 935-938
    • Uhm, W.S.1    Na, K.2    Song, G.W.3    Jung, S.S.4    Lee, T.5    Park, M.H.6
  • 64
    • 67049162417 scopus 로고    scopus 로고
    • Efficacy and safety of infliximab in active SLE: a pilot study
    • Uppal S.S. Hayat S.J. Raghupathy R. (2009) Efficacy and safety of infliximab in active SLE: a pilot study. Lupus 18: 690–697.
    • (2009) Lupus , vol.18 , pp. 690-697
    • Uppal, S.S.1    Hayat, S.J.2    Raghupathy, R.3
  • 65
    • 79251500705 scopus 로고    scopus 로고
    • BAFF/APRIL pathway in Sjögren syndrome and systemic lupus erythematosus: relationship with chronic inflammation and disease activity
    • Vadacca M. Margiotta D. Sambataro D. Buzzulini F. Lo Vullo M. Rigon A. et al (2010) BAFF/APRIL pathway in Sjögren syndrome and systemic lupus erythematosus: relationship with chronic inflammation and disease activity. Reumatismo 62: 259–265.
    • (2010) Reumatismo , vol.62 , pp. 259-265
    • Vadacca, M.1    Margiotta, D.2    Sambataro, D.3    Buzzulini, F.4    Lo Vullo, M.5    Rigon, A.6
  • 66
    • 44849117329 scopus 로고    scopus 로고
    • MEDI-545, an anti-interferon alpha monoclonal antibody, shows evidence of clinical activity in systemic lupus erythematosus
    • Wallace D.J. Petri M. Olsen N. Kirou K. Dennis G. Yao Y. et al (2007) MEDI-545, an anti-interferon alpha monoclonal antibody, shows evidence of clinical activity in systemic lupus erythematosus. Arthritis Rheum 56: S526–S527.
    • (2007) Arthritis Rheum , vol.56 , pp. S526-S527
    • Wallace, D.J.1    Petri, M.2    Olsen, N.3    Kirou, K.4    Dennis, G.5    Yao, Y.6
  • 67
    • 78650826030 scopus 로고    scopus 로고
    • Epratuzumab demonstrates clinically meaningful improvements in patients with moderate to severe systemic lupus erythematosus: results from EMBLEMTM, a phase IIb study
    • Abstract SAT0212
    • Wallace, D., Kalunian, K., Petri, M., Strand, V., Kilgallen, B., Barry, A., et al. (2010) Epratuzumab demonstrates clinically meaningful improvements in patients with moderate to severe systemic lupus erythematosus: results from EMBLEMTM, a phase IIb study. Ann Rheum Dis 69(suppl 3): 558. Abstract SAT0212.
    • (2010) Ann Rheum Dis , vol.69 , Issue.3 , pp. 558
    • Wallace, D.1    Kalunian, K.2    Petri, M.3    Strand, V.4    Kilgallen, B.5    Barry, A.6
  • 68
  • 70
    • 78649955057 scopus 로고    scopus 로고
    • Belimumab: a BLyS-specific inhibitor for systemic lupus erythematosus
    • Wiglesworth A.K. Ennis K.M. Kockler D.R. (2010) Belimumab: a BLyS-specific inhibitor for systemic lupus erythematosus. Ann Pharmacother 44: 1955–1961.
    • (2010) Ann Pharmacother , vol.44 , pp. 1955-1961
    • Wiglesworth, A.K.1    Ennis, K.M.2    Kockler, D.R.3
  • 71
    • 0037637475 scopus 로고    scopus 로고
    • Evaluation of inducible costimulator/B7-related protein-1 as a therapeutic target in a murine model of allergic airway inflammation
    • Wiley R.E. Goncharova S. Shea T. Johnson J.R. Coyle A.J. Jordana M. (2003) Evaluation of inducible costimulator/B7-related protein-1 as a therapeutic target in a murine model of allergic airway inflammation. Am J Respir Cell Mol Biol 28: 722–730.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 722-730
    • Wiley, R.E.1    Goncharova, S.2    Shea, T.3    Johnson, J.R.4    Coyle, A.J.5    Jordana, M.6
  • 72
    • 45249097325 scopus 로고    scopus 로고
    • Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity
    • Wong C.K. Lit L.C. Tam L.S. Li E.K. Wong P.T. Lam C.W. (2008) Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin Immunol 127: 385–393.
    • (2008) Clin Immunol , vol.127 , pp. 385-393
    • Wong, C.K.1    Lit, L.C.2    Tam, L.S.3    Li, E.K.4    Wong, P.T.5    Lam, C.W.6
  • 73
    • 66449097622 scopus 로고    scopus 로고
    • Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an antiinterferon-alpha monoclonal antibody in systemic lupus erythematosus
    • Yao Y. Richman L. Higgs B.W. Morehouse C.A. de los Reyes M. Brohawn P. et al (2009) Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an antiinterferon-alpha monoclonal antibody in systemic lupus erythematosus. Arthritis Rheum 60: 1785–1796.
    • (2009) Arthritis Rheum , vol.60 , pp. 1785-1796
    • Yao, Y.1    Richman, L.2    Higgs, B.W.3    Morehouse, C.A.4    de los Reyes, M.5    Brohawn, P.6
  • 75
    • 78649720274 scopus 로고    scopus 로고
    • Anticytokine therapy in systemic lupus erythematosus
    • Yoo D.-H. (2010) Anticytokine therapy in systemic lupus erythematosus. Lupus 19: 1460–1467.
    • (2010) Lupus , vol.19 , pp. 1460-1467
    • Yoo, D.-H.1
  • 76
    • 0033809736 scopus 로고    scopus 로고
    • Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS
    • Yoshinaga S.K. Zhang M. Pistillo J. Horan T. Khare S.D. Miner K. et al (2000) Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. Int Immunol 12: 1439–1447.
    • (2000) Int Immunol , vol.12 , pp. 1439-1447
    • Yoshinaga, S.K.1    Zhang, M.2    Pistillo, J.3    Horan, T.4    Khare, S.D.5    Miner, K.6


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