Local delivery of modified paclitaxel-loaded poly(ε-caprolactone)/ pluronic F68 nanoparticles for long-term inhibition of hyperplasia

Journal of Pharmaceutical Sciences

Volumn 98, Issue 6, 2009, Pages 2040-2050

  Mei, Lin ^a,b   Sun, Hongfan ^a   Song, Cunxian ^a  

^a INSTITUTE OF BIOMEDICAL ENGINEERING   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Biodegradable polymers; Controlled release; Drug effects; Nanoparticles; Polymer synthesis; Polymeric drug delivery systems

Indexed keywords

DIDODECYLDIMETHYLAMMONIUM BROMIDE; NANOPARTICLE; PACLITAXEL; POLOXAMER; POLYCAPROLACTONE; SOLVENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SYNTHESIS; ELECTRICITY; HYPERPLASIA; IN VITRO STUDY; NONHUMAN; PARTICLE SIZE; RABBIT; RESTENOSIS; SURFACE CHARGE; SURFACE PROPERTY;

EID: 67049143093     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21581     Document Type: Article

References (41)

1. Uwatoku T, Shimokawa H, Abe K, Matsumoto Y, Hattori T, Oi K, Matsuda T, Kataoka K, Takeshita A. 2003. Application of nanoparticle technology for the prevention of restenosis after balloon injury in rats. Circ Res 92:e62-e69.
2. Westedt U, Kalinowski M, Wittmar M, Merdan T, Unger F, Fuchs J, Schäller S, Bakowsky U, Kissel T. 2007. Poly(vinyl alcohol)-graft- poly(lactide-co-glycolide) nanoparticles for local delivery of paclitaxel for restenosis treatment. J Control Release 119:41-51. (Pubitemid 46561540)
3. Shi Y, O'Brien JE, Ala-Kokko L, Chung W, Mannion JD, Zalewski A. 1997. Origin of extracellular matrix synthesis during coronary repair. Circulation 95:997-1006. (Pubitemid 27091546)
4. Brieger D, Topol E. 1997. Local drug delivery systems and prevention of restenosis. Cardiovasc Res 35:405-413. (Pubitemid 27469401)
5. Regar E, Sianos G, Serruys PW. 2001. Stent development and local drug delivery. Br Med Bull 59:227-248. (Pubitemid 34076026)
6. Grube E, Silber S, Hauptmann KE, Mueller R, Buellesfeld L, Gerckens U, Russell ME. 2003. TAXUS I: Six- and 12-month results from a randomized, double-blind trial on a slow-release paclitaxel eluting stent for de novo coronary lesions. Circulation 107:38-42. (Pubitemid 36070930)
7. Park SJ, Shim WH, Ho DS, Raizner AE, Park SW, Hong MK, Lee CW, Choi D, Jang Y, Lam R, Weissman NJ, Mintz GS. 2003. A paclitaxel-eluting stent for the prevention of coronary restenosis. N Engl J Med 348:1537-1545. (Pubitemid 36437930)
8. Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O'Shaughnessy C, Caputo RP, Kereiakes DJ, Williams DO, Teirstein PS, Jaeger JL, Kuntz RE. 2003. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med 349:1315-1323. (Pubitemid 37186209)
9. Banai S, Chorny M, Gertz SD, Fishbein I, Gao J, Perez L, Lazarovichi G, Gazit A, Levitzki A, Golomb G. 2005. Locally delivered nanoencapsulated tyrphostin (AGL-2043) reduces neointima formation in balloon-injured rat carotid and stented porcine coronary arteries. Biomaterials 26:4898-4901. (Pubitemid 38951112)
10. Wolinsky H, Thung SN. 1990. Use of a perforated balloon catheter to deliver concentrated heparin into the wall of the normal canine artery. J Am Coll Cardiol 15:475-481. (Pubitemid 20067509)
11. Valero F, Hamon M, Fournier C, Meurice T, Flautre B, Van Belle E, Lablanche JM, Gosselin B, Bauters C, Bertrand M. 1998. Intramural injection of biodegradable microspheres as a local drug-delivery system to inhibit neointimal thickening in a rabbit model of balloon angioplasty. J Cardiovasc Pharmacol 31:513-519. (Pubitemid 28153126)
12. Wilensky RL, March KL, Gradus-Pizlo I, Schauwecker D, Michaels MB, Robinson J, Carlson K, Hathaway DR. 1995. Regional and arterial localization of radioactive microparticles after local delivery by unsupported or supported porous balloon catheters. Am Heart J 129:852-859.
13. Guzman LA, Labhasetwar V, Song C, Jang Y, Lincoff AM, Levy R, Topol EJ. 1996. Local intraluminal infusion of biodegradable polymeric nanoparticles: A novel approach for prolonged drug delivery after balloon angioplasty. Circulation 94:1441-1448. (Pubitemid 26307277)
14. Song CX, Labhasetwar V, Murphy H, Qu X, Humphrey WR, Shebuski RJ, Levy RJ. 1997. Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J Control Release 43:197-212. (Pubitemid 26390968)
15. Labhasetwar V, Song C, Levy RJ. 1997. Nanoparticle drug delivery system for restenosis. Adv Drug Deliv Rev 24:63-85. (Pubitemid 27062762)
16. Mei L, Sun H, Jin X, Zhu D, Sun R, Zhang M, Song C. 2007. Modified paclitaxel-loaded nanoparticles for inhibition of hyperplasia in a rabbit arterial balloon injury model. Pharm Res 24:955-962. (Pubitemid 46675396)
17. Cyrus T, Zhang H, Allen JS, Williams TA, Hu G, Caruther SD, Wickline SA, Lanza GM. 2008. Intramural delivery of rapamycin with avb3-targeted paramagnetic nanoparticles inhibits stenosis after balloon injury. Arterioscler Thromb Vasc Biol 28:820-826. (Pubitemid 351544094)
18. Humphrey WR, Erickson LA, Simmons CA, Northrup JL, Wishka DG, Morris J, Labhasetwar V, Song C, Levy RJ, Shebuski RJ. 1997. The effect of intramural delivery of polymeric nanoparticles loaded with the anti-proliferative 2-aminochromone U-86983 on neointimal hyperplasia development in balloon-injured porcine coronary. Adv Drug Deliv Rev 24:87-108. (Pubitemid 27062763)
19. Song C, Labhasetwar V, Cui X, Underwood T, Levy RJ. 1998. Arterial uptake of biodegradable nanoparticles for intravascular local drug delivery: Results with an acute dog model. J Control Release 54:201-211. (Pubitemid 28342699)
20. Labhasetwar V, Song C, Humphrey W, Shebuski R, Levy RJ. 1998. Arterial uptake of biodegradable nanoparticles: Effect of surface modifications. J Pharm Sci 87:1229-1234. (Pubitemid 28455614)
21. Rupert LAM, Hoekstra D, Engberts BFN. 1985. Fusogenic behavior of didodecyldimethylammonium bromide bilayer vesicles. J Am Chem Soc 107:2628-2631.
22. Wade A, Weller PJ. 1994. Handbook of pharmaceutical excipients. 2nd edition. Washington: American Pharmaceutical Association. pp. 352-354.
23. Ma G, Song C. 2007. PCL/poloxamer 188 blend microsphere for paclitaxel delivery: Influence of poloxamer 188 on morphology and drug release. J Appl Polym Sci 104:1895-1899. (Pubitemid 46587796)
24. Moghimi SM, Hunter AC. 2000. Poloxamers and poloxamines in nanoparticle engineering and experimental medicine. Trends Biotechnol 18:412-420. (Pubitemid 30682350)
25. Schaer GL, Spaccavento LJ, Browne KF, Krueger KA, Krichbaum D, Phelan JM, Fletcher WO, Grines CL, Edwards S, Jolly MK, Gibbons RJ. 1996. Beneficial effects of RheothRx injection in patients receiving thrombolytic therapy for acute myocardial infarction-Results of a randomized, double-blind trail, placebo-controlled trail. Circulation 94:298-307. (Pubitemid 26266112)
26. Kamath KR, Barry JJ, Miller KM. 2006. The TaxusTM drug-eluting stent: A new paradigm in controlled drug delivery. Adv Drug Deliv Rev 58:412-436. (Pubitemid 43949060)
27. Kim DW, Kwon JS, Kim YG, Kim MS, Lee GS, Youn TJ, Cho MC. 2004. Novel oral formulation of paclitaxel inhibits neointimal hyperplasia in a rat carotid artery injury model. Circulation 109:1558-1563. (Pubitemid 38425477)
28. Sun H, Mei L, Song C, Cui X, Wang P. 2006. The in vivo degradation, absorption and excretion of PCL-based implant. Biomaterials 27:1735-1740. (Pubitemid 41759467)
29. Chawla JS, Amiji MM. 2002. Biodegradable poly(epsilon-caprolactone) nanoparticles for tumortargeted delivery of tamoxifen. Int J Pharm 249:127-138. (Pubitemid 35333439)
30. Nasser TK, Wilensky RL, Mehdi K, March KL. 1996. Microparticle deposition in periarterial microvasculature and intramural dissections after porous balloon delivery into atherosclerotic vessels: Quantitation and localization by confocal scanning laser microscopy. Am Heart J 131:892-898. (Pubitemid 26135751)
31. Rome JJ, Shayani V, Flugelman MY, Newman KD, Farb A, Virmani R, Dichek DA. 1994. Anatomic barriers influence the distribution of in vivo gene transfer into the arterial wall: Modeling with microscopic tracer particles and verification with a recombinant adenoviral vector. Arterioscler Thromb 14:148-161. (Pubitemid 2035496)
32. Anderson JM, Shive MS. 1997. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 28:5-24. (Pubitemid 27497671)
33. Gradus-Pizlo I, Wilensky RL, March KL, Fineberg N, Michaels M, Sandusky GE, Hathaway DR. 1995. Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue: Effects on restenosis and implications for catheter-based drug delivery. J Am Coll Cardiol 26:1549-1557.
34. Dev V, Eigler N, Fishbein MC, Tian Y, Hickey A, Rechavia E, Forrester JS, Litvack F. 1997. Sustained local drug delivery to the arterial wall via biodegradable microspheres. Cathet Cardiovasc Diagn 41:324-332. (Pubitemid 27283817)
35. Suh H, Jeong B, Rathi R, Kim SW. 1998. Regulation of smooth muscle cell proliferation using paclitaxel-loaded poly(ethyleneoxide)-poly(lactide/ glycolide) nanospheres. J Biomed Mater Res 42:331-338. (Pubitemid 28446976)
36. Jackson JK, Skinner KC, Burgess L, Sun T, Hunter WL, Burt HM. 2002. Paclitaxel-loaded crosslinked hyaluronic acid films for the prevention of postsurgical adhesions. Pharm Res 19:411-417. (Pubitemid 34408937)
37. Libby P, Ganz P. 1997. Restenosis revisited: New targets, new therapies. N Engl J Med 337:418-419. (Pubitemid 27328372)
38. Bennett MR. 2003. In-stent stenosis: Pathology and implications for the development of drug eluting stents. Heart 89:218-224. (Pubitemid 36115115)
39. Xiang D, He J, Yang C, Gong Z, Lai H, Fu R, Yi S, Qiu J. 2002. Dynamic changes in type I collagen, MMP-1 and TIMP-1 after angioplasty. Chin Med J (Engl) 115:352-354.
40. Manil L, Davin J, Duchenne C, Kubiak C, Foidart J, Couvreur P, Mahieu P. 1994. Uptake of nanoparticles by rat glomerular mesangial cells in vivo and in vitro. Pharm Res 11:1160-1167. (Pubitemid 24259857)
41. Wright JJ, Illum L. 1992. Active targeting of microcapsules and microspheres to specific regions. In: M, Donbrow editor. Microcapsules and nanoparticles in medicine and pharmacy. Boca Raton, FL: CRC Press. pp. 282-293.