Synthesis and in vitro release of adriamycin from star-shaped poly(lactide-co-glycolide) nano- and microparticles

Journal of Pharmaceutical Sciences

Volumn 99, Issue 8, 2010, Pages 3389-3397

  Mooguee, Mohammad ^a   Omidi, Yadollah ^b   Davaran, Soodabeh ^b,c  

^a AJA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Adriamycin; Micro and nanoparticles; Star shaped poly lactide co glycolide; cyclodextrin

Indexed keywords

BETA CYCLODEXTRIN; DOXORUBICIN; NANOPARTICLE; POLYGLACTIN; 2-ETHYLHEXANOIC ACID TIN(II) SALT; ANTINEOPLASTIC ANTIBIOTIC; BETA CYCLODEXTRIN DERIVATIVE; EXCIPIENT; HEXANOIC ACID DERIVATIVE; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; SOLVENT; TIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; CHEMICAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; EMULSION; ENCAPSULATION; INFRARED SPECTROSCOPY; MICROPARTICLE ENZYME IMMUNOASSAY; PARTICLE SIZE; PROTON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ANTIBIOTICS, ANTINEOPLASTIC; BETA-CYCLODEXTRINS; CALORIMETRY, DIFFERENTIAL SCANNING; CAPROATES; CATALYSIS; DOXORUBICIN; EXCIPIENTS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; SOLVENTS; TIN;

EID: 77955113609     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22106     Document Type: Article

References (22)

1. Peppas LB, Blanchette JO. 2004. Nanoparticle and targeted systems for cancer therapy. Adv Drug Del Rev 56:1649-1659. (Pubitemid 39177694)
2. Teicher BA. 2000. Molecular targets and cancer therapeutics: Discovery, development and clinical validation. Drug Resist Update 3:67-73.
3. Sledge G, Miller K. 2003. Exploiting the hallmarks of cancer: The future conquest of breast cancer. Eur J Cancer 39:1668-1675.
4. Eatock MM, Schätzlain A, Kaye SB. 2000. Tumor vasculature as a target for anticancer therapy. Cancer Treat Rev 26:191-204.
5. Reynolds AR, Moghimi SM, Hodivala-Dilk K. 2003. Nanoparticle-mediated gene delivery to tumor vasculature. Trends Mol Med 9:2-4.
6. Panyam J, Labhasetwar V. 2003. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Del Rev 55:329-347.
7. Birnbaum DT, Brannon-Peppas L. 2004. Microparticle drug delivery systems. In: Brown DM, editor. Drug delivery systems in cancer therapy. Humana Press, New Jersey. pp 117-135.
8. Orive G, Hernández RM, Gascon AR, Pedraz JL. 2005. Micro and nano drug delivery systems in cancer therapy. Cancer Ther 3:131-138.
9. Li YP, Pei Y, Zhang X, Gu Z, Zhou Z, Yuan W, Zhou J, Zhu J, Gao X. 2001. PEGylated PLGA nanoparticles as protein carriers: Synthesis, preparation and biodistribution in rats. J Control Release 71:203-211.
10. Beletsi A, Panagi Z, Avgoustakis K. 2005. Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA-PEG diblock copolymers. Int J Pharm 298:233-241.
11. Yoo HS, Park TG. 2000. In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates. Polym Prepr 41:992-993.
12. Kwon GS, Naito M, Yokoyama M, Okano T, Sakurai Y, Kataoka K. 1995. Physical entrapment of adriamycin in AB block copolymer micelle. Pharm Res 12:192-195.
13. Mitra S, Gaur U, Ghosh PC, Maitra AN. 2001. Tumor targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosane nanoparticles as carrier. J Control Release 74:317-323.
14. Na K, Lee ES, Bae YH. 2003. Adriamycin loaded pulluan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependant cell interaction, internalization and cytotoxicity. J Control Release 87:3-13.
15. Shikata F, Tokumitso H, Ichikava H, Fukumori Y. 2002. In vitro cellular accumulation of gadolinium incorporated into chitosane nanoparticles designed for neutron-capture therapy of cancer. Eur J Pharm Biopharm 53:57-63.
16. Davaran S, Rashidi MR, Pourabbas B, Dadashzadeh M, Moti Haghshenas N. 2006. Adriamycin release from poly(lactide-coglycolide)-polyethylene glycol nanoparticles synthesis and invitro characterization. Int J Nanomed 1:535-539.
17. Avgoustakis K, Beletsi A, Panagi Z, Klepetsanis P, Livaniou E, Evangelatos G, Ithakissios DS. 2003. Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticles. Int J Pharm 259:115-127.
18. Beletsi A, Leondiadis L, Klepetsanis P, Ithakissios DS, Avgoustakis K. 1999. Effect of preparative variables on the properties of PLGA-mPEG copolymers related to their applications in controlled drug delivery. Int J Pharm 182:187-197.
19. Gref R, Minamitake Y, Peracchia MT, Trubetskoy V, Torchilin V, Langer R. 1994. Biodegradable long-circulating polymeric nanosphers. Science 263:1600-1603.
20. Jeong Y, Nah JW, Lee HC, Kim SH, Cho CS. 1999. Adriamycin release from flower-type polymeric micelles based on star-block copolymer composed of poly (g-benzyl L-glutamate) as the hydrophobic part and poly(ethylene oxide) as the hydrophilic part. Int J Pharm 188:49-58.
21. Stubbs M, McSheely PMJ, Griffiths JR, Bashford CL. 2000. Causes and consequence of tumor acidity and implications for treatment. Mol Med Today 6:15-19. (Pubitemid 30010232)
22. Tannock IF, Rotin D. 1989. Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res 49:4373-4384. (Pubitemid 19208329)