Novel water-soluble polyurethane nanomicelles for cancer chemotherapy: Physicochemical characterization and cellular activities

Journal of Nanobiotechnology

Volumn 10, Issue , 2012, Pages

  Khosroushahi, Ahmad Y ^a   Naderi Manesh, Hossein ^a   Yeganeh, Hamid ^c   Barar, Jaleh ^b,d   Omidi, Yadollah ^b,d  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c IRAN POLYMER AND PETROCHEMICAL INSTITUTE   (Iran)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bioactive biocompatible polymer; Cancer chemotherapy; Nanomicelle; Nanoparticle; Paclitaxel; Polyurethane

Indexed keywords

AMPHIPHILICS; ANTI-CANCER CHEMOTHERAPY; BIOCOMPATIBLE POLYMER; CANCER CHEMOTHERAPY; CARBOXYL GROUPS; CELLULAR ACTIVITIES; CLINICAL USE; COMET ASSAYS; CRITICAL MICELLE CONCENTRATION (CMC); CYTOCHROME C; DELIVERY SYSTEMS; DIMETHYLOL PROPIONIC ACID; DNA FRAGMENTATION; DRUG RELEASE; FASTER RATES; HIGH LOADINGS; HIGUCHI MODEL; HUMAN BREAST CANCER; HYDROXYL GROUPS; IN-VITRO; ISOCYANATE GROUP; LOW LEVEL; MCF-7 CELLS; NANOCARRIERS; NANOMICELLE; NANOMICELLES; NEGATIVE ZETA POTENTIALS; OVARIAN CANCERS; PACLITAXEL; PH SENSITIVE; PHYSICAL STABILITY; PHYSICO-CHEMICAL CHARACTERIZATION; POLYMER BACKBONES; REAL TIME RT-PCR; TOLUENE DIISOCYANATES; TRIETHYLAMINES; WATERBORNE POLYURETHANE;

ACTIVATION ANALYSIS; BIOCOMPATIBILITY; CELL DEATH; CHEMOTHERAPY; CRITICAL MICELLE CONCENTRATION; DISEASES; ETHERS; GLYCOLS; NANOPARTICLES; PHENOLS; POLYMERASE CHAIN REACTION; POLYURETHANES; SATURATED FATTY ACIDS; TOLUENE; ZETA POTENTIAL;

POLYMERS;

CARBOXYL GROUP; CYTOCHROME C; DIMETHYLOL PROPIONIC ACID; DNA FRAGMENT; GLYCOLIC ACID DERIVATIVE; HYDROXYL GROUP; ISOCYANATE; PACLITAXEL; PHENOL; POLY(TETRAMETHYLENE ETHER)GLYCOL; POLYURETHAN; PROPIONIC ACID DERIVATIVE; TOLUENE DIISOCYANATE; TRIETHYLAMINE; UNCLASSIFIED DRUG; URETHAN; ANTINEOPLASTIC AGENT; CASP3 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE 3; CASPASE 9; DRUG CARRIER; GLYCOL; NANOMATERIAL; POLYTETRAMETHYLENE GLYCOL; STAT1 PROTEIN; STAT1 PROTEIN, HUMAN; WATER;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL STRAIN MCF 7; CHEMICAL BINDING; CHEMICAL REACTION; CLINICAL EFFECTIVENESS; COMET ASSAY; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; DNA FRAGMENTATION; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG RELEASE; HUMAN; HUMAN CELL; IN VIVO STUDY; IONIZATION; MOLECULAR STABILITY; PH; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNTHESIS; ZETA POTENTIAL; BREAST TUMOR; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; INFRARED SPECTROSCOPY; METHODOLOGY; MICELLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; PATHOLOGY; SOLUBILITY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOLS; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; NANOSTRUCTURES; PACLITAXEL; PARTICLE SIZE; POLYURETHANES; REAL-TIME POLYMERASE CHAIN REACTION; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STAT1 TRANSCRIPTION FACTOR; WATER;

EID: 84857439988     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/1477-3155-10-2     Document Type: Article

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