Azaindenoisoquinolines as topoisomerase i inhibitors and potential anticancer agents: A systematic study of structure-activity relationships

Journal of Medicinal Chemistry

Volumn 55, Issue 4, 2012, Pages 1682-1697

  Kiselev, Evgeny ^a   Agama, Keli ^b   Pommier, Yves ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 AZA 5,6 DIHYDRO 2,3 DIMETHOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 10 AZA 5,6 DIHYDRO 2,3 DIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 10 AZA 5,6 DIHYDRO 2,3,9 TRIMETHOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE TRIFLUOROACETATE; 10 AZA 5,6 DIHYDRO 2,3,9 TRIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE TRIFLUOROACETATE; 10 AZA 5,6 DIHYDRO 6 (3 DIMETHYLAMINOPROPYL) 2,3,9 TRIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE TRIFLUOROACETATE; 10 AZA 5,6 DIHYDRO 6 [3 (4 MORPHOLINO)PROPYL] 2,3 DIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE TRIFLUOROACETATE; 10 AZA 5,6 DIHYDRO 6 [3 (4 MORPHOLINO)PROPYL] 2,3,9 TRIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE TRIFLUOROACETATE; 10 AZA 5,6 DIHYDRO 6 [3 (4 MORPHOLINO)PROPYL] 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE TRIFLUOROACETATE; 7 AZA 5,6 DIHYDRO 2,3,9 TRIMETHOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 7 AZA 5,6 DIHYDRO 2,3,9 TRIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 7 AZA 5,6 DIHYDRO 3 NITRO 9 METHOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 7 AZA 5,6 DIHYDRO 3 NITRO 9 METHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 7 AZA 5,6 DIHYDRO 6 (3 DIMETHYLAMINOPROPYL) 2,3,9 TRIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 7 AZA 5,6 DIHYDRO 6 (3 DIMETHYLAMINOPROPYL) 9 METHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 7 AZA 5,6 DIHYDRO 6 [3 (4 MORPHOLINO)PROPYL] 2,3,9 TRIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 7 AZA 5,6 DIHYDRO 6 [3 (4 MORPHOLINO)PROPYL] 9 METHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 7 AZA 5,6 DIHYDRO 9 METHOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 7 AZA 5,6 DIHYDRO 9 METHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 8 AZA 5,6 DIHYDRO 2,3 DIMETHOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 8 AZA 5,6 DIHYDRO 2,3 DIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 8 AZA 5,6 DIHYDRO 6 (3 DIMETHYLAMINOPROPYL) 2,3 DIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE TRIFLUOROACETATE; 8 AZA 5,6 DIHYDRO 6 [3 (4 MORPHOLINO)PROPYL] 2,3 DIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE TRIFLUOROACETATE; 9 AZA 5,6 DIHYDRO 2,3 DIMETHOXY 5 OXO 11H INDENO[1,2 C]ISOQUINOLINE; 9 AZA 5,6 DIHYDRO 2,3 DIMETHOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 9 AZA 5,6 DIHYDRO 6 (3 DIMETHYLAMINOPROPYL) 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE TRIFLUOROACETATE; 9 AZA 5,6 DIHYDRO 6 [3 (4 MORPHOLINO)PROPYL] 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE TRIFLUOROACETATE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; AZA COMPOUNDS; CELL LINE, TUMOR; DNA; DNA CLEAVAGE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDENES; ISOQUINOLINES; MODELS, MOLECULAR; QUANTUM THEORY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TOPOISOMERASE I INHIBITORS;

EID: 84857431452     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201512x     Document Type: Article

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