Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells

British Journal of Pharmacology

Volumn 165, Issue 6, 2012, Pages 1836-1847

  Fahrmayr, C ^a   Konig J ^a   Auge, D ^a   Mieth, M ^a   Fromm, M F ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

drug metabolism; drug transport; etoposide; ezetimibe; MDCK; MRP2; OATP1B1; triple transfected cells; UGT1A1

Indexed keywords

DRUG METABOLITE; ETOPOSIDE; EZETIMIBE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE 1A1; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1B1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; DRUG UPTAKE; GENE; GENE LOCATION; GENETIC TRANSFECTION; MOLECULAR CLONING; MONOLAYER CULTURE; MRP2 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; OATP1B1 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UGT1A1 GENE;

ANIMALS; AZETIDINES; CELL LINE; DOGS; ETOPOSIDE; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HEK293 CELLS; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANIC ANION TRANSPORT PROTEIN 1; RNA, MESSENGER; TRANSFECTION;

EID: 84857461950     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01672.x     Document Type: Article

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