Soy foods: Are they useful for optimal bone health?

Therapeutic Advances in Musculoskeletal Disease

Volumn 3, Issue 6, 2011, Pages 293-300

  Lanou, Amy J ^a  

^a UNIVERSITY OF NORTH CAROLINA AT ASHEVILLE   (United States)

Author keywords

dietary patterns; fracture risk; plant based

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; CALCIUM; COLECALCIFEROL; DEOXYPYRIDINOLINE; GENISTEIN; ISOFLAVONE DERIVATIVE; OSTEOCALCIN; VITAMIN D;

ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE HEALTH; BONE TURNOVER; CROSS-SECTIONAL STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; HEALTH; HIP FRACTURE; HUMAN; NUTRITIONAL ASSESSMENT; OBSERVATIONAL STUDY; OSSIFICATION; OSTEOLYSIS; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; SOYBEAN; VEGETARIAN DIET;

EID: 84857459541     PISSN: 1759720X     EISSN: 17597218     Source Type: Journal    
DOI: 10.1177/1759720X11417749     Document Type: Article

References (46)

1. Abelow B.J. Holford T.R. Insogna K.L. (1992) Cross-cultural association between dietary animal protein and hip fracture: a hypothesis. Calcif Tissue Int 50: 14–18.
2. Alekel D.L. van Loan M.D. Koehler K.J. Hanson L.M. Stewart J.W. Hanson K.B. et al. (2010) The Soy Isoflavones for Reducing Bone Loss (SIRBL) Study: a 3-y randomized controlled trial in postmenopausal women. Am J Clin Nutr 91: 218–230.
3. Appel L.J. Moore T.J. Obarzanek E. Vollmer W.M. Svetkey L.P. Sacks F.M. et al. (1997) A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 336: 1117–1124.
4. Atmaca A. Kleerekoper M. Bayraktar M. Kucuk O. (2008) Soy isoflavones in the management of postmenopausal osteoporosis. Menopause 15: 748–757.
5. Atteritano M. Mazzaferro S. Frisina A. Cannata M.L. Bitto A. D'Anna R. et al. (2009) Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopenic postmenopausal women. Osteoporos Int 20: 1947–1954.
6. Barnard N.D. Cohen J. Jenkins D.J. Turner-McGrievy G. Gloede L. Green A. et al. (2009) A low-fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74-wk clinical trial. Am J Clin Nutr 89: 1588S–1596S.
7. Barzel US Massey L.K. (1998) Excess dietary protein can adversely affect bone. J Nutr 128: 1051–1053.
8. Bischoff-Ferrari H.A. Dawson-Hughes B. Baron J.A. Burckhardt P. Li R. Spiegelman D. et al. (2007) Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr 86: 1780–1790.
9. Bischoff-Ferrari H.A. Dawson-Hughes B. Baron J.A. Kanis J.A. Orav E.J. Staehelin H.B. et al. (2011) Milk intake and risk of hip fracture in men and women: A meta-analysis of prospective cohort studies. J Bone Miner Res 26: 833–839.
10. Campbell T.C. Campbell T.M. (2004) The China Study: Startling Implications for Diet, Weight Loss, and Long-term Health, BenBella Books: Dallas, TX, p. 286.
11. Esselstyn C.B. Jr (1999) Updating a 12-year experience with arrest and reversal therapy for coronary heart disease (an overdue requiem for palliative cardiology). Am J Cardiol 84: 339–341 A8.
12. Frassetto L.A. Todd K.M. Morris R.C. Jr Sebastian A. (2000) Worldwide incidence of hip fracture in elderly women: relation to consumption of animal and vegetable foods. J Gerontol A Biol Sci Med Sci 55: M585–M592.
13. Frattaroli J. Weidner G. Dnistrian A.M. Kemp C. Daubenmier J.J. Marlin R.O. et al. (2008) Clinical events in prostate cancer lifestyle trial: results from two years of follow-up. Urology 72: 1319–1323.
14. Greendale G.A. FitzGerald G. Huang M.H. Sternfeld B. Gold E. Seeman T. et al. (2002) Dietary soy isoflavones and bone mineral density: results from the study of Women's health across the nation. Am J Epidemiol 155: 746–754.
15. Hirota T. Kusu T. Hirota K. (2005) Improvement of nutrition stimulated bone mineral gain in Japanese school children and adolescents. Osteoporos Int 16: 1057–1064.
16. Ho S.C. Chan S.G. Yip Y.B. Chan C.S.Y. Woo J.L.F. Sham A. (2008) Change in bone mineral density and its determinants in pre- and perimenopausal Chinese women: the Hong Kong perimenopausal women osteoporosis study. Osteoporosis Int 19: 1785–1796.
17. Ho S.C. Woo J. Lam S. Chen Y. Sham A. Lau J. (2003) Soy protein consumption and bone mass in early postmenopausal Chinese women. Osteoporosis Int 14: 835–842.
18. Horiuchi T. Onouchi T. Takahashi M. Ito H. Orimo H. (2000) Effect of soy protein on bone metabolism in postmenopausal Japanese women. Osteoporos Int 11: 721–724.
19. Jackson R.D. LaCroix A.Z. Gass M. Wallace R.B. Robbins J. Lewis C.E. et al. (2006) Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354: 670–683.
20. Jacobs D.R. Gross M.D. Tapsell L.C. (2009) Food synergy: an operational concept for understanding nutrition. Am J Clin Nutr 89: 1543S–1548S.
21. Jenkins D.J. Kendall C.W. Faulkner D.A. Nguyen T. Kemp T. Marchie A. et al. (2006) Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia. Am J Clin Nutr 83: 582–591.
22. Jenkins D.J. Kendall C.W. Faulkner D. Vidgen E. Trautwein E.A. Parker T.L. et al. (2002) A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metabolism 51: 1596–1604.
23. Koh W.P. Wu A.H. Wang R. Ang L.W. Heng D. Yuan J.M. et al. (2009) Gender-specific associations between soy and risk of hip fracture in the Singapore Chinese Health Study. Am J Epidemiol 170: 901–909.
24. Kritz-Silverstein D. Goodman-Gruen D.L. (2002) Usual dietary isoflavone intake, bone mineral density, and bone mineral metabolism in postmenopausal women. J Womens Health Gend Based Med 11: 69–78.
25. Lampe J.W. (2009) Is equol the key to the efficacy of soy foods?. Am J Clin Nutr 89: 1664S–1667S.
26. Lanou A.J. Berkow S.E. Barnard N.D. (2005) Calcium, dairy products and bone health in children and young adults: A reevaluation of the evidence. Pediatrics 115: 736–743.
27. Liu J. Ho S.C. Su Y. Chen W. Cai-xia Z. Dhen Y. (2009) Effect of long-term intervention of soy isoflavones on bone mineral density in women: A meta-analysis of randomized controlled trials. Bone 44: 948–953.
28. Ma D.F. Qin L.Q. Wang P.Y. Katoh R. (2008 a) Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials. Clin Nutr 27: 57–64.
29. Ma D.F. Qin L.Q. Wang P.Y. Katoh R. (2008 b) Soy isoflavone inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. Eur J Clin Nutr 62: 155–161.
30. Marini H. Minutoli L. Polito F. Bitto A. Altavilla D. Atteritano M. et al. (2007) Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Ann Intern Med 146: 839–847.
31. Mei J. Yeung S.S.C. Kung A.W.C. (2001) High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. J Clin Endocrinol Metab 86: 5217–5221.
32. Messina M. Watanabe S. Setchell K.D.R. (2009) Report of the 8th International Symposium on the Role of Soy in Health Promotion and Chronic Disease Prevention and Treatment. J Nutr 139: 796S–802S.
33. New S.A. (2003) Intake of fruit and vegetables: implications for bone health. Proc Nutr Soc 62: 889–899.
34. Ornish D. Scherwitz L.W. Billings J.H. Brown S.E. Gould K.L. Merritt T.A. et al. (1998) Intensive lifestyle changes for the reversal of coronary heart disease. JAMA 280: 2001–2007.
35. Ornish D. Weidner G. Fair W.R. Marlin R. Pettengill E.B. Raisin C.J. et al. (2005) Intensive lifestyle changes may affect the progression of prostate cancer. J Urol 174: 1065–1069,, discussion 1069–1070.
36. Poulsen R.C. Kruger M. (2008) Soy phytoestrogens: impact on postmenopausal bone loss and mechanism of action. Nutr Rev 66: 359–374.
37. Sellmeyer D.E. Stone K.L. Sebastian A. Cummings S.R. (2001) A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group. Am J Clin Nutr 73: 118–122.
38. Song Y.J. Paik H.Y. Joung H. (2008) Soybean and soy isoflavone intake indicate a positive change in bone mineral density for 2 years in young Korean women. Nutr Res 28: 25–30.
39. Taku K. Melby M.K. Kurzer M.S. Mizuno S. Watanabe S. Ishimi Y. (2010) Effects of soy isoflavone supplements on bone turnover markers in menopausal women: a systematic review and meta-analysis of randomized controlled trials. Bone 47: 413–423.
40. Tempfer C.B. Bentz E.K. Leodolter S. Tscherne G. Reuss F. Cross H.S. et al. (2007) Phytoestrogens in clinical practice: a review of the literature. Fertil Steril 87: 1243–1249.
41. Turner-McGrievy G.M. Barnard N.D. Scialli A.R. (2007) A two-year randomized weight loss trial comparing a vegan diet to a more moderate low-fat diet. Obesity (Silver Spring) 15: 2276–2281.
42. Warensjö E. Byberg L. Melhus H.K. Gedeborg R. Mallmin H. Wolk A. et al. (2011) Dietary calcium intake and risk of fracture and osteoporosis: prospective longitudinal cohort study. BMJ 342: d1473.
43. Winzenberg T. Shaw K. Fryer J. Jones G. (2006) Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials. BMJ 333: 775.
44. Zemel M.B. (1988) Calcium utilization: effect of varying level and source of dietary protein. Am J Clin Nutr 48(3 Suppl): 880–883.
45. Zhang X. Shu X.O. Li H. Yang G. Li Q. Gao Y.T. et al. (2005) Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med 165: 1890–1895.
46. Zhang Y. Chen W.F. Lai W.P. Wong M.S. (2008) Soy isoflavones and their bone protective effects. Inflammopharmacology 16: 213–215.